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W. Marston Linehan
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Journal Articles

Belzutifan for von Hippel–Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study

Tobias Else, Eric Jonasch, Othon Iliopoulos, Kathryn E. Beckermann, Vivek Narayan, Benjamin L. Maughan, Stephane Oudard, Jodi K. Maranchie, Ane B. Iversen, Cynthia M. Goldberg, Wei Fu, Rodolfo F. Perini, Yanfang Liu, W. Marston Linehan, Ramaprasad Srinivasan
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1750–1757.
https://doi.org/10.1158/1078-0432.CCR-23-2592
Published: 01 May 2024
View article titled, Belzutifan for von Hippel–Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study
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Includes: Supplementary data
Journal Articles

A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma

John A. Ligon, R. Taylor Sundby, Mary F. Wedekind, Fernanda I. Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan Lei, John Shern, Seth M. Steinberg, William D. Figg, Cody J. Peer, Sara Zimmerman, Josquin Moraly, Xia Xu, Stephen Fox, King Chan, Michael I. Barbato, Thorkell Andresson, Naomi Taylor, Karel Pacak, J. Keith Killian, Eva Dombi, W. Marston Linehan, Markku Miettinen, Richard Piekarz, Lee J. Helman, Paul Meltzer, Brigitte Widemann, John Glod
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 341–348.
https://doi.org/10.1158/1078-0432.CCR-22-2168
Published: 17 January 2023
View article titled, A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor

John Glod, Fernanda I. Arnaldez, Lori Wiener, Melissa Spencer, J. Keith Killian, Paul Meltzer, Eva Dombi, Claudia Derse-Anthony, Joanne Derdak, Ramaprasad Srinivasan, W. Marston Linehan, Markku Miettinen, Seth M. Steinberg, Lee Helman, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6302–6308.
https://doi.org/10.1158/1078-0432.CCR-19-0986
Published: 01 November 2019
View article titled, A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor
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Journal Articles

Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma

Nur P. Damayanti, Justin A. Budka, Heba W.Z Khella, Mary W. Ferris, Sheng Yu Ku, Eric Kauffman, Anthony C. Wood, Khunsha Ahmed, Venkata Nithinsai Chintala, Remi Adelaiye-Ogala, May Elbanna, Ashley Orillion, Sreenivasulu Chintala, Chinghai Kao, W. Marston Linehan, George M. Yousef, Peter C. Hollenhorst, Roberto Pili
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5977–5989.
https://doi.org/10.1158/1078-0432.CCR-18-0269
Published: 03 December 2018
View article titled, Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays

Apurva K. Srivastava, Melinda G. Hollingshead, Jennifer Weiner, Tony Navas, Yvonne A. Evrard, Sonny A. Khin, Jiuping Jay Ji, Yiping Zhang, Suzanne Borgel, Thomas D. Pfister, Robert J. Kinders, Donald P. Bottaro, W. Marston Linehan, Joseph E. Tomaszewski, James H. Doroshow, Ralph E. Parchment
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3683–3694.
https://doi.org/10.1158/1078-0432.CCR-15-2323
Published: 14 July 2016
View article titled, Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays
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Includes: Supplementary data
Journal Articles

New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease

Ramaprasad Srinivasan, Christopher J. Ricketts, Carole Sourbier, W. Marston Linehan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (1): 10–17.
https://doi.org/10.1158/1078-0432.CCR-13-2993
Published: 05 January 2015
View article titled, New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease
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Journal Articles

Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer—Targeting the Warburg Effect in Cancer

W. Marston Linehan, Tracey A. Rouault
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3345–3352.
https://doi.org/10.1158/1078-0432.CCR-13-0304
Published: 30 June 2013
View article titled, Molecular Pathways: <em>Fumarate Hydratase</em>-Deficient Kidney Cancer—Targeting the Warburg Effect in Cancer
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Journal Articles

Impact of Ischemia and Procurement Conditions on Gene Expression in Renal Cell Carcinoma

