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Vivek Subbiah
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Journal Articles

Abstract P4-08-24: AKTive-001: A Phase 1/1b Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation (Trial in Progress)

Free
Anthony Tolcher, Andreas Varkaris, Jordi Rodón, Alexander I. Spira, Kari Wisinski, Vivek Subbiah, Gerald Falchook, Judy Wang, Sarah Sammons, Marla D. Lipsyc-Sharf, Rebecca Shatsky, Nancy Chan, Cynthia X. Ma, Andrew Chi, Eric Murphy, Dana Peters, Vicky Kang, Kevin M. Kalinsky
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P4-08-24.
https://doi.org/10.1158/1557-3265.SABCS24-P4-08-24
Published: 13 June 2025
View articletitled, Abstract P4-08-24: AKTive-001: A Phase 1/1b Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation (Trial in Progress)
Journal Articles

Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types

Open Access
Pashtoon M. Kasi, Jessica K. Lee, Lincoln W. Pasquina, Brennan Decker, Pierre Vanden Borre, Dean C. Pavlick, Justin M. Allen, Christine Parachoniak, Julia C. F. Quintanilha, Ryon P. Graf, Alexa B. Schrock, Geoffrey R. Oxnard, Christine M. Lovly, Hanna Tukachinsky, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 836–848.
https://doi.org/10.1158/1078-0432.CCR-23-2693
Published: 16 February 2024
View articletitled, Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
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Includes: Supplementary data
Journal Articles

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes

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Ryan A. Denu, Richard K. Yang, Alexander J. Lazar, Shalin S. Patel, Valerae O. Lewis, Jason Roszik, J. Andrew Livingston, Wei-Lien Wang, Kenna R. Shaw, Ravin Ratan, Maria A. Zarzour, Justin Bird, Shaan Raza, Kadir C. Akdemir, Jordi Rodon Ahnert, Vivek Subbiah, Shreyaskumar Patel, Anthony P. Conley
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4844–4852.
https://doi.org/10.1158/1078-0432.CCR-23-1703
Published: 01 December 2023
View articletitled, Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes
Open the PDF for Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes in another window
Includes: Supplementary data
Journal Articles

The Landscape of Alterations from 1407 Ultra-Rare Sarcomas from the AACR GENIE Database: Clinical Implications

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Ryan A. Denu, Justin T. Moyers, Mohamed A. Gouda, Anthony P. Conley, Alexander J. Lazar, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4669–4678.
https://doi.org/10.1158/1078-0432.CCR-23-0876
Published: 14 November 2023
View articletitled, The Landscape of Alterations from 1407 Ultra-Rare Sarcomas from the AACR GENIE Database: Clinical Implications
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Includes: Supplementary data
Journal Articles

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

Open Access
Vivek Subbiah, Sant P. Chawla, Anthony P. Conley, Breelyn A. Wilky, Anthony Tolcher, Nehal J. Lakhani, David Berz, Vasily Andrianov, William Crago, Monica Holcomb, Abrahim Hussain, Carson Veldstra, James Kalabus, Brianne O’Neill, Lane Senne, Emily Rowell, Analeah B. Heidt, Katelyn M. Willis, Brendan P. Eckelman
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 2988–3003.
https://doi.org/10.1158/1078-0432.CCR-23-0974
Published: 15 August 2023
View articletitled, Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma
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Includes: Supplementary data
Journal Articles

Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications

Open Access
Mohamed A. Gouda, Blessie E. Nelson, Lars Buschhorn, Adam Wahida, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (15): 2753–2760.
https://doi.org/10.1158/1078-0432.CCR-23-0090
Published: 01 August 2023
View articletitled, Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications
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Includes: Supplementary data
Journal Articles

Direct-to-Patient Clinical Trials: One Small Step or a Giant Leap?

