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Journal Articles

Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study

Vivek Subbiah, Irene Braña, Alessandra Longhi, Valentina Boni, Jean-Pierre Delord, Ahmad Awada, Pascaline Boudou-Rouquette, John Sarantopoulos, Geoffrey I. Shapiro, Anthony Elias, Ravin Ratan, Cristian Fernandez, Carmen Kahatt, Martin Cullell-Young, Mariano Siguero, Ali Zeaiter, Sant P. Chawla

Clin Cancer Res OF1–OF9.

DOI: https://doi.org/10.1158/1078-0432.CCR-22-0696

Published: 20 May 2022

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Journal Articles

A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Florence Atrafi, Oliver Boix, Vivek Subbiah, Jennifer R. Diamond, Sant P. Chawla, Anthony W. Tolcher, Patricia M. LoRusso, Joseph P. Eder, Martin Gutierrez, Kumar Sankhala, Prabhu Rajagopalan, Isabelle Genvresse, Simon Langer, Ron H.J. Mathijssen, Jaap Verweij, Ingmar Bruns, Martijn P. Lolkema

Clin Cancer Res (2021) 27 (23): 6366–6375.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4185

Published: 01 December 2021

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Includes: Supplementary data

Journal Articles

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

Clin Cancer Res (2021) 27 (15): 4160–4167.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-0800

Published: 01 August 2021

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Includes: Supplementary data

Journal Articles

First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

George D. Demetri, Jason J. Luke, Antoine Hollebecque, John D. Powderly, II, Alexander I. Spira, Vivek Subbiah, Louie Naumovski, Chris Chen, Hua Fang, Dominic W. Lai, Huibin Yue, Akshanth R. Polepally, James W. Purcell, Randy Robinson, Padmanee Sharma, James P. Allison, Anthony Tolcher, Victor M. Villalobos

Clin Cancer Res (2021) 27 (13): 3556–3566.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4513

Published: 01 July 2021

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Includes: Supplementary data

Journal Articles

A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies

Clin Cancer Res (2021) 27 (11): 3050–3060.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4118

Published: 01 June 2021

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Includes: Supplementary data

Journal Articles

Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game

Roman Groisberg, Vivek Subbiah

Clin Cancer Res (2021) 27 (10): 2672–2674.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-0254

Published: 15 May 2021

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Journal Articles

Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors

Alexej Ballhausen, Jennifer J. Wheler, Daniel D. Karp, Sarina A. Piha-Paul, Siqing Fu, Shubham Pant, Apostolia M. Tsimberidou, David S. Hong, Vivek Subbiah, Veronica R. Holley, Helen J. Huang, Abenaa M. Brewster, Kimberly B. Koenig, Nuhad K. Ibrahim, Funda Meric-Bernstam, Filip Janku

Clin Cancer Res (2021) 27 (5): 1247–1255.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-2878

Published: 01 March 2021

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Journal Articles

Progresses Toward Precision Medicine in RET-altered Solid Tumors

Carmen Belli, Santosh Anand, Justin F. Gainor, Frederique Penault-Llorca, Vivek Subbiah, Alexander Drilon, Fabrice Andrè, Giuseppe Curigliano

Clin Cancer Res (2020) 26 (23): 6102–6111.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-1587

Published: 01 December 2020

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Journal Articles

Phase I Study of P-cadherin–targeted Radioimmunotherapy with ⁹⁰Y-FF-21101 Monoclonal Antibody in Solid Tumors

Clin Cancer Res (2020) 26 (22): 5830–5842.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-0037

Published: 13 November 2020

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Includes: Supplementary data

Journal Articles

Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma

Clin Cancer Res (2020) 26 (21): 5579–5587.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-1215

Published: 02 November 2020

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Includes: Supplementary data

Journal Articles

Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer

Seyed Pairawan, Kenneth R. Hess, Filip Janku, Nora S. Sanchez, Kenna R. Mills Shaw, Cathy Eng, Senthilkumar Damodaran, Milind Javle, Ahmed O. Kaseb, David S. Hong, Vivek Subbiah, Siqing Fu, David R. Fogelman, Victoria M. Raymond, Richard B. Lanman, Funda Meric-Bernstam

Clin Cancer Res (2020) 26 (8): 1924–1931.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0306

Published: 15 April 2020

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Includes: Supplementary data

