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Driving CAR T-cell Therapy Forward

This free-to-read collection of articles published in 2021 in Cancer Immunology Research, includes research and review articles that showcase a wide array of strategies for advancing CAR T-cell therapy through cutting-edge approaches to immune-cell engineering, tracking, and enhancing persistence. We hope you enjoy this collection!

Research Articles

Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses

Yanping Yang; Jaclyn E. McCloskey; Huan Yang; Janusz Puc; Yago Alcaina; Yogindra Vedvyas; Angel A. Gomez Gallegos; Elizabeth Ortiz-Sánchez; Elisa de Stanchina; Irene M. Min; Eric von Hofe; Moonsoo M. Jin

https://doi.org/10.1158/2326-6066.CIR-21-0062

Research Articles

CD19/CD22 Dual-Targeted CAR T-cell Therapy for Relapsed/Refractory Aggressive B-cell Lymphoma: A Safety and Efficacy Study

Guoqing Wei; Yanlei Zhang; Houli Zhao; Yiyun Wang; Yandan Liu; Bin Liang; Xiujian Wang; Huijun Xu; Jiazhen Cui; Wenjun Wu; Kui Zhao; Arnon Nagler; Alex H. Chang; Yongxian Hu; He Huang

https://doi.org/10.1158/2326-6066.CIR-20-0675

Priority Brief

CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function

Ali Can Sahillioglu; Mireille Toebes; Georgi Apriamashvili; Raquel Gomez; Ton N. Schumacher

https://doi.org/10.1158/2326-6066.CIR-21-0095

Research Articles

Rationally Designed Transgene-Encoded Cell-Surface Polypeptide Tag for Multiplexed Programming of CAR T-cell Synthetic Outputs

Adam J. Johnson; Jia Wei; James M. Rosser; Annette Künkele; Cindy A. Chang; Aquene N. Reid; Michael C. Jensen

https://doi.org/10.1158/2326-6066.CIR-20-0470

Research Articles

Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity

Reona Sakemura; Aditya Bansal; Elizabeth L. Siegler; Mehrdad Hefazi; Nan Yang; Roman H. Khadka; Alysha N. Newsom; Michael J. Hansen; Michelle J. Cox; Claudia Manriquez Roman; Kendall J. Schick; Ismail Can; Erin E. Tapper; Wendy K. Nevala; Mohamad M. Adada; Evandro D. Bezerra; Lionel Aurelien Kankeu Fonkoua; Paulina Horvei; Michael W. Ruff; Sameer A. Parikh; Mukesh K. Pandey; Timothy R. DeGrado; Lukkana Suksanpaisan; Neil E. Kay; Kah-Whye Peng; Stephen J. Russell; Saad S. Kenderian

https://doi.org/10.1158/2326-6066.CIR-20-0901

Cancer Immunology at the Crossroads

Mitochondria as Playmakers of CAR T-cell Fate and Longevity

Hosein Rostamian; Mohammad Khakpoor-Koosheh; Keyvan Fallah-Mehrjardi; Hamid R. Mirzaei; Christine E. Brown

https://doi.org/10.1158/2326-6066.CIR-21-0110

Research Articles

Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Elisa Landoni; Giovanni Fucá; Jian Wang; Venkat R. Chirasani; Zhiyuan Yao; Elena Dukhovlinova; Soldano Ferrone; Barbara Savoldo; Lee K. Hong; Peishun Shou; Silvia Musio; Francesco Padelli; Gaetano Finocchiaro; Miriam Droste; Brian Kuhlman; Abdijapar Shamshiev; Serena Pellegatta; Nikolay V. Dokholyan; Gianpietro Dotti

https://doi.org/10.1158/2326-6066.CIR-20-0451

Research Articles Author Choice

CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

Justin C. Boucher; Gongbo Li; Hiroshi Kotani; Maria L. Cabral; Dylan Morrissey; Sae Bom Lee; Kristen Spitler; Nolan J. Beatty; Estelle V. Cervantes; Bishwas Shrestha; Bin Yu; Aslamuzzaman Kazi; Xuefeng Wang; Said M. Sebti; Marco L. Davila

https://doi.org/10.1158/2326-6066.CIR-20-0253

Driving CAR T-cell Therapy Forward

AACR Journals

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