2019
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November
Cancer Discovery
Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Cancer Discov November 2019
Cancer Epidemiology, Biomarkers & Prevention
Race/Ethnicity and Accuracy of Self-Reported Female First-Degree Family History of Breast and Other Cancers in the Northern California Breast Cancer Family Registry
Cancer Epidemiol Bio Prev November 2019
Cancer Immunology Research
The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance
Cancer Immunol Res November 2019
Cancer Prevention Research
Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma
Cancer Prev Res November 2019
Cancer Research
Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma
Cancer Res November 2019
Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy
Cancer Res November 2019
Clinical Cancer Research
A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor
Clin Cancer Res November 2019
POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients
Clin Cancer Res November 2019
Molecular Cancer Research
Intron 1–Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins
Mol Cancer Res November 2019
Molecular Cancer Therapeutics
First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer
Mol Cancer Ther November 2019
October
Cancer Discovery
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Cancer Discov October 2019
Cancer Epidemiology, Biomarkers & Prevention
Disparities in Cancer Incidence and Trends among American Indians and Alaska Natives in the United States, 2010–2015
Cancer Epidemiol Bio Prev October 2019
Cancer Immunology Research
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
Cancer Immunol Res October 2019
Cancer Prevention Research
A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers
Cancer Prev Res October 2019
Cancer Research
MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1
Cancer Res October 2019
The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Cancer Res October 2019
Clinical Cancer Research
Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
Clin Cancer Res October 2019
Antitumor Activity and Tolerability of hu14.18-IL2 with GMCSF and Isotretinoin in Recurrent or Refractory Neuroblastoma: A Children's Oncology Group Phase II Study
Clin Cancer Res October 2019
Molecular Cancer Research
CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
Mol Cancer Res October 2019
Molecular Cancer Therapeutics
Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells
Mol Cancer Ther October 2019
September
Cancer Discovery
Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming
Cancer Discov September 2019
Cancer Epidemiology, Biomarkers & Prevention
Providing Higher Resolution Indicators of Rurality in the Surveillance, Epidemiology, and End Results (SEER) Database: Implications for Patient Privacy and Research
Cancer Epidemiol Bio Prev September 2019
Cancer Immunology Research
Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer
Cancer Immunol Res September 2019
Cancer Prevention Research
Proteomic Analysis of Plasma Reveals Fat Mass Influences Cancer-Related Pathways in Healthy Humans Fed Controlled Diets Differing in Glycemic Load
Cancer Prev Res September 2019
Cancer Research
Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Cancer Res September 2019
Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer
Cancer Res September 2019
Clinical Cancer Research
A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer
Clin Cancer Res September 2019
First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors
Clin Cancer Res September 2019
Molecular Cancer Research
Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA–NF-κB
Mol Cancer Res September 2019
Molecular Cancer Therapeutics
MEN1309/OBT076, a First-In-Class Antibody–Drug Conjugate Targeting CD205 in Solid Tumors
Mol Cancer Ther September 2019
August
Cancer Discovery
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
Cancer Discov August 2019
Cancer Epidemiology, Biomarkers & Prevention
Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases
Cancer Epidemiol Bio Prev August 2019
Cancer Immunology Research
High Numbers of Circulating CD57+ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2+ Primary Breast Cancer
Cancer Immunol Res August 2019
Cancer Prevention Research
Three-Dimensional Nanoscale Nuclear Architecture Mapping of Rectal Biopsies Detects Colorectal Neoplasia in Patients with Inflammatory Bowel Disease
Cancer Prev Res August 2019
Cancer Research
Modeling Gliomas Using Two Recombinases
Cancer Res August 2019
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Cancer Res August 2019
Clinical Cancer Research
Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms
Clin Cancer Res August 2019
Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors
Clin Cancer Res August 2019
Molecular Cancer Research
T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis
Mol Cancer Res August 2019
Molecular Cancer Therapeutics
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
Mol Cancer Ther August 2019
July
Cancer Discovery
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
Cancer Discov July 2019
Cancer Epidemiology, Biomarkers & Prevention
Use of Statin Medications Following Diagnosis in Relation to Survival among Women with Ovarian Cancer
Cancer Epidemiol Bio Prev July 2019
Cancer Immunology Research
Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically
Cancer Immunol Res July 2019
Cancer Prevention Research
Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets
Cancer Prev Res July 2019
Cancer Research
Gaussian Mixture Models for Probabilistic Classification of Breast Cancer
Cancer Res July 2019
Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
Cancer Res July 2019
Clinical Cancer Research
Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases
Clin Cancer Res July 2019
Carfilzomib Weekly plus Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (IFM 2012-03): A Phase I Trial
Clin Cancer Res July 2019
Molecular Cancer Research
Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
Mol Cancer Res July 2019
Molecular Cancer Therapeutics
Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
Mol Cancer Ther July 2019
June
Cancer Discovery
A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors
Cancer Discov June 2019
Cancer Epidemiology, Biomarkers & Prevention
Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality
Cancer Epidemiol Bio Prev June 2019
Cancer Immunology Research
IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development
Cancer Immunol Res June 2019
Cancer Prevention Research
Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice
Cancer Prev Res June 2019
Cancer Research
Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition
Cancer Res June 2019
An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors
