Ovarian cancer is a major health concern for women as it is prominent among gynecologic cancers. Trichodermin is a sesquiterpene isolated from Nalanthamala psidii and found to induce apoptosis in human chondrosarcoma cells. In this study, A2780/CP70 and OVCAR-3 ovarian cancer cell lines were treated with trichodermin to determine whether it had an anti-cancer effect. Our data presented that trichodermin reduced the viability of both ovarian cancer cells by inducing G1/S cell cycle arrest rather than apoptosis. The underlying mechanism might be that trichodermin down-regulated the expression of Cyclin D1 via inhibiting AhR and c-Myc expression. Therefore, trichodermin is promising in ovarian cancer treatment.

Citation Format: Yi C. Chen, Ying Gao. Trichodermin induces G1/S cell cycle arrest in ovarian cancer cells. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr A01.

©2016 American Association for Cancer Research.
2016
American Association for Cancer Research.