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Liquid Biopsies

Molecular profiling and the adoption of next-generation sequencing technologies in the clinic for cancer diagnosis, prognosis, monitoring, and targeted therapy selection have dramatically expanded the toolkit available to oncologists and researchers. Such testing strategies often rely on direct sampling and assaying of tumor tissue, which may be complicated by challenges that include tumors being difficult to access surgically, limiting the feasibility, quantity, and longitudinal sampling; tumors being genotypically and phenotypically heterogeneous, limiting the representativeness of individual biopsies toward the whole tumor or metastatic load; and circulating tumor cells, cell-free DNA, extracellular vesicles, and other tumor-derived products having diagnostic and prognostic value potentially missed by tumor-only sampling. Liquid biopsies of blood or other bodily fluids represent non-invasive and repeatable methods for molecularly profiling tumors that overcome these challenges. This collection of content from the AACR journals showcases research into developing liquid biopsy technologies and leveraging liquid biopsy assays for patient monitoring and prognosis. David Gennert, PhD, Assistant Editor, Blood Cancer Discovery (David.Gennert@aacr.org)


Review

Liquid Biopsy: From Discovery to Clinical Application

Catherine Alix-Panabiéres; Klaus Pantel

Doi: 10.1158/2159-8290.CD-20-1311

Review

Circulating Tumor DNA in Lymphoma: Principles and Future Directions

Mark Roschewski; Davide Rossi; David M. Kurtz; Ash A. Alizadeh; Wyndham H. Wilson

