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Youcef M. Rustum
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Journal Articles

A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer

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Marwan G. Fakih, Lakshmi Pendyala, Gerald Fetterly, Karoli Toth, James A. Zwiebel, Igor Espinoza-Delgado, Alan Litwin, Youcef M. Rustum, Mary Ellen Ross, Julianne L. Holleran, Merrill J. Egorin
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3189–3195.
https://doi.org/10.1158/1078-0432.CCR-08-2999
Published: 30 April 2009
View articletitled, A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer
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Journal Articles

Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs

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Arup Bhattacharya, Mukund Seshadri, Steven D. Oven, Károly Tóth, Mary M. Vaughan, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3926–3932.
https://doi.org/10.1158/1078-0432.CCR-08-0212
Published: 16 June 2008
View articletitled, Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs
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Journal Articles

Celecoxib and Mucosal Protection: Translation from an Animal Model to a Phase I Clinical Trial of Celecoxib, Irinotecan, and 5-Fluorouracil

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Milind M. Javle, Shousong Cao, Farukh A. Durrani, Lakshmi Pendyala, David D. Lawrence, Patrick F. Smith, Patrick J. Creaven, Diane C. Noel, Renuka V. Iyer, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (3): 965–971.
https://doi.org/10.1158/1078-0432.CCR-06-0551
Published: 08 February 2007
View articletitled, Celecoxib and Mucosal Protection: Translation from an Animal Model to a Phase I Clinical Trial of Celecoxib, Irinotecan, and 5-Fluorouracil
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Journal Articles

A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors.

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Marwan G Fakih, Lakshmi Pendyala, Patrick F Smith, Patrick J Creaven, Mary E Reid, Vladimir Badmaev, Rami G Azrak, Joshua D Prey, David Lawrence, Youcef M Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (4): 1237–1244.
https://doi.org/10.1158/1078-0432.CCR-05-2004
Published: 17 February 2006
View articletitled, A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors.
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Journal Articles

Methylseleninic Acid Potentiates Apoptosis Induced by Chemotherapeutic Drugs in Androgen-Independent Prostate Cancer Cells

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Hongbo Hu, Cheng Jiang, Clement Ip, Youcef M. Rustum, Junxuan Lü
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2379–2388.
https://doi.org/10.1158/1078-0432.CCR-04-2084
Published: 23 March 2005
View articletitled, Methylseleninic Acid Potentiates Apoptosis Induced by Chemotherapeutic Drugs in Androgen-Independent Prostate Cancer Cells
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Journal Articles

Lack of Microvessels in Well-Differentiated Regions of Human Head and Neck Squamous Cell Carcinoma A253 Associated with Functional Magnetic Resonance Imaging Detectable Hypoxia, Limited Drug Delivery, and Resistance to Irinotecan Therapy

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Arup Bhattacharya, Károly Tóth, Richard Mazurchuk, Joseph A. Spernyak, Harry K. Slocum, Lakshmi Pendyala, Rami Azrak, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (23): 8005–8017.
https://doi.org/10.1158/1078-0432.CCR-04-1306
Published: 07 December 2004
View articletitled, Lack of Microvessels in Well-Differentiated Regions of Human Head and Neck Squamous Cell Carcinoma A253 Associated with Functional Magnetic Resonance Imaging Detectable Hypoxia, Limited Drug Delivery, and Resistance to Irinotecan Therapy
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Journal Articles

Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts

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Shousong Cao, Farukh A. Durrani, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (7): 2561–2569.
https://doi.org/10.1158/1078-0432.CCR-03-0268
Published: 08 April 2004
View articletitled, Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts
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Journal Articles

Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts

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Rami G. Azrak, Shousong Cao, Harry K. Slocum, Károly Tóth, Farukh A. Durrani, Ming-biao Yin, Lakshmi Pendyala, Wanghai Zhang, Howard L. McLeod, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (3): 1121–1129.
https://doi.org/10.1158/1078-0432.CCR-0913-3
Published: 10 February 2004
View articletitled, Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
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Journal Articles

Overexpression of Bax Enhances Antitumor Activity of Chemotherapeutic Agents in Human Head and Neck Squamous Cell Carcinoma

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Bin Guo, Shousong Cao, Károly Tóth, Rami G. Azrak, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (2): 718–724.
Published: 01 February 2000
View articletitled, Overexpression of Bax Enhances Antitumor Activity of Chemotherapeutic Agents in Human Head and Neck Squamous Cell Carcinoma
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Journal Articles

Antitumor Activity of ZD1694 (Tomudex) against Human Head and Neck Cancer in Nude Mouse Models: Role of Dosing Schedule and Plasma Thymidine

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Shousong Cao, John J. McGuire, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1925–1934.
Published: 01 July 1999
View articletitled, Antitumor Activity of ZD1694 (Tomudex) against Human Head and Neck Cancer in Nude Mouse Models: Role of Dosing Schedule and Plasma Thymidine
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Journal Articles

Persistent Induction of Apoptosis and Suppression of Mitosis as the Basis for Curative Therapy with S-1, an Oral 5-Fluorouracil Prodrug in a Colorectal Tumor Model

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Shousong Cao, Kun Lu, Karoly Tóth, Harry K. Slocum, Tetsuhiko Shirasaka, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (2): 267–274.
Published: 01 February 1999
View articletitled, Persistent Induction of Apoptosis and Suppression of Mitosis as the Basis for Curative Therapy with S-1, an Oral 5-Fluorouracil Prodrug in a Colorectal Tumor Model
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