AACR Journals Editors' picks

Cancer Discovery

Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Maya Kansara et al.
Cancer Discov November 2019

Cancer Epidemiology, Biomarkers & Prevention

Race/Ethnicity and Accuracy of Self-Reported Female First-Degree Family History of Breast and Other Cancers in the Northern California Breast Cancer Family Registry
Esther M. John et al.
Cancer Epidemiol Bio Prev November 2019

Cancer Immunology Research

The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance
Annalisa Del Prete et al.
Cancer Immunol Res November 2019

Cancer Prevention Research

Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma
Altaf Mohammed et al.
Cancer Prev Res November 2019

Cancer Research

Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma
M. Herman Chui et al.
Cancer Res November 2019

Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy
Katherine D. Castle and David G. Kirsch
Cancer Res November 2019

Clinical Cancer Research

A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor
John Glod et al.
Clin Cancer Res November 2019

POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients
Richard D. Baird et al.
Clin Cancer Res November 2019

Molecular Cancer Research

Intron 1–Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins
Nathan M. Jameson et al.
Mol Cancer Res November 2019

Molecular Cancer Therapeutics

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer
Anna Capasso et al.
Mol Cancer Ther November 2019

Cancer Discovery

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Justin Taylor et al.
Cancer Discov October 2019

Cancer Epidemiology, Biomarkers & Prevention

Disparities in Cancer Incidence and Trends among American Indians and Alaska Natives in the United States, 2010–2015
Stephanie C. Melkonian et al.
Cancer Epidemiol Bio Prev October 2019

Cancer Immunology Research

Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
Wen-Chao Wu et al.
Cancer Immunol Res October 2019

Cancer Prevention Research

A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers
Robert L. Keith et al.
Cancer Prev Res October 2019

Cancer Research

MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1
Huai-Chia Chuang et al.
Cancer Res October 2019

The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Derek S. Park et al.
Cancer Res October 2019

Clinical Cancer Research

Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
Umamaheswar Duvvuri et al.
Clin Cancer Res October 2019

Antitumor Activity and Tolerability of hu14.18-IL2 with GMCSF and Isotretinoin in Recurrent or Refractory Neuroblastoma: A Children's Oncology Group Phase II Study
Suzanne Shusterman et al.
Clin Cancer Res October 2019

Molecular Cancer Research

CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
Casey J. Moure et al.
Mol Cancer Res October 2019

Molecular Cancer Therapeutics

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells
Ping Fan et al.
Mol Cancer Ther October 2019

Cancer Discovery

Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming
Mautin Hundeyin et al.
Cancer Discov September 2019

Cancer Epidemiology, Biomarkers & Prevention

Providing Higher Resolution Indicators of Rurality in the Surveillance, Epidemiology, and End Results (SEER) Database: Implications for Patient Privacy and Research
Jennifer L. Moss et al.
Cancer Epidemiol Bio Prev September 2019

Cancer Immunology Research

Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer
Kristin G. Anderson et al.
Cancer Immunol Res September 2019

Cancer Prevention Research

Proteomic Analysis of Plasma Reveals Fat Mass Influences Cancer-Related Pathways in Healthy Humans Fed Controlled Diets Differing in Glycemic Load
Carly B. Garrison et al.
Cancer Prev Res September 2019

Cancer Research

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Ana-Rita Pedrosa et al.
Cancer Res September 2019

Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer
Avihai Ron et al.
Cancer Res September 2019

Clinical Cancer Research

A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer
James J. Harding et al.
Clin Cancer Res September 2019

First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors
Jessica J. Tao et al.
Clin Cancer Res September 2019

Molecular Cancer Research

Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA–NF-κB
Yi Zhu et al.
Mol Cancer Res September 2019

Molecular Cancer Therapeutics

MEN1309/OBT076, a First-In-Class Antibody–Drug Conjugate Targeting CD205 in Solid Tumors
Giuseppe Merlino et al.
Mol Cancer Ther September 2019

Cancer Discovery

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
Ela Elyada et al.
Cancer Discov August 2019

Cancer Epidemiology, Biomarkers & Prevention

Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases
Rashid N. Lui et al.
Cancer Epidemiol Bio Prev August 2019

Cancer Immunology Research

High Numbers of Circulating CD57⁺ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2⁺ Primary Breast Cancer
Aura Muntasell et al.
Cancer Immunol Res August 2019

Cancer Prevention Research

Three-Dimensional Nanoscale Nuclear Architecture Mapping of Rectal Biopsies Detects Colorectal Neoplasia in Patients with Inflammatory Bowel Disease
Shikhar Uttam et al.
Cancer Prev Res August 2019

Cancer Research

Modeling Gliomas Using Two Recombinases
Toshiro Hara and Inder M. Verma
Cancer Res August 2019

Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Luca D'Agostino et al.
Cancer Res August 2019

Clinical Cancer Research

Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms
Estrella Carrillo-Cruz et al.
Clin Cancer Res August 2019

Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors
Rastislav Bahleda et al.
Clin Cancer Res August 2019

Molecular Cancer Research

T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis
Christophe Cataisson et al.
Mol Cancer Res August 2019

Molecular Cancer Therapeutics

EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
Suryavathi Viswanadhapalli et al.
Mol Cancer Ther August 2019

Cancer Discovery

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
Else Driehuis et al.
Cancer Discov July 2019

Cancer Epidemiology, Biomarkers & Prevention

Use of Statin Medications Following Diagnosis in Relation to Survival among Women with Ovarian Cancer
Barbara N. Harding et al.
Cancer Epidemiol Bio Prev July 2019

Cancer Immunology Research

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically
Shawn C. Chafe et al.
Cancer Immunol Res July 2019

Cancer Prevention Research

Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets
Jelena Mustra Rakic et al.
Cancer Prev Res July 2019

Cancer Research

Gaussian Mixture Models for Probabilistic Classification of Breast Cancer
Indira Prabakaran et al.
Cancer Res July 2019

Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
Yuezhen Xue et al.
Cancer Res July 2019

Clinical Cancer Research

Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases
Aki Morikawa et al.
Clin Cancer Res July 2019

Carfilzomib Weekly plus Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (IFM 2012-03): A Phase I Trial
Xavier Leleu et al.
Clin Cancer Res July 2019

Molecular Cancer Research

Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
Mayuri Prasad et al.
Mol Cancer Res July 2019

Molecular Cancer Therapeutics

Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
Lu Zhang et al.
Mol Cancer Ther July 2019

Cancer Discovery

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors
Salah-Eddine Bentebibel et al.
Cancer Discov June 2019

Cancer Epidemiology, Biomarkers & Prevention

Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality
Upekha E. Liyanage et al.
Cancer Epidemiol Bio Prev June 2019

Cancer Immunology Research

IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development
Federica Riva et al.
Cancer Immunol Res June 2019

Cancer Prevention Research

Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT₁₂₁ Mice
James C. Fleet et al.
Cancer Prev Res June 2019

Cancer Research

Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition
Satoshi Sakai et al.
Cancer Res June 2019

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors
Martin Indarte et al.
Cancer Res June 2019

Clinical Cancer Research

Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma
Meng Duan et al.
Clin Cancer Res June 2019

Surufatinib in Advanced Well-Differentiated Neuroendocrine Tumors: A Multicenter, Single-Arm, Open-Label, Phase Ib/II Trial
Jianming Xu et al.
Clin Cancer Res June 2019

Molecular Cancer Research

Loss of TP63 promotes the metastasis of head and neck squamous cell carcinoma by activating MAPK and STAT3 signaling
Senthilnath Lakshmanachetty et al.
Mol Cancer Res June 2019

Molecular Cancer Therapeutics

Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo
Jason J. Zoeller et al.
Mol Cancer Ther June 2019

Cancer Discovery

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
Triparna Sen et al.
Cancer Discov May 2019

Cancer Epidemiology, Biomarkers & Prevention

Examining Urban and Rural Differences in How Distance to Care Influences the Initiation and Completion of Treatment among Insured Cervical Cancer Patients
Lisa P. Spees et al.
Cancer Epidemiol Bio Prev May 2019

Cancer Immunology Research

Siglec-9 Regulates an Effector Memory CD8⁺ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment
Quentin Haas et al.
Cancer Immunol Res May 2019

Cancer Prevention Research

Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells
Wanshui Yang et al.
Cancer Prev Res May 2019

Cancer Research

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma
Mary Hoffman et al.
Cancer Res May 2019

Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Shangze Li et al.
Cancer Res May 2019

Clinical Cancer Research

Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer
Vipul Bhatia et al.
Clin Cancer Res May 2019

A Variant of a Killer Cell Immunoglobulin-like Receptor Is Associated with Resistance to PD-1 Blockade in Lung Cancer
Marcel P. Trefny et al.
Clin Cancer Res May 2019

Molecular Cancer Research

Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition
Ahmed Diab et al.
Mol Cancer Res May 2019

Molecular Cancer Therapeutics

Prospective Clinical Sequencing of Adult Glioma
Siyuan Zheng et al.
Mol Cancer Ther May 2019

Cancer Discovery

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition
Daisuke Ennishi et al.
Cancer Discov April 2019

Cancer Epidemiology, Biomarkers & Prevention

Current Prevalence of Major Cancer Risk Factors and Screening Test Use in the United States: Disparities by Education and Race/Ethnicity
Ann Goding Sauer et al.
Cancer Epidemiol Bio Prev April 2019

Cancer Immunology Research

CD96 Is an Immune Checkpoint That Regulates CD8⁺ T-cell Antitumor Function
Deepak Mittal et al.
Cancer Immunol Res April 2019

Cancer Prevention Research

Thermally Abused Frying Oil Potentiates Metastasis to Lung in a Murine Model of Late-Stage Breast Cancer
Anthony Cam et al.
Cancer Prev Res April 2019

