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Developmental Therapeutics
Building upon decades of foundational knowledge, the field of cancer research continues its push into new molecular territory for the development of novel therapeutic agents. These innovative approaches have the potential to shift paradigms in cancer treatment and improve clinical outcomes for patients. This collection of review and research articles from the AACR journals encompasses the preclinical and early clinical validation of novel and exciting therapeutics currently under development. Danielle Large, PhD, Assistant Editor, Molecular Cancer Therapeutics ([email protected]).
Review
Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating
Mohamad Hamieh; Jorge Mansilla-Soto; Isabelle Rivière; Michel Sadelain
Doi: 10.1158/2159-8290.CD-23-0101
Review
Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants
Marco H. Hofmann; Daniel Gerlach; Sandra Misale; Mark Petronczki; Norbert Kraut
Doi: 10.1158/2159-8290.CD-21-1331
First Disclosures
Dorin Toader; Shawn P. Fessler; Scott D. Collins; Patrick R. Conlon; Reddy Bollu; Kalli C. Catcott; Chen-Ni Chin; Anouk Dirksen; Bingfan Du; Jeremy R. Duvall; Stacy Higgins; Mariya V. Kozytska; Kamela Bellovoda; Chelsey Faircloth; David Lee; Fu Li; Liuliang Qin; Caitlin Routhier; Pamela Shaw; Cheri A. Stevenson; Jason Wang; Phonphimon Wongthida; Elena Ter-Ovanesyan; Elizabeth Ditty; Stephen P. Bradley; Ling Xu; Mao Yin; Alexandr V. Yurkovetskiy; Rebecca Mosher; Marc Damelin; Timothy B. Lowinger
First Disclosure
Bartlomiej Borek; Julita Nowicka; Anna Gzik; Marek Dziegielewski; Karol Jedrzejczak; Joanna Brzezinska; Marcin Grzybowski; Paulina Stanczak; Paulina Pomper; Agnieszka Zagozdzon; Tomasz Rejczak; Krzysztof Matyszewski; Adam Golebiowski; Jacek Olczak; Kamil Lisiecki; Magdalena Tyszkiewicz; Magdalena Kania; Sylwia Piasecka; Anna Cabaj; Paulina Dera; Krzysztof Mulewski; Jacek Chrzanowski; Damian Kusmirek; Elzbieta Sobolewska; Marta Magdycz; Lukasz Mucha; Marek Masnyk; Jakub Golab; Marcin Nowotny; Elzbieta Nowak; Agnieszka Napiorkowska-Gromadzka; Stanislaw Pikul; Radoslaw Jazwiec; Karolina Dzwonek; Pawel Dobrzanski; Michael Meyring; Krzysztof Skowronek; Piotr Iwanowski; Zbigniew Zaslona; Roman Blaszczyk
Zoë Johnson; Chiara Tarantelli; Elisa Civanelli; Luciano Cascione; Filippo Spriano; Amy Fraser; Pritom Shah; Tyzoon Nomanbhoy; Sara Napoli; Andrea Rinaldi; Karolina Niewola-Staszkowska; Michael Lahn; Dominique Perrin; Mathias Wenes; Denis Migliorini; Francesco Bertoni; Lars van der Veen; Giusy Di Conza
Research Briefs
Alfred L. Garfall; Adam D. Cohen; Sandra P. Susanibar-Adaniya; Wei-Ting Hwang; Dan T. Vogl; Adam J. Waxman; Simon F. Lacey; Vanessa E. Gonzalez; Joseph A. Fraietta; Minnal Gupta; Irina Kulikovskaya; Lifeng Tian; Fang Chen; Natalka Koterba; Robert L. Bartoszek; Margaret Patchin; Rong Xu; Gabriela Plesa; Don L. Siegel; Andrea Brennan; Anne Marie Nelson; Regina Ferthio; Angela Cosey; Kim-Marie Shea; Rachel Leskowitz; Megan Four; Wesley V. Wilson; Fei Miao; Eric Lancaster; Beatriz M. Carreno; Gerald P. Linette; Elizabeth O. Hexner; Regina M. Young; Dexiu Bu; Keith G. Mansfield; Jennifer L. Brogdon; Carl H. June; Michael C. Milone; Edward A. Stadtmauer
Clinical Trials: Immunotherapy
Funda Meric-Bernstam; Randy F. Sweis; Stefan Kasper; Omid Hamid; Shailender Bhatia; Reinhard Dummer; Agostina Stradella; Georgina V. Long; Anna Spreafico; Toshio Shimizu; Neeltje Steeghs; Jason J. Luke; Sarah M. McWhirter; Thomas Müller; Nitya Nair; Nancy Lewis; Xinhui Chen; Andrew Bean; Lisa Kattenhorn; Marc Pelletier; Shahneen Sandhu
