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Drug Resistance

Approximately 12 oncology therapeutics are approved by the U.S. Food and Drug Administration each year. However, resistance to anticancer therapies almost invariably arises and is the primary reason for relapse and mortality in patients with cancers. The interplay among multiple factors such as tumor heterogeneity, dose-limiting drug toxicity, and the variety of anticancer therapy resistance mechanisms presents a particularly difficult challenge to overcome. This collection of review and research articles from the AACR journals features recent advances in the development and refinement of tools such as pre-clinical models, single-cell technologies, and real-world databases which have led to the elucidation of additional resistance mechanisms as well as the identification of potential biomarkers and therapeutic strategies to overcome drug resistance and improve patient response and outcome. I-Mei Siu, PhD, Senior Editor, Cancer Discovery ([email protected])


Perspective

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Maria Karasarides; Alexandria P. Cogdill; Paul B. Robbins; Michaela Bowden; Elizabeth M. Burton; Lisa H. Butterfield; Alessandra Cesano; Christian Hammer; Cara L. Haymaker; Christine E. Horak; Heather M. McGee; Anne Monette; Nils-Petter Rudqvist; Christine N. Spencer; Randy F. Sweis; Benjamin G. Vincent; Erik Wennerberg; Jianda Yuan; Roberta Zappasodi; Vanessa M. Hubbard Lucey; Daniel K. Wells; Theresa LaVallee

Doi: 10.1158/2326-6066.CIR-20-0586

Reviews

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Jeffrey W. Tyner; Franziska Haderk; Anbarasu Kumaraswamy; Linda B. Baughn; Brian Van Ness; Song Liu; Himangi Marathe; Joshi J. Alumkal; Trever G. Bivona; Keith Syson Chan; Brian J. Druker; Alan D. Hutson; Peter S. Nelson; Charles L. Sawyers; Christopher D. Willeyfor the Drug Resistance and Sensitivity Network