Available to Purchase
Aakash Desai, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2339–2341.
https://doi.org/10.1158/1078-0432.CCR-23-0746
Published: 05 July 2023
View articletitled, Direct-to-Patient Clinical Trials: One Small Step or a Giant Leap?
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Journal Articles

Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)

Open Access
Roberto Carmagnani Pestana, Justin T. Moyers, Jason Roszik, Shiraj Sen, David S. Hong, Aung Naing, Cynthia E. Herzog, Siqing Fu, Sarina A. Piha-Paul, Jordi Rodon, Timothy A. Yap, Daniel D. Karp, Apostolia M. Tsimberidou, Shubham Pant, Maria A. Zarzour, Ravin Ratan, Vinod Ravi, Robert S. Benjamin, Alexander J. Lazar, Wei-Lien Wang, Najat Daw, Jonathan B. Gill, Douglas J. Harrison, Valerae O. Lewis, Christina L. Roland, Shreyaskumar R. Patel, J. Andrew Livingston, Neeta Somaiah, Joseph A. Ludwig, Anthony P. Conley, Nelson Hamerschlak, Richard Gorlick, Funda Meric-Bernstam, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (9): 1708–1718.
https://doi.org/10.1158/1078-0432.CCR-22-3629
Published: 01 May 2023
View articletitled, Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)
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Includes: Supplementary data
Journal Articles

Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)

Open Access
Justin T. Moyers, Roberto Carmagnani Pestana, Jason Roszik, David S. Hong, Aung Naing, Siqing Fu, Sarina Piha-Paul, Timothy A. Yap, Daniel Karp, Jordi Rodon, Andy Livingston, Maria Alejandra Zarzour, Vinod Ravi, Shreyaskumar Patel, Robert S. Benjamin, Joseph Ludwig, Cynthia Herzog, Ravin Ratan, Neeta Somaiah, Anthony Conley, Richard Gorlick, Funda Meric-Bernstam, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 401–409.
https://doi.org/10.1158/1078-0432.CCR-22-2509
Published: 17 January 2023
View articletitled, Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)
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Includes: Supplementary data
Journal Articles

Tilsotolimod Exploits the TLR9 Pathway to Promote Antigen Presentation and Type 1 IFN Signaling in Solid Tumors: A Multicenter International Phase I/II Trial (ILLUMINATE-101)

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Hani Babiker, Erkut Borazanci, Vivek Subbiah, Sanjiv Agarwala, Alain Algazi, Jacob Schachter, Michael Lotem, Corinne Maurice-Dror, Daniel Hendler, Shah Rahimian, Hans Minderman, Cara Haymaker, Daruka Mahadevan, Chantale Bernatchez, Ravi Murthy, Rolf Hultsch, Nadia Kaplan, Gregory Woodhead, Charles Hennemeyer, Srinivas Chunduru, Peter M. Anderson, Adi Diab, Igor Puzanov
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5079–5087.
https://doi.org/10.1158/1078-0432.CCR-21-4486
Published: 01 December 2022
View articletitled, Tilsotolimod Exploits the TLR9 Pathway to Promote Antigen Presentation and Type 1 IFN Signaling in Solid Tumors: A Multicenter International Phase I/II Trial (ILLUMINATE-101)
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Includes: Supplementary data
Journal Articles

Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?

Available to Purchase
Vivek Subbiah, Boyi Gan
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3408–3410.
https://doi.org/10.1158/1078-0432.CCR-22-1257
Published: 15 August 2022
View articletitled, Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?
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Journal Articles

Correction: A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Free
Florence Atrafi, Oliver Boix, Vivek Subbiah, Jennifer R. Diamond, Sant P. Chawla, Anthony W. Tolcher, Patricia M. LoRusso, Joseph P. Eder, Martin Gutierrez, Kumar Sankhala, Prabhu Rajagopalan, Isabelle Genvresse, Simon Langer, Ron H.J. Mathijssen, Jaap Verweij, Ingmar Bruns, Martijn P. Lolkema
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2969.
https://doi.org/10.1158/1078-0432.CCR-22-1792
Published: 01 July 2022
View articletitled, Correction: A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation
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Journal Articles

Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study

Open Access
Vivek Subbiah, Irene Braña, Alessandra Longhi, Valentina Boni, Jean-Pierre Delord, Ahmad Awada, Pascaline Boudou-Rouquette, John Sarantopoulos, Geoffrey I. Shapiro, Anthony Elias, Ravin Ratan, Cristian Fernandez, Carmen Kahatt, Martin Cullell-Young, Mariano Siguero, Ali Zeaiter, Sant P. Chawla
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2762–2770.
https://doi.org/10.1158/1078-0432.CCR-22-0696
Published: 01 July 2022
View articletitled, Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study
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Journal Articles

