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Clinical Research and Trials

Studies involving patients that investigate the efficacy of novel screening strategies, therapeutics, combinations, or regimens in the setting of clinical investigation

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Latest in Clinical Research and Trials

January 14 2025

Real-World Incidence of Anaplastic Lymphoma Kinase alterations in Hispanics with Non-Small Cell Lung Cancer at a Large Academic Institution in Los Angeles

Darin Poei, Sana Ali et al.

Race and ethnicity affect the distribution of molecular alterations seen in patients with non-small cell lung cancer (NSCLC). While anaplastic lymphoma kinase (ALK) alterations are known to occur in 4-5% of the population, data specific to the Hispanic population remains limited. This study describes the real-world ...

January 13 2025

Ternary complex components responsible for rapid LDL internalization as biomarkers for breast cancer associated with proliferation and early recurrence.

Elizabeth S McDonald, Tien-Chi Pan et al.

December 11 2024

Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma

Todd Shearer, Melissa Comstock et al.

B-cell maturation antigen (BCMA) is the target of several investigational and approved drugs for multiple myeloma. BCMA expressed on plasma cells (PC) and multiple myeloma cells is cleaved by the enzyme γ-secretase, reducing membrane-bound BCMA (mbBCMA) receptor density. γ-Secretase inhibitors (GSI) have been shown to ...

December 09 2024

First-in-human study of 23ME-00610, an antagonistic antibody for genetically validated CD200R1 immune checkpoint, in participants with advanced solid malignancies

Shivaani Kummar, Albiruni Abdul Razak et al.

December 05 2024

Potential synergistic effect between niraparib and statins in ovarian cancer clinical trials

Hailei Zhang, Anna Rutkowska et al.

This study investigates the potential clinical synergy between the poly(adenosine 5'-diphosphate [ADP]-ribose) polymerase (PARP) inhibitor niraparib (Zejula®) and concomitant statins, exploring their combined effects on progression-free survival (PFS) in ovarian cancer patients. We retrospectively analysed niraparib ...

November 14 2024

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

Maxim Kuznetsov, Vikram Adhikarla et al.

Targeted radionuclide therapy (TRT) is based on injections of cancer-specific molecules conjugated with radioactive nuclides. Despite the specificity of this treatment, it is not devoid of side effects limiting its use and is especially harmful for rapidly proliferating organs well perfused by blood, like bone marrow. ...

June 28 2024

First-line Avelumab plus Chemotherapy in Patients with Advanced Solid Tumors: Results from the Phase Ib/II JAVELIN Chemotherapy Medley Study

Duncan A. Wheatley, Rossana Berardi et al.

Chemotherapy can potentially enhance the activity of immune checkpoint inhibitors by promoting immune priming. The phase Ib/II JAVELIN Chemotherapy Medley trial (NCT03317496) evaluated first-line avelumab + concurrent chemotherapy in patients with advanced urothelial carcinoma or non–small cell lung cancer (NSCLC).

June 25 2024

Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1

Ling He, Angeliki Ioannidis et al.

Glioblastoma (GBM) is the deadliest adult brain cancer. Under the current standard of care, almost all patients succumb to the disease and novel treatments are urgently needed. Recognizing that GBMs are addicted to cholesterol, past clinical trials have repurposed statins against GBM but failed. The purpose of this study ...

June 10 2024

Multi-omics Analysis of a Fecal Microbiota Transplantation Trial Identifies Novel Aspects of Acute GVHD Pathogenesis

Armin Rashidi, Maryam Ebadi et al.

Acute GVHD (aGVHD) is a major complication of allogeneic hematopoietic cell transplantation (alloHCT) associated with gut microbiota disruptions. However, whether therapeutic microbiota modulation prevents aGVHD is unknown. We conducted a randomized, placebo-controlled trial of third-party fecal microbiota transplantation ...

May 29 2024

Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Nicholas J. Hornstein, Mohammad A. Zeineddine et al.

Appendiceal adenocarcinoma (AA) remains an orphan disease with limited treatment options for patients unable to undergo surgical resection. Evidence supporting the efficacy of combined VEGF and PD-1 inhibition in other tumor types provided a compelling rationale for investigating this combination in AA, where immune ...

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Topics in Clinical Research and Trials

Expand/Collapse Section CLINICAL IMAGING
Expand/Collapse Section TUMOR STAGING
Expand/Collapse Section RADIATION ONCOLOGY
- Experimental radiotherapeutics
- Clinical radiotherapeutic studies
- Combined modality therapies
- Modification of radiation sensitivity
- Radiation-induced late effects
- Radiation resistance
- Radioprotectors and radiosensitizers
- Molecular targets of radiation response
- Normal tissue response to radiation
- Photobiology/photodynamic therapy
Expand/Collapse Section SURGICAL ONCOLOGY
Expand/Collapse Section CLINICAL-STAGE RESEARCH
Expand/Collapse Section CLINICAL TRIAL OPERATIONS
- Clinical trial design
- Clinical trial specimen handling
- Community engagement
- Patient navigation, recruitment & retention
- Analysis in clinical trials
- Statistical modeling in clinical trials
Expand/Collapse Section CLINICAL TRIAL RESULTS
- Phase I clinical trials
- Phase II clinical trials
- Phase III clinical trials
- Clinical trials in pediatric cancer
- Clinical trials in the elderly
- Clinical trials in minorities & underserved populations

Clinical Research and Trials

Topics in Clinical Research and Trials

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