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Journal Articles

Editor's Note: Epigenetic Modifications of RASSF1A Gene through Chromatin Remodeling in Prostate Cancer

Ken Kawamoto, Steven T. Okino, Robert F. Place, Shinji Urakami, Hiroshi Hirata, Nobuyuki Kikuno, Toshifumi Kawakami, Yuichiro Tanaka, Deepa Pookot, Zhong Chen, Shahana Majid, Hideki Enokida, Masayuki Nakagawa, Rajvir Dahiya
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2665.
https://doi.org/10.1158/1078-0432.CCR-21-0847
Published: 01 May 2021
View article titled, Editor's Note: Epigenetic Modifications of <em>RASSF1A</em> Gene through Chromatin Remodeling in Prostate Cancer
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Journal Articles

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

Roy Xiao, Yi An, Wenda Ye, Adeeb Derakhshan, Hui Cheng, Xinping Yang, Clint Allen, Zhong Chen, Nicole C. Schmitt, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6463–6474.
https://doi.org/10.1158/1078-0432.CCR-18-3802
Published: 01 November 2019
View article titled, Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV<sup>−</sup> and HPV<sup>+</sup> Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy
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Includes: Supplementary data
Journal Articles

Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer

Anthony D. Saleh, Hui Cheng, Scott E. Martin, Han Si, Pinar Ormanoglu, Sophie Carlson, Paul E. Clavijo, Xinping Yang, Rita Das, Shaleeka Cornelius, Jamie Couper, Douglas Chepeha, Ludmila Danilova, Thomas M. Harris, Michael B. Prystowsky, Geoffrey J. Childs, Richard V. Smith, A. Gordon Robertson, Steven J. M. Jones, Andrew D. Cherniack, Sang S. Kim, Antonina Rait, Kathleen F. Pirollo, Esther H. Chang, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (9): 2860–2873.
https://doi.org/10.1158/1078-0432.CCR-18-0716
Published: 01 May 2019
View article titled, Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

Adeeb Derakhshan, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1379–1387.
https://doi.org/10.1158/1078-0432.CCR-16-2172
Published: 14 March 2017
View article titled, Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways
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Journal Articles

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

Suresh Mohan, Robert Vander Broek, Sujay Shah, Danielle F. Eytan, Matthew L. Pierce, Sophie G. Carlson, Jamie F. Coupar, Jialing Zhang, Hui Cheng, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17): 3946–3956.
https://doi.org/10.1158/1078-0432.CCR-14-3377
Published: 31 August 2015
View article titled, MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

Amanda Herzog, Yansong Bian, Robert Vander Broek, Bradford Hall, Jamie Coupar, Hui Cheng, Anastasia L. Sowers, John D. Cook, James B. Mitchell, Zhong Chen, Ashok B. Kulkarni, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (14): 3808–3819.
https://doi.org/10.1158/1078-0432.CCR-12-2716
Published: 15 July 2013
View article titled, PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis

Xin Gao, Liao-Yuan Li, Fang-Jian Zhou, Ke-Ji Xie, Chun-Kui Shao, Zu-Lan Su, Qi-Peng Sun, Ming-Kun Chen, Jun Pang, Xiang-Fu Zhou, Jian-Guang Qiu, Xing-Qiao Wen, Ming Yang, Xian-Zhong Bai, Hao Zhang, Li Ling, Zhong Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (15): 4163–4172.
https://doi.org/10.1158/1078-0432.CCR-11-2449
Published: 30 July 2012
View article titled, <em>ERG</em> Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis
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Journal Articles

Early Tumor Progression Associated with Enhanced EGFR Signaling with Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer

Athanassios Argiris, Austin G. Duffy, Shivaani Kummar, Nicole L. Simone, Yoshio Arai, Seungwon W. Kim, Susan F. Rudy, Vishnu R. Kannabiran, Xinping Yang, Minyoung Jang, Zhong Chen, Nanette Suksta, Theresa Cooley-Zgela, Susmita G. Ramanand, Aarif Ahsan, Mukesh K. Nyati, John J. Wright, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5755–5764.
https://doi.org/10.1158/1078-0432.CCR-11-0861
Published: 01 September 2011
View article titled, Early Tumor Progression Associated with Enhanced EGFR Signaling with Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides In vitro or In vivo via Sub–50-nm Nanocapsules

Matthew S. Brown, Oumou T. Diallo, Michael Hu, Reza Ehsanian, Xinping Yang, Pattatheyil Arun, Hai Lu, Vicci Korman, Gretchen Unger, Khalil Ahmed, Carter Van Waes, Zhong Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (8): 2295–2307.
https://doi.org/10.1158/1078-0432.CCR-09-3200
Published: 14 April 2010
View article titled, CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <em>In vitro</em> or <em>In vivo</em> via Sub–50-nm Nanocapsules
Open the PDF for CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <em>In vitro</em> or <em>In vivo</em> via Sub–50-nm Nanocapsules in another window
Includes: Supplementary data
Journal Articles

Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

Pattatheyil Arun, Matthew S. Brown, Reza Ehsanian, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 5974–5984.
https://doi.org/10.1158/1078-0432.CCR-09-1352
Published: 30 September 2009
View article titled, Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer

Francisco G. Pernas, Clint T. Allen, Mary E. Winters, Bin Yan, Jay Friedman, Bhavana Dabir, Kunal Saigal, Gerhard S. Mundinger, Xiaojiang Xu, John C. Morris, Katherine R. Calvo, Carter Van Waes, Zhong Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (7): 2361–2372.
https://doi.org/10.1158/1078-0432.CCR-08-1011
Published: 01 April 2009
View article titled, Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-κB Subunits in Head and Neck Cancer

Clint Allen, Kunal Saigal, Liesl Nottingham, Pattatheyil Arun, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (13): 4175–4185.
https://doi.org/10.1158/1078-0432.CCR-07-4470
Published: 01 July 2008
View article titled, Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-κB Subunits in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

Jay Friedman, Liesl Nottingham, Praveen Duggal, Francisco G. Pernas, Bin Yan, Xin Ping Yang, Zhong Chen, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6568–6578.
https://doi.org/10.1158/1078-0432.CCR-07-1591
Published: 15 November 2007
View article titled, Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

A Novel Nuclear Factor-κB Gene Signature Is Differentially Expressed in Head and Neck Squamous Cell Carcinomas in Association with TP53 Status

Tin Lap Lee, Xin Ping Yang, Bin Yan, Jay Friedman, Praveen Duggal, Lorena Bagain, Gang Dong, Ning T. Yeh, Jie Wang, Jian Zhou, Abdel Elkahloun, Carter Van Waes, Zhong Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19): 5680–5691.
https://doi.org/10.1158/1078-0432.CCR-07-0670
Published: 01 October 2007
View article titled, A Novel Nuclear Factor-κB Gene Signature Is Differentially Expressed in Head and Neck Squamous Cell Carcinomas in Association with TP53 Status
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Includes: Supplementary data
Journal Articles

Nuclear Factor-κB–Related Serum Factors as Longitudinal Biomarkers of Response and Survival in Advanced Oropharyngeal Carcinoma

Clint Allen, Sonia Duffy, Theodoros Teknos, Mozaffarul Islam, Zhong Chen, Paul S. Albert, Gregory Wolf, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (11): 3182–3190.
https://doi.org/10.1158/1078-0432.CCR-06-3047
Published: 01 June 2007
View article titled, Nuclear Factor-κB–Related Serum Factors as Longitudinal Biomarkers of Response and Survival in Advanced Oropharyngeal Carcinoma
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Journal Articles

Epigenetic Modifications of RASSF1A Gene through Chromatin Remodeling in Prostate Cancer

Ken Kawamoto, Steven T. Okino, Robert F. Place, Shinji Urakami, Hiroshi Hirata, Nobuyuki Kikuno, Toshifumi Kawakami, Yuichiro Tanaka, Deepa Pookot, Zhong Chen, Shahana Majid, Hideki Enokida, Masayuki Nakagawa, Rajvir Dahiya
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2541–2548.
https://doi.org/10.1158/1078-0432.CCR-06-2225
Published: 01 May 2007
View article titled, Epigenetic Modifications of <em>RASSF1A</em> Gene through Chromatin Remodeling in Prostate Cancer
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Journal Articles

2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

Justin L. Ricker, Zhong Chen, Xin Ping Yang, Victor S. Pribluda, Glenn M. Swartz, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8665–8673.
https://doi.org/10.1158/1078-0432.CCR-04-1393
Published: 28 December 2004
View article titled, 2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma
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Journal Articles

IL (Interleukin)-1α Promotes Nuclear Factor-κB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas

Jeffrey S. Wolf, Zhong Chen, Gang Dong, John B. Sunwoo, Caren C. Bancroft, David E. Capo, Ning T. Yeh, Naofumi Mukaida, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (6): 1812–1820.
Published: 01 June 2001
View article titled, IL (Interleukin)-1α Promotes Nuclear Factor-κB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas
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Journal Articles

Novel Proteasome Inhibitor PS-341 Inhibits Activation of Nuclear Factor-κB, Cell Survival, Tumor Growth, and Angiogenesis in Squamous Cell Carcinoma

John B. Sunwoo, Zhong Chen, Gang Dong, Ning Yeh, Caren Crowl Bancroft, Edward Sausville, Julian Adams, Peter Elliott, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1419–1428.
Published: 01 May 2001
View article titled, Novel Proteasome Inhibitor PS-341 Inhibits Activation of Nuclear Factor-κB, Cell Survival, Tumor Growth, and Angiogenesis in Squamous Cell Carcinoma
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Journal Articles

Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-κB Signal Pathways

Caren C. Bancroft, Zhong Chen, Gang Dong, John B. Sunwoo, Ning Yeh, Catherine Park, Carter Van Waes
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (2): 435–442.
Published: 01 February 2001
View article titled, Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-κB Signal Pathways
Open the PDF for Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-κB Signal Pathways in another window