Translational Cancer Mechanisms and Therapy
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Open Access
Giuditta Illuzzi; Anna D. Staniszewska; Sonja J. Gill; Andy Pike; Lisa McWilliams; Susan E. Critchlow; Anna Cronin; Stephen Fawell; Glen Hawthorne; Kunzah Jamal; Jeffrey Johannes; Emilyanne Leonard; Ruth Macdonald; Gareth Maglennon; Jenni Nikkilä; Mark J. O'Connor; Aaron Smith; Harriet Southgate; Joanne Wilson; James Yates; Sabina Cosulich; Elisabetta Leo
Kristie A. Blum; Jeffrey G. Supko; Michael B. Maris; Ian W. Flinn; Andre Goy; Anas Younes; Suresh Bobba; Adrian M. Senderowicz; Sergey Efuni; Ronda Rippley; Gozde Colak; Patrick Trojer; Jeremy S. Abramson
Tumor Biology and Immunology
Siler H. Panowski; Surabhi Srinivasan; Nguyen Tan; Silvia K. Tacheva-Grigorova; Bryan Smith; Yvonne S.L. Mak; Hongxiu Ning; Jonathan Villanueva; Dinali Wijewarnasuriya; Shanshan Lang; Zea Melton; Adit Ghosh; Mathilde Dusseaux; Roman Galetto; Jonathan R. Heyen; Tao Sai; Thomas Van Blarcom; Javier Chaparro-Riggers; Barbra J. Sasu
Large Molecule Therapeutics
Sakshi Tomar; Jingli Zhang; Manakamana Khanal; Jessica Hong; Abhilash Venugopalan; Qun Jiang; Manjistha Sengupta; Markku Miettinen; Nan Li; Ira Pastan; Mitchell Ho; Raffit Hassan
Research Articles
Andreas Weiss; Edwige Lorthiois; Louise Barys; Kim S. Beyer; Claudio Bomio-Confaglia; Heather Burks; Xueying Chen; Xiaoming Cui; Ruben de Kanter; Lekshmi Dharmarajan; Carmine Fedele; Marc Gerspacher; Daniel Alexander Guthy; Victoria Head; Ashley Jaeger; Eloísa Jiménez Núñez; Jeffrey D. Kearns; Catherine Leblanc; Sauveur-Michel Maira; Jason Murphy; Helen Oakman; Nils Ostermann; Johannes Ottl; Pascal Rigollier; Danielle Roman; Christian Schnell; Richard Sedrani; Toshio Shimizu; Rowan Stringer; Andrea Vaupel; Hans Voshol; Peter Wessels; Toni Widmer; Rainer Wilcken; Kun Xu; Frederic Zecri; Anna F. Farago; Simona Cotesta; Saskia M. Brachmann
Research Articles
Holly K. Koblish; Liangxing Wu; Liang-Chuan S. Wang; Phillip C.C. Liu; Richard Wynn; Jonathan Rios-Doria; Susan Spitz; Hao Liu; Alla Volgina; Nina Zolotarjova; Kanishk Kapilashrami; Elham Behshad; Maryanne Covington; Yan-ou Yang; Jingwei Li; Sharon Diamond; Maxim Soloviev; Kevin O'Hayer; Stephen Rubin; Chrysi Kanellopoulou; Gengjie Yang; Mark Rupar; Darlise DiMatteo; Luping Lin; Christina Stevens; Yue Zhang; Pramod Thekkat; Ryan Geschwindt; Cindy Marando; Swamy Yeleswaram; Jeff Jackson; Peggy Scherle; Reid Huber; Wenqing Yao; Gregory Hollis
Husain Yar Khan; Misako Nagasaka; Yiwei Li; Amro Aboukameel; Md. Hafiz Uddin; Rachel Sexton; Sahar Bannoura; Yousef Mzannar; Mohammed Najeeb Al-Hallak; Steve Kim; Rafic Beydoun; Yosef Landesman; Hirva Mamdani; Dipesh Uprety; Philip A. Philip; Ramzi M. Mohammad; Anthony F. Shields; Asfar S. Azmi
Research Brief
Alison M. Schram; Igor Odintsov; Madelyn Espinosa-Cotton; Inna Khodos; Whitney J. Sisso; Marissa S. Mattar; Allan J.W. Lui; Morana Vojnic; Sara H. Shameem; Thrusha Chauhan; Jean Torrisi; Jim Ford; Marie N. O'Connor; Cecile A.W. Geuijen; Ron C.J. Schackmann; Jeroen J. Lammerts van Bueren; Ernesto Wasserman; Elisa de Stanchina; Eileen M. O'Reilly; Marc Ladanyi; Alexander Drilon; Romel Somwar
Small Molecule Therapeutics
Junhui Li; Rati Lama; Samuel L. Galster; Joseph R. Inigo; Jin Wu; Dhyan Chandra; Sherry R. Chemler; Xinjiang Wang
Large Molecule Therapeutics
Michiko Yamato; Jun Hasegawa; Takanori Maejima; Chiharu Hattori; Kazuyoshi Kumagai; Akiko Watanabe; Yumi Nishiya; Tomoko Shibutani; Tetsuo Aida; Ichiro Hayakawa; Takashi Nakada; Yuki Abe; Toshinori Agatsuma
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