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Immune Checkpoints

T cells play a key role in cancer surveillance and elimination. However, tumor cells evade T cell recognition and activation using several immunosuppressive features of the tumor microenvironment including upregulation of T cell inhibitory molecules such as PD-L1. Blocking the activation of immune checkpoint inhibitors to overcome immune suppression has revolutionized the treatment of cancer patients and allowed long term survival of patients with metastatic disease. This collection of articles highlights recent development in the understanding of T cell immunity and the clinical use of immune checkpoint inhibitors. Avital Lev, PhD, Senior Editor, Cancer Discovery ([email protected])


Review

Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade

Natalija Budimir; Graham D. Thomas; Joseph S. Dolina; Shahram Salek-Ardakani

Doi: 10.1158/2326-6066.CIR-21-0515

Perspective

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Maria Karasarides; Alexandria P. Cogdill; Paul B. Robbins; Michaela Bowden; Elizabeth M. Burton; Lisa H. Butterfield; Alessandra Cesano; Christian Hammer; Cara L. Haymaker; Christine E. Horak; Heather M. McGee; Anne Monette; Nils-Petter Rudqvist; Christine N. Spencer; Randy F. Sweis; Benjamin G. Vincent; Erik Wennerberg; Jianda Yuan; Roberta Zappasodi; Vanessa M. Hubbard Lucey; Daniel K. Wells; Theresa LaVallee

