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Journal Articles

Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy, Capucine Heraud, Albert Grinshpun, Qi Zhang, Allegra Freelander, Mathew Joseph Leventhal, Avery Feit, Gabriella Cohen Feit, Ariel Feiglin, Weihan Liu, Francisco Hermida-Prado, Nikolas Kesten, Wen Ma, Carmine De Angelis, Antonio Morlando, Madison O'Donnell, Sergey Naumenko, Shixia Huang, Quang-Dé Nguyen, Ying Huang, Luca Malorni, Johann S. Bergholz, Jean J. Zhao, Ernest Fraenkel, Elgene Lim, Rachel Schiff, Geoffrey I. Shapiro, Rinath Jeselsohn
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1889–1905.
https://doi.org/10.1158/1078-0432.CCR-23-2975
Published: 01 May 2024
View article titled, Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer
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Includes: Supplementary data
Journal Articles

Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study

Deborah M. Stephens, Ying Huang, Amy S. Ruppert, Janek S. Walker, Daniel Canfield, Casey B. Cempre, Qiang Fu, Sharyn Baker, Boyu Hu, Harsh Shah, Renee Vadeboncoeur, Kerry A. Rogers, Seema Bhat, Samantha M. Jaglowski, Hank Lockman, Rosa Lapalombella, John C. Byrd, Jennifer A. Woyach
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (15): 3242–3247.
https://doi.org/10.1158/1078-0432.CCR-21-3867
Published: 02 August 2022
View article titled, Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study
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Includes: Supplementary data
Journal Articles

Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA

ChongFeng Gao, Luke Wisniewski, Ying Liu, Ben Staal, Ian Beddows, Dennis Plenker, Mohammed Aldakkak, Johnathan Hall, Daniel Barnett, Mirna Kheir Gouda, Peter Allen, Richard Drake, Amer Zureikat, Ying Huang, Douglas Evans, Aatur Singhi, Randall E. Brand, David A. Tuveson, Susan Tsai, Brian B. Haab
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 226–236.
https://doi.org/10.1158/1078-0432.CCR-20-2475
Published: 04 January 2021
View article titled, Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA
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Includes: Supplementary data
Journal Articles

Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation

Konrad H. Stopsack, Ying Huang, Svitlana Tyekucheva, Travis A. Gerke, Clyde Bango, Habiba Elfandy, Michaela Bowden, Kathryn L. Penney, Thomas M. Roberts, Giovanni Parmigiani, Philip W. Kantoff, Lorelei A. Mucci, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5903–5913.
https://doi.org/10.1158/1078-0432.CCR-20-2000
Published: 13 November 2020
View article titled, Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
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Includes: Supplementary data
Journal Articles

PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Abdallah Flaifel, Wanling Xie, David A. Braun, Miriam Ficial, Ziad Bakouny, Amin H. Nassar, Rebecca B. Jennings, Bernard Escudier, Daniel J. George, Robert J. Motzer, Michael J. Morris, Thomas Powles, Evelyn Wang, Ying Huang, Gordon J. Freeman, Toni K. Choueiri, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6080–6088.
https://doi.org/10.1158/1078-0432.CCR-19-1135
Published: 15 October 2019
View article titled, PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN
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Includes: Supplementary data
Journal Articles

Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study

Jennifer A. Ligibel, Deborah Dillon, Anita Giobbie-Hurder, Anne McTiernan, Elizabeth Frank, MacIntosh Cornwell, Matthew Pun, Nancy Campbell, Ryan J.O. Dowling, Martin C. Chang, Sara Tolaney, Anees B. Chagpar, Rachel L. Yung, Rachel A. Freedman, Laura S. Dominici, Mehra Golshan, Esther Rhei, Krishan Taneja, Ying Huang, Myles Brown, Eric P. Winer, Rinath Jeselsohn, Melinda L. Irwin
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (17): 5398–5406.
https://doi.org/10.1158/1078-0432.CCR-18-3143
Published: 03 September 2019
View article titled, Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
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Includes: Supplementary data
Journal Articles

The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis

Ben Staal, Ying Liu, Daniel Barnett, Peter Hsueh, Zonglin He, ChongFeng Gao, Katie Partyka, Mark W. Hurd, Aatur D. Singhi, Richard R. Drake, Ying Huang, Anirban Maitra, Randall E. Brand, Brian B. Haab
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (9): 2745–2754.
https://doi.org/10.1158/1078-0432.CCR-18-3310
Published: 01 May 2019
View article titled, The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis
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Includes: Supplementary data
Journal Articles

FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia

Maura C. O'Leary, Xiaobin Lu, Ying Huang, Xue Lin, Iftekhar Mahmood, Donna Przepiorka, Denise Gavin, Shiowjen Lee, Ke Liu, Bindu George, Wilson Bryan, Marc R. Theoret, Richard Pazdur
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1142–1146.
https://doi.org/10.1158/1078-0432.CCR-18-2035
Published: 15 February 2019
View article titled, FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Complete and Durable Responses in Primary Central Nervous System Posttransplant Lymphoproliferative Disorder with Zidovudine, Ganciclovir, Rituximab, and Dexamethasone

James P. Dugan, Bradley M. Haverkos, Lynda Villagomez, Ludmila K. Martin, Mark Lustberg, John Patton, Marisa Martin, Ying Huang, Gerard Nuovo, Fengting Yan, Robert Cavaliere, Joyce Fingeroth, Shannon C. Kenney, Richard F. Ambinder, Gerard Lozanski, Pierluigi Porcu, Michael A. Caligiuri, Robert A. Baiocchi
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (14): 3273–3281.
https://doi.org/10.1158/1078-0432.CCR-17-2685
Published: 15 July 2018
View article titled, Complete and Durable Responses in Primary Central Nervous System Posttransplant Lymphoproliferative Disorder with Zidovudine, Ganciclovir, Rituximab, and Dexamethasone
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Includes: Supplementary data
Journal Articles

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup

David P. Labbé, Christopher J. Sweeney, Myles Brown, Phillip Galbo, Spencer Rosario, Kristine M. Wadosky, Sheng-Yu Ku, Martin Sjöström, Mohammed Alshalalfa, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Edward M. Schaeffer, Robert B. Jenkins, Robert B. Den, Ashley E. Ross, Michaela Bowden, Ying Huang, Kathryn P. Gray, Felix Y. Feng, Daniel E. Spratt, David W. Goodrich, Kevin H. Eng, Leigh Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7072–7083.
https://doi.org/10.1158/1078-0432.CCR-17-0413
Published: 14 November 2017
View article titled, TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup
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Includes: Supplementary data
Journal Articles

Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib

Chien-Feng Li, Fu-Min Fang, Yen-Yang Chen, Ting-Ting Liu, Ti-Chun Chan, Shih-Chen Yu, Li-Tzong Chen, Hsuan-Ying Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4908–4918.
https://doi.org/10.1158/1078-0432.CCR-16-2770
Published: 14 August 2017
View article titled, Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib
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Includes: Supplementary data
Journal Articles

Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti–Prostate Cancer Activity

Xiaodong Wang, Ying Huang, Amanda Christie, Michaela Bowden, Gwo-Shu Mary Lee, Philip W. Kantoff, Christopher J. Sweeney
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5578–5587.
https://doi.org/10.1158/1078-0432.CCR-15-0824
Published: 14 December 2015
View article titled, Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti–Prostate Cancer Activity
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Includes: Supplementary data
Journal Articles

AMACR Amplification in Myxofibrosarcomas: A Mechanism of Overexpression That Promotes Cell Proliferation with Therapeutic Relevance

Chien-Feng Li, Fu-Min Fang, Jui Lan, Jun-Wen Wang, Hsing-Jien Kung, Li-Tzong Chen, Tzu-Ju Chen, Shau-Hsuan Li, Yu-Hui Wang, Hui-Chun Tai, Shih-Chen Yu, Hsuan-Ying Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 6141–6152.
https://doi.org/10.1158/1078-0432.CCR-14-1182
Published: 30 November 2014
View article titled, <em>AMACR</em> Amplification in Myxofibrosarcomas: A Mechanism of Overexpression That Promotes Cell Proliferation with Therapeutic Relevance
Open the PDF for <em>AMACR</em> Amplification in Myxofibrosarcomas: A Mechanism of Overexpression That Promotes Cell Proliferation with Therapeutic Relevance in another window
Includes: Supplementary data
Journal Articles

Gender differences in expression of drug transporter genes in human livers: Microarray and real-time PCR analysis

Beverly Lyn-Cook, Athena Starlard-Davenport, Beverly Word, Bridgette Green, Carolyn Wise, Baitang Ning, Ying Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15_Supplement): B34.
Published: 15 August 2014
View article titled, Gender differences in expression of drug transporter genes in human livers: Microarray and real-time PCR analysis
Journal Articles

ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

Hsuan-Ying Huang, Wen-Ren Wu, Yu-Hui Wang, Jun-Wen Wang, Fu-Min Fang, Jen-Wei Tsai, Shau-Hsuan Li, Hsiao-Chin Hung, Shih-Chen Yu, Jui Lan, Yow-Ling Shiue, Chung-His Hsing, Li-Tzong Chen, Chien-Feng Li
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2861–2872.
https://doi.org/10.1158/1078-0432.CCR-12-2641
Published: 30 May 2013
View article titled, <em>ASS1</em> as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Open the PDF for <em>ASS1</em> as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance in another window
Includes: Supplementary data
Journal Articles

Characterization of Gene Amplification–Driven SKP2 Overexpression in Myxofibrosarcoma: Potential Implications in Tumor Progression and Therapeutics

Chien-Feng Li, Ju-Ming Wang, Hong-Yo Kang, Chiung-Kuei Huang, Jun-Wen Wang, Fu-Min Fang, Yu-Hui Wang, Wen-Ren Wu, Shau-Hsuan Li, Shih-Chen Yu, Jen-Chieh Lee, Jui Lan, Yow-Ling Shiue, Li-Ching Wu, Hsuan-Ying Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (6): 1598–1610.
https://doi.org/10.1158/1078-0432.CCR-11-3077
Published: 14 March 2012
View article titled, Characterization of Gene Amplification–Driven SKP2 Overexpression in Myxofibrosarcoma: Potential Implications in Tumor Progression and Therapeutics
Open the PDF for Characterization of Gene Amplification–Driven SKP2 Overexpression in Myxofibrosarcoma: Potential Implications in Tumor Progression and Therapeutics in another window
Includes: Supplementary data
Journal Articles

EGFR L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients

Shi-Yi Yang, Tsung-Ying Yang, Kun-Chieh Chen, Yao-Jen Li, Kuo-Hsuan Hsu, Chi-Rne Tsai, Chih-Yi Chen, Chung-Ping Hsu, Jiun-Yi Hsia, Cheng-Yen Chuang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao A. Hsiung, Chen-Yang Shen, Gee-Chen Chang, Pan-Chyr Yang, Chien-Jen Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2149–2158.
https://doi.org/10.1158/1078-0432.CCR-10-2045
Published: 14 April 2011
View article titled, <em>EGFR</em> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Open the PDF for <em>EGFR</em> L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients in another window
Includes: Supplementary data
Journal Articles

Homozygous Deletion of MTAP Gene as a Poor Prognosticator in Gastrointestinal Stromal Tumors

Hsuan-Ying Huang, Shau-Hsuan Li, Shih-Chen Yu, Fong-Fu Chou, Ching-Cherng Tzeng, Tsung-Hui Hu, Yih-Huei Uen, Yu-Fang Tian, Yu-Hui Wang, Fu-Min Fang, Wen-Wei Huang, Yu-Ching Wei, Jing-Mei Wu, Chien-Feng Li
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6963–6972.
https://doi.org/10.1158/1078-0432.CCR-09-1511
Published: 11 November 2009
View article titled, Homozygous Deletion of <em>MTAP</em> Gene as a Poor Prognosticator in Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies

David Z. Qian, Chung-Ying Huang, Catherine A. O'Brien, Ilsa M. Coleman, Mark Garzotto, Lawrence D. True, Celestia S. Higano, Robert Vessella, Paul H. Lange, Peter S. Nelson, Tomasz M. Beer
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3135–3142.
https://doi.org/10.1158/1078-0432.CCR-08-1982
Published: 30 April 2009
View article titled, Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies
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Includes: Supplementary data
Journal Articles

Heat Shock Protein 90 Overexpression Independently Predicts Inferior Disease-Free Survival with Differential Expression of the α and β Isoforms in Gastrointestinal Stromal Tumors

Chien-Feng Li, Wen-Wei Huang, Jing-Mei Wu, Shih-Chen Yu, Tsung-Hui Hu, Yih-Huei Uen, Yu-Fang Tian, Ching-Nan Lin, David Lu, Fu-Min Fang, Hsuan-Ying Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7822–7831.
https://doi.org/10.1158/1078-0432.CCR-08-1369
Published: 01 December 2008
View article titled, Heat Shock Protein 90 Overexpression Independently Predicts Inferior Disease-Free Survival with Differential Expression of the α and β Isoforms in Gastrointestinal Stromal Tumors
Open the PDF for Heat Shock Protein 90 Overexpression Independently Predicts Inferior Disease-Free Survival with Differential Expression of the α and β Isoforms in Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data