2021
AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
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:: 2021 Picks :: 2020 Picks
April
Blood Cancer Discovery
A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase–Deficient Cells in Myeloid Neoplasms
Cancer Discov April 2021
Cancer Discovery
Special April Issue!
Cancer Discov April 2021
Cancer Epidemiology, Biomarkers & Prevention
Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation
Cancer Epidemiol Bio Prev April 2021
Cancer Immunology Research
Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect
Cancer Immunol Res April 2021
Cancer Prevention Research
Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers
Cancer Prev Res April 2021
Cancer Research
Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation
Cancer Res April 2021
Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Cancer Res April 2021
Clinical Cancer Research
Preclinical Evaluation and Phase Ib Study of Prexasertib, a CHK1 Inhibitor, and Samotolisib (LY3023414), a Dual PI3K/mTOR Inhibitor
Clin Cancer Res April 2021
Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
Clin Cancer Res April 2021
Molecular Cancer Research
Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System
Mol Cancer Res April 2021
Molecular Cancer Therapeutics
F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd
Mol Cancer Ther April 2021
March
Blood Cancer Discovery
Recommendations on Eliminating Racial Disparities in Multiple Myeloma Therapies: A Step toward Achieving Equity in Healthcare
Cancer Discov March 2021
Cancer Discovery
Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations
Cancer Discov March 2021
Cancer Epidemiology, Biomarkers & Prevention
Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
Cancer Epidemiol Bio Prev March 2021
Cancer Immunology Research
Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin
Cancer Immunol Res March 2021
Cancer Prevention Research
An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
Cancer Prev Res March 2021
Cancer Research
Replication Gaps Underlie BRCA Deficiency and Therapy Response
Cancer Res March 2021
EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Cancer Res March 2021
Clinical Cancer Research
Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors
Clin Cancer Res March 2021
Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903)
Clin Cancer Res March 2021
Molecular Cancer Research
Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Mol Cancer Res March 2021
Molecular Cancer Therapeutics
Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor
Mol Cancer Ther March 2021
February
Blood Cancer Discovery
Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Cancer Discov February 2021
Cancer Discovery
Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Cancer Discov February 2021
Cancer Epidemiology, Biomarkers & Prevention
Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Cancer Epidemiol Bio Prev February 2021
Cancer Immunology Research
Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Cancer Immunol Res February 2021
Cancer Prevention Research
The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital
Cancer Prev Res February 2021
Cancer Research
Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Cancer Res February 2021
Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Cancer Res February 2021
Clinical Cancer Research
Phase II Study of Avelumab in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib
Clin Cancer Res February 2021
Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
Clin Cancer Res February 2021
Molecular Cancer Research
Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
Mol Cancer Res February 2021
Molecular Cancer Therapeutics
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Mol Cancer Ther February 2021
January
Blood Cancer Discovery
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Blood Cancer Discov January 2021
Cancer Discovery
Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Cancer Discov January 2021
Cancer Epidemiology, Biomarkers & Prevention
Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study
Cancer Epidemiol Bio Prev January 2021
Cancer Immunology Research
The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Cancer Immunol Res January 2021
Cancer Prevention Research
Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Cancer Prev Res January 2021
Cancer Research
The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Cancer Res January 2021
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Cancer Res January 2021
Clinical Cancer Research
Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
Clin Cancer Res January 2021
A Phase Ib Study of Alpelisib or Buparlisib Combined with Tamoxifen Plus Goserelin in Premenopausal Women with HR-Positive HER2-Negative Advanced Breast Cancer
Clin Cancer Res January 2021
Molecular Cancer Research
Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Mol Cancer Res January 2021
Molecular Cancer Therapeutics
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Mol Cancer Ther January 2021
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