AACR Journals Editors' picks

Blood Cancer Discovery

A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors
David J. Young et al.
Blood Cancer Discovery October 2021

Cancer Discovery

Discovery and Features of an Alkylating Signature in Colorectal Cancer
Carino Gurjao et al.
Cancer Discov October 2021

Cancer Epidemiology, Biomarkers & Prevention

Hereditary and Inflammatory Bowel Disease-Related Early Onset Colorectal Cancer Have Unique Characteristics and Clinical Course Compared with Sporadic Disease
Arif A. Arif et al.
Cancer Epidemiol Bio Prev October 2021

Cancer Immunology Research

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Momeneh Foroutan et al.
Cancer Immunol Res October 2021

Cancer Prevention Research

Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model
Jill P. Smith et al.
Cancer Prev Res October 2021

Cancer Research

The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Hidenari Hirata et al.
Cancer Res October 2021

Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset
Danielle N. Huggins et al.
Cancer Res October 2021

Clinical Cancer Research

Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
Timothy A. Yap et al.
Clin Cancer Res October 2021

Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5–13/TESARO PR-30–50–10-C BRAVO Study
Nicholas C. Turner et al.
Clin Cancer Res October 2021

Molecular Cancer Research

Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow
Brian S. Canter et al.
Mol Cancer Res October 2021

Molecular Cancer Therapeutics

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
Joanne M. Munck et al.
Mol Cancer Ther October 2021

Blood Cancer Discovery

Predictors of Humoral Response to SARS-CoV-2 Vaccination after Hematopoietic Cell Transplantation and CAR T Cell Therapy
Roni Tamari et al.
Blood Cancer Discovery September 2021

Cancer Discovery

Discovery of Candidate DNA Methylation Cancer Driver Genes
Heng Pan et al.
Cancer Discov September 2021

Cancer Epidemiology, Biomarkers & Prevention

Updated Methodology for Projecting U.S.- and State-Level Cancer Counts for the Current Calendar Year: Part I: Spatio-temporal Modeling for Cancer Incidence
Benmei Liu et al.
Cancer Epidemiol Bio Prev September 2021

Cancer Immunology Research

Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
Tao Li et al.
Cancer Immunol Res September 2021

Cancer Prevention Research

Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology
Kristin Wallace et al.
Cancer Prev Res September 2021

Cancer Research

A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis
Fei Yue et al.
Cancer Res September 2021

Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis
Anat Shriki et al.
Cancer Res September 2021

Clinical Cancer Research

Phase I Study of Ceralasertib (AZD6738), a Novel DNA Damage Repair Agent, in Combination with Weekly Paclitaxel in Refractory Cancer
Seung Tae Kim et al.
Clin Cancer Res September 2021

Relevance of Platinum-free Interval and BRCA Reversion Mutations for Veliparib Monotherapy after Progression on Carboplatin/Paclitaxel for gBRCA Advanced Breast Cancer (BROCADE3 Crossover)
Shannon L. Puhalla et al.
Clin Cancer Res September 2021

Molecular Cancer Research

High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab
Chung-Han Lee et al.
Mol Cancer Res September 2021

Molecular Cancer Therapeutics

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations
Brion W. Murray et al.
Mol Cancer Ther September 2021

Blood Cancer Discovery

Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia from Nonmalignant Clonal Hematopoiesis
Laura W. Dillon et al.
Blood Cancer Discovery August 2021

Cancer Discovery

Clinical Acquired Resistance to KRAS^G12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Noritaka Tanaka et al.
Cancer Discov August 2021

Cancer Epidemiology, Biomarkers & Prevention

Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort
Piera M. Cirillo et al.
Cancer Epidemiol Bio Prev August 2021

Cancer Immunology Research

Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming
Mark S. Diamond et al.
Cancer Immunol Res August 2021

Cancer Prevention Research

Local Anti–PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model
Yewen Shi et al.
Cancer Prev Res August 2021

Cancer Research

Gut Microbiota–Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling
Makoto Matsushita et al.
Cancer Res August 2021

Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study
Anna H. Wu et al.
Cancer Res August 2021

Clinical Cancer Research

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial
Vivek Subbiah et al.
Clin Cancer Res August 2021

Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
Ingo K. Mellinghoff et al.
Clin Cancer Res August 2021

Molecular Cancer Research

Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress
Tom M. Thomas et al.
Mol Cancer Res August 2021

Molecular Cancer Therapeutics

ASN004, A 5T4-targeting scFv-Fc Antibody–Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models
Roger A. Smith et al.
Mol Cancer Ther August 2021

