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Journal Articles

Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer

Open Access
Jia-Tao Zhang, Si-Yang Liu, Xuan Gao, Si-Yang Maggie Liu, Bingfa Yan, Chen Huang, Zicong Jiao, Hong-Hong Yan, Yi Pan, Song Dong, Wei Gao, Yuhua Gong, Hai-Yan Tu, Xue-Feng Xia, Qing Zhou, Wen-Zhao Zhong, Xue-Ning Yang, Xin Yi, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (7): 1305–1314.
https://doi.org/10.1158/1078-0432.CCR-24-2909
Published: 01 April 2025
View articletitled, Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Open the PDF for Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA

Available to Purchase
Jhanelle E. Gray, Myung-Ju Ahn, Geoffrey R. Oxnard, Frances A. Shepherd, Fumio Imamura, Ying Cheng, Isamu Okamoto, Byoung Chul Cho, Meng-Chih Lin, Yi-Long Wu, Margarita Majem, Oliver Gautschi, Michael Boyer, Krishna C. Bulusu, Aleksandra Markovets, J. Carl Barrett, Rachel Hodge, Astrid McKeown, Ryan J. Hartmaier, Juliann Chmielecki, Vassiliki A. Papadimitrakopoulou, Suresh S. Ramalingam
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3340–3351.
https://doi.org/10.1158/1078-0432.CCR-22-3146
Published: 01 September 2023
View articletitled, Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Open the PDF for Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA in another window
Includes: Supplementary data
Journal Articles

Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis

Open Access
Chong Kin Liam, Azura Rozila Ahmad, Te-Chun Hsia, Jianying Zhou, Dong-Wan Kim, Ross Andrew Soo, Ying Cheng, Shun Lu, Sang Won Shin, James Chih-Hsin Yang, Yiping Zhang, Jun Zhao, Karin Berghoff, Rolf Bruns, Andreas Johne, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (10): 1879–1886.
https://doi.org/10.1158/1078-0432.CCR-22-3318
Published: 15 May 2023
View articletitled, Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
Open the PDF for Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis in another window
Includes: Supplementary data
Journal Articles

Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer Who Received Adjuvant Osimertinib in the Phase III ADAURA Trial

Open Access
Margarita Majem, Jonathan W. Goldman, Thomas John, Christian Grohe, Konstantin Laktionov, Sang-We Kim, Terufumi Kato, Huu Vinh Vu, Shun Lu, Shanqing Li, Kye Young Lee, Charuwan Akewanlop, Chong-Jen Yu, Filippo de Marinis, Laura Bonanno, Manuel Domine, Frances A. Shepherd, Shinji Atagi, Lingmin Zeng, Dakshayini Kulkarni, Nenad Medic, Masahiro Tsuboi, Roy S. Herbst, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2286–2296.
https://doi.org/10.1158/1078-0432.CCR-21-3530
Published: 01 June 2022
View articletitled, Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer Who Received Adjuvant Osimertinib in the Phase III ADAURA Trial
Open the PDF for Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer Who Received Adjuvant Osimertinib in the Phase III ADAURA Trial in another window
Includes: Supplementary data
Journal Articles

A Novel Third-generation EGFR Tyrosine Kinase Inhibitor Abivertinib for EGFR T790M-mutant Non–Small Cell Lung Cancer: a Multicenter Phase I/II Study

Open Access
Qing Zhou, Lin Wu, Pei Hu, Tongtong An, Jianying Zhou, Li Zhang, Xiao-Qing Liu, Feng Luo, Xin Zheng, Ying Cheng, Nong Yang, Junling Li, Jifeng Feng, Baohui Han, Yong Song, Kai Wang, Li Zhang, Jian Fang, Hong Zhao, Yongqian Shu, Xiao-Yan Lin, Zhihong Chen, Bin Gan, Wan-Hong Xu, Wei Tang, Xiaoying Zhang, Jin-Ji Yang, Xiao Xu, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (6): 1127–1135.
https://doi.org/10.1158/1078-0432.CCR-21-2595
Published: 15 March 2022
View articletitled, A Novel Third-generation EGFR Tyrosine Kinase Inhibitor Abivertinib for EGFR T790M-mutant Non–Small Cell Lung Cancer: a Multicenter Phase I/II Study
Open the PDF for A Novel Third-generation EGFR Tyrosine Kinase Inhibitor Abivertinib for EGFR T790M-mutant Non–Small Cell Lung Cancer: a Multicenter Phase I/II Study in another window
Includes: Supplementary data
Journal Articles

Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells

Free
Ben-Yuan Jiang, Yang-Si Li, Wei-Bang Guo, Xu-Chao Zhang, Zhi-Hong Chen, Jian Su, Wen-Zhao Zhong, Xue-Ning Yang, Jin-Ji Yang, Yang Shao, Biao Huang, Yan-Hui Liu, Qing Zhou, Hai-Yan Tu, Hua-Jun Chen, Zhen Wang, Chong-Rui Xu, Bin-Chao Wang, Shu-Yu Wu, Cun-Yi Gao, Xian Zhang, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (18): 5480–5488.
https://doi.org/10.1158/1078-0432.CCR-17-0047
Published: 14 September 2017
View articletitled, Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells
Open the PDF for Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells in another window
Journal Articles

Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non–Small Cell Lung Cancer

Free
Anna Li, Jin-ji Yang, Xu-chao Zhang, Zhou Zhang, Jian Su, Lan-ying Gou, Yu Bai, Qing Zhou, Zhenfan Yang, Han Han-Zhang, Wen-Zhao Zhong, Shannon Chuai, Qi Zhang, Zhi Xie, Hongfei Gao, Huajun Chen, Zhen Wang, Zheng Wang, Xue-ning Yang, Bin-chao Wang, Bin Gan, Zhi-hong Chen, Ben-yuan Jiang, Si-pei Wu, Si-yang Liu, Chong-rui Xu, Yi-long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4929–4937.
https://doi.org/10.1158/1078-0432.CCR-16-3273
Published: 14 August 2017
View articletitled, Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non–Small Cell Lung Cancer
Open the PDF for Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma

Free
Zhong-Yi Dong, Wen-Zhao Zhong, Xu-Chao Zhang, Jian Su, Zhi Xie, Si-Yang Liu, Hai-Yan Tu, Hua-Jun Chen, Yue-Li Sun, Qing Zhou, Jin-Ji Yang, Xue-Ning Yang, Jia-Xin Lin, Hong-Hong Yan, Hao-Ran Zhai, Li-Xu Yan, Ri-Qiang Liao, Si-Pei Wu, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 3012–3024.
https://doi.org/10.1158/1078-0432.CCR-16-2554
Published: 14 June 2017
View articletitled, Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
Open the PDF for Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy

Free
Tony Mok, Yi-Long Wu, Jin Soo Lee, Chong-Jen Yu, Virote Sriuranpong, Jennifer Sandoval-Tan, Guia Ladrera, Sumitra Thongprasert, Vichien Srimuninnimit, Meilin Liao, Yunzhong Zhu, Caicun Zhou, Fatima Fuerte, Benjamin Margono, Wei Wen, Julie Tsai, Matt Truman, Barbara Klughammer, David S. Shames, Lin Wu
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (14): 3196–3203.
https://doi.org/10.1158/1078-0432.CCR-14-2594
Published: 14 July 2015
View articletitled, Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy
Open the PDF for Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation

Free
Jin-Ji Yang, Xu-Chao Zhang, Jian Su, Chong-Rui Xu, Qing Zhou, Hong-Xia Tian, Zhi Xie, Hua-Jun Chen, Yi-Sheng Huang, Ben-Yuan Jiang, Zhen Wang, Bin-Chao Wang, Xue-Ning Yang, Wen-Zhao Zhong, Qiang Nie, Ri-Qiang Liao, Tony S. Mok, Yi-Long Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (5): 1383–1392.
https://doi.org/10.1158/1078-0432.CCR-13-0699
Published: 02 March 2014
View articletitled, Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation
Open the PDF for Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation in another window
Includes: Supplementary data
Journal Articles

Abstract A8: Mutation mapping in non-small cell lung cancer: A meta-analysis by geography and histology (MutMap)

Free
Simon P. Dearden, James Stevens, Yi-Long Wu, David Blowers
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): A8.
https://doi.org/10.1158/1078-0432.12AACRIASLC-A8
Published: 01 February 2012
View articletitled, Abstract A8: Mutation mapping in non-small cell lung cancer: A meta-analysis by geography and histology (MutMap)
Open the PDF for Abstract A8: Mutation mapping in non-small cell lung cancer: A meta-analysis by geography and histology (MutMap) in another window