The cover image shows a comprehensive look at four immunohistochemical markers of PI3K activation in prostate cancer. Martin and colleagues sought to define a combined “score” of activation according to PTEN, pAKT, pS6 and stathmin staining. Here the authors show individual tumors ranked according to this four-marker score as well as how this relates to clinical and pathologic features including Ki67, TUNEL, age at diagnosis, lethal outcome, and Gleason score. Please see the article by Martin and colleagues (beginning on page 1431) for more information.