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Epidemiology and Prevention

Population-level studies that investigate the genetic and environmental risk factors of cancer and their application in disease prevention and interception

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Latest in Epidemiology and Prevention

March 18 2025

A Blood-based Assay for Detection of Patients with Advanced Adenomas

Kamel Lahouel, Christopher Douville et al.

March 11 2025

Age and sex differences in the prevalence of specific comorbidities among pediatric acute lymphoblastic leukemia and lymphoblastic lymphoma patients at diagnosis

Xin Yang, Maua Mosha et al.

February 26 2025

Analysis of Urban Indian Organizations’ Promotion of Cancer Services

William O. Carson, Alyssa Little et al.

The burden of cancer remains elevated for American Indians/Alaska Natives (AI/AN) in the United States, particularly in urban communities. Urban Indian Organizations (UIO) are a part of the Indian healthcare system for urban AI/AN populations to receive culturally competent care; therefore, it is important that UIOs ...

February 13 2025

Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer

Rachel A. Francis, Sean Tavtigian et al.

The increasing burden of colorectal cancer among adults younger than age 50 years (early-onset colorectal cancer) and new National Comprehensive Cancer Network guidelines recommending universal genetic testing in early-onset colorectal cancer emphasize the need for accurate and timely variant classification in clinical ...

February 10 2025

Real-World Incidence of Anaplastic Lymphoma Kinase Alterations in Hispanics with Non–Small Cell Lung Cancer at a Large Academic Institution in Los Angeles

Darin Poei, Sana Ali et al.

Race and ethnicity affect the distribution of molecular alterations seen in patients with non–small cell lung cancer (NSCLC). Although anaplastic lymphoma kinase (ALK) alterations are known to occur in 4% to 5% of the population, data specific to the Hispanic population remain limited. This study describes the real-world ...

February 07 2025

Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium

Magda J. Vandeloo, Eliane Kellen et al.

This study evaluated the association between age at first full-term pregnancy (FFTP) and mammographic breast density (MBD) in postmenopausal women. A total of 1,034 women, ages 50 to 69 years, were recruited from the Flemish (Belgium) population–based breast cancer screening program. Participants completed a questionnaire ...

January 30 2025

Evaluating Ovarian Cancer Risk–Reducing Salpingectomy Acceptance: A Survey

Alexandra Lukey, Ramlogan Sowamber et al.

With evidence that salpingectomy is effective in preventing high-grade serous carcinoma, it is time to consider offering this procedure to people at higher-than-average lifetime risk for ovarian cancer, despite not having a pathogenic genetic variant that increases the risk for ovarian cancer. This targeted approach has ...

January 22 2025

Molecular Differences in Pancreatic Ductal Adenocarcinomas from Black versus White Patients

Saurabh Mandal, Emily A. Teslow et al.

Pancreatic cancer is the third leading cause of cancer-related death in the United States. Black or African American patients have a higher incidence of pancreatic cancer compared with other racial groups. It is unclear whether distinct molecular mechanisms are involved in the development of pancreatic cancer in different ...

November 21 2024

The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study

Takeshi Watanabe, Tien Van Nguyen et al.

The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects ...

June 27 2024

Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study

Nijole P. Tjader, Abigail J. Beer et al.

In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. Emerging data suggest tumor mutation status is associated with germline variants and genetic ancestry. We aimed to identify germline variants that are associated with somatic TP53 or PIK3CA mutation status in breast ...

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Topics in Epidemiology and Prevention

Expand/Collapse Section ENDOGENOUS RISK FACTORS
- Gene polymorphisms
- Obesity
- Hormonal
- Reproductive
- Inflammation
- Epigenetics
Expand/Collapse Section ENVIRONMENTAL RISK FACTORS
- Radiation exposure
- Carcinogen exposure
- Viral infection
- Microbiome
Expand/Collapse Section LIFESTYLE RISK FACTORS
- Tobacco use
- Electronic cigarettes
- Alcohol
- Diet
Expand/Collapse Section DESCRIPTIVE STUDIES
- Behavioral epidemiology
- Cancer Disparities
- Occupational epidemiology
Expand/Collapse Section EPIDEMIOLOGY
Expand/Collapse Section GENETICS OF CANCER RISK & OUTCOME
- Carcinogen metabolism polymorphisms
- Cell growth and development polymorphisms
- Immune response polymorphisms
- Familial and hereditary cancers
Expand/Collapse Section METHODOLOGY AND MODELING
Expand/Collapse Section CANCER PREVENTION
- In vitro models in prevention
- Animal models of prevention
- Clinical prevention studies
- Biological mechanisms in prevention
- Cancer risk assessment
- Identification of new risk factors
- Early detection
- Personalized cancer prevention
- Pre-neoplasia
Expand/Collapse Section CANCER INTERCEPTION
- Biomarkers and intervention
- Cancer surveillance and screening
- Chemoprevention
- Immunoprevention

Epidemiology and Prevention

Topics in Epidemiology and Prevention

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