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Epidemiology and Prevention

Population-level studies that investigate the genetic and environmental risk factors of cancer and their application in disease prevention and interception

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Latest in Epidemiology and Prevention

April 08 2022

A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Xiaoliang Wang, Hongjie Chen et al.

Genome-wide association studies (GWAS) have identified more than 200 susceptibility loci for breast cancer, but these variants explain less than a fifth of the disease risk. Although gene–environment interactions have been proposed to account for some of the remaining heritability, few studies have empirically assessed ...

March 31 2022

Serum Carotenoids and Cancer-Related Fatigue: An Analysis of the 2005–2006 National Health and Nutrition Examination Survey

Amber S. Kleckner, Edwin van Wijngaarden et al.

Cancer-related fatigue is a prevalent, debilitating condition, and preliminary evidence suggests a relationship between higher diet quality and lower fatigue. Serum-based carotenoids, Vitamin A, and Vitamin E are biomarkers of fruit and vegetable intake and therefore diet quality. To further elucidate the link between ...

February 17 2022

Race-associated Molecular Changes in Gynecologic Malignancies

Amma Asare, Hui Yao et al.

The difference in cancer morbidity and mortality between individuals of different racial groups is complex. Health disparities provide a framework to explore potential connections between poor outcomes and individuals of different racial backgrounds. This study identifies genomic changes in African American patients with ...

January 27 2022

Affordable Prices Without Threatening the Oncological R&D Pipeline—An Economic Experiment on Transparency in Price Negotiations

Nora Franzen, Andreas Ziegler et al.

The high prices of innovative medicines endanger access to care worldwide. Sustainable prices need to be affordable while sufficiently incentivizing research and development (R&D) investments. A proposed solution is increased transparency. Proponents argue that price and R&D cost confidentiality are drivers of ...

January 11 2022

A Randomized Clinical Trial of Precision Prevention Materials Incorporating MC1R Genetic Risk to Improve Skin Cancer Prevention Activities Among Hispanics

John Charles A. Lacson, Scarlet H. Doyle et al.

Skin cancer incidence is increasing among Hispanics, who experience worse outcomes than non-Hispanic Whites. Precision prevention incorporating genetic testing for (melanocortin-1 receptor) MC1R, a skin cancer susceptibility marker, may improve prevention behavior.

December 08 2021

Influence of Germline BRCA Genotype on the Survival of Patients with Triple-Negative Breast Cancer

Cynthia Villarreal-Garza, Ana S. Ferrigno et al.

The presence of BRCA pathogenic variants (PV) in triple-negative breast cancer (TNBC) is associated with a distinctive genomic profile that makes the tumor particularly susceptible to DNA-damaging treatments. However, patients with BRCA PVs can develop treatment resistance through the appearance of reversion mutations and ...

October 13 2021

Comprehensive Immunoprofiling of High-Risk Oral Proliferative and Localized Leukoplakia

Glenn J. Hanna, Alessandro Villa et al.

Oral leukoplakia is common and may, in some cases, progress to carcinoma. Proliferative leukoplakia is a progressive, often multifocal subtype with a high rate of malignant transformation compared with the more common localized leukoplakia. We hypothesized that the immune microenvironment and gene expression patterns ...

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Topics in Epidemiology and Prevention

Expand/Collapse Section ENDOGENOUS RISK FACTORS
- Gene polymorphisms
- Obesity
- Hormonal
- Reproductive
- Inflammation
- Epigenetics
Expand/Collapse Section ENVIRONMENTAL RISK FACTORS
- Radiation exposure
- Carcinogen exposure
- Viral infection
- Microbiome
Expand/Collapse Section LIFESTYLE RISK FACTORS
- Tobacco use
- Electronic cigarettes
- Alcohol
- Diet
Expand/Collapse Section DESCRIPTIVE STUDIES
- Behavioral epidemiology
- Cancer Disparities
- Occupational epidemiology
Expand/Collapse Section EPIDEMIOLOGY
Expand/Collapse Section GENETICS OF CANCER RISK & OUTCOME
- Carcinogen metabolism polymorphisms
- Cell growth and development polymorphisms
- Immune response polymorphisms
- Familial and hereditary cancers
Expand/Collapse Section METHODOLOGY AND MODELING
Expand/Collapse Section CANCER PREVENTION
- In vitro models in prevention
- Animal models of prevention
- Clinical prevention studies
- Biological mechanisms in prevention
- Cancer risk assessment
- Identification of new risk factors
- Early detection
- Personalized cancer prevention
- Pre-neoplasia
Expand/Collapse Section CANCER INTERCEPTION
- Biomarkers and intervention
- Cancer surveillance and screening
- Chemoprevention
- Immunoprevention

Epidemiology and Prevention

Tweets by @CRC_AACR

Tweets by @CRC_AACR

Topics in Epidemiology and Prevention

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