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Precision Oncology

Precision Oncology is an evolving concept. What began with targeted therapy has expanded to include genomic biomarker screening through liquid or tumor biopsy for patient selection and to guide therapies. Precision medicine in oncology has further developed to include the individual’s tumor immune environment, lifestyle (diet and exercise) and overall health that can be used to further design therapeutic intervention. Marlowe Tessmer, PhD Executive Editor, Clinical Cancer Research ([email protected]).

Review

The New NCI Precision Medicine Trials

Lyndsay N. Harris; Charles D. Blanke; Harry P. Erba; James M. Ford; Robert J. Gray; Michael L. LeBlanc; Siwen Hu-Lieskovan; Mark R. Litzow; Selina M. Luger; Funda Meric-Bernstam; Peter J. O'Dwyer; Megan K.D. Othus; Katerina Politi; Lois E. Shepherd; Carmen J. Allegra; Helen X. Chen; S. Percy Ivy; Larissa A. Korde; Richard F. Little; Lisa M. McShane; Jeffrey A. Moscow; David R. Patton; Magdalena Thurin; Laura M. Yee; James H. Doroshow

Doi: 10.1158/1078-0432.CCR-23-0917

Review

Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications

Mohamed A. Gouda; Blessie E. Nelson; Lars Buschhorn; Adam Wahida; Vivek Subbiah

Doi: 10.1158/1078-0432.CCR-23-0090

In Focus

Precision Oncology: 2023 in Review

Yonina R. Murciano-Goroff; Sarah P. Suehnholz; Alexander Drilon; Debyani Chakravarty

