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Journal Articles

Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer

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Kristen K. Ciombor, Seong-Woo Bae, Jennifer G. Whisenant, Gregory D. Ayers, Quanhu Sheng, Todd E. Peterson, Gary T. Smith, Kangyu Lin, Saikat Chowdhury, Preeti Kanikarla Marie, Alexey Sorokin, Allison S. Cohen, Laura W. Goff, Dana B. Cardin, John Paul Shen, Scott Kopetz, Cathy Eng, Yu Shyr, Jordan Berlin, H. Charles Manning
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (8): 1437–1448.
https://doi.org/10.1158/1078-0432.CCR-24-3133
Published: 14 April 2025
View articletitled, Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation

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Timothy A. Lin, Zachary R. McCaw, Alex Koong, Christine Lin, Joseph Abi Jaoude, Roshal Patel, Ramez Kouzy, Molly B. El Alam, Alexander D. Sherry, Sonal S. Noticewala, Clifton D. Fuller, Charles R. Thomas, Jr, Ryan Sun, J. Jack Lee, Ruitao Lin, Ying Yuan, Yu Shyr, Tomer Meirson, Ethan B. Ludmir
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4791–4799.
https://doi.org/10.1158/1078-0432.CCR-24-0566
Published: 15 October 2024
View articletitled, Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation
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Includes: Supplementary data
Journal Articles

A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop

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Daniel D. Von Hoff, Gary M. Clark, Charles A. Coltman, Mary L. Disis, S.G. Eckhardt, Lee M. Ellis, Margaret Foti, Elizabeth Garrett-Mayer, Mithat Gönen, Manuel Hidalgo, Susan G. Hilsenbeck, John H. Littlefield, Patricia M. LoRusso, H. Kim Lyerly, Neal J. Meropol, Jyoti D. Patel, Steven Piantadosi, Dean A. Post, Meredith M. Regan, Yu Shyr, Margaret A. Tempero, Joel E. Tepper, Jamie Von Roenn, Louis M. Weiner, Donn C. Young, Nu V. Vu
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5472–5481.
https://doi.org/10.1158/1078-0432.CCR-21-1799
Published: 15 October 2021
View articletitled, A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop
Open the PDF for A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop in another window
Includes: Supplementary data
Journal Articles

Abstract S01-02: Assessing vulnerability of patients with lung cancer to SARS-CoV-2 infection based on serological antibody analyses

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Amy C. Moore, Paul A Bunn, Jr., Beatriz Fontoura, Adolfo García-Sastre, Jorge Gomez, Florian Krammer, Phillip Mack, John D. Minna, Christian Rolfo, Yu Shyr, Peter Ujhazy, Fred R. Hirsch
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6_Supplement): S01-02.
https://doi.org/10.1158/1557-3265.COVID-19-21-S01-02
Published: 15 March 2021
View articletitled, Abstract S01-02: Assessing vulnerability of patients with lung cancer to SARS-CoV-2 infection based on serological antibody analyses
Journal Articles

Abstract S12-03: Thoracic cancers international COVID-19 collaboration (TERAVOLT): Small-cell lung cancer and other rare thoracic malignancies

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Alessio Cortellini, Anne-Marie C. Dingemans, Oscar Arrieta, Javier Baena, Matteo Brighenti, Enriqueta Felip, Marina Chiara Garassino, Pilar Garrido, Carlo Genova, Federica Grosso, Leora Horn, Li-Ching Huang, Jan Van Meerbeeck, Solange Peters, Ernest Nadal, Jacobo Rogado, Yu Shyr, Marcello Tiseo, Valter Torri, Annalisa Trama, Heather Wakelee, Jennifer G Whisenant, Giuseppe Viscardi, Fabrice Barlesi, Sanjay Popat
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18_Supplement): S12-03.
https://doi.org/10.1158/1557-3265.COVID-19-S12-03
Published: 15 September 2020
View articletitled, Abstract S12-03: Thoracic cancers international COVID-19 collaboration (TERAVOLT): Small-cell lung cancer and other rare thoracic malignancies
Journal Articles

TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer

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Brian D. Lehmann, Vandana G. Abramson, Melinda E. Sanders, Erica L. Mayer, Tufia C. Haddad, Rita Nanda, Catherine Van Poznak, Anna Maria Storniolo, Julie R. Nangia, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Kimberly N. Johnson, Richard G. Abramson, Sheau-Chiann Chen, Yu Shyr, Carlos L. Arteaga, Antonio C. Wolff, Jennifer A. Pietenpol
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (9): 2111–2123.
https://doi.org/10.1158/1078-0432.CCR-19-2170
Published: 01 May 2020
View articletitled, TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer
Open the PDF for TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations—The Lung Cancer Mutation Consortium (LCMC2)

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Dara L. Aisner, Lynette M. Sholl, Lynne D. Berry, Michael R. Rossi, Heidi Chen, Junya Fujimoto, Andre L. Moreira, Suresh S. Ramalingam, Liza C. Villaruz, Gregory A. Otterson, Eric Haura, Katerina Politi, Bonnie Glisson, Jeremy Cetnar, Edward B. Garon, Joan Schiller, Saiama N. Waqar, Lecia V. Sequist, Julie Brahmer, Yu Shyr, Kelly Kugler, Ignacio I. Wistuba, Bruce E. Johnson, John D. Minna, Mark G. Kris, Paul A. Bunn, David J. Kwiatkowski
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (5): 1038–1047.
https://doi.org/10.1158/1078-0432.CCR-17-2289
Published: 28 February 2018
View articletitled, The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations—The Lung Cancer Mutation Consortium (LCMC2)
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Includes: Supplementary data
Journal Articles

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67

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Bojana Jovanović, Ingrid A. Mayer, Erica L. Mayer, Vandana G. Abramson, Aditya Bardia, Melinda E. Sanders, M. Gabriela Kuba, Monica V. Estrada, J. Scott Beeler, Timothy M. Shaver, Kimberly C. Johnson, Violeta Sanchez, Jennifer M. Rosenbluth, Patrick M. Dillon, Andres Forero-Torres, Jenny C. Chang, Ingrid M. Meszoely, Ana M. Grau, Brian D. Lehmann, Yu Shyr, Quanhu Sheng, Sheau-Chiann Chen, Carlos L. Arteaga, Jennifer A. Pietenpol
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4035–4045.
https://doi.org/10.1158/1078-0432.CCR-16-3055
Published: 01 August 2017
View articletitled, A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67
Open the PDF for A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67 in another window
Includes: Supplementary data
Journal Articles

Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy

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Daniel N. Cohen, Steven K. Lawson, Aaron C. Shaver, Liping Du, Harrison P. Nguyen, Qin He, Douglas B. Johnson, Wilfred A. Lumbang, Brent R. Moody, James L. Prescott, Pranil K. Chandra, Alan S. Boyd, Jeffrey P. Zwerner, Jason B. Robbins, Stephen K. Tyring, Peter L. Rady, James D. Chappell, Yu Shyr, Jeffrey R. Infante, Jeffrey A. Sosman
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (11): 2624–2634.
https://doi.org/10.1158/1078-0432.CCR-14-2667
Published: 31 May 2015
View articletitled, Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy
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Includes: Supplementary data
Journal Articles

RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors

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Yingjun Su, Anna E. Vilgelm, Mark C. Kelley, Oriana E. Hawkins, Yan Liu, Kelli L. Boyd, Sara Kantrow, Ryan C. Splittgerber, Sarah P. Short, Tammy Sobolik, Snjezana Zaja-Milatovic, Kimberly Brown Dahlman, Katayoun I. Amiri, Aixiang Jiang, Pengcheng Lu, Yu Shyr, Darrin D. Stuart, Shawn Levy, Jeffrey A. Sosman, Ann Richmond
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2184–2198.
https://doi.org/10.1158/1078-0432.CCR-11-1122
Published: 16 April 2012
View articletitled, RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors
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Includes: Supplementary data
Journal Articles

