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1 September 2015
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Cover Image
Cover Image
The 1.1 Å x-ray crystal structure of oncogenic KRAS G13D, reported by Hunter and colleagues (p.1325), reveals a destabilizing interaction between the aspartate side-chain and GDP. The calculated electrostatic potential surface map highlights the negative charge (red) introduced by the aspartate, which disrupts the normally positively charged (blue) nucleotide binding pocket and repels adjacent negatively charged phosphates in GDP, explaining the enhanced rate of nucleotide exchange observed for this mutant. - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Molecular Cancer Research
Table of Contents
Highlights
Review
Cell Death and Survival
DNA Damage and Repair
Genomics
Oncogenes and Tumor Suppressors
Signal Transduction
Journal Archive
Molecular Cancer Research
(2002-Present; volumes 1-current)Published monthly since November, 2002.
(ISSN 0008-5472)
Cell Growth & Differentiation
(1990-2002; volumes 1-13)Published monthly 1990- September, 2002.
(ISSN 1044-9523)
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