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1 November 2018
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Cover Image
Cover Image
ABOUT THE COVER
Retinoblastoma is a primary intraocular cancer that develops in young children. Unlike most solid tumors, invasive tissue biopsy of retinoblastoma is contraindicated for fear of extraocular tumor spread. In this issue, a study by Berry and colleagues (beginning on page 1701) demonstrates that tumor derived cell-free DNA is present in the aqueous humor, the clear fluid in front of the eye, which is safe to extract. The cover image shows histopathology from an enucleated eye. The top arrow indicates the paracentesis site (break at Bowman's layer) created by a 32-gauge needle which was used to enter the eye via the cornea to extract aqueous. The needle track was well healed, with a small break in Descemet's membrane (lower arrow) and without evidence of tumor. Somatic Copy Number Alterations from the cell-free DNA in the aqueous were correlated with clinical outcomes. The authors found that the risk of an eye failing treatment and requiring surgical removal was 10-fold greater if gain of chromosome 6p was found in the aqueous humor. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1541-7786
EISSN 1557-3125
Molecular Cancer Research
Table of Contents
Highlights
Review
Cell Cycle and Senescence
Author Choice
Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence
Rekha Jakhar; Monique N.H. Luijten; Alex X.F. Wong; Bing Cheng; Ke Guo; Suat P. Neo; Bijin Au; Madhura Kulkarni; Kah J. Lim; Jiamila Maimaiti; Han C. Chong; Elaine H. Lim; Tee B.K. Tan; Kong W. Ong; Yirong Sim; Jill S.L. Wong; James B.K. Khoo; Juliana T.S. Ho; Boon T. Chua; Indrajit Sinha; Xiaomeng Wang; John E. Connolly; Jayantha Gunaratne; Karen C. Crasta
Cell Death and Survival
Chromatin, Epigenetics and RNA Regulation
DNA Damage and Repair
Metabolism
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools
Jeffrey P. Chmielewski; Sarah C. Bowlby; Frances B. Wheeler; Lihong Shi; Guangchao Sui; Amanda L. Davis; Timothy D. Howard; Ralph B. D'Agostino, Jr; Lance D. Miller; S. Joseph Sirintrapun; Scott D. Cramer; Steven J. Kridel
Genomics
Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Jesse L. Berry; Liya Xu; Irsan Kooi; A. Linn Murphree; Rishvanth K. Prabakar; Mark Reid; Kevin Stachelek; Bao Han A. Le; Lisa Welter; Bibiana J. Reiser; Patricia Chévez-Barrios; Rima Jubran; Thomas C. Lee; Jonathan W. Kim; Peter Kuhn; David Cobrinik; James Hicks
Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Sun Young Yim; Jae-Jun Shim; Ji-Hyun Shin; Yun Seong Jeong; Sang-Hee Kang; Sang-Bae Kim; Young Gyu Eun; Dong Jin Lee; Elizabeth A. Conner; Valentina M. Factor; David D. Moore; Randy L. Johnson; Snorri S. Thorgeirsson; Ju-Seog Lee
Oncogenes and Tumor Suppressors
Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression
Priyanka Kulkarni; Pritha Dasgupta; Nadeem S. Bhat; Varahram Shahryari; Marisa Shiina; Yutaka Hashimoto; Shahana Majid; Guoren Deng; Sharanjot Saini; Z. Laura Tabatabai; Soichiro Yamamura; Yuichiro Tanaka; Rajvir Dahiya
Signal Transduction
Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis
Tarah M. Regan Anderson; Shihong Ma; Carlos Perez Kerkvliet; Yan Peng; Taylor M. Helle; Raisa I. Krutilina; Ganesh V. Raj; John A. Cidlowski; Julie H. Ostrander; Kathryn L. Schwertfeger; Tiffany N. Seagroves; Carol A. Lange
Tumor Microenvironment and Immunobiology
Letters to the Editor
Correction
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
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