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Tumor Evolution

Accumulation and selection of genetic variations and subsequent expansion of subclonal cancer cell populations are a key source of intratumoral heterogeneity, which presents both challenges and opportunities for cancer therapeutics. Breakthroughs in the study of tumor evolution have been critical to advancing cancer detection, surveillance, therapy, and prevention. This collection highlights recent studies exploring various aspects of tumor evolution including evolutionary events underlying cancer development and progression, time scales of genetic and structural variation emergence and the rise of driver events, novel forms of structural variation, and evolutionary mechanisms of resistance and treatment evasion. The research featured in this collection present new and exciting avenues in the development of novel molecular diagnostic tools, patient stratification, selection of personalized treatment regimens, and strategies for overcoming resistance, with the goal of improving patient outcomes. Bailee Sliker, PhD, Associate Editor, Cancer Discovery ([email protected]); Rachel Hodge, PhD, Assistant Editor, Clinical Cancer Research ([email protected]).


Review

Cancer Evolution: A Multifaceted Affair

Giovanni Ciriello; Luca Magnani; Sarah J. Aitken; Leila Akkari; Sam Behjati; Douglas Hanahan; Dan A. Landau; Nuria Lopez-Bigas; Darío G. Lupiáñez; Jean-Christophe Marine; Ana Martin-Villalba; Gioacchino Natoli; Anna C. Obenauf; Elisa Oricchio; Paola Scaffidi; Andrea Sottoriva; Alexander Swarbrick; Giovanni Tonon; Sakari Vanharanta; Johannes Zuber