Doi: 10.1158/2326-6066.CIR-20-0586

Special Collection Image
Ernesto Gargiulo; Elodie Viry; Pablo Elías Morande; Anne Largeot; Susanne Gonder; Feng Xian; Nikolaos Ioannou; Mohaned Benzarti; Felix Bruno Kleine Borgmann; Michel Mittelbronn; Gunnar Dittmar; Petr V. Nazarov; Johannes Meiser; Basile Stamatopoulos; Alan G. Ramsay; Etienne Moussay; Jérôme Paggetti
Varintra E. Lander; Jad I. Belle; Natalie L. Kingston; John M. Herndon; Graham D. Hogg; Xiuting Liu; Liang-I Kang; Brett L. Knolhoff; Savannah J. Bogner; John M. Baer; Chong Zuo; Nicholas C. Borcherding; Daniel P. Lander; Cedric Mpoy; Jalen Scott; Michael Zahner; Buck E. Rogers; Julie K. Schwarz; Hyun Kim; David G. DeNardo
Joseph B. Hiatt; Holly Sandborg; Sarah M. Garrison; Henry U. Arnold; Sheng-You Liao; Justin P. Norton; Travis J. Friesen; Feinan Wu; Kate D. Sutherland; Hugh Y. Rienhoff, Jr; Renato Martins; A. McGarry Houghton; Shivani Srivastava; David MacPherson
Anne-Gaëlle Goubet; Leonardo Lordello; Carolina Alves Costa Silva; Isabelle Peguillet; Marianne Gazzano; Maxime Descartes Mbogning-Fonkou; Cassandra Thelemaque; Cédric Lebacle; Constance Thibault; François Audenet; Géraldine Pignot; Gwenaelle Gravis; Carole Helissey; Luca Campedel; Morgan Roupret; Evanguelos Xylinas; Idir Ouzaid; Agathe Dubuisson; Marine Mazzenga; Caroline Flament; Pierre Ly; Virginie Marty; Nicolas Signolle; Allan Sauvat; Thomas Sbarrato; Mounia Filahi; Caroline Davin; Gabriel Haddad; Jacques Bou Khalil; Camille Bleriot; François-Xavier Danlos; Garett Dunsmore; Kevin Mulder; Aymeric Silvin; Thibault Raoult; Baptiste Archambaud; Shaima Belhechmi; Ivo Gomperts Boneca; Nadège Cayet; Maryse Moya-Nilges; Adeline Mallet; Romain Daillere; Etienne Rouleau; Camelia Radulescu; Yves Allory; Jacques Fieschi; Mathieu Rouanne; Florent Ginhoux; Gwénaël Le Teuff; Lisa Derosa; Aurélien Marabelle; Jeroen Van Dorp; Nick Van Dijk; Michiel S. Van Der Heijden; Benjamin Besse; Fabrice Andre; Miriam Merad; Guido Kroemer; Jean-Yves Scoazec; Laurence Zitvogel; Yohann Loriot
Robin Reschke; Jason W. Shapiro; Jovian Yu; Sherin J. Rouhani; Daniel J. Olson; Yuanyuan Zha; Thomas F. Gajewski
Liam Jenkins; Ute Jungwirth; Alexandra Avgustinova; Marjan Iravani; Adam Mills; Syed Haider; James Harper; Clare M. Isacke
Christopher Alvarez-Breckenridge; Samuel C. Markson; Jackson H. Stocking; Naema Nayyar; Matt Lastrapes; Matthew R. Strickland; Albert E. Kim; Magali de Sauvage; Ashish Dahal; Juliana M. Larson; Joana L. Mora; Andrew W. Navia; Robert H. Klein; Benjamin M. Kuter; Corey M. Gill; Mia Bertalan; Brian Shaw; Alexander Kaplan; Megha Subramanian; Aarushi Jain; Swaminathan Kumar; Husain Danish; Michael White; Osmaan Shahid; Kristen E. Pauken; Brian C. Miller; Dennie T. Frederick; Christine Hebert; McKenzie Shaw; Maria Martinez-Lage; Matthew Frosch; Nancy Wang; Elizabeth Gerstner; Brian V. Nahed; William T. Curry; Bob Carter; Daniel P. Cahill; Genevieve Marie Boland; Benjamin Izar; Michael A. Davies; Arlene H. Sharpe; Mario L. Suvà; Ryan J. Sullivan; Priscilla K. Brastianos; Scott L. Carter
Min Liu; Nabihah Tayob; Livius Penter; MacLean Sellars; Anna Tarren; Vipheaviny Chea; Isabel Carulli; Teddy Huang; Shuqiang Li; Su-Chun Cheng; Phuong Le; Laura Frackiewicz; Julia Fasse; Courtney Qi; Joyce F. Liu; Elizabeth H. Stover; Jennifer Curtis; Kenneth J. Livak; Donna Neuberg; Guanglan Zhang; Ursula A. Matulonis; Catherine J. Wu; Derin B. Keskin; Panagiotis A. Konstantinopoulos
Anand V.R. Kornepati; Jacob T. Boyd; Clare E. Murray; Julia Saifetiarova; Bárbara de la Peña Avalos; Cody M. Rogers; Haiyan Bai; Alvaro S. Padron; Yiji Liao; Carlos Ontiveros; Robert S. Svatek; Robert Hromas; Rong Li; Yanfen Hu; Jose R. Conejo-Garcia; Ratna K. Vadlamudi; Weixing Zhao; Eloïse Dray; Patrick Sung; Tyler J. Curiel
Benoit Rousseau; Ivan Bieche; Eric Pasmant; Nadim Hamzaoui; Nicolas Leulliot; Lucas Michon; Aurelien de Reynies; Valerie Attignon; Michael B. Foote; Julien Masliah-Planchon; Magali Svrcek; Romain Cohen; Victor Simmet; Paule Augereau; David Malka; Antoine Hollebecque; Damien Pouessel; Carlos Gomez-Roca; Rosine Guimbaud; Amandine Bruyas; Marielle Guillet; Jean-Jacques Grob; Muriel Duluc; Sophie Cousin; Christelle de la Fouchardiere; Aude Flechon; Frederic Rolland; Sandrine Hiret; Esma Saada-Bouzid; Olivier Bouche; Thierry Andre; Diane Pannier; Farid El Hajbi; Stephane Oudard; Christophe Tournigand; Jean-Charles Soria; Stephane Champiat; Drew G. Gerber; Dennis Stephens; Michelle F. Lamendola-Essel; Steven B. Maron; Bill H. Diplas; Guillem Argiles; Asha R. Krishnan; Severine Tabone-Eglinger; Anthony Ferrari; Neil H. Segal; Andrea Cercek; Natalie Hoog-Labouret; Frederic Legrand; Clotilde Simon; Assia Lamrani-Ghaouti; Luis A. Diaz, Jr; Pierre Saintigny; Sylvie Chevret; Aurelien Marabelle
Thabet Alhousami; Michael Diny; Faiza Ali; Jennifer Shin; Gaurav Kumar; Vikas Kumar; Joshua D. Campbell; Vikki Noonan; Glenn J. Hanna; Gerald V. Denis; Stefano Monti; Maria A. Kukuruzinska; Xaralabos Varelas; Manish V. Bais
Denise L. Cecil; Ekram A. Gad; Lauren R. Corulli; Nicholas Drovetto; Ronald A. Lubet; Mary L. Disis
Michiko Yamato; Jun Hasegawa; Takanori Maejima; Chiharu Hattori; Kazuyoshi Kumagai; Akiko Watanabe; Yumi Nishiya; Tomoko Shibutani; Tetsuo Aida; Ichiro Hayakawa; Takashi Nakada; Yuki Abe; Toshinori Agatsuma
Xian-Yang Li; Dillon Corvino; Bianca Nowlan; Amelia Roman Aguilera; Susanna S. Ng; Matthias Braun; Anthony R. Cillo; Tobias Bald; Mark J. Smyth; Christian R. Engwerda
Erin W. Meermeier; Seth J. Welsh; Meaghen E. Sharik; Megan T. Du; Victoria M. Garbitt; Daniel L. Riggs; Chang-Xin Shi; Caleb K. Stein; Marco Bergsagel; Bryant Chau; Matthew L. Wheeler; Natalie Bezman; Feng Wang; Pavel Strop; P. Leif Bergsagel; Marta Chesi
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