Doi:10.1158/2643-3230.BCD-21-0029

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Navonil De Sarkar; Robert D. Patton; Anna-Lisa Doebley; Brian Hanratty; Mohamed Adil; Adam J. Kreitzman; Jay F. Sarthy; Minjeong Ko; Sandipan Brahma; Michael P. Meers; Derek H. Janssens; Lisa S. Ang; Ilsa M. Coleman; Arnab Bose; Ruth F. Dumpit; Jared M. Lucas; Talina A. Nunez; Holly M. Nguyen; Heather M. McClure; Colin C. Pritchard; Michael T. Schweizer; Colm Morrissey; Atish D. Choudhury; Sylvan C. Baca; Jacob E. Berchuck; Matthew L. Freedman; Kami Ahmad; Michael C. Haffner; R. Bruce Montgomery; Eva Corey; Steven Henikoff; Peter S. Nelson; Gavin Ha
Zachariah H. Foda; Akshaya V. Annapragada; Kavya Boyapati; Daniel C. Bruhm; Nicholas A. Vulpescu; Jamie E. Medina; Dimitrios Mathios; Stephen Cristiano; Noushin Niknafs; Harry T. Luu; Michael G. Goggins; Robert A. Anders; Jing Sun; Shruti H. Meta; David L. Thomas; Gregory D. Kirk; Vilmos Adleff; Jillian Phallen; Robert B. Scharpf; Amy K. Kim; Victor E. Velculescu
Kristopher R. Bosse; Anna Maria Giudice; Maria V. Lane; Brendan McIntyre; Patrick M. Schürch; Guillem Pascual-Pasto; Samantha N. Buongervino; Sriyaa Suresh; Alana Fitzsimmons; Adam Hyman; Maria Gemino-Borromeo; Jennifer Saggio; Esther R. Berko; Alexander A. Daniels; Jennifer Stundon; Megan Friedrichsen; Xin Liu; Matthew L. Margolis; Marilyn M. Li; Marni Brisson Tierno; Geoffrey R. Oxnard; John M. Maris; Yael P. Mossé
Viswam S. Nair; Angela Bik-Yu Hui; Jacob J. Chabon; Mohammad S. Esfahani; Henning Stehr; Barzin Y. Nabet; Li Zhou; Aadel A. Chaudhuri; Jalen Benson; Kelsey Ayers; Harmeet Bedi; Meghan Ramsey; Ryan Van Wert; Sanja Antic; Natalie Lui; Leah Backhus; Mark Berry; Arthur W. Sung; Pierre P. Massion; Joseph B. Shrager; Ash A. Alizadeh; Maximilian Diehn
Liang Xia; Jiandong Mei; Ran Kang; Senyi Deng; Yaohui Chen; Ying Yang; Gang Feng; Yulan Deng; Fanyi Gan; Yidan Lin; Qiang Pu; Lin Ma; Feng Lin; Yong Yuan; Yang Hu; Chenglin Guo; Hu Liao; Chengwu Liu; Yunke Zhu; Wenping Wang; Zheng Liu; Yuyang Xu; Kaidi Li; Chuan Li; Qingyun Li; Ji He; Weizhi Chen; Xiaolong Zhang; Yingli Kou; Yun Wang; Zhu Wu; Guowei Che; Longqi Chen; Lunxu Liu
Mary Jo Fackler; Suzana Tulac; Neesha Venkatesan; Adam J. Aslam; Timothy N. de Guzman; Claudia Mercado-Rodriguez; Leslie M. Cope; Bradley M. Downs; Abdul Hussain Vali; Wanjun Ding; Jennifer Lehman; Rita Denbow; Jeffrey Reynolds; Morgan E. Buckley; Kala Visvanathan; Christopher B. Umbricht; Antonio C. Wolff; Vered Stearns; Michael Bates; Edwin W. Lai; Saraswati Sukumar
Tenna Vesterman Henriksen; Noelia Tarazona; Amanda Frydendahl; Thomas Reinert; Francisco Gimeno-Valiente; Juan Antonio Carbonell-Asins; Shruti Sharma; Derrick Renner; Dina Hafez; Desamparados Roda; Marisol Huerta; Susana Roselló; Anders Husted Madsen; Uffe S. Løve; Per Vadgaard Andersen; Ole Thorlacius-Ussing; Lene Hjerrild Iversen; Kåre Andersson Gotschalck; Himanshu Sethi; Alexey Aleshin; Andres Cervantes; Claus Lindbjerg Andersen
Michael A. Pulsipher; Xia Han; Shannon L. Maude; Theodore W. Laetsch; Muna Qayed; Susana Rives; Michael W. Boyer; Hidefumi Hiramatsu; Gregory A. Yanik; Tim Driscoll; G. Doug Myers; Peter Bader; Andre Baruchel; Jochen Buechner; Heather E. Stefanski; Creton Kalfoglou; Kevin Nguyen; Edward R. Waldron; Karen Thudium Mueller; Harald J. Maier; Gabor Kari; Stephan A. Grupp
Shoujie Chai; Nicholas Matsumoto; Ryan Storgard; Chen-Ching Peng; Ana Aparicio; Benjamin Ormseth; Kate Rappard; Katherine Cunningham; Anand Kolatkar; Rafael Nevarez; Kai-Han Tu; Ching-Ju Hsu; Paymaneh Malihi; Paul Corn; Amado Zurita; James Hicks; Peter Kuhn; Carmen Ruiz-Velasco
Aparna R. Parikh; Emily E. Van Seventer; Giulia Siravegna; Anna V. Hartwig; Ariel Jaimovich; Yupeng He; Katie Kanter; Madeleine G. Fish; Kathryn D. Fosbenner; Benchun Miao; Susannah Phillips; John H. Carmichael; Nihaarika Sharma; Joy Jarnagin; Islam Baiev; Yojan S. Shah; Isobel J. Fetter; Heather A. Shahzade; Jill N. Allen; Lawrence S. Blaszkowsky; Jeffrey W. Clark; Jon S. Dubois; Joseph W. Franses; Bruce J. Giantonio; Lipika Goyal; Samuel J. Klempner; Ryan D. Nipp; Eric J. Roeland; David P. Ryan; Colin D. Weekes; Jennifer Y. Wo; Theodore S. Hong; Liliana Bordeianou; Cristina R. Ferrone; Motaz Qadan; Hiroko Kunitake; David Berger; Rocco Ricciardi; James C. Cusack; Victoria M. Raymond; AmirAli Talasaz; Genevieve M. Boland; Ryan B. Corcoran
Avanthi Tayi Shah; Tej D. Azad; Marcus R. Breese; Jacob J. Chabon; Emily G. Hamilton; Krystal Straessler; David M. Kurtz; Stanley G. Leung; Aviv Spillinger; Heng-Yi Liu; Inge H. Behroozfard; Frederick M. Wittber; Florette K. Hazard; Soo-Jin Cho; Heike E. Daldrup-Link; Kieuhoa T. Vo; Arun Rangaswami; Allison Pribnow; Sheri L. Spunt; Norman J. Lacayo; Maximilian Diehn; Ash A. Alizadeh; E. Alejandro Sweet-Cordero
Sima Jeha; John Choi; Kathryn G. Roberts; Deqing Pei; Elaine Coustan-Smith; Hiroto Inaba; Jeffrey E. Rubnitz; Raul C. Ribeiro; Tanja A. Gruber; Susana C. Raimondi; Seth E. Karol; Chunxu Qu; Samuel W. Brady; Zhaohui Gu; Jun J. Yang; Cheng Cheng; James R. Downing; Williams E. Evans; Mary V. Relling; Dario Campana; Charles G. Mullighan; Ching-Hon Pui
Hanna Tukachinsky; Russell W. Madison; Jon H. Chung; Ole V. Gjoerup; Eric A. Severson; Lucas Dennis; Bernard J. Fendler; Samantha Morley; Lei Zhong; Ryon P. Graf; Jeffrey S. Ross; Brian M. Alexander; Wassim Abida; Simon Chowdhury; Charles J. Ryan; Karim Fizazi; Tony Golsorkhi; Simon P. Watkins; Andrew Simmons; Andrea Loehr; Jeffrey M. Venstrom; Geoffrey R. Oxnard
Hariti Saluja; Graeme P. Young; Feruza Kholmurodova; Erin L. Symonds
Jiaolin Zhou; Changxi Wang; Guole Lin; Yi Xiao; Wenzhuo Jia; Gang Xiao; Qian Liu; Bin Wu; Aiwen Wu; Huizhong Qiu; Fuquan Zhang; Ke Hu; Huadan Xue; Zhanlong Shen; Zhenjun Wang; Jiagang Han; Beizhan Niu; Yaping Xu; Zicheng Yu; Ling Yang
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