A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Available to Purchase
Florence Atrafi, Oliver Boix, Vivek Subbiah, Jennifer R. Diamond, Sant P. Chawla, Anthony W. Tolcher, Patricia M. LoRusso, Joseph P. Eder, Martin Gutierrez, Kumar Sankhala, Prabhu Rajagopalan, Isabelle Genvresse, Simon Langer, Ron H.J. Mathijssen, Jaap Verweij, Ingmar Bruns, Martijn P. Lolkema
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6366–6375.
https://doi.org/10.1158/1078-0432.CCR-20-4185
Published: 01 December 2021
View articletitled, A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation
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Includes: Supplementary data
Journal Articles

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

Open Access
Vivek Subbiah, Justin F. Gainor, Geoffrey R. Oxnard, Daniel S.W. Tan, Dwight H. Owen, Byoung Chul Cho, Herbert H. Loong, Caroline E. McCoach, Jared Weiss, Yu Jung Kim, Lyudmila Bazhenova, Keunchil Park, Haruko Daga, Benjamin Besse, Oliver Gautschi, Christian Rolfo, Edward Y. Zhu, Jennifer F. Kherani, Xin Huang, Suhyun Kang, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4160–4167.
https://doi.org/10.1158/1078-0432.CCR-21-0800
Published: 01 August 2021
View articletitled, Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial
Open the PDF for Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial in another window
Includes: Supplementary data
Journal Articles

First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

Free
George D. Demetri, Jason J. Luke, Antoine Hollebecque, John D. Powderly, II, Alexander I. Spira, Vivek Subbiah, Louie Naumovski, Chris Chen, Hua Fang, Dominic W. Lai, Huibin Yue, Akshanth R. Polepally, James W. Purcell, Randy Robinson, Padmanee Sharma, James P. Allison, Anthony Tolcher, Victor M. Villalobos
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (13): 3556–3566.
https://doi.org/10.1158/1078-0432.CCR-20-4513
Published: 01 July 2021
View articletitled, First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors
Open the PDF for First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors in another window
Includes: Supplementary data
Journal Articles

A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies

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Aparna Hegde, Priyamvada Jayaprakash, Coline A. Couillault, Sarina Piha-Paul, Daniel Karp, Jordi Rodon, Shubham Pant, Siqing Fu, Ecaterina E. Dumbrava, Timothy A. Yap, Vivek Subbiah, Priya Bhosale, Cristian Coarfa, Jack P. Higgins, Eric T. Williams, Thomas F. Wilson, JoAnn Lim, Funda Meric-Bernstam, Elizabeth Sumner, Hira Zain, Di Nguyen, Ly M. Nguyen, Kimal Rajapakshe, Michael A. Curran, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3050–3060.
https://doi.org/10.1158/1078-0432.CCR-20-4118
Published: 01 June 2021
View articletitled, A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies
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Includes: Supplementary data
Journal Articles

Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game

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Roman Groisberg, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2672–2674.
https://doi.org/10.1158/1078-0432.CCR-21-0254
Published: 15 May 2021
View articletitled, Combination Therapies for Precision Oncology: The Ultimate Whack-A-Mole Game
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Journal Articles

Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors

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Alexej Ballhausen, Jennifer J. Wheler, Daniel D. Karp, Sarina A. Piha-Paul, Siqing Fu, Shubham Pant, Apostolia M. Tsimberidou, David S. Hong, Vivek Subbiah, Veronica R. Holley, Helen J. Huang, Abenaa M. Brewster, Kimberly B. Koenig, Nuhad K. Ibrahim, Funda Meric-Bernstam, Filip Janku
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1247–1255.
https://doi.org/10.1158/1078-0432.CCR-20-2878
Published: 01 March 2021
View articletitled, Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors
Open the PDF for Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors in another window
Journal Articles

Progresses Toward Precision Medicine in RET-altered Solid Tumors

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Carmen Belli, Santosh Anand, Justin F. Gainor, Frederique Penault-Llorca, Vivek Subbiah, Alexander Drilon, Fabrice Andrè, Giuseppe Curigliano
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6102–6111.
https://doi.org/10.1158/1078-0432.CCR-20-1587
Published: 01 December 2020
View articletitled, Progresses Toward Precision Medicine in RET-altered Solid Tumors
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