Metabolism and Cancer Collection

The AACR editors are proud to present this selection of impactful journal articles focusing on metabolism and cancer, published from across the AACR journal portfolio.

• A2AR Antagonism with CPI-444 Induces Anti-Tumor Responses and Augments Efficacy to Anti-PD-L1 and Anti-CTLA-4 in Preclinical Models
  Willingham SB…Miller RA Cancer Immunology Research Online First August 2018.
• Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins
  Zhang M…White RM Cancer Discovery August 2018.
• Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway
  Lee HJ…Cheng JX Molecular Cancer Research June 2018.
• Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo
  Mycielska ME…Geissler EK Cancer Research May 2018.
• GITR agonism enhances cellular metabolism to support CD8⁺ T cell proliferation and effector cytokine production in a mouse tumor model
  Sabharwal SS…Zuniga LA Cancer Immunology Research Online First August 2018.
• High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
  Avanzato D…Lanzetti L Cancer Research July 2018.
• Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells
  Rodrigues NV…Dias S Cancer Immunology Research April 2018.
• Metabolic Imaging of the Human Brain with Hyperpolarized ¹³C Pyruvate Demonstrates ¹³C Lactate Production in Brain Tumor Patients
  Miloushev VZ…Keshari KR Cancer Research July 2018.
• PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8⁺ T cells and facilitates anti-PD-1 therapy
  Chowdhury PS…Honjo T Cancer Immunology Research Online First August 2018.
• Prediction of Chemotherapeutic Efficacy in Non–Small Cell Lung Cancer by Serum Metabolomic Profiling
  Tian Y…Wang J Clinical Cancer Research May 2018.
• PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells
  Kim SM…Edinger AL Cancer Discovery July 2018.
• Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma
  Kesarwani P…Chinnaiyan P Clinical Cancer Research August 2018.