Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Metabolism and Cancer

Metabolic reprogramming is a cancer hallmark that supports tumor growth and progression. In addition to altered metabolism of cancer cells, metabolic processes in the tumor microenvironment can impact cancer development, metastasis, and response to therapy. Cells in the tumor microenvironment can provide nutrients to cancer cells but can also be a source of metabolic competition. Overall host factors like diet, exercise, and obesity also regulate cancer risk and prognosis. This collection of articles published across AACR journals illustrates the intricate interplay between metabolism and cancer, describing mechanisms mediating metabolic rewiring in cancer and strategies to harness metabolism to improve cancer treatment and prevention. Harmony Turk, PhD, Executive Editor, Cancer Research ([email protected]).

Perspective

Diet and Exercise in Cancer Metabolism

Jason W. Locasale

Doi: 10.1158/2159-8290.CD-22-0096

Cancer Research Landmarks

Fueling the Tumor Microenvironment with Cancer-Associated Adipocytes

Caroline Bouche; Daniela F. Quail

Doi: 10.1158/0008-5472.CAN-23-0505

Review

Monounsaturated Fatty Acids: Key Regulators of Cell Viability and Intracellular Signaling in Cancer

Julia S. Scott; Zeyad D. Nassar; Johannes V. Swinnen; Lisa M. Butler

Doi: 10.1158/1541-7786.MCR-21-1069

Cancer Metabolism and Molecular Mechanisms
Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Yannan Zheng; Rui Zhou; Jianan Cai; Nanyan Yang; Zhaowei Wen; Zhihua Zhang; Huiying Sun; Genjie Huang; Yijin Guan; Na Huang; Min Shi; Yulin Liao; Jianping Bin; Wangjun Liao
https://doi.org/10.1158/0008-5472.CAN-23-0025
Cancer Immunology
Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells
Ziwen Zhong; Hao Zhang; Ke Nan; Jing Zhong; Qichao Wu; Lihong Lu; Ying Yue; Zhenyu Zhang; Miaomiao Guo; Zhiqiang Wang; Jie Xia; Yun Xing; Ying Fu; Baichao Yu; Wenchang Zhou; Xingfeng Sun; Yang Shen; Wankun Chen; Jie Zhang; Jin Zhang; Duan Ma; Yiwei Chu; Ronghua Liu; Changhong Miao
https://doi.org/10.1158/0008-5472.CAN-23-0323
Tumor Microenvironment and Immunobiology
Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins
Angela M. Schab; Molly M. Greenwade; Elizabeth Stock; Elena Lomonosova; Kevin Cho; Whitney R. Grither; Hollie Noia; Daniel Wilke; Mary M. Mullen; Andrea R. Hagemann; Ian S. Hagemann; Premal H. Thaker; Lindsay M. Kuroki; Carolyn K. McCourt; Dineo Khabele; Matthew A. Powell; David G. Mutch; Peinan Zhao; Leah P. Shriver; Gary J. Patti; Gregory D. Longmore; Katherine C. Fuh
https://doi.org/10.1158/1541-7786.MCR-23-0347
Targeting Drug Resistance
A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
Geetha Venkateswaran; Paul C. McDonald; Shawn C. Chafe; Wells S. Brown; Zachary J. Gerbec; Shannon J. Awrey; Seth J. Parker; Shoukat Dedhar
https://doi.org/10.1158/1535-7163.MCT-23-0041
Research Articles
HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Kosuke Toyoda; Jun-ichirou Yasunaga; Takafumi Shichijo; Yuichiro Arima; Kenichi Tsujita; Azusa Tanaka; Tarig Salah; Wenyi Zhang; Osama Hussein; Miyu Sonoda; Miho Watanabe; Daisuke Kurita; Kazutaka Nakashima; Kyohei Yamada; Hiroaki Miyoshi; Koichi Ohshima; Masao Matsuoka
https://doi.org/10.1158/2643-3230.BCD-22-0139
Research Articles
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Marie Sabatier; Rudy Birsen; Laura Lauture; Sarah Mouche; Paolo Angelino; Jonas Dehairs; Léa Goupille; Ismael Boussaid; Maël Heiblig; Emeline Boet; Ambrine Sahal; Estelle Saland; Juliana C. Santos; Marc Armengol; Miranda Fernández-Serrano; Thomas Farge; Guillaume Cognet; Federico Simonetta; Corentin Pignon; Antoine Graffeuil; Céline Mazzotti; Hervé Avet-Loiseau; Océane Delos; Justine Bertrand-Michel; Amélie Chedru; Vilma Dembitz; Paolo Gallipoli; Natasha S. Anstee; Sun Loo; Andrew H. Wei; Martin Carroll; Armelle Goubard; Rémy Castellano; Yves Collette; François Vergez; Véronique Mansat-De Mas; Sarah Bertoli; Suzanne Tavitian; Muriel Picard; Christian Récher; Nathalie Bourges-Abella; Fanny Granat; Olivier Kosmider; Pierre Sujobert; Benoit Colsch; Carine Joffre; Lucille Stuani; Johannes V. Swinnen; Hervé Guillou; Gael Roué; Nawad Hakim; Anne S. Dejean; Petros Tsantoulis; Clément Larrue; Didier Bouscary; Jerome Tamburini; Jean-Emmanuel Sarry
