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Cancer Early Detection
Recent advancements in early cancer detection technologies, particularly blood-based multicancer early detection tests, have progressed rapidly. These innovations hold promise in expanding the spectrum of cancers suitable for screening and ultimately reducing cancer mortality. This collection comprises studies recently published in AACR journals, highlighting breakthroughs in early cancer detection. The topics covered span the identification of new biomarkers, the development of innovative methods utilizing specimens beyond blood (such as urine, fecal matter, and breast milk) for single or multiple cancer types, and the design of cancer screening trials to evaluate the tests. Review and commentary articles within this collection provide insights into the current progress, challenges, and future prospects of these technologies, offering a comprehensive overview of the evolving field. Jing Peng, PhD, Associate Editor, Cancer Prevention Research and Cancer Epidemiology, Biomarkers & Prevention ([email protected])
Review
Multicancer Early Detection Technologies: A Review Informed by Past Cancer Screening Studies
Sana Raoof; Richard J. Lee; Kunal Jajoo; Joseph D. Mancias; Timothy R. Rebbeck; Steven J. Skates
Doi: 10.1158/1055-9965.EPI-21-1443
Review
Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era
Eric A. Klein; Sarina Madhavan; Tomasz M. Beer; Chetan Bettegowda; Minetta C. Liu; Anne-Renee Hartman; Allan Hackshaw
Doi: 10.1158/1055-9965.EPI-22-1275
Commentary
Cancer Screening Companies Are Rapidly Proliferating: Are They Ready for Business?
Amaia Fernandez-Uriarte; Oscar D. Pons-Belda; Eleftherios P. Diamandis
Doi: 10.1158/1055-9965.EPI-22-0102
Research Articles
Jamie E. Medina; Akshaya V. Annapragada; Pien Lof; Sarah Short; Adrianna L. Bartolomucci; Dimitrios Mathios; Shashikant Koul; Noushin Niknafs; Michaël Noë; Zachariah H. Foda; Daniel C. Bruhm; Carolyn Hruban; Nicholas A. Vulpescu; Euihye Jung; Renu Dua; Jenna V. Canzoniero; Stephen Cristiano; Vilmos Adleff; Heather Symecko; Daan van den Broek; Lori J. Sokoll; Stephen B. Baylin; Michael F. Press; Dennis J. Slamon; Gottfried E. Konecny; Christina Therkildsen; Beatriz Carvalho; Gerrit A. Meijer; Claus Lindbjerg Andersen; Susan M. Domchek; Ronny Drapkin; Robert B. Scharpf; Jillian Phallen; Christine A.R. Lok; Victor E. Velculescu
Research Articles
Peter J. Mazzone; Peter B. Bach; Jacob Carey; Caitlin A. Schonewolf; Katalin Bognar; Manmeet S. Ahluwalia; Marcia Cruz-Correa; David Gierada; Sonali Kotagiri; Kathryn Lloyd; Fabien Maldonado; Jesse D. Ortendahl; Lecia V. Sequist; Gerard A. Silvestri; Nichole Tanner; Jeffrey C. Thompson; Anil Vachani; Kwok-Kin Wong; Ali H. Zaidi; Joseph Catallini; Ariel Gershman; Keith Lumbard; Laurel K. Millberg; Jeff Nawrocki; Carter Portwood; Aakanksha Rangnekar; Carolina Campos Sheridan; Niti Trivedi; Tony Wu; Yuhua Zong; Lindsey Cotton; Allison Ryan; Christopher Cisar; Alessandro Leal; Nicholas Dracopoli; Robert B. Scharpf; Victor E. Velculescu; Luke R. G. Pike
Research Articles
Eric Y. Stutheit-Zhao; Enrique Sanz-Garcia; Zhihui (Amy) Liu; Derek Wong; Kayla Marsh; Albiruni R. Abdul Razak; Anna Spreafico; Philippe L. Bedard; Aaron R. Hansen; Stephanie Lheureux; Dax Torti; Bernard Lam; Shih Yu Cindy Yang; Justin Burgener; Ping Luo; Yong Zeng; Nicholas Cheng; Philip Awadalla; Scott V. Bratman; Pamela S. Ohashi; Trevor J. Pugh; Lillian L. Siu
Special Commentaries
Valsamo Anagnostou; Victor E. Velculescu
Translational Cancer Mechanisms and Therapy
Maria Coakley; Guillermo Villacampa; Prithika Sritharan; Claire Swift; Kathryn Dunne; Lucy Kilburn; Katie Goddard; Christodoulos Pipinikas; Patricia Rojas; Warren Emmett; Peter Hall; Catherine Harper-Wynne; Tamas Hickish; Iain Macpherson; Alicia Okines; Andrew Wardley; Duncan Wheatley; Simon Waters; Carlo Palmieri; Matthew Winter; Rosalind J. Cutts; Isaac Garcia-Murillas; Judith Bliss; Nicholas C. Turner
Research Articles
Derek Wong; Ping Luo; Leslie E. Oldfield; Haifan Gong; Ledia Brunga; Ron Rabinowicz; Vallijah Subasri; Clarissa Chan; Tiana Downs; Kirsten M. Farncombe; Beatrice Luu; Maia Norman; Julia A. Sobotka; Precious Uju; Jenna Eagles; Stephanie Pedersen; Johanna Wellum; Arnavaz Danesh; Stephenie D. Prokopec; Eric Y. Stutheit-Zhao; Nadia Znassi; Lawrence E. Heisler; Richard Jovelin; Bernard Lam; Beatriz E. Lujan Toro; Kayla Marsh; Yogi Sundaravadanam; Dax Torti; Carina Man; Anna Goldenberg; Wei Xu; Patrick Veit-Haibach; Andrea S. Doria; David Malkin; Raymond H. Kim; Trevor J. Pugh
Research Articles
Martin S. Taylor; Connie Wu; Peter C. Fridy; Stephanie J. Zhang; Yasmeen Senussi; Justina C. Wolters; Tatiana Cajuso; Wen-Chih Cheng; John D. Heaps; Bryant D. Miller; Kei Mori; Limor Cohen; Hua Jiang; Kelly R. Molloy; Brian T. Chait; Michael G. Goggins; Irun Bhan; Joseph W. Franses; Xiaoyu Yang; Mary-Ellen Taplin; Xinan Wang; David C. Christiani; Bruce E. Johnson; Matthew Meyerson; Ravindra Uppaluri; Ann Marie Egloff; Elyssa N. Denault; Laura M. Spring; Tian-Li Wang; Ie-Ming Shih; Jennifer E. Fairman; Euihye Jung; Kshitij S. Arora; Osman H. Yilmaz; Sonia Cohen; Tatyana Sharova; Gary Chi; Bryanna L. Norden; Yuhui Song; Linda T. Nieman; Leontios Pappas; Aparna R. Parikh; Matthew R. Strickland; Ryan B. Corcoran; Tomas Mustelin; George Eng; Ömer H. Yilmaz; Ursula A. Matulonis; Andrew T. Chan; Steven J. Skates; Bo R. Rueda; Ronny Drapkin; Samuel J. Klempner; Vikram Deshpande; David T. Ting; Michael P. Rout; John LaCava; David R. Walt; Kathleen H. Burns
Research Articles
Rachel M. Bramblet; Jamie N. Bakkum-Gamez; Seth W. Slettedahl; Patrick H. Foote; William R. Taylor; Calise K. Berger; Brianna J. Gysbers; Jacquelyn Arndt; Longwen Chen; Karen A. Doering; Kelli N. Burger; Douglas W. Mahoney; Mark E. Sherman; John B. Kisiel; N. Jewel Samadder
Research Briefs
Cristina Saura; Carolina Ortiz; Judit Matito; Enrique J. Arenas; Anna Suñol; Ágatha Martín; Octavi Córdoba; Alex Martínez-Sabadell; Itziar García-Ruiz; Ignacio Miranda; Clara Morales-Comas; Estela Carrasco; Cristina Viaplana; Vicente Peg; Paolo Nuciforo; Neus Bayó-Puxan; Alberto Gonzalez-Medina; Josep M. Miquel; Marina Gómez-Rey; Guillermo Villacampa; Silvia Arévalo; Martín Espinosa-Bravo; Judith Balmaña; Rodrigo Dienstmann; Joaquin Arribas; Josep Tabernero; Ana Vivancos; Miriam Sansó
Vallijah Subasri; Nicholas Light; Nisha Kanwar; Jack Brzezinski; Ping Luo; Jordan R. Hansford; Elizabeth Cairney; Carol Portwine; Christine Elser; Jonathan L. Finlay; Kim E. Nichols; Noa Alon; Ledia Brunga; Jo Anson; Wendy Kohlmann; Kelvin C. de Andrade; Payal P. Khincha; Sharon A. Savage; Joshua D. Schiffman; Rosanna Weksberg; Trevor J. Pugh; Anita Villani; Adam Shlien; Anna Goldenberg; David Malkin
Research Articles
Thomas F. Imperiale; Philip T. Lavin; Tara N. Marti; Debbie Jakubowski; Steven H. Itzkowitz; Folasade P. May; Paul J. Limburg; Seth Sweetser; Anas Daghestani; Barry M. Berger
Priority Reports
Shinichi Namba; Yuki Saito; Yasunori Kogure; Tatsuo Masuda; Melissa L. Bondy; Puya Gharahkhani; Ines Gockel; Dominik Heider; Axel Hillmer; Janusz Jankowski; Stuart MacGregor; Carlo Maj; Beatrice Melin; Quinn T. Ostrom; Claire Palles; Johannes Schumacher; Ian Tomlinson; David C. Whiteman; Yukinori Okada; Keisuke Kataoka
Molecular Cell Biology
Yeh Wang; Peng Huang; Brant G. Wang; Tricia Murdock; Leslie Cope; Fang-Chi Hsu; Tian-Li Wang; Ie-Ming Shih
Jung Eun Baik; Li Li; Manish A. Shah; Daniel E. Freedberg; Zhezhen Jin; Timothy C. Wang; Yiping W. Han
Precision Medicine and Imaging
Ming Yu; Helen R. Moinova; Amber Willbanks; Victoria K. Cannon; Ting Wang; Kelly Carter; Andrew Kaz; Deepti Reddi; John Inadomi; Georg Luebeck; Prasad G. Iyer; Marcia I. Canto; Jean S. Wang; Nicholas J. Shaheen; Prashanti N. Thota; Joseph E. Willis; Thomas LaFramboise; Amitabh Chak; Sanford D. Markowitz; William M. Grady
Research Articles
Lukas Owens; Roman Gulati; Ruth Etzioni
Research Articles
Haejin In; Srawani Sarkar; Jessica Ward; Patricia Friedmann; Michael Parides; Julie Yang; Meira Epplein
Precision Medicine and Imaging
Rianne van den Helder; Renske D.M. Steenbergen; Annina P. van Splunter; Constantijne H. Mom; Ming Y. Tjiong; Ivonne Martin; Fleur M.F. Rosier-van Dunné; Irene A.M. van der Avoort; Maaike C.G. Bleeker; Nienke E. van Trommel
Genome and Epigenome
Julia Matas; Brendan Kohrn; Jeanne Fredrickson; Kelly Carter; Ming Yu; Ting Wang; Xianyong Gui; Thierry Soussi; Victor Moreno; William M. Grady; Miguel A. Peinado; Rosa Ana Risques
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