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Varsha Gandhi
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Journal Articles

Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies

Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 446–457.
https://doi.org/10.1158/1078-0432.CCR-22-2088
Published: 17 January 2023
View article titled, Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies
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Includes: Supplementary data
Journal Articles

AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia

Xue Yi, Aloke Sarkar, Gorkem Kismali, Burcu Aslan, Mary Ayres, LaKesla R. Iles, Michael J. Keating, William G. Wierda, James P. Long, Maria Teresa Sabrina Bertilaccio, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3856–3867.
https://doi.org/10.1158/1078-0432.CCR-19-1397
Published: 15 July 2020
View article titled, AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells

Viralkumar Patel, Kumudha Balakrishnan, Elena Bibikova, Mary Ayres, Michael J. Keating, William G. Wierda, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3734–3743.
https://doi.org/10.1158/1078-0432.CCR-16-1446
Published: 13 July 2017
View article titled, Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells
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Includes: Supplementary data
Journal Articles

Idelalisib Impacts Cell Growth through Inhibiting Translation-Regulatory Mechanisms in Mantle Cell Lymphoma

Qingshan Yang, Lisa S. Chen, Min Jin Ha, Kim-Anh Do, Sattva S. Neelapu, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (1): 181–192.
https://doi.org/10.1158/1078-0432.CCR-15-3135
Published: 02 January 2017
View article titled, Idelalisib Impacts Cell Growth through Inhibiting Translation-Regulatory Mechanisms in Mantle Cell Lymphoma
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Includes: Supplementary data
Journal Articles

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses

Betty Lamothe, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (18): 4712–4726.
https://doi.org/10.1158/1078-0432.CCR-15-2522
Published: 15 September 2016
View article titled, Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses
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Includes: Supplementary data
Journal Articles

Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia

Fabiola Cervantes-Gomez, Betty Lamothe, Jennifer A. Woyach, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16): 3705–3715.
https://doi.org/10.1158/1078-0432.CCR-14-2809
Published: 13 August 2015
View article titled, Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma

Qingshan Yang, Prexy Modi, Terry Newcomb, Christophe Quéva, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1537–1542.
https://doi.org/10.1158/1078-0432.CCR-14-2034
Published: 31 March 2015
View article titled, Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma
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Journal Articles

Omacetaxine: A Protein Translation Inhibitor for Treatment of Chronic Myelogenous Leukemia

Varsha Gandhi, William Plunkett, Jorge E. Cortes
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (7): 1735–1740.
https://doi.org/10.1158/1078-0432.CCR-13-1283
Published: 31 March 2014
View article titled, Omacetaxine: A Protein Translation Inhibitor for Treatment of Chronic Myelogenous Leukemia
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Journal Articles

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K. Tumula, Monique B. Nilsson, Jayanthi Gudikote, Hai Tran, Robert J.G. Cardnell, David J. Bearss, Steven L. Warner, Jason M. Foulks, Steven B. Kanner, Varsha Gandhi, Nancy Krett, Steven T. Rosen, Edward S. Kim, Roy S. Herbst, George R. Blumenschein, J. Jack Lee, Scott M. Lippman, K. Kian Ang, Gordon B. Mills, Waun K. Hong, John N. Weinstein, Ignacio I. Wistuba, Kevin R. Coombes, John D. Minna, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 279–290.
https://doi.org/10.1158/1078-0432.CCR-12-1558
Published: 02 January 2013
View article titled, An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

Bendamustine in B-Cell Malignancies: The New 46-Year-Old Kid on the Block

Varsha Gandhi, Jan A. Burger
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7456–7461.
https://doi.org/10.1158/1078-0432.CCR-08-3041
Published: 14 December 2009
View article titled, Bendamustine in B-Cell Malignancies: The New 46-Year-Old Kid on the Block
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Journal Articles

Expression of ABCC-Type Nucleotide Exporters in Blasts of Adult Acute Myeloid Leukemia: Relation to Long-term Survival

Yanping Guo, Kathleen Köck, Christoph A. Ritter, Zhe-Sheng Chen, Markus Grube, Gabriele Jedlitschky, Thomas Illmer, Mary Ayres, James F. Beck, Werner Siegmund, Gerhard Ehninger, Varsha Gandhi, Heyo K. Kroemer, Gary D. Kruh, Markus Schaich
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (5): 1762–1769.
https://doi.org/10.1158/1078-0432.CCR-08-0442
Published: 27 February 2009
View article titled, Expression of ABCC-Type Nucleotide Exporters in Blasts of Adult Acute Myeloid Leukemia: Relation to Long-term Survival
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Journal Articles

Clinical and Pharmacokinetic Study of Clofarabine in Chronic Lymphocytic Leukemia: Strategy for Treatment

Varsha Gandhi, William Plunkett, Peter L. Bonate, Min Du, Billie Nowak, Susan Lerner, Michael J. Keating
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 4011–4017.
https://doi.org/10.1158/1078-0432.CCR-05-2664
Published: 03 July 2006
View article titled, Clinical and Pharmacokinetic Study of Clofarabine in Chronic Lymphocytic Leukemia: Strategy for Treatment
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Journal Articles

Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH2-Adenosine

Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (18): 6745–6752.
https://doi.org/10.1158/1078-0432.CCR-05-0553
Published: 15 September 2005
View article titled, Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH<sub>2</sub>-Adenosine
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Journal Articles

Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias

Varsha Gandhi, Hagop Kantarjian, Stefan Faderl, Peter Bonate, Min Du, Mary Ayres, Mary Beth Rios, Michael J. Keating, William Plunkett
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (17): 6335–6342.
Published: 24 December 2003
View article titled, Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias
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