https://doi.org/10.1158/2159-8290.CD-22-0411
Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Simona Lombardi; Aaron R. Goldman; Hsin-Yao Tang; Andrew V. Kossenkov; Heng Liu; Wei Zhou; Meenhard Herlyn; Jianhuang Lin; Rugang Zhang
https://doi.org/10.1158/2767-9764.CRC-23-0030
Research Articles
Influence of Adipose Tissue Distribution, Sarcopenia, and Nutritional Status on Clinical Outcomes After CD19 CAR T-cell Therapy
Kai Rejeski; David M. Cordas dos Santos; Nathan H. Parker; Veit L. Bücklein; Michael Winkelmann; Khushali S. Jhaveri; Lian Liu; Paul Trinkner; Sophie Günther; Philipp Karschnia; Viktoria Blumenberg; Christian Schmidt; Wolfgang G. Kunz; Michael von Bergwelt-Baildon; Michael D. Jain; Sebastian Theurich; Marion Subklewe
https://doi.org/10.1158/2326-6066.CIR-22-0487
Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Sandrina Nóbrega-Pereira; Francisco Santos; Miguel Oliveira Santos; Teresa L. Serafim; Ana Patrícia Lopes; Diogo Coutinho; Filipa S. Carvalho; Rosário M. Domingues; Pedro Domingues; Bruno Bernardes de Jesus; Vanessa A. Morais; Sérgio Dias
https://doi.org/10.1158/2767-9764.CRC-22-0394
Research Articles
Serum Lipid Profiles and Cholesterol-Lowering Medication Use in Relation to Subsequent Risk of Colorectal Cancer in the UK Biobank Cohort
Fangcheng Yuan; Wanqing Wen; Guochong Jia; Jirong Long; Xiao-Ou Shu; Wei Zheng
https://doi.org/10.1158/1055-9965.EPI-22-1170
Metabolism and Chemical Biology
An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Danna Sheinboim; Shivang Parikh; Paulee Manich; Irit Markus; Sapir Dahan; Roma Parikh; Elisa Stubbs; Gali Cohen; Valentina Zemser-Werner; Rachel E. Bell; Sara Arciniegas Ruiz; Ruth Percik; Ronen Brenner; Stav Leibou; Hananya Vaknine; Gali Arad; Yariv Gerber; Lital Keinan-Boker; Tal Shimony; Lior Bikovski; Nir Goldstein; Keren Constantini; Sapir Labes; Shimonov Mordechai; Hila Doron; Ariel Lonescu; Tamar Ziv; Eran Nizri; Guy Choshen; Hagit Eldar-Finkelman; Yuval Tabach; Aharon Helman; Shamgar Ben-Eliyahu; Neta Erez; Eran Perlson; Tamar Geiger; Danny Ben-Zvi; Mehdi Khaled; Yftach Gepner; Carmit Levy
https://doi.org/10.1158/0008-5472.CAN-22-0237
Research Articles
TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate
Rebecca S. Hesterberg; Min Liu; Aya G. Elmarsafawi; John M. Koomen; Eric A. Welsh; Stephen G. Hesterberg; Sujeewa Ranatunga; Chunying Yang; Weimin Li; Harshani R. Lawrence; Paulo C. Rodriguez; Anders E. Berglund; John L. Cleveland
https://doi.org/10.1158/2326-6066.CIR-21-0813
Cancer Genes and Networks
Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism
Bhopal C. Mohapatra; Sameer Mirza; Aditya Bele; Channabasavaiah B. Gurumurthy; Mohsin Raza; Irfana Saleem; Matthew D. Storck; Aniruddha Sarkar; Sai Sundeep Kollala; Surendra K. Shukla; Siddesh Southekal; Kay-Uwe Wagner; Fang Qiu; Subodh M. Lele; Mansour A. Alsaleem; Emad A. Rakha; Chittibabu Guda; Pankaj K. Singh; Robert D. Cardiff; Hamid Band; Vimla Band
https://doi.org/10.1158/1541-7786.MCR-22-0122
Precision Medicine and Imaging
Spatial Metabolomics Identifies Distinct Tumor-Specific Subtypes in Gastric Cancer Patients
Jun Wang; Thomas Kunzke; Verena M. Prade; Jian Shen; Achim Buck; Annette Feuchtinger; Ivonne Haffner; Birgit Luber; Drolaiz H.W. Liu; Rupert Langer; Florian Lordick; Na Sun; Axel Walch
https://doi.org/10.1158/1078-0432.CCR-21-4383
Translational Cancer Mechanisms and Therapy
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Emanuela Dylgjeri; Vishal Kothari; Ayesha A. Shafi; Galina Semenova; Peter T. Gallagher; Yi F. Guan; Angel Pang; Jonathan F. Goodwin; Swati Irani; Jennifer J. McCann; Amy C. Mandigo; Saswati Chand; Christopher M. McNair; Irina Vasilevskaya; Matthew J. Schiewer; Costas D. Lallas; Peter A. McCue; Leonard G. Gomella; Erin L. Seifert; Jason S. Carroll; Lisa M. Butler; Jeff Holst; William K. Kelly; Karen E. Knudsen
https://doi.org/10.1158/1078-0432.CCR-21-1846

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept