AACR Journals Editors' picks

Blood Cancer Discovery

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Helene Kretzmer et al.
Cancer Discov February 2021

Cancer Discovery

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Joanna C. Fowler et al.
Cancer Discov February 2021

Cancer Epidemiology, Biomarkers & Prevention

Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Megan A. Smith et al.
Cancer Epidemiol Bio Prev February 2021

Cancer Immunology Research

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott et al.
Cancer Immunol Res February 2021

Cancer Prevention Research

The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital
Denise Peixoto Guimarães et al.
Cancer Prev Res February 2021

Cancer Research

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Spencer Arnesen et al.
Cancer Res February 2021

Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Gabriele Greve et al.
Cancer Res February 2021

Clinical Cancer Research

Phase II Study of Avelumab in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib
Dae-Won Lee et al.
Clin Cancer Res February 2021

Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
Priyanka Sharma et al.
Clin Cancer Res February 2021

Molecular Cancer Research

Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
Elisenda Alsina-Sanchis et al.
Mol Cancer Res February 2021

Molecular Cancer Therapeutics

AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Vikki Flemington et al.
Mol Cancer Ther February 2021

Blood Cancer Discovery

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Stephanie Z. Xie et al.
Blood Cancer Discov January 2021

Cancer Discovery

Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Stephen Sakuma et al.
Cancer Discov January 2021

Cancer Epidemiology, Biomarkers & Prevention

Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study
Jacqueline M. Mix et al.
Cancer Epidemiol Bio Prev January 2021

Cancer Immunology Research

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Juha P. Väyrynen et al.
Cancer Immunol Res January 2021

Cancer Prevention Research

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Courtney Macdonald et al.
Cancer Prev Res January 2021

Cancer Research

The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Emmi Kapiainen et al.
Cancer Res January 2021

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Jessica M. Rusert et al.
Cancer Res January 2021

Clinical Cancer Research

Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
Jonathan M. Loree et al.
Clin Cancer Res January 2021

A Phase Ib Study of Alpelisib or Buparlisib Combined with Tamoxifen Plus Goserelin in Premenopausal Women with HR-Positive HER2-Negative Advanced Breast Cancer
Yen-Shen Lu et al.
Clin Cancer Res January 2021

Molecular Cancer Research

Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Yuri Park et al.
Mol Cancer Res January 2021

Molecular Cancer Therapeutics

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Shauni Lien Geeraerts et al.
Mol Cancer Ther January 2021