AACR Journals Editors' picks

Blood Cancer Discovery

Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Hiroto Ohguchi et al.
Blood Cancer Discovery July 2021

Cancer Discovery

Activity and Safety of Mobocertinib (TAK-788) in Previously Treated Non–Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations from a Phase I/II Trial
Gregory J. Riely et al.
Cancer Discov July 2021

Cancer Epidemiology, Biomarkers & Prevention

Solid Organ Transplantation and Survival among Individuals with a History of Cancer
Eric A. Engels et al.
Cancer Epidemiol Bio Prev July 2021

Cancer Immunology Research

Exercise Training Improves Tumor Control by Increasing CD8⁺ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade
Igor L. Gomes-Santos et al.
Cancer Immunol Res July 2021

Cancer Prevention Research

Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D₂ Receptors
Kai Lu et al.
Cancer Prev Res July 2021

Cancer Research

TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Benjamin Schoeps et al.
Cancer Res July 2021

Hypothermia Effectively Treats Tumors with Temperature-Sensitive p53 Mutations
Junhao Lu et al.
Cancer Res July 2021

Clinical Cancer Research

Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
Jennifer H. Foster et al.
Clin Cancer Res July 2021

Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors
Naoko Takebe et al.
Clin Cancer Res July 2021

Molecular Cancer Research

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma
Jennifer A. Jiménez et al.
Mol Cancer Res July 2021

Molecular Cancer Therapeutics

Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis
Anu Gupta et al.
Mol Cancer Ther July 2021

Blood Cancer Discovery

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia
Dongqing Yan et al.
Blood Cancer Discovery June 2021

Cancer Discovery

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
Shengqing Stan Gu et al.
Cancer Discov June 2021

Cancer Epidemiology, Biomarkers & Prevention

Long-term Patterns of Excess Mortality among Endometrial Cancer Survivors
Chelsea Anderson et al.
Cancer Epidemiol Bio Prev June 2021

Cancer Immunology Research

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer
Owen Heath et al.
Cancer Immunol Res June 2021

Cancer Prevention Research

Serum Levels of Androgens, Estrogens, and Sex Hormone Binding Globulin and Risk of Primary Gastric Cancer in Chinese Men: A Nested Case–Control Study
Zhikai Zhu et al.
Cancer Prev Res June 2021

Cancer Research

GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer
Alexandra Adamczyk et al.
Cancer Res June 2021

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining
Qin Zhou et al.
Cancer Res June 2021

Clinical Cancer Research

Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors
James M. Cleary et al.
Clin Cancer Res June 2021

Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas
Jing Wu et al.
Clin Cancer Res June 2021

Molecular Cancer Research

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Matthew S. Crowe et al.
Mol Cancer Res June 2021

Molecular Cancer Therapeutics

The KRAS^G12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy
David M. Briere et al.
Mol Cancer Ther June 2021

Blood Cancer Discovery

Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers
Julie E. Feusier et al.
Blood Cancer Discovery May 2021

Cancer Discovery

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death
Vicente Fresquet et al.
Cancer Discov May 2021

Cancer Epidemiology, Biomarkers & Prevention

Cancer Progress and Priorities: Breast Cancer
Serena C. Houghton and Susan E. Hankinson et al.
Cancer Epidemiol Bio Prev May 2021

Cancer Immunology Research

Targeted Therapy Given after Anti–PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity
Manali S. Phadke et al.
Cancer Immunol Res May 2021

Cancer Prevention Research

Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer
Neil M. Iyengar et al.
Cancer Prev Res May 2021

Cancer Research

Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry
Yadav Sapkota et al.
Cancer Res May 2021

The Landscape of the Heritable Cancer Genome
Viola Fanfani et al.
Cancer Res May 2021

Clinical Cancer Research

A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study
Mariko D. DeWire et al.
Clin Cancer Res May 2021

Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results
Joseph Pidala et al.
Clin Cancer Res May 2021

Molecular Cancer Research

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
Jong Hyuk Kim et al.
Mol Cancer Res May 2021

Molecular Cancer Therapeutics

Robust Antitumor Activity and Low Cytokine Production by Novel Humanized Anti-CD19 CAR T Cells
Alka Dwivedi et al.
Mol Cancer Ther May 2021

Blood Cancer Discovery

A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase–Deficient Cells in Myeloid Neoplasms
Yihong Guan et al.
Cancer Discov April 2021

Cancer Discovery

Special April Issue!
Cancer Discov April 2021

Cancer Epidemiology, Biomarkers & Prevention

Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation
Bernard Rosner et al.
Cancer Epidemiol Bio Prev April 2021

