AACR Journals Editors' picks

Blood Cancer Discovery

Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape–Driven Relapse in Multiple Myeloma
Carlos Fernández de Larrea et al.
Blood Cancer Discov September 2020

Cancer Discovery

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
Cécile Gstalder et al.
Cancer Discov September 2020

Cancer Epidemiology, Biomarkers & Prevention

Utilizing SEER Cancer Registries for Population-Based Cancer Survivor Epidemiologic Studies: A Feasibility Study
Lisa Gallicchio et al.
Cancer Epidemiol Bio Prev September 2020

Cancer Immunology Research

Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Caroline Spenlé et al.
Cancer Immunol Res September 2020

Cancer Prevention Research

Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor
Christian Njatcha et al.
Cancer Prev Res September 2020

Cancer Research

Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer
Fei Li et al.
Cancer Res September 2020

BRG1 loss predisposes lung cancers to replicative stress and ATR dependency
Manav Gupta et al.
Cancer Res September 2020

Clinical Cancer Research

Efficacy and Safety Exposure–Response Relationships of Apalutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer
Carlos Perez-Ruixo et al.
Clin Cancer Res September 2020

Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Dean A. Fennell et al.
Clin Cancer Res September 2020

Molecular Cancer Research

A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer
Eisei Endo et al.
Mol Cancer Res September 2020

Molecular Cancer Therapeutics

ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers
Lillian Skidmore et al.
Mol Cancer Ther September 2020

Blood Cancer Discovery

Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia
Esmé Waanders et al.
Blood Cancer Discov August 2020

Cancer Discovery

Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers
Jia Luo et al.
Cancer Discov August 2020

Cancer Epidemiology, Biomarkers & Prevention

Challenges and Approaches to Measuring Repeat Fecal Immunochemical Test for Colorectal Cancer Screening
Caitlin C. Murphy et al.
Cancer Epidemiol Bio Prev August 2020

Cancer Immunology Research

Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma
Jennifer Eom et al.
Cancer Immunol Res August 2020

Cancer Prevention Research

The Role of Lysosome-associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane
Eun-Ryeong Hahm et al.
Cancer Prev Res August 2020

Cancer Research

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy
Daniel R. Principe et al.
Cancer Res August 2020

Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles
Liu Han et al.
Cancer Res August 2020

Clinical Cancer Research

Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study
John C. Byrd et al.
Clin Cancer Res August 2020

EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression
Stephanie Lheureux et al.
Clin Cancer Res August 2020

Molecular Cancer Research

Targeting RET Kinase in Neuroendocrine Prostate Cancer
Halena R. VanDeusen et al.
Mol Cancer Res August 2020

Molecular Cancer Therapeutics

The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2
Laetitia Marzi et al.
Mol Cancer Ther August 2020

Cancer Discovery

Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Allison R. Pine et al.
Cancer Discov July 2020

Cancer Epidemiology, Biomarkers & Prevention

Medical Care Costs Associated with Cancer Survivorship in the United States
Angela B. Mariotto et al.
Cancer Epidemiol Bio Prev July 2020

Cancer Immunology Research

Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors
Greta Garrido et al.
Cancer Immunol Res July 2020

Cancer Prevention Research

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development
Nina J. Chu et al.
Cancer Prev Res July 2020

Cancer Research

A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants
Jesse T. Chao et al.
Cancer Res July 2020

Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome
Hiroshi Kikuchi et al.
Cancer Res July 2020

Clinical Cancer Research

Phase I Trial of Trametinib with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer
Christina Wu et al.
Clin Cancer Res July 2020

Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study
Edwin M. Posadas et al.
Clin Cancer Res July 2020

Molecular Cancer Research

Fibrinogen Alpha Chain Knockout Promotes Tumor Growth and Metastasis through Integrin–AKT Signaling Pathway in Lung Cancer
Meng Wang et al.
Mol Cancer Res July 2020

Molecular Cancer Therapeutics

MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
Gavin Bennett et al.
Mol Cancer Ther July 2020

Cancer Discovery

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Mengyuan Dai et al.
Cancer Discov June 2020

Cancer Epidemiology, Biomarkers & Prevention

Birth Characteristics and Risk of Early-Onset Synovial Sarcoma
Joseph L. Wiemels et al.
Cancer Epidemiol Bio Prev June 2020

Cancer Immunology Research

Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Nana Dang et al.
Cancer Immunol Res June 2020

Cancer Prevention Research

Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma
Mozhdeh Sojoodi et al.
Cancer Prev Res June 2020

Cancer Research

FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress
Roberto Ronca et al.
Cancer Res June 2020

Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation-induced intestinal toxicity
Daniela Leonetti et al.
Cancer Res June 2020

Clinical Cancer Research

BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer
Gary Middleton et al.
Clin Cancer Res June 2020

ANG1005, a Brain-Penetrating Peptide–Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases
Priya Kumthekar et al.
Clin Cancer Res June 2020

Molecular Cancer Research

PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice
Darío García-Carracedo et al.
Mol Cancer Res June 2020

Molecular Cancer Therapeutics

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab
Beth Hutchins et al.
Mol Cancer Ther June 2020

Cancer Discovery

Tuning the Antigen Density Requirement for CAR T-cell Activity
Robbie G. Majzner et al.
Cancer Discov May 2020

Cancer Epidemiology, Biomarkers & Prevention

Projected Reductions in Absolute Cancer–Related Deaths from Diagnosing Cancers Before Metastasis, 2006–2015
Christina A. Clarke et al.
Cancer Epidemiol Bio Prev May 2020

Cancer Immunology Research

A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation
Danica Chiu et al.
Cancer Immunol Res May 2020

Cancer Prevention Research

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers
Yi Wang et al.
Cancer Prev Res May 2020

