AACR Journals Editors' picks

Cancer Discovery

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Peiwen Chen et al.
Cancer Discov March 2020

Cancer Epidemiology, Biomarkers & Prevention

Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study
Yu-Wen Chien et al.
Cancer Epidemiol Bio Prev March 2020

Cancer Immunology Research

B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
Bhalchandra Mirlekar et al.
Cancer Immunol Res March 2020

Cancer Prevention Research

Combination of Erlotinib and Naproxen Employing Pulsatile or Intermittent Dosing Profoundly Inhibits Urinary Bladder Cancers
Altaf Mohammed et al.
Cancer Prev Res March 2020

Cancer Research

Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Marwa Asem et al.
Cancer Res March 2020

Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Bedrich L. Eckhardt et al.
Cancer Res March 2020

Clinical Cancer Research

A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
Paul G. Corn et al.
Clin Cancer Res March 2020

Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
Kristina A. Cole et al.
Clin Cancer Res March 2020

Molecular Cancer Research

PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression
Shumei Song et al.
Mol Cancer Res March 2020

Molecular Cancer Therapeutics

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas
Long-Sheng Chang et al.
Mol Cancer Ther March 2020

Cancer Discovery

Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Thomas L. Clarke et al.
Cancer Discov February 2020

Cancer Epidemiology, Biomarkers & Prevention

Medical Financial Hardship Intensity and Financial Sacrifice Associated with Cancer in the United States
Xuesong Han et al.
Cancer Epidemiol Bio Prev February 2020

Cancer Immunology Research

Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
Michael Kvorjak et al.
Cancer Immunol Res February 2020

Cancer Prevention Research

Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model
Venkateshwar Madka et al.
Cancer Prev Res February 2020

Cancer Research

Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes
Robert S. Oakes et al.
Cancer Res February 2020

A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition
Philip Kitchen et al.
Cancer Res February 2020

Clinical Cancer Research

Everolimus and Octreotide for Patients with Recurrent Meningioma: Results from the Phase II CEVOREM Trial
Thomas Graillon et al.
Clin Cancer Res February 2020

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma
Kevin D. Courtney et al.
Clin Cancer Res February 2020

Molecular Cancer Research

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer
Samuel A. Miller et al.
Mol Cancer Res February 2020

Molecular Cancer Therapeutics

10D1F, an Anti-HER3 Antibody That Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models
Dipti Thakkar et al.
Mol Cancer Ther February 2020

Cancer Discovery

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Yun-Han Huang et al.
Cancer Discov January 2020

Cancer Epidemiology, Biomarkers & Prevention

Comparative Effectiveness of Two Interventions to Increase Colorectal Cancer Screening for Those at Increased Risk Based on Family History: Results of a Randomized Trial
Electra D. Paskett et al.
Cancer Epidemiol Bio Prev January 2020

Cancer Immunology Research

Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers
Delia Hoffmann et al.
Cancer Immunol Res January 2020

Cancer Prevention Research

Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype–like Cluster
Yanfei Chen et al.
Cancer Prev Res January 2020

Cancer Research

Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Joseph Chen et al.
Cancer Res January 2020

Twist1-induced epithelial dissemination requires Prkd1 signaling
Dan Georgess et al.
Cancer Res January 2020

Clinical Cancer Research

Clinical Assessment of 5-Fluorouracil/Leucovorin, Nab-Paclitaxel, and Irinotecan (FOLFIRABRAX) in Untreated Patients with Gastrointestinal Cancer Using UGT1A1 Genotype–Guided Dosing
Smita S. Joshi et al.
Clin Cancer Res January 2020

A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma
Irene M. Ghobrial et al.
Clin Cancer Res January 2020

Molecular Cancer Research

Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition
Ryan A. Denu et al.
Mol Cancer Res January 2020

Molecular Cancer Therapeutics

A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
Limin Zhang et al.
Mol Cancer Ther January 2020