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Emerging Targets and First Disclosures

Despite significant scientific and clinical advancement in the field of anticancer therapeutics, cancer remains the second highest cause of mortality in the world. The identification and preclinical validation of new molecular targets are fundamental to pushing the field of cancer research forward. This collection of review and research articles from across the AACR journals, provides a sampling of recent insights into emerging targets and includes a selection of First Disclosure articles from Molecular Cancer Therapeutics. Danielle Large, PhD, Assistant Editor, Molecular Cancer Therapeutics (Danielle.Large@aacr.org)


Review

Hallmarks of RET and Co-occuring Genomic Alterations in RET-aberrant Cancers

Jacob J. Adashek; Aakash P. Desai; Alexander Y. Andreev-Drakhlin; Jason Roszik; Gilbert J. Cote; Vivek Subbiah

Doi: 10.1158/1535-7163.MCT-21-0329

Review

Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants

Marco H. Hofmann; Daniel Gerlach; Sandra Misale; Mark Petronczki; Norbert Kraut

Doi: 10.1158/2159-8290.CD-21-1331

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Michael Rigby; Gavin Bennett; Liuhong Chen; Gemma E. Mudd; Helen Harrison; Paul J. Beswick; Katerine Van Rietschoten; Sophie M. Watcham; Heather S. Scott; Amy N. Brown; Peter U. Park; Carly Campbell; Eric Haines; Johanna Lahdenranta; Michael J. Skynner; Phil Jeffrey; Nicholas Keen; Kevin Lee
Emad Darvishi; Lila Ghamsari; Siok F. Leong; Ricardo Ramirez; Mark Koester; Erin Gallagher; Miao Yu; Jody M. Mason; Gene Merutka; Barry J. Kappel; Jim A. Rotolo
Raffaella Iurlaro; Inja Waldhauer; Ester Planas-Rigol; Ester Bonfill-Teixidor; Alexandra Arias; Valeria Nicolini; Anne Freimoser-Grundschober; Isabel Cuartas; Alba Martínez-Moreno; Francisco Martínez-Ricarte; Esteban Cordero; Marta Cicuendez; Simona Casalino; Xavier Guardia-Reyes; Linda Fahrni; Thomas Pöschinger; Virginie Steinhart; Marine Richard; Stefanie Briner; Joerg Mueller; Franz Osl; Johannes Sam; Sara Colombetti; Marina Bacac; Christian Klein; Estela Pineda; Luis Reyes-Figueroa; Alberto Di Somma; Josep González; Paolo Nuciforo; Joan Carles; Maria Vieito; Josep Tabernero; Pablo Umaña; Joan Seoane
Erik H. Knelson; Elena V. Ivanova; Mubin Tarannum; Marco Campisi; Patrick H. Lizotte; Matthew A. Booker; Ismail Ozgenc; Moataz Noureddine; Brittany Meisenheimer; Minyue Chen; Brandon Piel; Nathaniel Spicer; Bonje Obua; Cameron M. Messier; Erin Shannon; Navin R. Mahadevan; Tetsuo Tani; Pieter J. Schol; Anna M. Lee-Hassett; Ari Zlota; Ha V. Vo; Minh Ha; Arrien A. Bertram; Saemi Han; Tran C. Thai; Corinne E. Gustafson; Kartika Venugopal; Timothy J. Haggerty; Thomas P. Albertson; Antja-Voy Hartley; Pinar O. Eser; Ze-Hua Li; Israel Cañadas; Marina Vivero; Assunta De Rienzo; William G. Richards; Adnan O. Abu-Yousif; Vicky A. Appleman; Richard C. Gregory; Alexander Parent; Neil Lineberry; Eric L. Smith; Pasi A. Jänne; Juan J. Miret; Michael Y. Tolstorukov; Rizwan Romee; Cloud P. Paweletz; Raphael Bueno; David A. Barbie
Yong Du; Yongfeng Chen; Yuxia Wang; Jinju Chen; Xiaorong Lu; Li Zhang; Yan Li; Zhaofu Wang; Guozhong Ye; George Zhang
Elizabeth Carideo Cunniff; Yosuke Sato; Doanh Mai; Vicky A. Appleman; Shinji Iwasaki; Vihren Kolev; Atsushi Matsuda; Judy Shi; Michiyo Mochizuki; Masato Yoshikawa; Jian Huang; Luhua Shen; Satyajeet Haridas; Vaishali Shinde; Chris Gemski; Emily R. Roberts; Omid Ghasemi; Hojjat Bazzazi; Saurabh Menon; Tary Traore; Pu Shi; Tennille D. Thelen; Joseph Conlon; Adnan O. Abu-Yousif; Christopher Arendt; Michael H. Shaw; Masanori Okaniwa
