Tumor Evolution
Accumulation and selection of genetic variations and subsequent expansion of subclonal cancer cell populations are a key source of intratumoral heterogeneity, which presents both challenges and opportunities for cancer therapeutics. Breakthroughs in the study of tumor evolution have been critical to advancing cancer detection, surveillance, therapy, and prevention. This collection highlights recent studies exploring various aspects of tumor evolution including evolutionary events underlying cancer development and progression, time scales of genetic and structural variation emergence and the rise of driver events, novel forms of structural variation, and evolutionary mechanisms of resistance and treatment evasion. The research featured in this collection present new and exciting avenues in the development of novel molecular diagnostic tools, patient stratification, selection of personalized treatment regimens, and strategies for overcoming resistance, with the goal of improving patient outcomes. Bailee Sliker, PhD, Associate Editor, Cancer Discovery ([email protected]); Rachel Hodge, PhD, Assistant Editor, Clinical Cancer Research ([email protected]).
Review
Cancer Evolution: A Multifaceted Affair
Giovanni Ciriello; Luca Magnani; Sarah J. Aitken; Leila Akkari; Sam Behjati; Douglas Hanahan; Dan A. Landau; Nuria Lopez-Bigas; Darío G. Lupiáñez; Jean-Christophe Marine; Ana Martin-Villalba; Gioacchino Natoli; Anna C. Obenauf; Elisa Oricchio; Paola Scaffidi; Andrea Sottoriva; Alexander Swarbrick; Giovanni Tonon; Sakari Vanharanta; Johannes Zuber
Doi: 10.1158/2159-8290.CD-23-0530
Review
The Genetic Evolution of Metastasis
Aljosja Rogiers; Irene Lobon; Lavinia Spain; Samra Turajlic
Doi: 10.1158/0008-5472.CAN-21-3863