Journal Articles

Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations

Thereasa A. Rich, Karen L. Reckamp, Young Kwang Chae, Robert C. Doebele, Wade T. Iams, Michael Oh, Victoria M. Raymond, Richard B. Lanman, Jonathan W. Riess, Thomas E. Stinchcombe, Vivek Subbiah, David R. Trevarthen, Stephen Fairclough, Jennifer Yen, Oliver Gautschi

Clin Cancer Res (2019) 25 (19): 5832–5842.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-4049

Published: 01 October 2019

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Includes: Supplementary data

Journal Articles

A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers

Razelle Kurzrock, Douglas W. Ball, Marianna L. Zahurak, Barry D. Nelkin, Vivek Subbiah, Shabina Ahmed, Ashley O'Connor, Enusha Karunsena, Rose M. Parkinson, Justin A. Bishop, Yoonji Ha, Rajni Sharma, Christopher D. Gocke, Ralph Zinner, Michelle A. Rudek, Steven I. Sherman, Nilofer S. Azad

Clin Cancer Res (2019) 25 (18): 5475–5484.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-1881

Published: 13 September 2019

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Includes: Supplementary data

Journal Articles

Alpha Particle Radium 223 Dichloride in High-risk Osteosarcoma: A Phase I Dose Escalation Trial

Vivek Subbiah, Pete M. Anderson, Kalevi Kairemo, Kenneth Hess, Winston W. Huh, Vinod Ravi, Najat C. Daw, Neeta Somaiah, Joseph A. Ludwig, Robert S. Benjamin, Sant Chawla, David S. Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie Kleinerman, Homer Macapinlac, Eric Rohren

Clin Cancer Res (2019) 25 (13): 3802–3810.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-3964

Published: 01 July 2019

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Includes: Supplementary data

Journal Articles

Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival

Clin Cancer Res (2018) 24 (19): 4865–4873.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-0202

Published: 01 October 2018

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Includes: Supplementary data

Journal Articles

Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers

Vivek Subbiah, Ravi Murthy, David S. Hong, Robert M. Prins, Chitra Hosing, Kyle Hendricks, Deepthi Kolli, Lori Noffsinger, Robert Brown, Mary McGuire, Siquing Fu, Sarina Piha-Paul, Aung Naing, Anthony P. Conley, Robert S. Benjamin, Indreshpal Kaur, Marnix L. Bosch

Clin Cancer Res (2018) 24 (16): 3845–3856.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-2707

Published: 14 August 2018

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Includes: Supplementary data

Journal Articles

Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers

Clin Cancer Res (2018) 24 (1): 181–188.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-2007

Published: 02 January 2018

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Includes: Supplementary data

Journal Articles

Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors

Vivek Subbiah, Juneko E. Grilley-Olson, Austin J. Combest, Neelesh Sharma, Richard H. Tran, Iulian Bobe, Atsushi Osada, Kazuhiro Takahashi, Jaikrishna Balkissoon, Aaron Camp, Atsuhiro Masada, Dirk J. Reitsma, Lyudmila A. Bazhenova

Clin Cancer Res (2018) 24 (1): 43–51.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-1114

Published: 02 January 2018

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Includes: Supplementary data

Journal Articles

Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer

Clin Cancer Res (2017) 23 (18): 5648–5656.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-0291

Published: 14 September 2017

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Includes: Supplementary data

Journal Articles

Insurance Clearance for Early-Phase Oncology Clinical Trials Following the Affordable Care Act

Kenneth L. Kehl, Cheryl P. Fullmer, Siqing Fu, Goldy C. George, Kenneth R. Hess, Filip Janku, Daniel D. Karp, Shumei Kato, Cynthia K. Kizer, Razelle Kurzrock, Aung Naing, Shubham Pant, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, David S. Hong

Clin Cancer Res (2017) 23 (15): 4155–4162.

DOI: https://doi.org/10.1158/1078-0432.CCR-16-3027

Published: 01 August 2017

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Includes: Supplementary data

NARROW

Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study

A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies

Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game

Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors

Progresses Toward Precision Medicine in RET-altered Solid Tumors

Phase I Study of P-cadherin–targeted Radioimmunotherapy with ⁹⁰Y-FF-21101 Monoclonal Antibody in Solid Tumors

Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma

Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer

Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations

A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers

Alpha Particle Radium 223 Dichloride in High-risk Osteosarcoma: A Phase I Dose Escalation Trial

Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival

Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers

Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers

Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors

Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer

Insurance Clearance for Early-Phase Oncology Clinical Trials Following the Affordable Care Act

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