Nick W. Liu, Thomas Sanford, Ramaprasad Srinivasan, Jack L. Liu, Kiranpreet Khurana, Olga Aprelikova, Vladimir Valero, Charles Bechert, Robert Worrell, Peter A. Pinto, Youfeng Yang, Maria Merino, W. Marston Linehan, Gennady Bratslavsky
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 42–49.
https://doi.org/10.1158/1078-0432.CCR-12-2606
Published: 02 January 2013
View article titled, Impact of Ischemia and Procurement Conditions on Gene Expression in Renal Cell Carcinoma
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Journal Articles

Targeting Cancer Metabolism

Beverly A. Teicher, W. Marston Linehan, Lee J. Helman
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5537–5545.
https://doi.org/10.1158/1078-0432.CCR-12-2587
Published: 14 October 2012
View article titled, Targeting Cancer Metabolism
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Journal Articles

Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

Michael L. Nickerson, Erich Jaeger, Yangu Shi, Jeffrey A. Durocher, Sunil Mahurkar, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Anush Mukeria, Ivana Holcatova, Laura S. Schmidt, Jorge R. Toro, Sara Karami, Rayjean Hung, Gary F. Gerard, W. Marston Linehan, Maria Merino, Berton Zbar, Paolo Boffetta, Paul Brennan, Nathaniel Rothman, Wong-Ho Chow, Frederic M. Waldman, Lee E. Moore
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15): 4726–4734.
https://doi.org/10.1158/1078-0432.CCR-07-4921
Published: 01 August 2008
View article titled, Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
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Includes: Supplementary data
Journal Articles

Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions

Sabina Signoretti, Gennady Bratslavsky, Frederick M. Waldman, Victor E. Reuter, John Haaga, Maria Merino, George V. Thomas, Michael R. Pins, Towia Libermann, John Gillespie, Joseph E. Tomaszewski, Carolyn C. Compton, Andrew Hruszkewycz, W. Marston Linehan, Michael B. Atkins
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3699–3705.
https://doi.org/10.1158/1078-0432.CCR-07-4733
Published: 16 June 2008
View article titled, Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions
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Journal Articles

Evidence for Microtubule Target Engagement in Tumors of Patients Receiving Ixabepilone

Sen H. Zhuang, Y. Elizabeth Hung, Laura Hung, Robert W. Robey, Dan L. Sackett, W. Marston Linehan, Susan E. Bates, Tito Fojo, Marianne S. Poruchynsky
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7480–7486.
https://doi.org/10.1158/1078-0432.CCR-06-2883
Published: 19 December 2007
View article titled, Evidence for Microtubule Target Engagement in Tumors of Patients Receiving Ixabepilone
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Includes: Supplementary data
Journal Articles

Pseudohypoxic Pathways in Renal Cell Carcinoma

Gennady Bratslavsky, Sunil Sudarshan, Len Neckers, W. Marston Linehan
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4667–4671.
https://doi.org/10.1158/1078-0432.CCR-06-2510
Published: 15 August 2007
View article titled, Pseudohypoxic Pathways in Renal Cell Carcinoma
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Journal Articles

Identification of the Genes for Kidney Cancer: Opportunity for Disease-Specific Targeted Therapeutics

W. Marston Linehan, Peter A. Pinto, Ramaprasad Srinivasan, Maria Merino, Peter Choyke, Lynda Choyke, Jonathan Coleman, Jorge Toro, Gladys Glenn, Cathy Vocke, Bert Zbar, Laura S. Schmidt, Donald Bottaro, Len Neckers
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (2): 671s–679s.
https://doi.org/10.1158/1078-0432.CCR-06-1870
Published: 25 January 2007
View article titled, Identification of the Genes for Kidney Cancer: Opportunity for Disease-Specific Targeted Therapeutics
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Journal Articles

Innovations and Challenges in Renal Cell Carcinoma: Summary Statement from the Second Cambridge Conference