Cancer Immunology Research

Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect
Erez N. Baruch et al.
Cancer Immunol Res April 2021

Cancer Prevention Research

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers
Michael J. Hall et al.
Cancer Prev Res April 2021

Cancer Research

Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation
Mineh Markarian et al.
Cancer Res April 2021

Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Martina Di Modica et al.
Cancer Res April 2021

Clinical Cancer Research

Preclinical Evaluation and Phase Ib Study of Prexasertib, a CHK1 Inhibitor, and Samotolisib (LY3023414), a Dual PI3K/mTOR Inhibitor
David S. Hong et al.
Clin Cancer Res April 2021

Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
James J. Harding et al.
Clin Cancer Res April 2021

Molecular Cancer Research

Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System
Anne Trinh et al.
Mol Cancer Res April 2021

Molecular Cancer Therapeutics

F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd
Joel Morris et al.
Mol Cancer Ther April 2021

Blood Cancer Discovery

Recommendations on Eliminating Racial Disparities in Multiple Myeloma Therapies: A Step toward Achieving Equity in Healthcare
Nicole Gormley et al.
Cancer Discov March 2021

Cancer Discovery

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations
Jian Carrot-Zhang et al.
Cancer Discov March 2021

Cancer Epidemiology, Biomarkers & Prevention

Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
Earl Hubbell et al.
Cancer Epidemiol Bio Prev March 2021

Cancer Immunology Research

Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin
Jessica Wagner et al.
Cancer Immunol Res March 2021

Cancer Prevention Research

An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
Lori D. Dwyer-Nield et al.
Cancer Prev Res March 2021

Cancer Research

Replication Gaps Underlie BRCA Deficiency and Therapy Response
Nicholas J. Panzarino et al.
Cancer Res March 2021

EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Mélanie K. Prodhomme et al.
Cancer Res March 2021

Clinical Cancer Research

Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors
Alexej Ballhausen et al.
Clin Cancer Res March 2021

Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903)
Erin M. Bertino et al.
Clin Cancer Res March 2021

Molecular Cancer Research

Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Yasuyo Sano et al.
Mol Cancer Res March 2021

Molecular Cancer Therapeutics

Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor
Aaron Balog et al.
Mol Cancer Ther March 2021

Blood Cancer Discovery

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Helene Kretzmer et al.
Cancer Discov February 2021

Cancer Discovery

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Joanna C. Fowler et al.
Cancer Discov February 2021

Cancer Epidemiology, Biomarkers & Prevention

Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Megan A. Smith et al.
Cancer Epidemiol Bio Prev February 2021

Cancer Immunology Research

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott et al.
Cancer Immunol Res February 2021

Cancer Prevention Research

The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital
Denise Peixoto Guimarães et al.
Cancer Prev Res February 2021

Cancer Research

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Spencer Arnesen et al.
Cancer Res February 2021

Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Gabriele Greve et al.
Cancer Res February 2021

Clinical Cancer Research

Phase II Study of Avelumab in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib
Dae-Won Lee et al.
Clin Cancer Res February 2021

Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
Priyanka Sharma et al.
Clin Cancer Res February 2021

Molecular Cancer Research

Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
Elisenda Alsina-Sanchis et al.
Mol Cancer Res February 2021

Molecular Cancer Therapeutics

AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Vikki Flemington et al.
Mol Cancer Ther February 2021

Blood Cancer Discovery

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Stephanie Z. Xie et al.
Blood Cancer Discov January 2021

Cancer Discovery

Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Stephen Sakuma et al.
Cancer Discov January 2021

Cancer Epidemiology, Biomarkers & Prevention

Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study
Jacqueline M. Mix et al.
Cancer Epidemiol Bio Prev January 2021

Cancer Immunology Research

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Juha P. Väyrynen et al.
Cancer Immunol Res January 2021

Cancer Prevention Research

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Courtney Macdonald et al.
Cancer Prev Res January 2021

Cancer Research

The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Emmi Kapiainen et al.
Cancer Res January 2021

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Jessica M. Rusert et al.
Cancer Res January 2021

Clinical Cancer Research

Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
Jonathan M. Loree et al.
Clin Cancer Res January 2021

A Phase Ib Study of Alpelisib or Buparlisib Combined with Tamoxifen Plus Goserelin in Premenopausal Women with HR-Positive HER2-Negative Advanced Breast Cancer
Yen-Shen Lu et al.
Clin Cancer Res January 2021

Molecular Cancer Research

Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Yuri Park et al.
Mol Cancer Res January 2021

Molecular Cancer Therapeutics

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Shauni Lien Geeraerts et al.
Mol Cancer Ther January 2021