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Victor E. Velculescu
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Journal Articles

Abstract PR016: Dynamic chromatin landscapes of colorectal cancer development and cell-free DNA fragmentation

Free
Nicholas A. Vulpescu, Zachariah H. Foda, Pieter H.A. Wisse, Christopher Cherry, Jaime E. Medina, Vilmos Adleff, Remond J.A. Fijneman, Robert B. Scharpf, Gerrit A. Meijer, Beatriz Carvalho, Victor E. Velculescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): PR016.
https://doi.org/10.1158/1557-3265.LIQBIOP24-PR016
Published: 13 November 2024
View articletitled, Abstract PR016: Dynamic chromatin landscapes of colorectal cancer development and cell-free DNA fragmentation
Journal Articles

Abstract B067: Dynamic chromatin landscapes of colorectal cancer development and cell-free DNA fragmentation

Free
Nicholas A. Vulpescu, Zachariah H. Foda, Pieter H.A. Wisse, Christopher Cherry, Jaime E. Medina, Vilmos Adleff, Remond J.A. Fijneman, Robert B. Scharpf, Gerrit A. Meijer, Beatriz Carvalho, Victor E. Velculescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): B067.
https://doi.org/10.1158/1557-3265.LIQBIOP24-B067
Published: 13 November 2024
View articletitled, Abstract B067: Dynamic chromatin landscapes of colorectal cancer development and cell-free DNA fragmentation
Journal Articles

Abstract A050: Early detection of liver cancer from diverse populations using cfDNA fragmentome and protein biomarkers

Free
Zachariah H Foda, Daniel Bruhm C Bruhm, Akshaya V Annapragada, Shashikant Koul, Sarah Short, Keerti Boyapati, Adrianna Bartolomucci, Vilmos Adleff, Nicholas A Vulpescu, Hope Orjuela, Andrei Sorop, Razvan Iacob, Liana Gheorghe, Simona Dima, Katherine A McGlynn, Manuel Ramírez-Zea, Jillian Phallen, John Groopman, Robert B Sharpf, Victor E Velculescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): A050.
https://doi.org/10.1158/1557-3265.LIQBIOP24-A050
Published: 13 November 2024
View articletitled, Abstract A050: Early detection of liver cancer from diverse populations using cfDNA fragmentome and protein biomarkers
Journal Articles

Abstract PR008: Genome-wide analyses of cfDNA fragmentomes for therapeutic monitoring of patients with pancreatic cancer

Free
Carolyn A Hruban, Daniel C. Bruhm, Inna M Chen, Shashikant Koul, Akshaya V Annapragada, Nicholas A Vulpescu, Sarah Short, Susann Theile, Kavya Boyapati, Stephen Cristiano, Vilmos Adleff, Julia S Johannsen, Robert B Scharpf, Zachariah H Foda, Jillian A Phallen, Victor E Velculescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): PR008.
https://doi.org/10.1158/1557-3265.LIQBIOP24-PR008
Published: 13 November 2024
View articletitled, Abstract PR008: Genome-wide analyses of cfDNA fragmentomes for therapeutic monitoring of patients with pancreatic cancer
Journal Articles

Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer

Open Access
Joseph C. Murray, Lavanya Sivapalan, Karlijn Hummelink, Archana Balan, James R. White, Noushin Niknafs, Lamia Rhymee, Gavin Pereira, Nisha Rao, Benny Weksler, Nathan Bahary, Jillian Phallen, Alessandro Leal, David L. Bartlett, Kristen A. Marrone, Jarushka Naidoo, Akul Goel, Benjamin Levy, Samuel Rosner, Christine L. Hann, Susan C. Scott, Josephine Feliciano, Vincent K. Lam, David S. Ettinger, Qing Kay Li, Peter B. Illei, Kim Monkhorst, Robert B. Scharpf, Julie R. Brahmer, Victor E. Velculescu, Ali H. Zaidi, Patrick M. Forde, Valsamo Anagnostou
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (2): 389–403.
https://doi.org/10.1158/1078-0432.CCR-23-1469
Published: 17 January 2024
View articletitled, Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
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Includes: Supplementary data
Journal Articles

Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer

Open Access
Lavanya Sivapalan, Wade T. Iams, Zineb Belcaid, Susan C. Scott, Noushin Niknafs, Archana Balan, James R. White, Prasad Kopparapu, Christopher Cann, Blair V. Landon, Gavin Pereira, Victor E. Velculescu, Christine L. Hann, Christine M. Lovly, Valsamo Anagnostou
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (12): 2310–2323.
https://doi.org/10.1158/1078-0432.CCR-22-2242
Published: 13 June 2023
View articletitled, Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells

Open Access
Iris van 't Erve, Jamie E. Medina, Alessandro Leal, Eniko Papp, Jillian Phallen, Vilmos Adleff, Elaine Jiayuee Chiao, Adith S. Arun, Karen Bolhuis, John K. Simmons, Aanavi Karandikar, Kenneth C. Valkenburg, Mark Sausen, Samuel V. Angiuoli, Robert B. Scharpf, Cornelis J.A. Punt, Gerrit A. Meijer, Victor E. Velculescu, Remond J.A. Fijneman
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (5): 899–909.
https://doi.org/10.1158/1078-0432.CCR-22-2538
Published: 01 March 2023
View articletitled, Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
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Includes: Supplementary data
Journal Articles

Abstract PR11: Dual blockade of BRD4 and the ATR/WEE1 pathway exploits ARID1A loss in clear-cell ovarian cancers

Free
Yasuto Kinose, Hyoung Kim, Haineng Xu, Sergey Medvedev, Erin George, Sarah Gitto, Margaret Whicker, Dorothy Hallberg, Lauren Schwartz, Gordon Mills, Victor E. Velculescu, Tian-Li Wang, Ronny Drapkin, Fiona Simpkins
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): PR11.
https://doi.org/10.1158/1557-3265.OVCA19-PR11
Published: 01 July 2020
View articletitled, Abstract PR11: Dual blockade of BRD4 and the ATR/WEE1 pathway exploits ARID1A loss in clear-cell ovarian cancers
Journal Articles

Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer

Free
Jiajia Zhang, Zhicheng Ji, Justina X. Caushi, Margueritta El Asmar, Valsamo Anagnostou, Tricia R. Cottrell, Hok Yee Chan, Prerna Suri, Haidan Guo, Taha Merghoub, Jamie E. Chaft, Joshua E. Reuss, Ada J. Tam, Richard L. Blosser, Mohsen Abu-Akeel, John-William Sidhom, Ni Zhao, Jinny S. Ha, David R. Jones, Kristen A. Marrone, Jarushka Naidoo, Edward Gabrielson, Janis M. Taube, Victor E. Velculescu, Julie R. Brahmer, Franck Housseau, Matthew D. Hellmann, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (6): 1327–1337.
https://doi.org/10.1158/1078-0432.CCR-19-2931
Published: 13 March 2020
View articletitled, Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors

Free
César Serrano, Alessandro Leal, Yanan Kuang, Jeffrey A. Morgan, Constance M. Barysauskas, Jillian Phallen, Olivia Triplett, Adrián Mariño-Enríquez, Andrew J. Wagner, George D. Demetri, Victor E. Velculescu, Cloud P. Paweletz, Jonathan A. Fletcher, Suzanne George
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7287–7293.
https://doi.org/10.1158/1078-0432.CCR-19-2150
Published: 13 December 2019
View articletitled, Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors
Open the PDF for Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade

Free
Andrew Georgiadis, Jennifer N. Durham, Laurel A. Keefer, Bjarne R. Bartlett, Magdalena Zielonka, Derek Murphy, James R. White, Steve Lu, Ellen L. Verner, Finey Ruan, David Riley, Robert A. Anders, Erika Gedvilaite, Sam Angiuoli, Siân Jones, Victor E. Velculescu, Dung T. Le, Luis A. Diaz, Jr, Mark Sausen
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (23): 7024–7034.
https://doi.org/10.1158/1078-0432.CCR-19-1372
Published: 02 December 2019
View articletitled, Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade
Open the PDF for Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer

Free
Vincent P. Groot, Stacy Mosier, Ammar A. Javed, Jonathan A. Teinor, Georgios Gemenetzis, Ding Ding, Lisa M. Haley, Jun Yu, Richard A. Burkhart, Alina Hasanain, Marija Debeljak, Hirohiko Kamiyama, Amol Narang, Daniel A. Laheru, Lei Zheng, Ming-Tseh Lin, Christopher D. Gocke, Elliot K. Fishman, Ralph H. Hruban, Michael G. Goggins, I. Quintus Molenaar, John L. Cameron, Matthew J. Weiss, Victor E. Velculescu, Jin He, Christopher L. Wolfgang, James R. Eshleman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (16): 4973–4984.
https://doi.org/10.1158/1078-0432.CCR-19-0197
Published: 15 August 2019
View articletitled, Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA

Free
Sonya Parpart-Li, Bjarne Bartlett, Maria Popoli, Vilmos Adleff, Laura Tucker, Rebecca Steinberg, Andrew Georgiadis, Jill Phallen, Julie Brahmer, Nilo Azad, Ilene Browner, Daniel Laheru, Victor E. Velculescu, Mark Sausen, Luis A. Diaz, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (10): 2471–2477.
https://doi.org/10.1158/1078-0432.CCR-16-1691
Published: 14 May 2017
View articletitled, The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA
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Includes: Supplementary data
Journal Articles

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics

Free
Joyce F. Liu, Sangeetha Palakurthi, Qing Zeng, Shan Zhou, Elena Ivanova, Wei Huang, Ioannis K. Zervantonakis, Laura M. Selfors, Yiping Shen, Colin C. Pritchard, Mei Zheng, Vilmos Adleff, Eniko Papp, Huiying Piao, Marian Novak, Susan Fotheringham, Gerburg M. Wulf, Jessie English, Paul T. Kirschmeier, Victor E. Velculescu, Cloud Paweletz, Gordon B. Mills, David M. Livingston, Joan S. Brugge, Ursula A. Matulonis, Ronny Drapkin
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (5): 1263–1273.
https://doi.org/10.1158/1078-0432.CCR-16-1237
Published: 28 February 2017
View articletitled, Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics
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Includes: Supplementary data
Journal Articles

Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy

Free
Pedro J. Beltran, Frank J. Calzone, Petia Mitchell, Young-Ah Chung, Elaina Cajulis, Gordon Moody, Brian Belmontes, Chi-Ming Li, Steven Vonderfecht, Victor E. Velculescu, Guorong Yang, Jingwei Qi, Dennis J. Slamon, Gottfried E. Konecny
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (11): 2947–2958.
https://doi.org/10.1158/1078-0432.CCR-13-3448
Published: 29 May 2014
View articletitled, Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy
Open the PDF for Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

Free
Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Antonio Calles, Luis A. Diaz, Victor E. Velculescu, Alfonso Valencia, David Sidransky, Manuel Hidalgo
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2476–2484.
https://doi.org/10.1158/1078-0432.CCR-13-3047
Published: 30 April 2014
View articletitled, Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment
Open the PDF for Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment in another window
Includes: Supplementary data
Journal Articles

Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing

Free
Christine A. Iacobuzio-Donahue, Victor E. Velculescu, Christopher L. Wolfgang, Ralph H. Hruban
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4257–4265.
https://doi.org/10.1158/1078-0432.CCR-12-0315
Published: 14 August 2012
View articletitled, Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing
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Journal Articles

Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

Free
Gottfried E. Konecny, Boris Winterhoff, Teodora Kolarova, Jingwei Qi, Kanthinh Manivong, Judy Dering, Guorong Yang, Meenal Chalukya, He-Jing Wang, Lee Anderson, Kimberly R. Kalli, Richard S. Finn, Charles Ginther, Siân Jones, Victor E. Velculescu, Darren Riehle, William A. Cliby, Sophia Randolph, Maria Koehler, Lynn C. Hartmann, Dennis J. Slamon
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1591–1602.
https://doi.org/10.1158/1078-0432.CCR-10-2307
Published: 15 March 2011
View articletitled, Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

Free
Amanda Blackford, Oscar K. Serrano, Christopher L. Wolfgang, Giovanni Parmigiani, Siân Jones, Xiaosong Zhang, D. Williams Parsons, Jimmy Cheng-Ho Lin, Rebecca J. Leary, James R. Eshleman, Michael Goggins, Elizabeth M. Jaffee, Christine A. Iacobuzio-Donahue, Anirban Maitra, John L. Cameron, Kelly Olino, Richard Schulick, Jordan Winter, Joseph M. Herman, Daniel Laheru, Alison P. Klein, Bert Vogelstein, Kenneth W. Kinzler, Victor E. Velculescu, Ralph H. Hruban
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (14): 4674–4679.
https://doi.org/10.1158/1078-0432.CCR-09-0227
Published: 15 July 2009
View articletitled, SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer
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Journal Articles

PRL-3 Expression in Metastatic Cancers

Free
Alberto Bardelli, Saurabh Saha, Jason A. Sager, Kathy E. Romans, Baozhong Xin, Sanford D. Markowitz, Christoph Lengauer, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (15): 5607–5615.
Published: 03 December 2003
View articletitled, PRL-3 Expression in Metastatic Cancers
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