Blood Cancer Discovery

Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Hiroto Ohguchi et al.
Blood Cancer Discovery July 2021

Cancer Discovery

Activity and Safety of Mobocertinib (TAK-788) in Previously Treated Non–Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations from a Phase I/II Trial
Gregory J. Riely et al.
Cancer Discov July 2021

Cancer Epidemiology, Biomarkers & Prevention

Solid Organ Transplantation and Survival among Individuals with a History of Cancer
Eric A. Engels et al.
Cancer Epidemiol Bio Prev July 2021

Cancer Immunology Research

Exercise Training Improves Tumor Control by Increasing CD8⁺ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade
Igor L. Gomes-Santos et al.
Cancer Immunol Res July 2021

Cancer Prevention Research

Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D₂ Receptors
Kai Lu et al.
Cancer Prev Res July 2021

Cancer Research

TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Benjamin Schoeps et al.
Cancer Res July 2021

Hypothermia Effectively Treats Tumors with Temperature-Sensitive p53 Mutations
Junhao Lu et al.
Cancer Res July 2021

Clinical Cancer Research

Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
Jennifer H. Foster et al.
Clin Cancer Res July 2021

Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors
Naoko Takebe et al.
Clin Cancer Res July 2021

Molecular Cancer Research

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma
Jennifer A. Jiménez et al.
Mol Cancer Res July 2021

Molecular Cancer Therapeutics

Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis
Anu Gupta et al.
Mol Cancer Ther July 2021

Blood Cancer Discovery

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia
Dongqing Yan et al.
Blood Cancer Discovery June 2021

Cancer Discovery

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
Shengqing Stan Gu et al.
Cancer Discov June 2021

Cancer Epidemiology, Biomarkers & Prevention

Long-term Patterns of Excess Mortality among Endometrial Cancer Survivors
Chelsea Anderson et al.
Cancer Epidemiol Bio Prev June 2021

Cancer Immunology Research

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer
Owen Heath et al.
Cancer Immunol Res June 2021

Cancer Prevention Research

Serum Levels of Androgens, Estrogens, and Sex Hormone Binding Globulin and Risk of Primary Gastric Cancer in Chinese Men: A Nested Case–Control Study
Zhikai Zhu et al.
Cancer Prev Res June 2021

Cancer Research

GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer
Alexandra Adamczyk et al.
Cancer Res June 2021

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining
Qin Zhou et al.
Cancer Res June 2021

Clinical Cancer Research

Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors
James M. Cleary et al.
Clin Cancer Res June 2021

Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas
Jing Wu et al.
Clin Cancer Res June 2021

Molecular Cancer Research

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Matthew S. Crowe et al.
Mol Cancer Res June 2021

Molecular Cancer Therapeutics

The KRAS^G12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy
David M. Briere et al.
Mol Cancer Ther June 2021

Blood Cancer Discovery

Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers
Julie E. Feusier et al.
Blood Cancer Discovery May 2021

Cancer Discovery

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death
Vicente Fresquet et al.
Cancer Discov May 2021

Cancer Epidemiology, Biomarkers & Prevention

Cancer Progress and Priorities: Breast Cancer
Serena C. Houghton and Susan E. Hankinson et al.
Cancer Epidemiol Bio Prev May 2021

Cancer Immunology Research

Targeted Therapy Given after Anti–PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity
Manali S. Phadke et al.
Cancer Immunol Res May 2021

Cancer Prevention Research

Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer
Neil M. Iyengar et al.
Cancer Prev Res May 2021

Cancer Research

Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry
Yadav Sapkota et al.
Cancer Res May 2021

The Landscape of the Heritable Cancer Genome
Viola Fanfani et al.
Cancer Res May 2021

Clinical Cancer Research

A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study
Mariko D. DeWire et al.
Clin Cancer Res May 2021

Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results
Joseph Pidala et al.
Clin Cancer Res May 2021

Molecular Cancer Research

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
Jong Hyuk Kim et al.
Mol Cancer Res May 2021

Molecular Cancer Therapeutics

Robust Antitumor Activity and Low Cytokine Production by Novel Humanized Anti-CD19 CAR T Cells
Alka Dwivedi et al.
Mol Cancer Ther May 2021

Blood Cancer Discovery

A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase–Deficient Cells in Myeloid Neoplasms
Yihong Guan et al.
Cancer Discov April 2021

Cancer Discovery

Special April Issue!
Cancer Discov April 2021

Cancer Epidemiology, Biomarkers & Prevention

Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation
Bernard Rosner et al.
Cancer Epidemiol Bio Prev April 2021

Cancer Immunology Research

Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect
Erez N. Baruch et al.
Cancer Immunol Res April 2021

Cancer Prevention Research

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers
Michael J. Hall et al.
Cancer Prev Res April 2021

Cancer Research

Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation
Mineh Markarian et al.
Cancer Res April 2021

Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Martina Di Modica et al.
Cancer Res April 2021

Clinical Cancer Research

Preclinical Evaluation and Phase Ib Study of Prexasertib, a CHK1 Inhibitor, and Samotolisib (LY3023414), a Dual PI3K/mTOR Inhibitor
David S. Hong et al.
Clin Cancer Res April 2021

Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
James J. Harding et al.
Clin Cancer Res April 2021

Molecular Cancer Research

Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System
Anne Trinh et al.
Mol Cancer Res April 2021

Molecular Cancer Therapeutics

F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd
Joel Morris et al.
Mol Cancer Ther April 2021

Blood Cancer Discovery

Recommendations on Eliminating Racial Disparities in Multiple Myeloma Therapies: A Step toward Achieving Equity in Healthcare
Nicole Gormley et al.
Cancer Discov March 2021

Cancer Discovery

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations
Jian Carrot-Zhang et al.
Cancer Discov March 2021

Cancer Epidemiology, Biomarkers & Prevention

Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
Earl Hubbell et al.
Cancer Epidemiol Bio Prev March 2021

Cancer Immunology Research

Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin
Jessica Wagner et al.
Cancer Immunol Res March 2021

Cancer Prevention Research

An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
Lori D. Dwyer-Nield et al.
Cancer Prev Res March 2021

Cancer Research

Replication Gaps Underlie BRCA Deficiency and Therapy Response
Nicholas J. Panzarino et al.
Cancer Res March 2021

EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Mélanie K. Prodhomme et al.
Cancer Res March 2021

Clinical Cancer Research

Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors
Alexej Ballhausen et al.
Clin Cancer Res March 2021

Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903)
Erin M. Bertino et al.
Clin Cancer Res March 2021

Molecular Cancer Research

Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Yasuyo Sano et al.
Mol Cancer Res March 2021

Molecular Cancer Therapeutics

Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor
Aaron Balog et al.
Mol Cancer Ther March 2021

Blood Cancer Discovery

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Helene Kretzmer et al.
Cancer Discov February 2021

Cancer Discovery

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Joanna C. Fowler et al.
Cancer Discov February 2021

Cancer Epidemiology, Biomarkers & Prevention

Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Megan A. Smith et al.
Cancer Epidemiol Bio Prev February 2021

Cancer Immunology Research

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott et al.
Cancer Immunol Res February 2021

Cancer Prevention Research

The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital
Denise Peixoto Guimarães et al.
Cancer Prev Res February 2021

Cancer Research

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Spencer Arnesen et al.
Cancer Res February 2021

Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Gabriele Greve et al.
Cancer Res February 2021

Clinical Cancer Research

Phase II Study of Avelumab in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib
Dae-Won Lee et al.
Clin Cancer Res February 2021

Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
Priyanka Sharma et al.
Clin Cancer Res February 2021

Molecular Cancer Research

Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
Elisenda Alsina-Sanchis et al.
Mol Cancer Res February 2021

Molecular Cancer Therapeutics

AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Vikki Flemington et al.
Mol Cancer Ther February 2021

Blood Cancer Discovery

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Stephanie Z. Xie et al.
Blood Cancer Discov January 2021

Cancer Discovery

Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Stephen Sakuma et al.
Cancer Discov January 2021

Cancer Epidemiology, Biomarkers & Prevention

Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study
Jacqueline M. Mix et al.
Cancer Epidemiol Bio Prev January 2021

Cancer Immunology Research

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Juha P. Väyrynen et al.
Cancer Immunol Res January 2021

Cancer Prevention Research

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Courtney Macdonald et al.
Cancer Prev Res January 2021

Cancer Research

The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Emmi Kapiainen et al.
Cancer Res January 2021

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Jessica M. Rusert et al.
Cancer Res January 2021

Clinical Cancer Research

Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
Jonathan M. Loree et al.
Clin Cancer Res January 2021

A Phase Ib Study of Alpelisib or Buparlisib Combined with Tamoxifen Plus Goserelin in Premenopausal Women with HR-Positive HER2-Negative Advanced Breast Cancer
Yen-Shen Lu et al.
Clin Cancer Res January 2021

Molecular Cancer Research

Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Yuri Park et al.
Mol Cancer Res January 2021

Molecular Cancer Therapeutics

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Shauni Lien Geeraerts et al.
Mol Cancer Ther January 2021