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Cellular Therapies

From bone marrow transplantation to genetically-engineered lymphocytes, successful cell-based therapies of cancers hold promise of becoming one-and-done treatments for every cancer type and every patient. To fulfill this promise, the next generation of "living drugs" will need to improve on safety, efficacy, durability of response, as well as on global accessibility and reproducibility. This collection of review and research articles from the AACR journals encompasses advances in these orthogonal directions, including new antigen targets, optimized production and performance of the cell products, molecular correlates and mechanisms of response and resistance, combination therapies, and minimizing adverse events. Tanya Bondar, PhD, Deputy Editor, Blood Cancer Discovery ([email protected])


Review

60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy

Nicoletta Cieri; Katie Maurer; Catherine J. Wu

Doi: 10.1158/0008-5472.CAN-21-0301

Review

Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy

Mohamed Abou-el-Enein; Magdi Elsallab; Steven A. Feldman; Andrew D. Fesnak; Helen E. Heslop; Peter Marks; Brian G. Till; Gerhard Bauer; Barbara Savoldo

Doi: 10.1158/2643-3230.BCD-21-0084

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N. Eric Olson; Seamus P. Ragan; David J. Reiss; Jerill Thorpe; Yeonhee Kim; Jeremy S. Abramson; Candice McCoy; Kathryn J. Newhall; Brian A. Fox
Sarah M. Larson; Christopher M. Walthers; Brenda Ji; Sanaz N. Ghafouri; Jacob Naparstek; Jacqueline Trent; Jia Ming Chen; Mobina Roshandell; Caitlin Harris; Mobina Khericha; Thomas Schweppe; Beata Berent-Maoz; Stanley B. Gosliner; Amr Almaktari; Melanie Ayala Ceja; Martin S. Allen-Auerbach; Jonathan Said; Karla Nawaly; Monica Mead; Sven de Vos; Patricia A. Young; Caspian Oliai; Gary J. Schiller; John M. Timmerman; Antoni Ribas; Yvonne Y. Chen
Kimberly R. Hagel; Rand Arafeh; Sydney Gang; Taylor E. Arnoff; Rebecca C. Larson; John G. Doench; Nathan D. Mathewson; Kai W. Wucherpfennig; Marcela V. Maus; William C. Hahn
Thomas Pfeiffer; Ifigeneia Tzannou; Mengfen Wu; Carlos Ramos; Ghadir Sasa; Caridad Martinez; Premal Lulla; Robert A. Krance; Lauren Scherer; Daniel Ruderfer; Swati Naik; Claire Bocchini; Iain P. Fraser; Badrish Patel; Dany Ward; Tao Wang; Helen E. Heslop; Ann M. Leen; Bilal Omer
Kavita M. Dhodapkar; Adam D. Cohen; Akhilesh Kaushal; Alfred L. Garfall; Renee Julia Manalo; Allison R. Carr; Samuel S. McCachren, III; Edward A. Stadtmauer; Simon F. Lacey; J. Joseph Melenhorst; Carl H. June; Michael C. Milone; Madhav V. Dhodapkar
Alfonso R. Sánchez-Paulete; Jaime Mateus-Tique; Gurkan Mollaoglu; Sebastian R. Nielsen; Adam Marks; Ashwitha Lakshmi; Jalal A. Khan; C. Matthias Wilk; Luisanna Pia; Alessia Baccarini; Miriam Merad; Brian D. Brown
Zachary Jackson; Changjin Hong; Robert Schauner; Boro Dropulic; Paolo F. Caimi; Marcos de Lima; Maria Florencia Giraudo; Kalpana Gupta; Jane S. Reese; Tae Hyun Hwang; David N. Wald
Erik H. Knelson; Elena V. Ivanova; Mubin Tarannum; Marco Campisi; Patrick H. Lizotte; Matthew A. Booker; Ismail Ozgenc; Moataz Noureddine; Brittany Meisenheimer; Minyue Chen; Brandon Piel; Nathaniel Spicer; Bonje Obua; Cameron M. Messier; Erin Shannon; Navin R. Mahadevan; Tetsuo Tani; Pieter J. Schol; Anna M. Lee-Hassett; Ari Zlota; Ha V. Vo; Minh Ha; Arrien A. Bertram; Saemi Han; Tran C. Thai; Corinne E. Gustafson; Kartika Venugopal; Timothy J. Haggerty; Thomas P. Albertson; Antja-Voy Hartley; Pinar O. Eser; Ze-Hua Li; Israel Cañadas; Marina Vivero; Assunta De Rienzo; William G. Richards; Adnan O. Abu-Yousif; Vicky A. Appleman; Richard C. Gregory; Alexander Parent; Neil Lineberry; Eric L. Smith; Pasi A. Jänne; Juan J. Miret; Michael Y. Tolstorukov; Rizwan Romee; Cloud P. Paweletz; Raphael Bueno; David A. Barbie
Qian Luo; John V. Napoleon; Xin Liu; Boning Zhang; Suilan Zheng; Philip S. Low
Ana M. Metelo; Agnieszka Jozwik; Le Anh Luong; Delaney Dominey-Foy; Charlotte Graham; Charlotte Attwood; Shafqat Inam; Alan Dunlop; Katy Sanchez; Kirsty Cuthill; Carmel Rice; Matthew Streetly; Trevor Bentley; Bijan Boldajipour; Cesar Sommer; Barbra Sasu; Reuben Benjamin
Rebecca M. Richards; Feifei Zhao; Katherine A. Freitas; Kevin R. Parker; Peng Xu; Amy Fan; Elena Sotillo; Mads Daugaard; Htoo Zarni Oo; Jie Liu; Wan-Jen Hong; Poul H. Sorensen; Howard Y. Chang; Ansuman T. Satpathy; Robbie G. Majzner; Ravindra Majeti; Crystal L. Mackall
Makoto Ando; Taisuke Kondo; Wataru Tomisato; Minako Ito; Shigeyuki Shichino; Tanakorn Srirat; Setsuko Mise-Omata; Kensuke Nakagawara; Akihiko Yoshimura
Rui Ma; Ting Lu; Zhenlong Li; Kun-Yu Teng; Anthony G. Mansour; Melissa Yu; Lei Tian; Bo Xu; Shoubao Ma; Jianying Zhang; Tasha Barr; Yong Peng; Michael A. Caligiuri; Jianhua Yu
Lucila N. Kerbauy; Nancy D. Marin; Mecit Kaplan; Pinaki P. Banerjee; Melissa M. Berrien-Elliott; Michelle Becker-Hapak; Rafet Basar; Mark Foster; Luciana Garcia Melo; Carly C. Neal; Ethan McClain; May Daher; Ana Karen Nunez Cortes; Sweta Desai; Francesca Wei Inng Lim; Mayela Carolina Mendt; Timothy Schappe; Li Li; Hila Shaim; Mayra Shanley; Emily L. Ensley; Nadima Uprety; Pamela Wong; Enli Liu; Sonny O. Ang; Rong Cai; Vandana Nandivada; Vakul Mohanty; Qi Miao; Yifei Shen; Natalia Baran; Natalie W. Fowlkes; Ken Chen; Luis Muniz-Feliciano; Richard E. Champlin; Yago L. Nieto; Joachim Koch; Martin Treder; Wolfgang Fischer; Oswaldo Keith Okamoto; Elizabeth J. Shpall; Todd A. Fehniger; Katayoun Rezvani
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