Doi: 10.1158/2159-8290.CD-23-1194

Precision Medicine and Imaging
Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer Open Access
Joseph C. Murray; Lavanya Sivapalan; Karlijn Hummelink; Archana Balan; James R. White; Noushin Niknafs; Lamia Rhymee; Gavin Pereira; Nisha Rao; Benny Weksler; Nathan Bahary; Jillian Phallen; Alessandro Leal; David L. Bartlett; Kristen A. Marrone; Jarushka Naidoo; Akul Goel; Benjamin Levy; Samuel Rosner; Christine L. Hann; Susan C. Scott; Josephine Feliciano; Vincent K. Lam; David S. Ettinger; Qing Kay Li; Peter B. Illei; Kim Monkhorst; Robert B. Scharpf; Julie R. Brahmer; Victor E. Velculescu; Ali H. Zaidi; Patrick M. Forde; Valsamo Anagnostou
https://doi.org/10.1158/1078-0432.CCR-23-1469
Translational Cancer Mechanisms and Therapy
Association of Molecular Subtypes with Pathologic Response, PFS, and OS in a Phase II Study of COXEN with Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer Available to Purchase
Seth P. Lerner; David J. McConkey; Catherine M. Tangen; Joshua J. Meeks; Thomas W. Flaig; Xing Hua; Siamak Daneshmand; Ajjai Shivaram Alva; M. Scott Lucia; Dan Theodorescu; Amir Goldkorn; Matthew I. Milowsky; Woonyoung Choi; Rick Bangs; Daniel L. Gustafson; Melissa Plets; Ian M. Thompson, Jr
https://doi.org/10.1158/1078-0432.CCR-23-0602
Research Brief
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer Open Access
Sarah P. Suehnholz; Moriah H. Nissan; Hongxin Zhang; Ritika Kundra; Subhiksha Nandakumar; Calvin Lu; Stephanie Carrero; Amanda Dhaneshwar; Nicole Fernandez; Benjamin W. Xu; Maria E. Arcila; Ahmet Zehir; Aijazuddin Syed; A. Rose Brannon; Julia E. Rudolph; Eder Paraiso; Paul J. Sabbatini; Ross L. Levine; Ahmet Dogan; Jianjiong Gao; Marc Ladanyi; Alexander Drilon; Michael F. Berger; David B. Solit; Nikolaus Schultz; Debyani Chakravarty
https://doi.org/10.1158/2159-8290.CD-23-0467
Research Articles
Gene–Environment Analyses in a UK Biobank Skin Cancer Cohort Identifies Important SNPs in DNA Repair Genes That May Help Prognosticate Disease Risk Available to Purchase
Richie Jeremian; Pingxing Xie; Misha Fotovati; Philippe Lefrançois; Ivan V. Litvinov
https://doi.org/10.1158/1055-9965.EPI-23-0545
Research Articles
Neoadjuvant Durvalumab Alone or Combined with Novel Immuno-Oncology Agents in Resectable Lung Cancer: The Phase II NeoCOAST Platform Trial Open Access
Tina Cascone; Gozde Kar; Jonathan D. Spicer; Rosario García-Campelo; Walter Weder; Davey B. Daniel; David R. Spigel; Maen Hussein; Julien Mazieres; Julio Oliveira; Edwin H. Yau; Alexander I. Spira; Valsamo Anagnostou; Raymond Mager; Oday Hamid; Lin-Yang Cheng; Ying Zheng; Jorge Blando; Tze Heng Tan; Michael Surace; Jaime Rodriguez-Canales; Vancheswaran Gopalakrishnan; Bret R. Sellman; Italia Grenga; Yee Soo-Hoo; Rakesh Kumar; Lara McGrath; Patrick M. Forde
https://doi.org/10.1158/2159-8290.CD-23-0436
Research Articles
Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma Open Access
Donagh Egan; Martina Kreileder; Myriam Nabhan; Luis F. Iglesias-Martinez; Simon J. Dovedi; Viia Valge-Archer; Amit Grover; Robert W. Wilkinson; Timothy Slidel; Claus Bendtsen; Ian P. Barrett; Donal J. Brennan; Walter Kolch; Vadim Zhernovkov
https://doi.org/10.1158/2326-6066.CIR-22-0563
Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit Open Access
Benjamin J. Bulen; Nickolay A. Khazanov; Daniel H. Hovelson; Laura E. Lamb; Marc Matrana; Mark E. Burkard; Eddy Shih-Hsin Yang; William J. Edenfield; Elizabeth Claire Dees; Adedayo A. Onitilo; Gary L. Buchschacher; Alan M. Miller; Benjamin M. Parsons; Timothy R. Wassenaar; Jennifer M. Suga; Robert D. Siegel; William Irvin; Suresh Nair; Jennifer N. Slim; Jamal Misleh; Jamil Khatri; Gregory A. Masters; Sachdev Thomas; Malek M. Safa; Daniel M. Anderson; Jonathan Mowers; Anna C. Dusenbery; Stephanie Drewery; Komal Plouffe; Travis Reeder; Hana Vakil; Lynnae Patrias; Amanda Falzetta; Ryan Hamilton; Kat Kwiatkowski; D. Bryan Johnson; Daniel R. Rhodes; Scott A. Tomlins
https://doi.org/10.1158/2767-9764.CRC-23-0036
Translational Cancer Biology
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma Open Access
Evangeline R. Jackson; Ryan J. Duchatel; Dilana E. Staudt; Mika L. Persson; Abdul Mannan; Sridevi Yadavilli; Sarah Parackal; Shaye Game; Wai Chin Chong; W. Samantha N. Jayasekara; Marion Le Grand; Padraic S. Kearney; Alicia M. Douglas; Izac J. Findlay; Zacary P. Germon; Holly P. McEwen; Tyrone S. Beitaki; Adjanie Patabendige; David A. Skerrett-Byrne; Brett Nixon; Nathan D. Smith; Bryan Day; Neevika Manoharan; Sumanth Nagabushan; Jordan R. Hansford; Dinisha Govender; Geoff B. McCowage; Ron Firestein; Meegan Howlett; Raelene Endersby; Nicholas G. Gottardo; Frank Alvaro; Sebastian M. Waszak; Martin R. Larsen; Yolanda Colino-Sanguino; Fatima Valdes-Mora; Andria Rakotomalala; Samuel Meignan; Eddy Pasquier; Nicolas André; Esther Hulleman; David D. Eisenstat; Nicholas A. Vitanza; Javad Nazarian; Carl Koschmann; Sabine Mueller; Jason E. Cain; Matthew D. Dun
https://doi.org/10.1158/0008-5472.CAN-23-0186
Research Articles
Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia Open Access
Andriana G. Kotini; Saul Carcamo; Nataly Cruz-Rodriguez; Malgorzata Olszewska; Tiansu Wang; Deniz Demircioglu; Chan-Jung Chang; Elsa Bernard; Mark P. Chao; Ravindra Majeti; Hanzhi Luo; Michael G. Kharas; Dan Hasson; Eirini P. Papapetrou
https://doi.org/10.1158/2643-3230.BCD-22-0167
Research Articles
Validation of an Abridged Breast Cancer Risk Prediction Model for the General Population Open Access
Erika L. Spaeth; Gillian S. Dite; John L. Hopper; Richard Allman
https://doi.org/10.1158/1940-6207.CAPR-22-0460

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