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Zachary A. Cooper
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Journal Articles

A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma

Open Access
Andrew L. Coveler, Matthew J. Reilley, Mark Zalupski, Teresa Macarulla, Christos Fountzilas, Mariano Ponz-Sarvisé, Adnan Nagrial, Nataliya V. Uboha, Sophia Frentzas, Michael Overman, Anne Noonan, Wells A. Messersmith, Nick Pavlakis, Niharika B. Mettu, Ina Bisha, Ying Wang, Paul Smith, Elina Murtomaki, Agata A. Bielska, Veronique Bragulat, Zachary A. Cooper, Rakesh Kumar, David R. Spigel
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4609–4617.
https://doi.org/10.1158/1078-0432.CCR-24-0499
Published: 15 October 2024
View articletitled, A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Open the PDF for A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors

Available to Purchase
Luana Guimaraes Sousa, Daniel J. McGrail, Felippe Lazar Neto, Kaiyi Li, Mario L. Marques-Piubelli, Sammy Ferri-Borgogno, Hui Dai, Yoshitsugu Mitani, Nicole Spardy Burr, Zachary A. Cooper, Krista Kinneer, Maria Angelica Cortez, Shiaw-Yih Lin, Diana Bell, Adel El Naggar, Jared Burks, Renata Ferrarotto
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3162–3171.
https://doi.org/10.1158/1078-0432.CCR-23-0514
Published: 15 August 2023
View articletitled, Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors
Open the PDF for Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors in another window
Includes: Supplementary data
Journal Articles

Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305

Available to Purchase
Krista Kinneer, Philipp Wortmann, Zachary A. Cooper, Niall J. Dickinson, Luke Masterson, Thais Cailleau, Ian Hutchinson, Balakumar Vijayakrishnan, Mary McFarlane, Kathryn Ball, Michael Davies, Arthur Lewis, Yue Huang, Anton I. Rosenbaum, Jiaqi Yuan, Jon Chesebrough, Judith Anderton, Noel Monks, Steven Novick, Jixin Wang, Nazzareno Dimasi, R. James Christie, Darrin Sabol, Frances Anne Tosto, Yann Wallez, Elisabetta Leo, Mark R. Albertella, Anna D. Staniszewska, David A. Tice, Philip W. Howard, Nadia Luheshi, Puja Sapra
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (6): 1086–1101.
https://doi.org/10.1158/1078-0432.CCR-22-2630
Published: 14 March 2023
View articletitled, Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
Open the PDF for Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 in another window
Includes: Supplementary data
Journal Articles

Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

Free
Laurence Feldmeyer, Courtney W. Hudgens, Genevieve Ray-Lyons, Priyadharsini Nagarajan, Phyu P. Aung, Jonathan L. Curry, Carlos A. Torres-Cabala, Barbara Mino, Jaime Rodriguez-Canales, Alexandre Reuben, Pei-Ling Chen, Jennifer S. Ko, Steven D. Billings, Roland L. Bassett, Ignacio I. Wistuba, Zachary A. Cooper, Victor G. Prieto, Jennifer A. Wargo, Michael T. Tetzlaff
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (22): 5553–5563.
https://doi.org/10.1158/1078-0432.CCR-16-0392
Published: 14 November 2016
View articletitled, Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Does It MEK a Difference? Understanding Immune Effects of Targeted Therapy

Free
Zachary A. Cooper, Alexandre Reuben, Jacob Austin-Breneman, Jennifer A. Wargo
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3102–3104.
https://doi.org/10.1158/1078-0432.CCR-15-0363
Published: 14 July 2015
View articletitled, Does It MEK a Difference? Understanding Immune Effects of Targeted Therapy
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Journal Articles

Abstract PR06: A co-clinical assessment of patterns of BRAF inhibitor resistance

Free
Lawrence N. Kwong, Genevieve Boland, Dennie T. Frederick, Timothy Helms, John P. Miller, Shan Jiang, Zachary A. Cooper, Alexei Protopopov, Gordon B. Mills, Keith Flaherty, Jennifer A. Wargo, Lynda Chin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): PR06.
https://doi.org/10.1158/1557-3265.PMS14-PR06
Published: 13 February 2015
View articletitled, Abstract PR06: A co-clinical assessment of patterns of BRAF inhibitor resistance
Journal Articles

BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma

Free
Dennie T. Frederick, Adriano Piris, Alexandria P. Cogdill, Zachary A. Cooper, Cecilia Lezcano, Cristina R. Ferrone, Devarati Mitra, Andrea Boni, Lindsay P. Newton, Chengwen Liu, Weiyi Peng, Ryan J. Sullivan, Donald P. Lawrence, F. Stephen Hodi, Willem W. Overwijk, Gregory Lizée, George F. Murphy, Patrick Hwu, Keith T. Flaherty, David E. Fisher, Jennifer A. Wargo
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1225–1231.
https://doi.org/10.1158/1078-0432.CCR-12-1630
Published: 03 March 2013
View articletitled, BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma
Open the PDF for BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma in another window
Includes: Supplementary data
Journal Articles

BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice

Free
Chengwen Liu, Weiyi Peng, Chunyu Xu, Yanyan Lou, Minying Zhang, Jennifer A. Wargo, Jie Qing Chen, Haiyan S. Li, Stephanie S. Watowich, Yan Yang, Dennie Tompers Frederick, Zachary A. Cooper, Rina M. Mbofung, Mayra Whittington, Keith T. Flaherty, Scott E. Woodman, Michael A. Davies, Laszlo G. Radvanyi, Willem W. Overwijk, Gregory Lizée, Patrick Hwu
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 393–403.
https://doi.org/10.1158/1078-0432.CCR-12-1626
Published: 16 January 2013
View articletitled, BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
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Includes: Supplementary data
Journal Articles

Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma

Free
Jahan S. Khalili, Shujuan Liu, Tania G. Rodríguez-Cruz, Mayra Whittington, Seth Wardell, Chengwen Liu, Minying Zhang, Zachary A. Cooper, Dennie T. Frederick, Yufeng Li, Min Zhang, Richard W. Joseph, Chantale Bernatchez, Suhendan Ekmekcioglu, Elizabeth Grimm, Laszlo G. Radvanyi, Richard E. Davis, Michael A. Davies, Jennifer A. Wargo, Patrick Hwu, Gregory Lizée
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5329–5340.
https://doi.org/10.1158/1078-0432.CCR-12-1632
Published: 30 September 2012
View articletitled, Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
Open the PDF for Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma in another window
Includes: Supplementary data