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Journal Articles

Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases

Jing Li, Jun Jiang, Xun Bao, Vineet Kumar, Stephen C. Alley, Scott Peterson, Anthony J. Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (15): 3329–3341.
https://doi.org/10.1158/1078-0432.CCR-22-0405
Published: 02 August 2022
View article titled, Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases
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Includes: Supplementary data
Journal Articles

A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma

Shwetal Mehta, Roberto Fiorelli, Xun Bao, Chelsea Pennington-Krygier, Alanna Derogatis, Seongho Kim, Wonsuk Yoo, Jing Li, Nader Sanai
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 289–297.
https://doi.org/10.1158/1078-0432.CCR-21-1096
Published: 19 January 2022
View article titled, A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma
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Journal Articles

A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort

An-Chi Tien, Jing Li, Xun Bao, Alanna Derogatis, Seongho Kim, Shwetal Mehta, Nader Sanai
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (19): 5777–5786.
https://doi.org/10.1158/1078-0432.CCR-19-0133
Published: 01 October 2019
View article titled, A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort
Open the PDF for A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort in another window
Includes: Supplementary data
Journal Articles

Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer

Rayna Rosati, Lisa Polin, Charles Ducker, Jing Li, Xun Bao, Dakshnamurthy Selvakumar, Seongho Kim, Besa Xhabija, Martha Larsen, Thomas McFall, Yanfang Huang, Benjamin L. Kidder, Andrew Fribley, Janice Saxton, Hiroki Kakuta, Peter Shaw, Manohar Ratnam
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (24): 6509–6522.
https://doi.org/10.1158/1078-0432.CCR-18-0982
Published: 13 December 2018
View article titled, Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer
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Includes: Supplementary data
Journal Articles

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

Jing Li, Jianmei Wu, Xun Bao, Norissa Honea, Youming Xie, Seongho Kim, Alex Sparreboom, Nader Sanai
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7454–7466.
https://doi.org/10.1158/1078-0432.CCR-17-0983
Published: 14 December 2017
View article titled, Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach
Open the PDF for Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach in another window
Includes: Supplementary data