Cancer Research

MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer
Sarah M. Judge et al.
Cancer Res May 2020

Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer
Shidan Wang et al.
Cancer Res May 2020

Clinical Cancer Research

Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study
Matthew S. Davids et al.
Clin Cancer Res May 2020

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
Michael J. Burke et al.
Clin Cancer Res May 2020

Molecular Cancer Research

27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
Shweta Dambal et al.
Mol Cancer Res May 2020

Molecular Cancer Therapeutics

Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Frank T. Zenke et al.
Mol Cancer Ther May 2020

Cancer Discovery

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Nathan Singh et al.
Cancer Discov April 2020

Cancer Epidemiology, Biomarkers & Prevention

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk
AUTHOR et al.
Cancer Epidemiol Bio Prev April 2020

Cancer Immunology Research

Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma
Handan Xiang et al.
Cancer Immunol Res April 2020

Cancer Prevention Research

Cancer Immunoprevention: A Case Report Raising the Possibility of "Immuno-interception"
Jessica G. Mancuso et al.
Cancer Prev Res April 2020

Cancer Research

Towards Multidrug Adaptive Therapy
Jeffrey West et al.
Cancer Res April 2020

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
Suman Mukhopadhyay et al.
Cancer Res April 2020

Clinical Cancer Research

Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors
Anna M. Varghese et al.
Clin Cancer Res April 2020

Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Jonathan G. Hiller et al.
Clin Cancer Res April 2020

Molecular Cancer Research

Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma
Paula Llabata et al.
Mol Cancer Res April 2020

Molecular Cancer Therapeutics

Preclinical Activity of HER2-Selective Tyrosine Kinase Inhibitor Tucatinib as a Single Agent or in Combination with Trastuzumab or Docetaxel in Solid Tumor Models
Anita Kulukian et al.
Mol Cancer Ther April 2020

Cancer Discovery

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Peiwen Chen et al.
Cancer Discov March 2020

Cancer Epidemiology, Biomarkers & Prevention

Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study
Yu-Wen Chien et al.
Cancer Epidemiol Bio Prev March 2020

Cancer Immunology Research

B cell–Derived IL35 Drives STAT3-Dependent CD8⁺ T-cell Exclusion in Pancreatic Cancer
Bhalchandra Mirlekar et al.
Cancer Immunol Res March 2020

Cancer Prevention Research

Combination of Erlotinib and Naproxen Employing Pulsatile or Intermittent Dosing Profoundly Inhibits Urinary Bladder Cancers
Altaf Mohammed et al.
Cancer Prev Res March 2020

Cancer Research

Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Marwa Asem et al.
Cancer Res March 2020

Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Bedrich L. Eckhardt et al.
Cancer Res March 2020

Clinical Cancer Research

A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
Paul G. Corn et al.
Clin Cancer Res March 2020

Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
Kristina A. Cole et al.
Clin Cancer Res March 2020

Molecular Cancer Research

PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression
Shumei Song et al.
Mol Cancer Res March 2020

Molecular Cancer Therapeutics

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas
Long-Sheng Chang et al.
Mol Cancer Ther March 2020

Cancer Discovery

Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Thomas L. Clarke et al.
Cancer Discov February 2020

Cancer Epidemiology, Biomarkers & Prevention

Medical Financial Hardship Intensity and Financial Sacrifice Associated with Cancer in the United States
Xuesong Han et al.
Cancer Epidemiol Bio Prev February 2020

Cancer Immunology Research

Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
Michael Kvorjak et al.
Cancer Immunol Res February 2020

Cancer Prevention Research

Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model
Venkateshwar Madka et al.
Cancer Prev Res February 2020

Cancer Research

Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes
Robert S. Oakes et al.
Cancer Res February 2020

A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition
Philip Kitchen et al.
Cancer Res February 2020

Clinical Cancer Research

Everolimus and Octreotide for Patients with Recurrent Meningioma: Results from the Phase II CEVOREM Trial
Thomas Graillon et al.
Clin Cancer Res February 2020

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma
Kevin D. Courtney et al.
Clin Cancer Res February 2020

Molecular Cancer Research

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer
Samuel A. Miller et al.
Mol Cancer Res February 2020

Molecular Cancer Therapeutics

10D1F, an Anti-HER3 Antibody That Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models
Dipti Thakkar et al.
Mol Cancer Ther February 2020

Cancer Discovery

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Yun-Han Huang et al.
Cancer Discov January 2020

Cancer Epidemiology, Biomarkers & Prevention

Comparative Effectiveness of Two Interventions to Increase Colorectal Cancer Screening for Those at Increased Risk Based on Family History: Results of a Randomized Trial
Electra D. Paskett et al.
Cancer Epidemiol Bio Prev January 2020

Cancer Immunology Research

Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers
Delia Hoffmann et al.
Cancer Immunol Res January 2020

Cancer Prevention Research

Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype–like Cluster
Yanfei Chen et al.
Cancer Prev Res January 2020

Cancer Research

Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Joseph Chen et al.
Cancer Res January 2020

Twist1-induced epithelial dissemination requires Prkd1 signaling
Dan Georgess et al.
Cancer Res January 2020

Clinical Cancer Research

Clinical Assessment of 5-Fluorouracil/Leucovorin, Nab-Paclitaxel, and Irinotecan (FOLFIRABRAX) in Untreated Patients with Gastrointestinal Cancer Using UGT1A1 Genotype–Guided Dosing
Smita S. Joshi et al.
Clin Cancer Res January 2020

A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma
Irene M. Ghobrial et al.
Clin Cancer Res January 2020

Molecular Cancer Research

Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition
Ryan A. Denu et al.
Mol Cancer Res January 2020

Molecular Cancer Therapeutics

A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
Limin Zhang et al.
Mol Cancer Ther January 2020