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W. Fraser Symmans
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Journal Articles

Abstract PS4-01: Predictor of benefit from dose-dense paclitaxel chemotherapy for patients with hormone receptor-positive HER2-negative breast cancer. A GEICAM/9906 sub-study

Free
Miguel Martin, Alvaro Rodriguez-Lescure, Lourdes Calvo, Eveline Chen, Manuel Ruiz-Borrego, Cesar A. Rodriguez, Noelia Martinez-Jañez, Emilio Alba, Kevin Tran, Ignacio Pelaez Fernandez, Isabel Alvarez, Miguel Angel Segui, Alberto de la Cruz, Vicente Valero, Antonio Anton-Torres, Raquel Andres, Kepa Amillano, Jose J. Ponce-Lorenzo, Severina Dominguez Fernandez, Jesus Herranz, Raul Rincon, Rosalia Caballero, Ana Santaballa Bertran, Angel Guerrero-Zotano, W. Fraser Symmans
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS4-01.
https://doi.org/10.1158/1557-3265.SABCS24-PS4-01
Published: 13 June 2025
View articletitled, Abstract PS4-01: Predictor of benefit from dose-dense paclitaxel chemotherapy for patients with hormone receptor-positive HER2-negative breast cancer. A GEICAM/9906 sub-study
Journal Articles

Abstract RF2-01: Factors Influencing Additional Nodal Disease and Pathologic Nodal Upstaging with Axillary Dissection in Patients with Residual Node-Positive Breast Cancer After Neoadjuvant Chemotherapy Enrolled on Alliance A011202 Clinical Trial

Free
Judy Boughey, Vera Suman, Kelly J. Hunt, Bruce G. Haffty, Thomas Buchholz, W. Fraser Symmans, Tracy L. Rieken, Travis J. Dockter, Jordan D. Campbell, Anna Weiss, Julie A. Bradley, Joshua M. V. Mammen, Ann H. Partridge, Lisa A. Carey
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): RF2-01.
https://doi.org/10.1158/1557-3265.SABCS24-RF2-01
Published: 13 June 2025
View articletitled, Abstract RF2-01: Factors Influencing Additional Nodal Disease and Pathologic Nodal Upstaging with Axillary Dissection in Patients with Residual Node-Positive Breast Cancer After Neoadjuvant Chemotherapy Enrolled on Alliance A011202 Clinical Trial
Journal Articles

Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy

Available to Purchase
Mark Jesus M. Magbanua, Ziad Ahmed, Rosalyn W. Sayaman, Lamorna Brown Swigart, Gillian L. Hirst, Christina Yau, Denise M. Wolf, Wen Li, Amy L. Delson, Jane Perlmutter, Paula Pohlmann, W. Fraser Symmans, Douglas Yee, Nola M. Hylton, Laura J. Esserman, Angela M. DeMichele, Hope S. Rugo, Laura J. van 't Veer
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (11): 2444–2451.
https://doi.org/10.1158/1078-0432.CCR-23-2928
Published: 03 June 2024
View articletitled, Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial—Efficacy and Biomarker Discovery

Available to Purchase
Kathy S. Albain, Christina Yau, Emanuel F. Petricoin, Denise M. Wolf, Julie E. Lang, A. Jo Chien, Tufia Haddad, Andres Forero-Torres, Anne M. Wallace, Henry Kaplan, Lajos Pusztai, David Euhus, Rita Nanda, Anthony D. Elias, Amy S. Clark, Constantine Godellas, Judy C. Boughey, Claudine Isaacs, Debu Tripathy, Janice Lu, Rachel L. Yung, Rosa I. Gallagher, Julia D. Wulfkuhle, Lamorna Brown-Swigart, Gregor Krings, Yunn Yi Chen, David A. Potter, Erica Stringer-Reasor, Sarah Blair, Smita M. Asare, Amy Wilson, Gillian L. Hirst, Ruby Singhrao, Meredith Buxton, Julia L. Clennell, Ashish Sanil, Scott Berry, Adam L. Asare, Jeffrey B. Matthews, Angela M. DeMichele, Nola M. Hylton, Michelle Melisko, Jane Perlmutter, Hope S. Rugo, W. Fraser Symmans, Laura J. van't Veer, Douglas Yee, Donald A. Berry, Laura J. Esserman
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 729–740.
https://doi.org/10.1158/1078-0432.CCR-22-2256
Published: 16 February 2024
View articletitled, Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial—Efficacy and Biomarker Discovery
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Includes: Supplementary data
Journal Articles

Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031)

Open Access
Vera J. Suman, Lili Du, Tanya Hoskin, Meenakshi Anurag, Cynthia Ma, Isabelle Bedrosian, Kelly K. Hunt, Matthew J. Ellis, W. Fraser Symmans
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (15): 3287–3295.
https://doi.org/10.1158/1078-0432.CCR-22-0068
Published: 02 August 2022
View articletitled, Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031)
Open the PDF for Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031) in another window
Includes: Supplementary data
Journal Articles

Interpreting the Complex Landscape of Immune–Tumor Interface

Available to Purchase
W. Fraser Symmans
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5446–5448.
https://doi.org/10.1158/1078-0432.CCR-21-2208
Published: 15 October 2021
View articletitled, Interpreting the Complex Landscape of Immune–Tumor Interface
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Journal Articles

Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer

Free
Kelly K. Hunt, Cansu Karakas, Min Jin Ha, Anna Biernacka, Min Yi, Aysegul A. Sahin, Opoku Adjapong, Gabriel N. Hortobagyi, Melissa L. Bondy, Patricia A. Thompson, Kwok Leung Cheung, Ian O. Ellis, Sarah Bacus, W. Fraser Symmans, Kim-Anh Do, Khandan Keyomarsi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 2991–3002.
https://doi.org/10.1158/1078-0432.CCR-16-2217
Published: 14 June 2017
View articletitled, Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer
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Includes: Supplementary data
Journal Articles

Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer

Free
Christos Hatzis, W. Fraser Symmans, Ya Zhang, Rebekah E. Gould, Stacy L. Moulder, Kelly K. Hunt, Maysa Abu-Khalaf, Erin W. Hofstatter, Donald Lannin, Anees B. Chagpar, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1): 26–33.
https://doi.org/10.1158/1078-0432.CCR-14-3304
Published: 03 January 2016
View articletitled, Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

CCR 20th Anniversary Commentary: Divide and Conquer—Breast Cancer Subtypes and Response to Therapy

Free
Lajos Pusztai, Roman Rouzier, W. Fraser Symmans
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16): 3575–3577.
https://doi.org/10.1158/1078-0432.CCR-14-3121
Published: 13 August 2015
View articletitled, CCR 20th Anniversary Commentary: Divide and Conquer—Breast Cancer Subtypes and Response to Therapy
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Journal Articles

Gene Signature–Guided Dasatinib Therapy in Metastatic Breast Cancer

Free
Lajos Pusztai, Stacy Moulder, Mehmet Altan, Danielle Kwiatkowski, Vicente Valero, Naoto T. Ueno, Francisco J. Esteva, Rony Avritscher, Yuan Qi, Lewis Strauss, Gabriel N. Hortobagyi, Christos Hatzis, W. Fraser Symmans
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (20): 5265–5271.
https://doi.org/10.1158/1078-0432.CCR-14-0800
Published: 14 October 2014
View articletitled, Gene Signature–Guided Dasatinib Therapy in Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes

Free
Hiroko Masuda, Keith A. Baggerly, Ying Wang, Ya Zhang, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam, Vicente Valero, Brian D. Lehmann, Jennifer A. Pietenpol, Gabriel N. Hortobagyi, W. Fraser Symmans, Naoto T. Ueno
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (19): 5533–5540.
https://doi.org/10.1158/1078-0432.CCR-13-0799
Published: 01 October 2013
View articletitled, Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes
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Includes: Supplementary data
Journal Articles

Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer

Free
Ke-Da Yu, Rui Zhu, Ming Zhan, Angel A. Rodriguez, Wei Yang, Stephen Wong, Andreas Makris, Brian D. Lehmann, Xi Chen, Ingrid Mayer, Jennifer A. Pietenpol, Zhi-Ming Shao, W. Fraser Symmans, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (10): 2723–2733.
https://doi.org/10.1158/1078-0432.CCR-12-2986
Published: 12 May 2013
View articletitled, Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Gene Expression, Molecular Class Changes, and Pathway Analysis after Neoadjuvant Systemic Therapy for Breast Cancer

Free
Ana M. Gonzalez-Angulo, Takayuki Iwamoto, Shuying Liu, Huiqin Chen, Kim-Anh Do, Gabriel N. Hortobagyi, Gordon B. Mills, Funda Meric-Bernstam, W. Fraser Symmans, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (4): 1109–1119.
https://doi.org/10.1158/1078-0432.CCR-11-2762
Published: 14 February 2012
View articletitled, Gene Expression, Molecular Class Changes, and Pathway Analysis after Neoadjuvant Systemic Therapy for Breast Cancer
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Includes: Supplementary data
Journal Articles

