Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 16, Issue 2
1 February 2018
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover
    ABOUT THE COVER
    Confocal image of PD-L1 (green) in autophagosomes (red) in MDA-MB-231 triple-negative breast cancer cells treated with a Sigma1 modulator (IPAG). Nuclei are labeled in blue. Beginning on page 243, Maher and colleagues demonstrate that small-molecule Sigma1 modulators can be used to regulate PD-L1 in cancer cells and trigger its degradation by selective autophagy.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 1541-7786
EISSN 1557-3125

Journal Archive

Molecular Cancer Research (2002-Present; volumes 1-current)

(ISSN 0008-5472) Published monthly since November, 2002.

Cell Growth & Differentiation (1990-2002; volumes 1-13)

(ISSN 1044-9523) Published monthly 1990- September, 2002.

Table of Contents

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
Open the PDF for in another window

Cell Cycle and Senescence

Author Choice
ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1
Nikhil Tyagi; Sachin K. Deshmukh; Sanjeev K. Srivastava; Shafquat Azim; Aamir Ahmad; Ahmed AL-Ghadhban; Ajay P. Singh; James E. Carter; Bin Wang; Seema Singh
View articletitled, ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1
Supplementary data
Open the PDF for in another window

Cell Death and Survival

Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth
Junichi Maruyama; Kazutoshi Inami; Fumiyoshi Michishita; Xinliang Jiang; Hiroaki Iwasa; Kentaro Nakagawa; Mari Ishigami-Yuasa; Hiroyuki Kagechika; Norio Miyamura; Jun Hirayama; Hiroshi Nishina; Daichi Nogawa; Kouhei Yamamoto; Yutaka Hata
View articletitled, Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth
Supplementary data
Open the PDF for in another window
Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU
Yan Yan; Yulan Qing; John J. Pink; Stanton L. Gerson
View articletitled, Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU
Supplementary data
Open the PDF for in another window

DNA Damage and Repair

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors
Leslie A. Parsels; David Karnak; Joshua D. Parsels; Qiang Zhang; Jonathan Vélez-Padilla; Zachery R. Reichert; Daniel R. Wahl; Jonathan Maybaum; Mark J. O'Connor; Theodore S. Lawrence; Meredith A. Morgan
View articletitled, PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors
Supplementary data
Open the PDF for in another window
ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response
Fotis Nikolos; Christoforos Thomas; Igor Bado; Jan-Åke Gustafsson
View articletitled, ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response
Supplementary data
Open the PDF for in another window

Metabolism

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1
Christina M. Maher; Jeffrey D. Thomas; Derick A. Haas; Charles G. Longen; Halley M. Oyer; Jane Y. Tong; Felix J. Kim
View articletitled, Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1
Supplementary data
Open the PDF for in another window
Reprogramming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis
Nissar Ahmad Wani; Bo Zhang; Kun-yu Teng; Juan M. Barajas; Tasneem Motiwala; Peng Hu; Lianbo Yu; Rafael Brüschweiler; Kalpana Ghoshal; Samson T. Jacob
View articletitled, Reprogramming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis
Supplementary data
Open the PDF for in another window

Genomics

Author Choice
Precision Oncology beyond Targeted Therapy: Combining Omics Data with Machine Learning Matches the Majority of Cancer Cells to Effective Therapeutics
Michael Q. Ding; Lujia Chen; Gregory F. Cooper; Jonathan D. Young; Xinghua Lu
View articletitled, Precision Oncology beyond Targeted Therapy: Combining Omics Data with Machine Learning Matches the Majority of Cancer Cells to Effective Therapeutics
Supplementary data
Open the PDF for in another window
Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia
Sadia Afrin; Christine R.C. Zhang; Claus Meyer; Caedyn L. Stinson; Thy Pham; Timothy J.C. Bruxner; Nicola C. Venn; Toby N. Trahair; Rosemary Sutton; Rolf Marschalek; J. Lynn Fink; Andrew S. Moore
View articletitled, Targeted Next-Generation Sequencing for Detecting <em>MLL</em> Gene Fusions in Leukemia
Supplementary data
Open the PDF for in another window

Oncogenes and Tumor Suppressors

FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation
Shuiyan Zou; Cunying Ma; Fenghua Yang; Xia Xu; Jihui Jia; Zhifang Liu
View articletitled, FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation
Open the PDF for in another window
Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms
Gage Brummer; Diana S. Acevedo; Qingting Hu; Mike Portsche; Wei Bin Fang; Min Yao; Brandon Zinda; Megan Myers; Nehemiah Alvarez; Patrick Fields; Yan Hong; Fariba Behbod; Nikki Cheng
View articletitled, Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms
Supplementary data
Open the PDF for in another window
Adipose-Derived VEGF–mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women
Subhransu S. Sahoo; Janine M. Lombard; Yvette Ius; Rachel O'Sullivan; Lisa G. Wood; Pravin Nahar; Kenneth Jaaback; Pradeep S. Tanwar
View articletitled, Adipose-Derived VEGF–mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women
Supplementary data
Open the PDF for in another window

Signal Transduction

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion
Zonghui Ding; Alison Roos; Jean Kloss; Harshil Dhruv; Sen Peng; Patrick Pirrotte; Jennifer M. Eschbacher; Nhan L. Tran; Joseph C. Loftus
View articletitled, A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion
Supplementary data
Open the PDF for in another window
Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling
Emily M. Cousins; Dennis Goldfarb; Feng Yan; Jose Roques; David Darr; Gary L. Johnson; Michael B. Major
View articletitled, Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling
Supplementary data
Open the PDF for in another window
Author Choice
Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival
Diana Vara-Ciruelos; Madhumita Dandapani; Alexander Gray; Ejaife O. Egbani; A. Mark Evans; D. Grahame Hardie
View articletitled, Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca<sup>2+</sup>/CaMKK2 Signaling to Enhance Tumor Cell Survival
Supplementary data
Open the PDF for in another window

Advertisement

Email alerts

eTOC Alert
Close Modal
Breaking
E-cigarette Use Drops Dramatically among Kids
The NCI Calls for $11.446 Billion in Funding for FY 2026
Changes at the Top for Dana-Farber
View more recent articles
Latest News
Reprogramming Turns Cancer Cells into Immune Allies
With Vorasidenib, Glioma Treatment Continues Evolving
Cancer Research on The Ballot: Moonshot and the Future of Oncology Priorities
View more recent articles
Research Watch
X Chromosome Translocations Drive Sex Bias in a Rare Kidney Cancer Subtype
PIK3CA Mutations and Metabolic Conditions Drive Clonal Expansion in Normal Esophagus
Macrophages Scavenge Myelin to Support Glioblastoma Metabolism
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1557-3125
  • Print ISSN 1541-7786

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept