2020
AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
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:: 2020 Picks :: 2019 Picks
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May
Cancer Discovery
Tuning the Antigen Density Requirement for CAR T-cell Activity
Cancer Discov May 2020
Cancer Epidemiology, Biomarkers & Prevention
Projected Reductions in Absolute Cancer–Related Deaths from Diagnosing Cancers Before Metastasis, 2006–2015
Cancer Epidemiol Bio Prev May 2020
Cancer Immunology Research
A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation
Cancer Immunol Res May 2020
Cancer Prevention Research
The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers
Cancer Prev Res May 2020
Cancer Research
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer
Cancer Res May 2020
Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer
Cancer Res May 2020
Clinical Cancer Research
Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study
Clin Cancer Res May 2020
Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
Clin Cancer Res May 2020
Molecular Cancer Research
27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
Mol Cancer Res May 2020
Molecular Cancer Therapeutics
Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Mol Cancer Ther May 2020
April
Cancer Discovery
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Cancer Discov April 2020
Cancer Epidemiology, Biomarkers & Prevention
Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk
Cancer Epidemiol Bio Prev April 2020
Cancer Immunology Research
Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma
Cancer Immunol Res April 2020
Cancer Prevention Research
Cancer Immunoprevention: A Case Report Raising the Possibility of "Immuno-interception"
Cancer Prev Res April 2020
Cancer Research
Towards Multidrug Adaptive Therapy
Cancer Res April 2020
Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
Cancer Res April 2020
Clinical Cancer Research
Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors
Clin Cancer Res April 2020
Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Clin Cancer Res April 2020
Molecular Cancer Research
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma
Mol Cancer Res April 2020
Molecular Cancer Therapeutics
Preclinical Activity of HER2-Selective Tyrosine Kinase Inhibitor Tucatinib as a Single Agent or in Combination with Trastuzumab or Docetaxel in Solid Tumor Models
Mol Cancer Ther April 2020
March
Cancer Discovery
Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Cancer Discov March 2020
Cancer Epidemiology, Biomarkers & Prevention
Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study
Cancer Epidemiol Bio Prev March 2020
Cancer Immunology Research
B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
Cancer Immunol Res March 2020
Cancer Prevention Research
Combination of Erlotinib and Naproxen Employing Pulsatile or Intermittent Dosing Profoundly Inhibits Urinary Bladder Cancers
Cancer Prev Res March 2020
Cancer Research
Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Cancer Res March 2020
Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Cancer Res March 2020
Clinical Cancer Research
A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
Clin Cancer Res March 2020
Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
Clin Cancer Res March 2020
Molecular Cancer Research
PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression
Mol Cancer Res March 2020
Molecular Cancer Therapeutics
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas
Mol Cancer Ther March 2020
February
Cancer Discovery
Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Cancer Discov February 2020
Cancer Epidemiology, Biomarkers & Prevention
Medical Financial Hardship Intensity and Financial Sacrifice Associated with Cancer in the United States
Cancer Epidemiol Bio Prev February 2020
Cancer Immunology Research
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
Cancer Immunol Res February 2020
Cancer Prevention Research
Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model
Cancer Prev Res February 2020
Cancer Research
Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes
Cancer Res February 2020
A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition
Cancer Res February 2020
Clinical Cancer Research
Everolimus and Octreotide for Patients with Recurrent Meningioma: Results from the Phase II CEVOREM Trial
Clin Cancer Res February 2020
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma
Clin Cancer Res February 2020
Molecular Cancer Research
Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer
Mol Cancer Res February 2020
Molecular Cancer Therapeutics
10D1F, an Anti-HER3 Antibody That Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models
Mol Cancer Ther February 2020
January
Cancer Discovery
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Cancer Discov January 2020
Cancer Epidemiology, Biomarkers & Prevention
Comparative Effectiveness of Two Interventions to Increase Colorectal Cancer Screening for Those at Increased Risk Based on Family History: Results of a Randomized Trial
Cancer Epidemiol Bio Prev January 2020
Cancer Immunology Research
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers
Cancer Immunol Res January 2020
Cancer Prevention Research
Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype–like Cluster
Cancer Prev Res January 2020
Cancer Research
Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Cancer Res January 2020
Twist1-induced epithelial dissemination requires Prkd1 signaling
Cancer Res January 2020
Clinical Cancer Research
Clinical Assessment of 5-Fluorouracil/Leucovorin, Nab-Paclitaxel, and Irinotecan (FOLFIRABRAX) in Untreated Patients with Gastrointestinal Cancer Using UGT1A1 Genotype–Guided Dosing
Clin Cancer Res January 2020
A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma
Clin Cancer Res January 2020
Molecular Cancer Research
Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition
Mol Cancer Res January 2020
Molecular Cancer Therapeutics
A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
Mol Cancer Ther January 2020
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