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1 May 2017
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ABOUT THE COVER
In this issue, Kaymaz and colleagues (beginning on page 563) investigate transcriptome expression and mutational profiles of patient-derived endemic Burkitt lymphoma (BL) tumors using RNA sequencing. The cover image shows the unsupervised hierarchical clustering heatmap of BL tumors based on their expression profiles of the most variant genes. While 2 sporadic BLs separate out from 28 endemic BLs, eBL tumor expression profiles demonstrate greater correlation within eBLs compared with sBLs. Transcriptome-wide gene expression correlations between eBLs did not reveal significant groupings suggesting that eBL tumors are relatively homogenous with no major underlying molecular phenotypes. Based on further analysis, the study reveals subtler differences in terms of gene expression as well as the pattern of somatic mutations that correlates EBV presence and EBV type in the tumor B cells. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1541-7786
EISSN 1557-3125
Molecular Cancer Research
Table of Contents
Highlights
Minireview
Cell Cycle and Senescence
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Christopher J. Pirozzi; Austin B. Carpenter; Matthew S. Waitkus; Catherine Y. Wang; Huishan Zhu; Landon J. Hansen; Lee H. Chen; Paula K. Greer; Jie Feng; Yu Wang; Cheryl B. Bock; Ping Fan; Ivan Spasojevic; Roger E. McLendon; Darell D. Bigner; Yiping He; Hai Yan
Cell Death and Survival
Chromatin, Epigenetics, and RNA Regulation
Author Choice
Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma
Eva Schulze Heuling; Felix Knab; Josefine Radke; Eskil Eskilsson; Emmanuel Martinez-Ledesma; Arend Koch; Marcus Czabanka; Christoph Dieterich; Roel G. Verhaak; Christoph Harms; Philipp Euskirchen
Genomics
Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Maria Antonella Laginestra; Claudio Tripodo; Claudio Agostinelli; Giovanna Motta; Sylvia Hartmann; Claudia Döring; Maura Rossi; Federica Melle; Maria Rosaria Sapienza; Valentina Tabanelli; Alessandro Pileri; Fabio Fuligni; Anna Gazzola; Claudia Mannu; Carlo Alberto Sagramoso; Silvia Lonardi; Luisa Lorenzi; Francesco Bacci; Elena Sabattini; Anita Borges; Ingrid Simonitsch-Klupp; Jose Cabecadas; Elias Campo; Juan Rosai; Martin-Leo Hansmann; Fabio Facchetti; Stefano Aldo Pileri
Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST
Maria A. Pantaleo; Milena Urbini; Valentina Indio; Gloria Ravegnini; Margherita Nannini; Matilde De Luca; Giuseppe Tarantino; Sabrina Angelini; Alessandro Gronchi; Bruno Vincenzi; Giovanni Grignani; Chiara Colombo; Elena Fumagalli; Lidia Gatto; Maristella Saponara; Manuela Ianni; Paola Paterini; Donatella Santini; M. Giulia Pirini; Claudio Ceccarelli; Annalisa Altimari; Elisa Gruppioni; Salvatore L. Renne; Paola Collini; Silvia Stacchiotti; Giovanni Brandi; Paolo G. Casali; Antonio D. Pinna; Annalisa Astolfi; Guido Biasco
Metabolism
Oncogenes and Tumor Suppressors
Signal Transduction
Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects
Haiming Chen; Mingjie Li; Eric Sanchez; Cathy S. Wang; Tiffany Lee; Camilia M. Soof; Christian E. Casas; Jasmin Cao; Colin Xie; Kyle A. Udd; Kevin DeCorso; George Y. Tang; Tanya M. Spektor; James R. Berenson
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
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