Doi: 10.1158/2159-8290.CD-23-0530

Review

The Genetic Evolution of Metastasis

Aljosja Rogiers; Irene Lobon; Lavinia Spain; Samra Turajlic

Doi: 10.1158/0008-5472.CAN-21-3863

Tathiane M. Malta; Thais S. Sabedot; Natalia S. Morosini; Indrani Datta; Luciano Garofano; Wies Vallentgoed; Frederick S. Varn; Kenneth Aldape; Fulvio D'Angelo; Spyridon Bakas; Jill S. Barnholtz-Sloan; Hui K. Gan; Mohammad Hasanain; Ann-Christin Hau; Kevin C. Johnson; Simona Cazacu; Ana C. deCarvalho; Mustafa Khasraw; Emre Kocakavuk; Mathilde C.M. Kouwenhoven; Simona Migliozzi; Simone P. Niclou; Johanna M. Niers; D. Ryan Ormond; Sun Ha Paek; Guido Reifenberger; Peter A. Sillevis Smitt; Marion Smits; Lucy F. Stead; Martin J. van den Bent; Erwin G. Van Meir; Annemiek Walenkamp; Tobias Weiss; Michael Weller; Bart A. Westerman; Bauke Ylstra; Pieter Wesseling; Anna Lasorella; Pim J. French; Laila M. Poisson; Consortium The GLASS; Adelheid Woehrer; Allison K Lowman; Ana C deCarvalho; Ana Valeria Castro; Andrea Transou; Andrew R Brodbelt; Ann-Christin Hau; Anna Lasorella; Anna Golebiewska; Annemiek Walenkamp; Annette M Molinaro; Antonio Iavarone; Azzam Ismail; Bart A Westerman; Bauke Ylstra; Christoph Bock; D. Ryan Ormond; Daniel J Brat; Emre Kocakavuk; Erwin G Van Meir; Floris P Barthel; Frederick S Varn; Fulvio D'Angelo; Gaetano Finocchiaro; Ganesh Rao; Gelareh Zadeh; Guido Reifenberger; Ho Keu ngNg; Hoon Kim; Houtan Noushmehr; Hrvoje Miletic; Hui K Gan; Indrani Datta; Jack Rock; James M Snyder; Jason T Huse; Jennifer M Connelly; Jill S Barnholtz-Sloan; Johanna M Niers; John F deGroot; Kadir C Akdemir; Kasthuri S Kannan; Keith L Ligon; Kenneth Aldape; Ketan R Bulsara; Kevin C Johnson; Kristin D Alfaro; Laila M Poisson; Luciano Garofano; Lucy F Stead; MacLean P Nasrallah; Marion Smits; Martin J van den Bent; Mathilde CM Kouwenhoven; Michael Weller; Mohammad Hasanain; Mustafa Khasraw; Peter V Gould; Peter A Sillevis Smitt; Peter S LaViolette; Philip D Tatman; Pieter Wesseling; Pim J French; Rameen Beroukhim; Roel G.W. Verhaak; Simona Migliozzi; Simone P Niclou; Spyridon Bakas; Steven Kalkanis; Sun Ha Paek; Susan C Short; Tabatabai Ghazaleh; Tathiane M Malta; Thais S Sabedot; Tobias Weiss; Tobias Walbert; Ujjwal Baid; Wies Vallentgoed; W. K. Alfred Yung; Roel G.W. Verhaak; Antonio Iavarone; Houtan Noushmehr
Dana K. Mitchell; Breanne Burgess; Emily E. White; Abbi E. Smith; Elizabeth A. Sierra Potchanant; Henry Mang; Brooke E. Hickey; Qingbo Lu; Shaomin Qian; Waylan Bessler; Xiaohong Li; Li Jiang; Kylee Brewster; Constance Temm; Andrew Horvai; Eric A. Albright; Melissa L. Fishel; Christine A. Pratilas; Steven P. Angus; D. Wade Clapp; Steven D. Rhodes
Bahar Rastegar; Natalie Andersson; Alexandra Petersson; Jenny Karlsson; Subhayan Chattopadhyay; Anders Valind; Caroline Jansson; Geoffroy Durand; Patrik Romerius; Karin Jirström; Linda Holmquist Mengelbier; David Gisselsson
Lavinia Spain; Alexander Coulton; Irene Lobon; Andrew Rowan; Desiree Schnidrig; Scott T.C. Shepherd; Benjamin Shum; Fiona Byrne; Maria Goicoechea; Elisa Piperni; Lewis Au; Kim Edmonds; Eleanor Carlyle; Nikki Hunter; Alexandra Renn; Christina Messiou; Peta Hughes; Jaime Nobbs; Floris Foijer; Hilda van den Bos; Rene Wardenaar; Diana C.J. Spierings; Charlotte Spencer; Andreas M. Schmitt; Zayd Tippu; Karla Lingard; Lauren Grostate; Kema Peat; Kayleigh Kelly; Sarah Sarker; Sarah Vaughan; Mary Mangwende; Lauren Terry; Denise Kelly; Jennifer Biano; Aida Murra; Justine Korteweg; Charlotte Lewis; Molly O'Flaherty; Anne-Laure Cattin; Max Emmerich; Camille L. Gerard; Husayn Ahmed Pallikonda; Joanna Lynch; Robert Mason; Aljosja Rogiers; Hang Xu; Ariana Huebner; Nicholas McGranahan; Maise Al Bakir; Jun Murai; Cristina Naceur-Lombardelli; Elaine Borg; Miriam Mitchison; David A. Moore; Mary Falzon; Ian Proctor; Gordon W.H. Stamp; Emma L. Nye; Kate Young; Andrew J.S. Furness; Lisa Pickering; Ruby Stewart; Ula Mahadeva; Anna Green; James Larkin; Kevin Litchfield; Charles Swanton; Mariam Jamal-Hanjani; for the PEACE Consortium; Samra Turajlic
