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Immune Ecosystems

The complex interactions involving immune cells, tumor cells, and soluble factors, all within a hypoxic niche, make up the diverse and dynamic ecosystems that physiologically occur in cancer. A deeper understanding of these networks, and how they can be targeted and/or modulated, can aid in improving not only patient care strategies, but also patient outcomes. This collection of reviews and original research from the AACR journals aims to provide you with an overview of immune ecosystems in cancer, their regulation, and therapeutic strategies that can be used to modulate these networks. The intersection of immunity with various cancer-associated factors is included and highlights the important interplay of immune cells with a wide variety of cell-intrinsic and -extrinsic factors that ultimately shape antitumor and treatment responses. Adriana Benavides, PhD, Associate Editor, Cancer Immunology Research ([email protected])


Perspective

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Maria Karasarides; Alexandria P. Cogdill; Paul B. Robbins; Michaela Bowden; Elizabeth M. Burton; Lisa H. Butterfield; Alessandra Cesano; Christian Hammer; Cara L. Haymaker; Christine E. Horak; Heather M. McGee; Anne Monette; Nils-Petter Rudqvist; Christine N. Spencer; Randy F. Sweis; Benjamin G. Vincent; Erik Wennerberg; Jianda Yuan; Roberta Zappasodi; Vanessa M. Hubbard Lucey; Daniel K. Wells; Theresa LaVallee

Doi: 10.1158/2326-6066.CIR-20-0586

Review

CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

Alexandra M. Miggelbrink; Joshua D. Jackson; Selena J. Lorrey; Ethan S. Srinivasan; Jessica Waibl-Polania; Daniel S. Wilkinson; Peter E. Fecci

