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William R. Wilson
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Journal Articles

Abstract PO-018: Hypoxia activated prodrugs of DNA-dependent protein kinase inhibitors as radiosensitisers of head and neck squamous cell carcinomas

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Michael P. Hay, Way W. Wong, Benjamin D. Dickson, Gary J. Cheng, Liew P. Liew, Cho R. Hong, William R. Wilson, Stephen M. Jamieson
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8_Supplement): PO-018.
https://doi.org/10.1158/1557-3265.RADSCI21-PO-018
Published: 15 April 2021
View articletitled, Abstract PO-018: Hypoxia activated prodrugs of DNA-dependent protein kinase inhibitors as radiosensitisers of head and neck squamous cell carcinomas
Journal Articles

The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia

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Jingli Wang, Annika Foehrenbacher, Jiechuang Su, Rita Patel, Michael P. Hay, Kevin O. Hicks, William R. Wilson
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (6): 1684–1695.
https://doi.org/10.1158/1078-0432.CCR-11-2296
Published: 14 March 2012
View articletitled, The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia
Open the PDF for The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia in another window
Includes: Supplementary data
Journal Articles

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

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Kevin O. Hicks, Bronwyn G. Siim, Jagdish K. Jaiswal, Frederik B. Pruijn, Annie M. Fraser, Rita Patel, Alison Hogg, H.D. Sarath Liyanage, Mary Jo Dorie, J. Martin Brown, William A. Denny, Michael P. Hay, William R. Wilson
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (20): 4946–4957.
https://doi.org/10.1158/1078-0432.CCR-10-1439
Published: 15 October 2010
View articletitled, Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
Open the PDF for Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors in another window
Includes: Supplementary data
Journal Articles

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

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Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds, Yongchuan Gu, Rachelle S. Singleton, Kashyap Patel, Susan M. Pullen, Kevin O. Hicks, Sophie P. Syddall, Graham J. Atwell, Shangjin Yang, William A. Denny, William R. Wilson
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (13): 3922–3932.
https://doi.org/10.1158/1078-0432.CCR-07-0478
Published: 02 July 2007
View articletitled, Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104
Open the PDF for Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104 in another window