Zena Wilson; Rajesh Odedra; Yann Wallez; Paul W.G. Wijnhoven; Adina M. Hughes; Joe Gerrard; Gemma N. Jones; Hannah Bargh-Dawson; Elaine Brown; Lucy A. Young; Mark J. O'Connor; Alan Lau
Anne Roulston; Michal Zimmermann; Robert Papp; Alexander Skeldon; Charles Pellerin; Émilie Dumas-Bérube; Valerie Dumais; Stéphane Dorich; Lee D. Fader; Sara Fournier; Li Li; Marie-Eve Leclaire; Shou Yun Yin; Amandine Chefson; Hunain Alam; William Yang; Chloe Fugère-Desjardins; Sabrina Vignini-Hammond; Kathryn Skorey; Amina Mulani; Victoria Rimkunas; Artur Veloso; Martine Hamel; Rino Stocco; Yael Mamane; Zuomei Li; Jordan T.F. Young; Michael Zinda; W. Cameron Black
Kristen Jensen-Pergakes; John Tatlock; Karen A. Maegley; Indrawan J. McAlpine; Michele McTigue; Tao Xie; Christopher P. Dillon; Yuli Wang; Shinji Yamazaki; Noah Spiegel; Manli Shi; Amy Nemeth; Natalie Miller; Eleanore Hendrickson; Hieu Lam; John Sherrill; Chi-Yeh Chung; Elizabeth A. McMillan; Shannon Karlicek Bryant; Prakash Palde; John Braganza; Alexei Brooun; Ya-Li Deng; Vesta Goshtasbi; Susan E. Kephart; Robert A. Kumpf; Wei Liu; Ryan L. Patman; Eugene Rui; Stephanie Scales; Michelle Tran-Dube; Fen Wang; Martin Wythes; Thomas A. Paul
David M. Briere; Shuai Li; Andrew Calinisan; Niranjan Sudhakar; Ruth Aranda; Lauren Hargis; David H. Peng; Jiehui Deng; Lars D. Engstrom; Jill Hallin; Sole Gatto; Julio Fernandez-Banet; Adam Pavlicek; Kwok-Kin Wong; James G. Christensen; Peter Olson
Tracy T. Tang; Andrei W. Konradi; Ying Feng; Xiao Peng; Mingyue Ma; Jian Li; Fa-Xing Yu; Kun-Liang Guan; Leonard Post
Krishanthan Vigneswaran; Nathaniel H. Boyd; Se-Yeong Oh; Shoeb Lallani; Andrew Boucher; Stewart G. Neill; Jeffrey J. Olson; Renee D. Read
Marco H. Hofmann; Michael Gmachl; Juergen Ramharter; Fabio Savarese; Daniel Gerlach; Joseph R. Marszalek; Michael P. Sanderson; Dirk Kessler; Francesca Trapani; Heribert Arnhof; Klaus Rumpel; Dana-Adriana Botesteanu; Peter Ettmayer; Thomas Gerstberger; Christiane Kofink; Tobias Wunberg; Andreas Zoephel; Szu-Chin Fu; Jessica L. Teh; Jark Böttcher; Nikolai Pototschnig; Franziska Schachinger; Katharina Schipany; Simone Lieb; Christopher P. Vellano; Jonathan C. O'Connell; Rachel L. Mendes; Jurgen Moll; Mark Petronczki; Timothy P. Heffernan; Mark Pearson; Darryl B. McConnell; Norbert Kraut
Timothy A. Yap; David S.P. Tan; Angelika Terbuch; Reece Caldwell; Christina Guo; Boon Cher Goh; Valerie Heong; Noor R. Md. Haris; Saira Bashir; Yvette Drew; David S. Hong; Funda Meric-Bernstam; Gary Wilkinson; Joseph Hreiki; Antje M. Wengner; Friedhelm Bladt; Andreas Schlicker; Matthias Ludwig; Yinghui Zhou; Li Liu; Sonal Bordia; Ruth Plummer; Eleni Lagkadinou; Johann S. de Bono
Ezra Y. Rosen; Melissa L. Johnson; Sarah E. Clifford; Romel Somwar; Jennifer F. Kherani; Jieun Son; Arrien A. Bertram; Monika A. Davare; Eric Gladstone; Elena V. Ivanova; Dahlia N. Henry; Elaine M. Kelley; Mika Lin; Marina S.D. Milan; Binoj C. Nair; Elizabeth A. Olek; Jenna E. Scanlon; Morana Vojnic; Kevin Ebata; Jaclyn F. Hechtman; Bob T. Li; Lynette M. Sholl; Barry S. Taylor; Marc Ladanyi; Pasi A. Jänne; S. Michael Rothenberg; Alexander Drilon; Geoffrey R. Oxnard
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