Cancer Research

Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress
Matthew V. Puccetti et al.
Cancer Res April 2019

Spleen Tyrosine Kinase-Mediated Autophagy is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer
Aparna Shinde et al.
Cancer Res April 2019

Clinical Cancer Research

The First-week Proliferative Response of Peripheral Blood PD-1⁺CD8⁺ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors
Kyung Hwan Kim et al.
Clin Cancer Res April 2019

Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study
Shin-Ae Kang et al.
Clin Cancer Res April 2019

Molecular Cancer Research

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer
Peter C. Hart et al.
Mol Cancer Res April 2019

Molecular Cancer Therapeutics

TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
Hiroki Irie et al.
Mol Cancer Ther April 2019

Cancer Discovery

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Alessandro Carrer et al.
Cancer Discov March 2019

Cancer Epidemiology, Biomarkers & Prevention

Trends in Pediatric Central Nervous System Tumor Incidence in the United States, 1998–2013
Diana R. Withrow et al.
Cancer Epidemiol Bio Prev March 2019

Cancer Immunology Research

SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion
Chunwan Lu et al.
Cancer Immunol Res March 2019

Cancer Prevention Research

Role of Krüppel-like Factor 4-p21^CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate
Su-Hyeong Kim et al.
Cancer Prev Res March 2019

Cancer Research

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Dustin J. Flanagan et al.
Cancer Res March 2019

Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
Song Fan et al.
Cancer Res March 2019

Clinical Cancer Research

Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
Sarah P. Blagden et al.
Clin Cancer Res March 2019

Brentuximab Vedotin Plus Chemotherapy in North American Patients with Newly Diagnosed Stage III or IV Hodgkin Lymphoma
Radhakrishnan Ramchandren et al.
Clin Cancer Res March 2019

Molecular Cancer Research

Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress
Victor Laurent et al.
Mol Cancer Res March 2019

Molecular Cancer Therapeutics

TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer
Daniel R. Principe et al.
Mol Cancer Ther March 2019

Cancer Discovery

EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Gnana P. Krishnamoorthy et al.
Cancer Discov February 2019

Cancer Epidemiology, Biomarkers & Prevention

Vigorous Physical Activity Is Associated with Lower Risk of Metastatic–Lethal Progression in Prostate Cancer and Hypomethylation in the CRACR2A Gene
James Y. Dai et al.
Cancer Epidemiol Bio Prev February 2019

Cancer Immunology Research

Intracellular Activation of Complement C3 Leads to PD-L1 Antibody Treatment Resistance by Modulating Tumor-Associated Macrophages
Haoran Zha et al.
Cancer Immunol Res February 2019

Cancer Prevention Research

Case-only Methods Identified Genetic Loci Predicting a Subgroup of Men with Reduced Risk of High-grade Prostate Cancer by Finasteride
James Y. Dai et al.
Cancer Prev Res February 2019

Cancer Research

A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Hila Doron et al.
Cancer Res February 2019

Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer
Kate T. Murphy et al.
Cancer Res February 2019

Clinical Cancer Research

Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
Giuseppe Lo Russo et al.
Clin Cancer Res February 2019

Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma
Shailender Bhatia et al.
Clin Cancer Res February 2019

Molecular Cancer Research

Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer
Yuqing Zhang et al.
Mol Cancer Res February 2019

Molecular Cancer Therapeutics

MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Stephanie L. Fricke et al.
Mol Cancer Ther February 2019

Cancer Discovery

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
Shunsuke Kitajima et al.
Cancer Discov January 2019

Cancer Epidemiology, Biomarkers & Prevention

Prediagnostic Serum Levels of Fatty Acid Metabolites and Risk of Ovarian Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Manila Hada et al.
Cancer Epidemiol Bio Prev January 2019

Cancer Immunology Research

Collapse of the Plasmacytoid Dendritic Cell Compartment in Advanced Cutaneous Melanomas by Components of the Tumor Cell Secretome
Raffaella Vescovi et al.
Cancer Immunol Res January 2019

Cancer Prevention Research

Trends in Lung Cancer and Cigarette Smoking: California Compared to the Rest of the United States
John P. Pierce et al.
Cancer Prev Res January 2019

Cancer Research

Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases
Jianqiang Bao et al.
Cancer Res January 2019

Ribosomal Lesions Promote Oncogenic Mutagenesis
Sergey O. Sulima et al.
Cancer Res January 2019

Clinical Cancer Research

Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer
Charu Aggarwal et al.
Clin Cancer Res January 2019

Serum Nardilysin, a Surrogate Marker for Epithelial–Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection
Tomoaki Yoh et al.
Clin Cancer Res January 2019

Molecular Cancer Research

The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
Sonia Manca et al.
Mol Cancer Res January 2019

Molecular Cancer Therapeutics

KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR
Kaori Nakatani et al.
Mol Cancer Ther January 2019