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1 November 2017
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ABOUT THE COVERClose Modal
The cover image depicts chromosomal copy alterations detected by next generation sequencing in olfactory neuroblastomas—rare, highly aggressive tumors of the sinonasal cavity. In this issue, Lazo de la Vega and colleagues (beginning on page 1551) demonstrate that olfactory neuroblastomas are characterized by recurrent chromosomal numerical alterations, including amplifications of the potential oncogenic driver FGFR3 in a subset. The finding suggests that FGFR3 may be a rational therapeutic target in olfactory neuroblastoma. - PDF Icon PDF LinkTable of Contents
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ISSN 1541-7786
EISSN 1557-3125
Highlights
Cell Death and Survival
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Georg Emons; Melanie Spitzner; Sebastian Reineke; Janneke Möller; Noam Auslander; Frank Kramer; Yue Hu; Tim Beissbarth; Hendrik A. Wolff; Margret Rave-Fränk; Elisabeth Heßmann; Jochen Gaedcke; B. Michael Ghadimi; Steven A. Johnsen; Thomas Ried; Marian Grade
Chromatin, Epigenetics, and RNA Regulation
Author Choice
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression
Muralidharan Anbalagan; Mei Sheng; Brian Fleischer; Yifang Zhang; Yuanjun Gao; Van Hoang; Margarite Matossian; Hope E. Burks; Matthew E. Burow; Bridgette M. Collins-Burow; David Hangauer; Brian G. Rowan
DNA Damage and Repair
EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Mohammad Saki; Haruhiko Makino; Prashanthi Javvadi; Nozomi Tomimatsu; Liang-Hao Ding; Jennifer E. Clark; Elaine Gavin; Kenichi Takeda; Joel Andrews; Debabrata Saha; Michael D. Story; Sandeep Burma; Chaitanya S. Nirodi
Metabolism
CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats
Aida I. Sacaan; Stephane Thibault; Miyoun Hong; Nagesha G. Kondegowda; Tim Nichols; Rosemary Li; Carolina Rosselot; Winston Evering; Rafael Fenutria; Allison Vitsky; Thomas Brown; Martin Finkelstein; Adolfo Garcia-Ocaña; Nasir Khan; Andrew F. Stewart; Rupangi C. Vasavada
Genomics
Comprehensive Molecular Profiling of Olfactory Neuroblastoma Identifies Potentially Targetable FGFR3 Amplifications
Lorena Lazo de la Vega; Jonathan B. McHugh; Andi K. Cani; Komal Kunder; Frances M. Walocko; Chia-Jen Liu; Daniel H. Hovelson; Dan Robinson; Arul M. Chinnaiyan; Scott A. Tomlins; Paul W. Harms
Author Choice
Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing
Jesper L.V. Maag; Oliver M. Fisher; Angelique Levert-Mignon; Dominik C. Kaczorowski; Melissa L. Thomas; Damian J. Hussey; David I. Watson; Antony Wettstein; Yuri V. Bobryshev; Melanie Edwards; Marcel E. Dinger; Reginald V. Lord
Oncogenes and Tumor Suppressors
Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity
Corina N.A.M. van den Heuvel; Anna C. Navis; Tessa de Bitter; Houshang Amiri; Kiek Verrijp; Arend Heerschap; Karen Rex; Isabelle Dussault; Sean Caenepeel; Angela Coxon; Paul N. Span; Pieter Wesseling; Wiljan Hendriks; William P.J. Leenders
Signal Transduction
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