Deregulation of cellular energetics and changes in cell metabolism are hallmarks of cancer cells. For decades, the prevailing hypotheses in this field revolved around the Warburg Effect and its influence on macromolecule, carbon, and redox balance. More recently, paradigm-shifting observations have expanded the field in new and exciting directions. This collection highlights groundbreaking work published in Molecular Cancer Research, which continues to pursue these novel trajectories and hypotheses. On behalf of our Editors, we present this collection in the hopes that it will stimulate innovative and thought-provoking ideas, and that it will serve as a symbol of the Journal's ongoing commitment to communicate these exciting new findings to the research community.