Francesco Maura; Bachisio Ziccheddu; Jenny Z. Xiang; Bhavneet Bhinder; Joel Rosiene; Federico Abascal; Kylee H. Maclachlan; Kenneth Wha Eng; Manik Uppal; Feng He; Wei Zhang; Qi Gao; Venkata D. Yellapantula; Vicenta Trujillo-Alonso; Sunita I. Park; Matthew J. Oberley; Elizabeth Ruckdeschel; Megan S. Lim; Gerald B. Wertheim; Matthew J. Barth; Terzah M. Horton; Andriy Derkach; Alexandra E. Kovach; Christopher J. Forlenza; Yanming Zhang; Ola Landgren; Craig H. Moskowitz; Ethel Cesarman; Marcin Imielinski; Olivier Elemento; Mikhail Roshal; Lisa Giulino-Roth
Sanjana Rajan; Simone Zaccaria; Matthew V. Cannon; Maren Cam; Amy C. Gross; Benjamin J. Raphael; Ryan D. Roberts
Keiko Akagi; David E. Symer; Medhat Mahmoud; Bo Jiang; Sara Goodwin; Darawalee Wangsa; Zhengke Li; Weihong Xiao; Joe Dan Dunn; Thomas Ried; Kevin R. Coombes; Fritz J. Sedlazeck; Maura L. Gillison
Isidro Cortes-Ciriano; Christopher D. Steele; Katherine Piculell; Alyaa Al-Ibraheemi; Vanessa Eulo; Marilyn M. Bui; Aikaterini Chatzipli; Brendan C. Dickson; Dana C. Borcherding; Andrew Feber; Alon Galor; Jesse Hart; Kevin B. Jones; Justin T. Jordan; Raymond H. Kim; Daniel Lindsay; Colin Miller; Yoshihiro Nishida; Paula Z. Proszek; Jonathan Serrano; R. Taylor Sundby; Jeffrey J. Szymanski; Nicole J. Ullrich; David Viskochil; Xia Wang; Matija Snuderl; Peter J. Park; Adrienne M. Flanagan; Angela C. Hirbe; Nischalan Pillay; David T. Miller; for the Genomics of MPNST (GeM) Consortium
Elisa ten Hacken; Tomasz Sewastianik; Shanye Yin; Gabriela Brunsting Hoffmann; Michaela Gruber; Kendell Clement; Livius Penter; Robert A. Redd; Neil Ruthen; Sébastien Hergalant; Alanna Sholokhova; Geoffrey Fell; Erin M. Parry; Julien Broséus; Romain Guieze; Fabienne Lucas; María Hernández-Sánchez; Kaitlyn Baranowski; Jackson Southard; Heather Joyal; Leah Billington; Fara Faye D. Regis; Elizabeth Witten; Mohamed Uduman; Binyamin A. Knisbacher; Shuqiang Li; Haoxiang Lyu; Tiziana Vaisitti; Silvia Deaglio; Giorgio Inghirami; Pierre Feugier; Stephan Stilgenbauer; Eugen Tausch; Matthew S. Davids; Gad Getz; Kenneth J. Livak; Ivana Bozic; Donna S. Neuberg; Ruben D. Carrasco; Catherine J. Wu
Kristopher R. Bosse; Anna Maria Giudice; Maria V. Lane; Brendan McIntyre; Patrick M. Schürch; Guillem Pascual-Pasto; Samantha N. Buongervino; Sriyaa Suresh; Alana Fitzsimmons; Adam Hyman; Maria Gemino-Borromeo; Jennifer Saggio; Esther R. Berko; Alexander A. Daniels; Jennifer Stundon; Megan Friedrichsen; Xin Liu; Matthew L. Margolis; Marilyn M. Li; Marni Brisson Tierno; Geoffrey R. Oxnard; John M. Maris; Yael P. Mossé
Ditte S. Christensen; Johanne Ahrenfeldt; Mateo Sokač; Judit Kisistók; Martin K. Thomsen; Lasse Maretty; Nicholas McGranahan; Nicolai J. Birkbak
Carlos R. Gil Del Alcazar; Anne Trinh; Maša Alečković; Ernesto Rojas Jimenez; Nicholas W. Harper; Michael U.J. Oliphant; Shanshan Xie; Ethan D. Krop; Bethlehem Lulseged; Katherine C. Murphy; Tanya E. Keenan; Eliezer M. Van Allen; Sara M. Tolaney; Gordon J. Freeman; Deborah A. Dillon; Senthil K. Muthuswamy; Kornelia Polyak
Alexandra Petersson; Natalie Andersson; Sofie Olsson Hau; Jakob Eberhard; Jenny Karlsson; Subhayan Chattopadhyay; Anders Valind; Jacob Elebro; Björn Nodin; Karin Leandersson; David Gisselsson; Karin Jirström
Xiansong Wang; Wei Hu; Xiangchun Li; Dan Huang; Qing Li; Hung Chan; Judeng Zeng; Chuan Xie; Huarong Chen; Xiaodong Liu; Tony Gin; Maggie Haitian Wang; Alfred Sze Lok Cheng; Wei Kang; Ka-Fai To; Dariusz Plewczynski; Qingpeng Zhang; Xiaoting Chen; Danny Cheuk Wing Chan; Ho Ko; Sunny Hei Wong; Jun Yu; Matthew Tak Vai Chan; Lin Zhang; William Ka Kei Wu
Mark Lee; Brian R. Untch; Bin Xu; Ronald Ghossein; Catherine Han; Fengshen Kuo; Cristina Valero; Zaineb Nadeem; Neal Patel; Vladimir Makarov; Snjezana Dogan; Richard J. Wong; Eric J. Sherman; Alan L. Ho; Timothy A. Chan; James A. Fagin; Luc G.T. Morris

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