A Gene Expression Signature from Human Breast Cancer Cells with Acquired Hormone Independence Identifies MYC as a Mediator of Antiestrogen Resistance

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Todd W. Miller, Justin M. Balko, Zara Ghazoui, Anita Dunbier, Helen Anderson, Mitch Dowsett, Ana M. González-Angulo, Gordon B. Mills, William R. Miller, Huiyun Wu, Yu Shyr, Carlos L. Arteaga
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (7): 2024–2034.
https://doi.org/10.1158/1078-0432.CCR-10-2567
Published: 31 March 2011
View articletitled, A Gene Expression Signature from Human Breast Cancer Cells with Acquired Hormone Independence Identifies MYC as a Mediator of Antiestrogen Resistance
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Includes: Supplementary data
Journal Articles

A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non–Small Cell Lung Cancer

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Robert Mutter, Bo Lu, David P. Carbone, Ildiko Csiki, Luigi Moretti, David H. Johnson, Jason D. Morrow, Alan B. Sandler, Yu Shyr, Fei Ye, Hak Choy
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2158–2165.
https://doi.org/10.1158/1078-0432.CCR-08-0629
Published: 16 March 2009
View articletitled, A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non–Small Cell Lung Cancer
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Journal Articles

Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

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Robbert J.C. Slebos, Yajun Yi, Kim Ely, Jesse Carter, Amy Evjen, Xueqiong Zhang, Yu Shyr, Barbara M. Murphy, Anthony J. Cmelak, Brian B. Burkey, James L. Netterville, Shawn Levy, Wendell G. Yarbrough, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (3): 701–709.
https://doi.org/10.1158/1078-0432.CCR-05-2017
Published: 07 February 2006
View articletitled, Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Targeting Cyclooxygenase-2 in Recurrent Non–Small Cell Lung Cancer: A Phase II Trial of Celecoxib and Docetaxel

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Ildiko Csiki, Jason D. Morrow, Alan Sandler, Yu Shyr, John Oates, Myles K. Williams, Thao Dang, David P. Carbone, David H. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (18): 6634–6640.
https://doi.org/10.1158/1078-0432.CCR-05-0436
Published: 15 September 2005
View articletitled, Targeting Cyclooxygenase-2 in Recurrent Non–Small Cell Lung Cancer: A Phase II Trial of Celecoxib and Docetaxel
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Journal Articles

A Training-Testing Approach to the Molecular Classification of Resected Non-Small Cell Lung Cancer

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Noboru Yamagata, Yu Shyr, Kiyoshi Yanagisawa, Mary Edgerton, Thao P. Dang, Adriana Gonzalez, Sorena Nadaf, Paul Larsen, John R. Roberts, Jonathan C. Nesbitt, Roy Jensen, Shawn Levy, Jason H. Moore, John D. Minna, David P. Carbone
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (13): 4695–4704.
Published: 27 October 2003
View articletitled, A Training-Testing Approach to the Molecular Classification of Resected Non-Small Cell Lung Cancer
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Journal Articles

Weekly Irinotecan and Cisplatin in Advanced Non-Small Cell Lung Cancer: A Multicenter Phase II Study

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Madan H. Jagasia, Corey J. Langer, David H. Johnson, Furhan Yunus, John S. Rodgers, Larry L. Schlabach, Alan G. Cohen, Yu Shyr, David P. Carbone, Russell F. DeVore
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (1): 68–73.
Published: 01 January 2001
View articletitled, Weekly Irinotecan and Cisplatin in Advanced Non-Small Cell Lung Cancer: A Multicenter Phase II Study
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Journal Articles

Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis

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Peter Nørgaard, Brian Law, Heather Joseph, David L. Page, Yu Shyr, Debbie Mays, Jennifer A. Pietenpol, Nancy E. Kohl, Allen Oliff, Robert J. Coffey, Jr., Hans Skovgaard Poulsen, Harold L. Moses
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 35–42.
Published: 01 January 1999
View articletitled, Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis
Open the PDF for Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis in another window