Epigenetic events like methylation are critically important to normal tissue homeostasis. As such, epigenetic changes often occur during tumorigenesis. Jumonji domain-containing protein 3 (JMJD3) demethylates tri- and dimethylated histone H3 at lysine 27 (H3K27) and is central in controlling the chromatin state as well as numerous biologic programs such as cellular senescence. Here, Perrigue and colleagues assessed the status of JMJD3 in the context of glioma and found intrinsic differences that reflected both phenotypes and variations associated with senescence. Mechanistic study demonstrated that JMJD3 activated the senescence-associated secretory phenotype (SASP) and, based on RNA-seq analysis, regulated cancer-related and inflammatory-related transcripts. Combined, the epigenetic reprogramming and secretory phenotype induced by JMJD3 may stimulate homing of nearby cells in the tumor microenvironment to the tumor.

Little is known about the molecular drivers of phyllodes tumors, which are rare stromal breast tumors with malignant potential. In the current Rapid Impact article, Cani and...

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