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Towards Degrader-Antibody Conjugates

Antibody drug conjugates (ADCs) and protein degraders are two unique classes of cancer-targeted therapeutic agents. This collection includes research and review articles on the preclinical to early clinical development of novel ADCs and protein degraders. Degrader-antibody conjugates are currently in preclinical development and represent the next frontier of antibody-conjugated therapeutics. Danielle Large, PhD, Assistant Editor, Molecular Cancer Therapeutics ([email protected]).


Reviews

Biomarkers for Antibody–Drug Conjugates in Solid Tumors

Jalissa Katrini; Laura Boldrini; Celeste Santoro; Carmine Valenza; Dario Trapani; Giuseppe Curigliano

Doi: 10.1158/1535-7163.MCT-23-0482

Reviews

PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer

Kailee A. Rutherford; Kirk J. McManus

Doi: 10.1158/1535-7163.MCT-23-0747

Commentary

Bruton Tyrosine Kinase Degraders in B-Cell Malignancies

Tiana Huynh; Sonia Rodriguez-Rodriguez; Alexey V. Danilov

Doi: 10.1158/1535-7163.MCT-23-0520

Special Collection Image
Matthew R. Levengood; Christopher M. Carosino; Xinqun Zhang; Sasha Lucas; David J. Ortiz; Lori Westendorf; Alice P. Chin; Arlan D. Martin; Abbie Wong; Shawna M. Hengel; Hao Sun; Weiping Zeng; Roma Yumul; Melissa MC. Dominguez; Yufei Chen; Janet H. Zheng; Courtney A B. Karlsson; Vivian H. Trang; Peter D. Senter; Shyra J. Gardai
Gregory S. Parker; Julia I. Toth; Sarah Fish; Gabrielle Blanco; Taylor Kampert; Xiaoming Li; Linette Yang; Craig R. Stumpf; Kenneth Steadman; Aleksandar Jamborcic; Stephen Chien; Elizabeth Daniele; Alejandro Dearie; Geoffray Leriche; Simon Bailey; Peggy A. Thompson
Kyle Begovich; Angela Schoolmeesters; Navin Rajapakse; Elena Martinez-Terroba; Maneesh Kumar; Arvind Shakya; Chon Lai; Steven Greene; Brandon Whitefield; Akinori Okano; Venkat Mali; Shenlin Huang; Aparajita H. Chourasia; Leah Fung
Vikram Malhi; Priya Agarwal; Mary R. Gates; Lichuan Liu; Jianshuang Wang; Tom De Bruyn; Scott Lam; Jennifer Eng-Wong; Pablo Perez-Moreno; Ya-Chi Chen; Jiajie Yu
Mandy Lawson; Natalie Cureton; Susana Ros; Azadeh Cheraghchi-Bashi; Jelena Urosevic; Sophie D'Arcy; Oona Delpuech; Michelle DuPont; David I. Fisher; Eric T. Gangl; Hilary Lewis; Dawn Trueman; Neha Wali; Stuart C. Williamson; Jennifer Moss; Elodie Montaudon; Heloise Derrien; Elisabetta Marangoni; Ricardo J. Miragaia; Sladjana Gagrica; Pablo Morentin-Gutierrez; Thomas A. Moss; Gareth Maglennon; Daniel Sutton; Radoslaw Polanski; Alan Rosen; Jonathan Cairns; Pei Zhang; Mònica Sánchez-Guixé; Violeta Serra; Susan E. Critchlow; James S. Scott; Justin P.O. Lindemann; Simon T. Barry; Teresa Klinowska; Christopher J. Morrow; Larissa S. Carnevalli
Funda Meric-Bernstam; Emiliano Calvo; Keun Seok Lee; Victor Moreno; Yeon Hee Park; Sun Young Rha; Pavani Chalasani; Wei Zhong; Li Zhou; Steven Pirie-Shepherd; Abraham C.F. Leung; Giuseppe Curigliano
Mengwu Pan; Valeria Solozobova; Nane C. Kuznik; Nicole Jung; Simone Gräßle; Victor Gourain; Yvonne M. Heneka; Christina A. Cramer von Clausbruch; Olaf Fuhr; Ravi S. N. Munuganti; Danilo Maddalo; Christine Blattner; Antje Neeb; Adam Sharp; Laura Cato; Carsten Weiss; Rinath M. Jeselsohn; Veronique Orian-Rousseau; Stefan Bräse; Andrew C. B. Cato
Clare M. Adams; Ramkrishna Mitra; Youcai Xiao; Peter Michener; Juan Palazzo; Allen Chao; Jitendra Gour; Joel Cassel; Joseph M. Salvino; Christine M. Eischen
Weining Weng; Tao Meng; Qianqian Zhao; Yi Shen; Guoxiang Fu; Jing Shi; Yue Zhang; Zhaohui Wang; Mingqiao Wang; Rong Pan; Linjie Ma; Caiwei Chen; Lijun Wang; Biao Zhou; Hui Zhang; Junyi Pu; Jianjian Zhang; Yi Peter Hu; Guoqiang Hua; Yu Qian; Shu-Hui Liu; Wenhao Hu; Xun Meng
Anna Kopp; Scott Hofsess; Thomas M. Cardillo; Serengulam V. Govindan; Jennifer Donnell; Greg M. Thurber
Filip Janku; Sae-Won Han; Toshihiko Doi; Alessio Amatu; Jaffer A. Ajani; Yasutoshi Kuboki; Alex Cortez; Susan E. Cellitti; Ping C. Mahling; Kulandayan Subramanian; Heidi A. Schoenfeld; Sarah M. Choi; Lori A. Iaconis; Lang Ho Lee; Marc R. Pelletier; Glenn Dranoff; Vasileios Askoxylakis; Salvatore Siena
Guy Jerusalem; Yeon Hee Park; Toshinari Yamashita; Sara A. Hurvitz; Shanu Modi; Fabrice Andre; Ian E. Krop; Xavier Gonzàlez Farré; Benoit You; Cristina Saura; Sung-Bae Kim; Cynthia R. Osborne; Rashmi K. Murthy; Lorenzo Gianni; Toshimi Takano; Yali Liu; Jillian Cathcart; Caleb Lee; Christophe Perrin
Yong Du; Yongfeng Chen; Yuxia Wang; Jinju Chen; Xiaorong Lu; Li Zhang; Yan Li; Zhaofu Wang; Guozhong Ye; George Zhang
Valentina Boni; Mary J. Fidler; Hendrik-Tobias Arkenau; Alexander Spira; Funda Meric-Bernstam; Nataliya Uboha; Rachel E. Sanborn; Randy F. Sweis; Patricia LoRusso; Misako Nagasaka; Javier Garcia-Corbacho; Shadia Jalal; James J. Harding; Stella K. Kim; Iris H.C. Miedema; Danielle J. Vugts; Marc C. Huisman; Gerben J.C. Zwezerijnen; Guus A.M.S. van Dongen; C. Willemien Menke van der Houven van Oordt; Song Wang; Tam Dang; Ivan A. Zein; Olga Vasiljeva; Susan K. Lyman; Virginia Paton; Alison Hannah; Joyce F. Liu
Michiko Yamato; Jun Hasegawa; Takanori Maejima; Chiharu Hattori; Kazuyoshi Kumagai; Akiko Watanabe; Yumi Nishiya; Tomoko Shibutani; Tetsuo Aida; Ichiro Hayakawa; Takashi Nakada; Yuki Abe; Toshinori Agatsuma
Adam D. Durbin; Tingjian Wang; Virangika K. Wimalasena; Mark W. Zimmerman; Deyao Li; Neekesh V. Dharia; Luca Mariani; Noha A.M. Shendy; Stephanie Nance; Anand G. Patel; Ying Shao; Maya Mundada; Lily Maxham; Paul M.C. Park; Logan H. Sigua; Ken Morita; Amy Saur Conway; Amanda L. Robichaud; Antonio R. Perez-Atayde; Melissa J. Bikowitz; Taylor R. Quinn; Olaf Wiest; John Easton; Ernst Schönbrunn; Martha L. Bulyk; Brian J. Abraham; Kimberly Stegmaier; A. Thomas Look; Jun Qi
Heidi M. Haikala; Timothy Lopez; Jens Köhler; Pinar O. Eser; Man Xu; Qing Zeng; Tyler J. Teceno; Kenneth Ngo; Yutong Zhao; Elena V. Ivanova; Arrien A. Bertram; Brittaney A. Leeper; Emily S. Chambers; Anika E. Adeni; Luke J. Taus; Mari Kuraguchi; Paul T. Kirschmeier; Channing Yu; Yoshinobu Shiose; Yasuki Kamai; Yang Qiu; Cloud P. Paweletz; Prafulla C. Gokhale; Pasi A. Jänne
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