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1 March 2014
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Cover Image
Cover Image
The cover image shows immunofluorescence staining of normal breast tissue obtained from surgical specimens. The staining was performed with anti-Afadin (red channel), anti–E-cadherin (green channel), and DAPI (blue channel). The staining pattern reveals Afadin staining that is largely membrane restricted and excluded from nuclei. By contrast, in surgical specimens obtained from invasive breast carcinoma, Afadin shows a predominately nuclear expression pattern with near complete loss of membrane localization. For more information, see the article by Elloul and colleagues, beginning on page 464 in this issue. In this study, the authors conclude that nuclear translocation of Afadin, mediated by the PI3K and Akt pathway, is associated with enhanced breast cancer cell migration and in turn, tumor progression.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1541-7786
EISSN 1557-3125
Highlights
Review
Cell Cycle and Senescence
Cell Death and Survival
Chromatin, Gene, and RNA Regulation
DNA Damage and Repair
Genomics
NF-κB Activation-Induced Anti-apoptosis Renders HER2-Positive Cells Drug Resistant and Accelerates Tumor Growth
Shannon T. Bailey; Penelope L. Miron; Yoon J. Choi; Bose Kochupurakkal; Gautam Maulik; Scott. J. Rodig; Ruiyang Tian; Kathleen M. Foley; Teresa Bowman; Alexander Miron; Myles Brown; J. Dirk. Iglehart; Debajit K. Biswas
Oncogenes and Tumor Suppressors
Signal Transduction
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