Cancer Res June 2019
Clinical Cancer Research
Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma
Clin Cancer Res June 2019
Surufatinib in Advanced Well-Differentiated Neuroendocrine Tumors: A Multicenter, Single-Arm, Open-Label, Phase Ib/II Trial
Clin Cancer Res June 2019
Molecular Cancer Research
Loss of TP63 promotes the metastasis of head and neck squamous cell carcinoma by activating MAPK and STAT3 signaling
Mol Cancer Res June 2019
Molecular Cancer Therapeutics
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo
Mol Cancer Ther June 2019
May
Cancer Discovery
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
Cancer Discov May 2019
Cancer Epidemiology, Biomarkers & Prevention
Examining Urban and Rural Differences in How Distance to Care Influences the Initiation and Completion of Treatment among Insured Cervical Cancer Patients
Cancer Epidemiol Bio Prev May 2019
Cancer Immunology Research
Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment
Cancer Immunol Res May 2019
Cancer Prevention Research
Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells
Cancer Prev Res May 2019
Cancer Research
Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma
Cancer Res May 2019
Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Cancer Res May 2019
Clinical Cancer Research
Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer
Clin Cancer Res May 2019
A Variant of a Killer Cell Immunoglobulin-like Receptor Is Associated with Resistance to PD-1 Blockade in Lung Cancer
Clin Cancer Res May 2019
Molecular Cancer Research
Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition
Mol Cancer Res May 2019
Molecular Cancer Therapeutics
Prospective Clinical Sequencing of Adult Glioma
Mol Cancer Ther May 2019
April
Cancer Discovery
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition
Cancer Discov April 2019
Cancer Epidemiology, Biomarkers & Prevention
Current Prevalence of Major Cancer Risk Factors and Screening Test Use in the United States: Disparities by Education and Race/Ethnicity
Cancer Epidemiol Bio Prev April 2019
Cancer Immunology Research
CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function
Cancer Immunol Res April 2019
Cancer Prevention Research
Thermally Abused Frying Oil Potentiates Metastasis to Lung in a Murine Model of Late-Stage Breast Cancer
Cancer Prev Res April 2019
Cancer Research
Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress
Cancer Res April 2019
Spleen Tyrosine Kinase-Mediated Autophagy is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer
Cancer Res April 2019
Clinical Cancer Research
The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors
Clin Cancer Res April 2019
Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study
Clin Cancer Res April 2019
Molecular Cancer Research
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer
Mol Cancer Res April 2019
Molecular Cancer Therapeutics
TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
Mol Cancer Ther April 2019
March
Cancer Discovery
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Cancer Discov March 2019
Cancer Epidemiology, Biomarkers & Prevention
Trends in Pediatric Central Nervous System Tumor Incidence in the United States, 1998–2013
Cancer Epidemiol Bio Prev March 2019
Cancer Immunology Research
SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion
Cancer Immunol Res March 2019
Cancer Prevention Research
Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate
Cancer Prev Res March 2019
Cancer Research
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Cancer Res March 2019
Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
Cancer Res March 2019
Clinical Cancer Research
Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
Clin Cancer Res March 2019
Brentuximab Vedotin Plus Chemotherapy in North American Patients with Newly Diagnosed Stage III or IV Hodgkin Lymphoma
Clin Cancer Res March 2019
Molecular Cancer Research
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress
Mol Cancer Res March 2019
Molecular Cancer Therapeutics
TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer
Mol Cancer Ther March 2019
February
Cancer Discovery
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Cancer Discov February 2019
Cancer Epidemiology, Biomarkers & Prevention
Vigorous Physical Activity Is Associated with Lower Risk of Metastatic–Lethal Progression in Prostate Cancer and Hypomethylation in the CRACR2A Gene
Cancer Epidemiol Bio Prev February 2019
Cancer Immunology Research
Intracellular Activation of Complement C3 Leads to PD-L1 Antibody Treatment Resistance by Modulating Tumor-Associated Macrophages
Cancer Immunol Res February 2019
Cancer Prevention Research
Case-only Methods Identified Genetic Loci Predicting a Subgroup of Men with Reduced Risk of High-grade Prostate Cancer by Finasteride
Cancer Prev Res February 2019
Cancer Research
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Cancer Res February 2019
Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer
Cancer Res February 2019
Clinical Cancer Research
Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
Clin Cancer Res February 2019
Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma
Clin Cancer Res February 2019
Molecular Cancer Research
Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer
Mol Cancer Res February 2019
Molecular Cancer Therapeutics
MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Mol Cancer Ther February 2019
January
Cancer Discovery
Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
Cancer Discov January 2019
Cancer Epidemiology, Biomarkers & Prevention
Prediagnostic Serum Levels of Fatty Acid Metabolites and Risk of Ovarian Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Cancer Epidemiol Bio Prev January 2019
Cancer Immunology Research
Collapse of the Plasmacytoid Dendritic Cell Compartment in Advanced Cutaneous Melanomas by Components of the Tumor Cell Secretome
Cancer Immunol Res January 2019
Cancer Prevention Research
Trends in Lung Cancer and Cigarette Smoking: California Compared to the Rest of the United States
Cancer Prev Res January 2019
Cancer Research
Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases
Cancer Res January 2019
Ribosomal Lesions Promote Oncogenic Mutagenesis
Cancer Res January 2019
Clinical Cancer Research
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer
Clin Cancer Res January 2019
Serum Nardilysin, a Surrogate Marker for Epithelial–Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection
Clin Cancer Res January 2019
Molecular Cancer Research
The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
Mol Cancer Res January 2019
Molecular Cancer Therapeutics
KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR
Mol Cancer Ther January 2019
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