Distinct p53 Gene Signatures Are Needed to Predict Prognosis and Response to Chemotherapy in ER-Positive and ER-Negative Breast Cancers

Free
Charles Coutant, Roman Rouzier, Yuan Qi, Jacqueline Lehmann-Che, Giampaolo Bianchini, Takayuki Iwamoto, Gabriel N. Hortobagyi, W. Fraser Symmans, Serge Uzan, Fabrice Andre, Hugues de Thé, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2591–2601.
https://doi.org/10.1158/1078-0432.CCR-10-1045
Published: 14 April 2011
View articletitled, Distinct p53 Gene Signatures Are Needed to Predict Prognosis and Response to Chemotherapy in ER-Positive and ER-Negative Breast Cancers
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Includes: Supplementary data
Journal Articles

Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer

Free
Adel Tabchy, Vicente Valero, Tatiana Vidaurre, Ana Lluch, Henry Gomez, Miguel Martin, Yuan Qi, Luis Javier Barajas-Figueroa, Eduardo Souchon, Charles Coutant, Franco D. Doimi, Nuhad K. Ibrahim, Yun Gong, Gabriel N. Hortobagyi, Kenneth R. Hess, W. Fraser Symmans, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5351–5361.
https://doi.org/10.1158/1078-0432.CCR-10-1265
Published: 31 October 2010
View articletitled, Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer
Open the PDF for Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer

Free
Jae K. Lee, Charles Coutant, Young-Chul Kim, Yuan Qi, Dan Theodorescu, W. Fraser Symmans, Keith Baggerly, Roman Rouzier, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 711–718.
https://doi.org/10.1158/1078-0432.CCR-09-2247
Published: 14 January 2010
View articletitled, Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer
Open the PDF for Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array

Free
Fabrice Andre, Bastien Job, Philippe Dessen, Attila Tordai, Stefan Michiels, Cornelia Liedtke, Catherine Richon, Kai Yan, Bailang Wang, Gilles Vassal, Suzette Delaloge, Gabriel N. Hortobagyi, W. Fraser Symmans, Vladimir Lazar, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (2): 441–451.
https://doi.org/10.1158/1078-0432.CCR-08-1791
Published: 15 January 2009
View articletitled, Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array
Open the PDF for Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array in another window
Includes: Supplementary data
Journal Articles

Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer

Free
Stacy L. Moulder, W. Fraser Symmans, Daniel J. Booser, Timothy L. Madden, Cindy Lipsanen, Linda Yuan, Abenaa M. Brewster, Massimo Cristofanilli, Kelly K. Hunt, Thomas A. Buchholz, James Zwiebel, Vicente Valero, Gabriel N. Hortobagyi, Francisco J. Esteva
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7909–7916.
https://doi.org/10.1158/1078-0432.CCR-08-1104
Published: 01 December 2008
View articletitled, Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer
Open the PDF for Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer in another window
Journal Articles

Thirty-Gene Pharmacogenomic Test Correlates with Residual Cancer Burden after Preoperative Chemotherapy for Breast Cancer

Free
Florentia Peintinger, Keith Anderson, Chafika Mazouni, Henry M. Kuerer, Christos Hatzis, Feng Lin, Gabriel N. Hortobagyi, W. Fraser Symmans, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (14): 4078–4082.
https://doi.org/10.1158/1078-0432.CCR-06-2600
Published: 18 July 2007
View articletitled, Thirty-Gene Pharmacogenomic Test Correlates with Residual Cancer Burden after Preoperative Chemotherapy for Breast Cancer
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Journal Articles

Standardizing Slide-Based Assays in Breast Cancer: Hormone Receptors, HER2, and Sentinel Lymph Nodes

Free
Jeffrey S. Ross, W. Fraser Symmans, Lajos Pusztai, Gabriel N. Hortobagyi
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (10): 2831–2835.
https://doi.org/10.1158/1078-0432.CCR-06-2522
Published: 15 May 2007
View articletitled, Standardizing Slide-Based Assays in Breast Cancer: Hormone Receptors, HER2, and Sentinel Lymph Nodes
Open the PDF for Standardizing Slide-Based Assays in Breast Cancer: Hormone Receptors, HER2, and Sentinel Lymph Nodes in another window