Doi: 10.1158/0008-5472.CAN-21-3695

Special Collection Image
Niklas Klümper; Damian J. Ralser; Jörg Ellinger; Florian Roghmann; Julia Albrecht; Eduard Below; Abdullah Alajati; Danijel Sikic; Johannes Breyer; Christian Bolenz; Friedemann Zengerling; Philipp Erben; Kristina Schwamborn; Ralph M. Wirtz; Thomas Horn; Dora Nagy; Marieta Toma; Glen Kristiansen; Thomas Büttner; Oliver Hahn; Viktor Grünwald; Christopher Darr; Eva Erne; Steffen Rausch; Jens Bedke; Katrin Schlack; Mahmoud Abbas; Stefanie Zschäbitz; Constantin Schwab; Alexander Mustea; Patrick Adam; Andreas Manseck; Bernd Wullich; Manuel Ritter; Arndt Hartmann; Jürgen Gschwend; Wilko Weichert; Franziska Erlmeier; Michael Hölzel; Markus Eckstein
Nele Loret; Niels Vandamme; Jordy De Coninck; Joachim Taminau; Kato De Clercq; Gillian Blancke; Sven Jonckheere; Steven Goossens; Kelly Lemeire; Sofie De Prijck; Kevin Verstaen; Ruth Seurinck; Jo Van Dorpe; Steven Weyers; Hannelore Denys; Koen Van de Vijver; Bart N. Lambrecht; Philippe Tummers; Yvan Saeys; Geert Berx
Yong Du; Yongfeng Chen; Yuxia Wang; Jinju Chen; Xiaorong Lu; Li Zhang; Yan Li; Zhaofu Wang; Guozhong Ye; George Zhang
Kyung-min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. González Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga
Jo Sasame; Naoki Ikegaya; Masahito Kawazu; Manabu Natsumeda; Takahiro Hayashi; Masataka Isoda; Kaishi Satomi; Arata Tomiyama; Akito Oshima; Hirokuni Honma; Yohei Miyake; Katsuhiro Takabayashi; Taishi Nakamura; Toshihide Ueno; Yuko Matsushita; Hiromichi Iwashita; Yu Kanemaru; Hidetoshi Murata; Akihide Ryo; Keita Terashima; Shoji Yamanaka; Yukihiko Fujii; Hiroyuki Mano; Takashi Komori; Koichi Ichimura; Daniel P. Cahill; Hiroaki Wakimoto; Tetsuya Yamamoto; Kensuke Tateishi
Jingwei Zhang; Adam J. Pearson; Nitin Sabherwal; Brian A. Telfer; Nisha Ali; Karmern Kan; Qiuping Xu; Wei Zhang; Fuhui Chen; Shiyang Li; Jinhua Wang; Nathanael S. Gray; Blanca Risa-Ebrí; Katherine G. Finegan; Michael J. Cross; Emanuele Giurisato; Alan J. Whitmarsh; Cathy Tournier
Fernanda G. Herrera; Catherine Ronet; Maria Ochoa de Olza; David Barras; Isaac Crespo; Massimo Andreatta; Jesus Corria-Osorio; Aodrenn Spill; Fabrizio Benedetti; Raphael Genolet; Angela Orcurto; Martina Imbimbo; Eleonora Ghisoni; Blanca Navarro Rodrigo; Dominik R. Berthold; Apostolos Sarivalasis; Khalil Zaman; Rafael Duran; Clarisse Dromain; John Prior; Niklaus Schaefer; Jean Bourhis; Georgia Dimopoulou; Zoi Tsourti; Marius Messemaker; Thomas Smith; Sarah E. Warren; Periklis Foukas; Sylvie Rusakiewicz; Mikaël J. Pittet; Stefan Zimmermann; Christine Sempoux; Urania Dafni; Alexandre Harari; Lana E. Kandalaft; Santiago J. Carmona; Denarda Dangaj Laniti; Melita Irving; George Coukos
Dinesh Thummuri; Sajid Khan; Patrick W. Underwood; Peiyi Zhang; Janet Wiegand; Xuan Zhang; Vivekananda Budamagunta; Amin Sobh; Abderrahmane Tagmount; Alexander Loguinov; Andrea N. Riner; Ashwin S. Akki; Elizabeth Williamson; Robert Hromas; Christopher D. Vulpe; Guangrong Zheng; Jose G. Trevino; Daohong Zhou
Arthur L. Shaffer, III; James D. Phelan; James Q. Wang; DaWei Huang; George W. Wright; Monica Kasbekar; Jaewoo Choi; Ryan M. Young; Daniel E. Webster; Yandan Yang; Hong Zhao; Xin Yu; Weihong Xu; Sandrine Roulland; Michele Ceribelli; Xiaohu Zhang; Kelli M. Wilson; Lu Chen; Crystal McKnight; Carleen Klumpp-Thomas; Craig J. Thomas; Björn Häupl; Thomas Oellerich; Zachary Rae; Michael C. Kelly; Inhye E. Ahn; Clare Sun; Erika M. Gaglione; Wyndham H. Wilson; Adrian Wiestner; Louis M. Staudt
Xinbo Wang; Yueqing Chen; Xudong Wang; Hongling Tian; Yanjin Wang; Jiali Jin; Zezhi Shan; Yu'e Liu; Zhenyu Cai; Xinyuan Tong; Yi Luan; Xiao Tan; Bing Luan; Xin Ge; Hongbin Ji; Xuejun Jiang; Ping Wang
Joshua L.D. Parris; Thibaut Barnoud; Julia I.-Ju Leu; Jessica C. Leung; Weili Ma; Nicole A. Kirven; Adi Naryana Reddy Poli; Andrew V. Kossenkov; Qin Liu; Joseph M. Salvino; Donna L. George; Ashani T. Weeraratna; Qing Chen; Maureen E. Murphy
Yukie Kashima; Daisuke Shibahara; Ayako Suzuki; Kyoko Muto; Ikei S. Kobayashi; David Plotnick; Hibiki Udagawa; Hiroki Izumi; Yuji Shibata; Kosuke Tanaka; Masanori Fujii; Akihiro Ohashi; Masahide Seki; Koichi Goto; Katsuya Tsuchihara; Yutaka Suzuki; Susumu S. Kobayashi
David J. Young; Bao Nguyen; Li Li; Tomoyasu Higashimoto; Mark J. Levis; Jun O. Liu; Donald Small
Noritaka Tanaka; Jessica J. Lin; Chendi Li; Meagan B. Ryan; Junbing Zhang; Lesli A. Kiedrowski; Alexa G. Michel; Mohammed U. Syed; Katerina A. Fella; Mustafa Sakhi; Islam Baiev; Dejan Juric; Justin F. Gainor; Samuel J. Klempner; Jochen K. Lennerz; Giulia Siravegna; Liron Bar-Peled; Aaron N. Hata; Rebecca S. Heist; Ryan B. Corcoran
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