Michael B. Atkins, Marc S. Ernstoff, Robert A. Figlin, Keith T. Flaherty, Daniel J. George, William G. Kaelin, Jr., Eugene D. Kwon, Towia A. Libermann, W. Marston Linehan, David F. McDermott, Augusto C. Ochoa, Allan J. Pantuck, Brian I. Rini, Mark A. Rosen, Jeffrey A. Sosman, Vikas P. Sukhatme, Johannes W. Vieweg, Christopher G. Wood, Laura King
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (2): 667s–670s.
https://doi.org/10.1158/1078-0432.CCR-06-2231
Published: 25 January 2007
View article titled, Innovations and Challenges in Renal Cell Carcinoma: Summary Statement from the Second Cambridge Conference
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Journal Articles

Multifocal Renal Cancer: Genetic Basis and Its Medical Relevance

Donald P. Bottaro, W. Marston Linehan
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (20): 7206–7208.
https://doi.org/10.1158/1078-0432.CCR-05-1343
Published: 20 October 2005
View article titled, Multifocal Renal Cancer: Genetic Basis and Its Medical Relevance
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Journal Articles

Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy

Carolyn J.M. Best, John W. Gillespie, Yajun Yi, Gadisetti V.R. Chandramouli, Mark A. Perlmutter, Yvonne Gathright, Heidi S. Erickson, Lauren Georgevich, Michael A. Tangrea, Paul H. Duray, Sergio González, Alfredo Velasco, W. Marston Linehan, Robert J. Matusik, Douglas K. Price, William D. Figg, Michael R. Emmert-Buck, Rodrigo F. Chuaqui
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (19): 6823–6834.
https://doi.org/10.1158/1078-0432.CCR-05-0585
Published: 03 October 2005
View article titled, Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy
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Includes: Supplementary data
Journal Articles

Coexpression of Erythropoietin and Erythropoietin Receptor in Von Hippel-Lindau Disease–Associated Renal Cysts and Renal Cell Carcinoma

Youn-Soo Lee, Alexander O. Vortmeyer, Irina A. Lubensky, Timothy W.A. Vogel, Barbara Ikejiri, Sophie Ferlicot, Gérard Benoît, Sophie Giraud, Edward H. Oldfield, W. Marston Linehan, Bin T. Teh, Stéphane Richard, Zhengping Zhuang
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1059–1064.
https://doi.org/10.1158/1078-0432.1059.11.3
Published: 11 February 2005
View article titled, Coexpression of Erythropoietin and Erythropoietin Receptor in Von Hippel-Lindau Disease–Associated Renal Cysts and Renal Cell Carcinoma
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Journal Articles

The In vitro and In vivo Effects of Re-Expressing Methylated von Hippel-Lindau Tumor Suppressor Gene in Clear Cell Renal Carcinoma with 5-Aza-2′-deoxycytidine

Wade G. Alleman, Ray L. Tabios, Gadisetti V. R. Chandramouli, Olga N. Aprelikova, Carlos Torres-Cabala, Arnulfo Mendoza, Craig Rodgers, Nikolai A. Sopko, W. Marston Linehan, James R. Vasselli
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (20): 7011–7021.
https://doi.org/10.1158/1078-0432.CCR-04-0516
Published: 22 October 2004
View article titled, The <em>In vitro</em> and <em>In vivo</em> Effects of Re-Expressing Methylated <em>von Hippel-Lindau</em> Tumor Suppressor Gene in Clear Cell Renal Carcinoma with 5-Aza-2′-deoxycytidine
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Journal Articles

Innovations and Challenges in Renal Cancer: Consensus Statement from the First International Conference

Michael B. Atkins, David E. Avigan, Ronald M. Bukowski, Richard W. Childs, Janice P. Dutcher, Tim G. Eisen, Robert A. Figlin, James H. Finke, Robert C. Flanigan, Daniel J. George, S. Nahum Goldberg, Michael S. Gordon, Othon Iliopoulos, William G. Kaelin, Jr., W. Marston Linehan, Allan Lipton, Robert J. Motzer, Andrew C. Novick, Walter M. Stadler, Bin Tean Teh, James C. Yang, Laura King
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (18): 6277S–6281S.
https://doi.org/10.1158/1078-0432.CCR-040720
Published: 15 September 2004
View article titled, Innovations and Challenges in Renal Cancer: <subtitle>Consensus Statement from the First International Conference</subtitle>
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