Doi: 10.1158/1078-0432.CCR-21-0206

Special Collection Image
Anuja Sathe; Kaishu Mason; Susan M. Grimes; Zilu Zhou; Billy T. Lau; Xiangqi Bai; Andrew Su; Xiao Tan; HoJoon Lee; Carlos J. Suarez; Quan Nguyen; George Poultsides; Nancy R. Zhang; Hanlee P. Ji
Thibaud Derippe; Sylvain Fouliard; Ibtissam Marchiq; Sandra Dupouy; Maria Almena-Carrasco; Julia Geronimi; Xavier Declèves; Marylore Chenel; Donald E. Mager
Anthony R. Cillo; Elina Mukherjee; Nathanael G. Bailey; Sayali Onkar; Jessica Daley; Claudia Salgado; Xiang Li; Dongyan Liu; Sarangarajan Ranganathan; Melissa Burgess; John Sembrat; Kurt Weiss; Rebecca Watters; Tullia C. Bruno; Dario A.A. Vignali; Kelly M. Bailey
Ainhoa Perez-Diez; Xiangdong Liu; Polly Matzinger
Claudio Vernieri; Giovanni Fucà; Francesca Ligorio; Veronica Huber; Andrea Vingiani; Fabio Iannelli; Alessandra Raimondi; Darawan Rinchai; Gianmaria Frigè; Antonino Belfiore; Luca Lalli; Claudia Chiodoni; Valeria Cancila; Federica Zanardi; Arta Ajazi; Salvatore Cortellino; Viviana Vallacchi; Paola Squarcina; Agata Cova; Samantha Pesce; Paola Frati; Raghvendra Mall; Paola Antonia Corsetto; Angela Maria Rizzo; Cristina Ferraris; Secondo Folli; Marina Chiara Garassino; Giuseppe Capri; Giulia Bianchi; Mario Paolo Colombo; Saverio Minucci; Marco Foiani; Valter Daniel Longo; Giovanni Apolone; Valter Torri; Giancarlo Pruneri; Davide Bedognetti; Licia Rivoltini; Filippo de Braud
Ziwei Li; Xiangqi Meng; Pengfei Wu; Caijun Zha; Bo Han; Lulu Li; Nan Sun; Tengfei Qi; Jie Qin; Yangong Zhang; Kaifu Tian; Shupeng Li; Changxiao Yang; Lejia Ren; Jianguang Ming; Pandeng Wang; Yifei Song; Chuanlu Jiang; Jinquan Cai
Cuicui Liu; Jiankun Qiang; Qiaodan Deng; Jie Xia; Lu Deng; Lei Zhou; Dong Wang; Xueyan He; Ying Liu; Botao Zhao; Jinhui Lv; Zuoren Yu; Qun-Ying Lei; Zhi-Ming Shao; Xiao-Yong Zhang; Lixing Zhang; Suling Liu
Victoria S. Pelly; Agrin Moeini; Lisanne M. Roelofsen; Eduardo Bonavita; Charlotte R. Bell; Colin Hutton; Adrian Blanco-Gomez; Antonia Banyard; Christian P. Bromley; Eimear Flanagan; Shih-Chieh Chiang; Claus Jørgensen; Ton N. Schumacher; Daniela S. Thommen; Santiago Zelenay
Kerstin Wennhold; Martin Thelen; Jonas Lehmann; Simon Schran; Ella Preugszat; Maria Garcia-Marquez; Axel Lechner; Alexander Shimabukuro-Vornhagen; Meryem S. Ercanoglu; Florian Klein; Fabinshy Thangarajah; Sebastian Eidt; Heike Löser; Christiane Bruns; Alexander Quaas; Michael von Bergwelt-Baildon; Hans A. Schlößer
Aasa Shimizu; Kenjiro Sawada; Masaki Kobayashi; Misa Yamamoto; Taro Yagi; Yasuto Kinose; Michiko Kodama; Kae Hashimoto; Tadashi Kimura
Junji Koya; Yuki Saito; Takuro Kameda; Yasunori Kogure; Mitsuhiro Yuasa; Joji Nagasaki; Marni B. McClure; Sumito Shingaki; Mariko Tabata; Yuki Tahira; Keiichi Akizuki; Ayako Kamiunten; Masaaki Sekine; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Akira Kitanaka; Nobuaki Nakano; Atae Utsunomiya; Yosuke Togashi; Seishi Ogawa; Kazuya Shimoda; Keisuke Kataoka
Tomohiro Fujiwara; Mohamed A. Yakoub; Andrew Chandler; Alexander B. Christ; Guangli Yang; Ouathek Ouerfelli; Vinagolu K. Rajasekhar; Aki Yoshida; Hiroya Kondo; Toshiaki Hata; Hiroshi Tazawa; Yildirim Dogan; Malcolm A.S. Moore; Toshiyoshi Fujiwara; Toshifumi Ozaki; Ed Purdue; John H. Healey
Hui Qin Wang; Iain J. Mulford; Fiona Sharp; Jinsheng Liang; Sema Kurtulus; Gina Trabucco; David S. Quinn; Tyler A. Longmire; Nidhi Patel; Roshani Patil; Matthew D. Shirley; Yan Chen; Hao Wang; David A. Ruddy; Claire Fabre; Juliet A. Williams; Peter S. Hammerman; Jennifer Mataraza; Barbara Platzer; Ensar Halilovic
Stephanie Z. Xie; Kerstin B. Kaufmann; Weijia Wang; Michelle Chan-Seng-Yue; Olga I. Gan; Elisa Laurenti; Laura Garcia-Prat; Shin-ichiro Takayanagi; Stanley W.K. Ng; ChangJiang Xu; Andy G.X. Zeng; Liqing Jin; Jessica McLeod; Elvin Wagenblast; Amanda Mitchell; James A. Kennedy; Qiang Liu; Héléna Boutzen; Melissa Kleinau; Joseph Jargstorf; Gareth Holmes; Yang Zhang; Veronique Voisin; Gary D. Bader; Jean C.Y. Wang; Yusuf A. Hannun; Chiara Luberto; Timm Schroeder; Mark D. Minden; John E. Dick
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