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Journal Articles

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

Clin Cancer Res (2023) 29 (2): 488–500.

https://doi.org/10.1158/1078-0432.CCR-22-0611

Published: 17 January 2023

View article titled, A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

Includes: Supplementary data

Journal Articles

Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling

Klaus G. Griewank, Christian Koelsche, Johannes A.P. van de Nes, Daniel Schrimpf, Marco Gessi, Inga Möller, Antje Sucker, Richard A. Scolyer, Michael E. Buckland, Rajmohan Murali, Torsten Pietsch, Andreas von Deimling, Dirk Schadendorf

Clin Cancer Res (2018) 24 (18): 4494–4504.

https://doi.org/10.1158/1078-0432.CCR-18-0763

Published: 14 September 2018

View article titled, Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling

Includes: Supplementary data

Journal Articles

Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors

Jörg Felsberg, Bettina Hentschel, Kerstin Kaulich, Dorothee Gramatzki, Angela Zacher, Bastian Malzkorn, Marcel Kamp, Michael Sabel, Matthias Simon, Manfred Westphal, Gabriele Schackert, Jörg C. Tonn, Torsten Pietsch, Andreas von Deimling, Markus Loeffler, Guido Reifenberger, Michael Weller

Clin Cancer Res (2017) 23 (22): 6846–6855.

https://doi.org/10.1158/1078-0432.CCR-17-0890

Published: 14 November 2017

View article titled, Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors

Includes: Supplementary data

Journal Articles

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

Clin Cancer Res (2017) 23 (2): 562–574.

https://doi.org/10.1158/1078-0432.CCR-15-2089

Published: 15 January 2017

View article titled, Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

Includes: Supplementary data

Journal Articles

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Jane Renshaw, Kathryn R. Taylor, Ryan Bishop, Melanie Valenti, Alexis De Haven Brandon, Sharon Gowan, Suzanne A. Eccles, Ruth R. Ruddle, Louise D. Johnson, Florence I. Raynaud, Joanna L. Selfe, Khin Thway, Torsten Pietsch, Andrew D. Pearson, Janet Shipley

Clin Cancer Res (2013) 19 (21): 5940–5951.

https://doi.org/10.1158/1078-0432.CCR-13-0850

Published: 31 October 2013

View article titled, Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Includes: Supplementary data

Journal Articles

Long-Term Survival in Primary Glioblastoma With Versus Without Isocitrate Dehydrogenase Mutations

Christian Hartmann, Bettina Hentschel, Matthias Simon, Manfred Westphal, Gabriele Schackert, Jörg C. Tonn, Markus Loeffler, Guido Reifenberger, Torsten Pietsch, Andreas von Deimling, Michael Weller, for the German Glioma Network

Clin Cancer Res (2013) 19 (18): 5146–5157.

https://doi.org/10.1158/1078-0432.CCR-13-0017

Published: 16 September 2013

View article titled, Long-Term Survival in Primary Glioblastoma With Versus Without Isocitrate Dehydrogenase Mutations

Includes: Supplementary data

Journal Articles

Anticancer Effects of Niclosamide in Human Glioblastoma

Clin Cancer Res (2013) 19 (15): 4124–4136.

https://doi.org/10.1158/1078-0432.CCR-12-2895

Published: 31 July 2013

View article titled, Anticancer Effects of Niclosamide in Human Glioblastoma

Includes: Supplementary data

Journal Articles

Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?

Christian Hartmann, Bettina Hentschel, Marcos Tatagiba, Johannes Schramm, Oliver Schnell, Clemens Seidel, Robert Stein, Guido Reifenberger, Torsten Pietsch, Andreas von Deimling, Markus Loeffler, Michael Weller

Clin Cancer Res (2011) 17 (13): 4588–4599.

https://doi.org/10.1158/1078-0432.CCR-10-3194

Published: 05 July 2011

View article titled, Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?

Includes: Supplementary data

Journal Articles

Activation of Phosphatidylinositol-3′-kinase/AKT Signaling Is Essential in Hepatoblastoma Survival

Wolfgang Hartmann, Jan Küchler, Arend Koch, Nicolaus Friedrichs, Anke Waha, Elmar Endl, Jacqueline Czerwitzki, Dagmar Metzger, Susanne Steiner, Peter Wurst, Ivo Leuschner, Dietrich von Schweinitz, Reinhard Buettner, Torsten Pietsch

Clin Cancer Res (2009) 15 (14): 4538–4545.

https://doi.org/10.1158/1078-0432.CCR-08-2878

Published: 15 July 2009

View article titled, Activation of Phosphatidylinositol-3′-kinase/AKT Signaling Is Essential in Hepatoblastoma Survival

Includes: Supplementary data

Journal Articles

Medulloblastoma Variants: Age-Dependent Occurrence and Relation to Gorlin Syndrome—A New Clinical Perspective

Clin Cancer Res (2009) 15 (7): 2463–2471.

https://doi.org/10.1158/1078-0432.CCR-08-2023

Published: 01 April 2009

View article titled, Medulloblastoma Variants: Age-Dependent Occurrence and Relation to Gorlin Syndrome—A New Clinical Perspective

Journal Articles

Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas

Jian Huang, Michael A. Grotzer, Takuya Watanabe, Ekkehard Hewer, Torsten Pietsch, Stefan Rutkowski, Hiroko Ohgaki

Clin Cancer Res (2008) 14 (13): 4053–4058.

https://doi.org/10.1158/1078-0432.CCR-08-0098

Published: 01 July 2008

View article titled, Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas

Journal Articles

Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker?

The German Glioma Network, Michael Weller, Hilmar Berger, Christian Hartmann, Johannes Schramm, Manfred Westphal, Matthias Simon, Roland Goldbrunner, Dietmar Krex, Joachim P. Steinbach, Christoph B. Ostertag, Markus Loeffler, Torsten Pietsch, Andreas von Deimling

Clin Cancer Res (2007) 13 (23): 6933–6937.

https://doi.org/10.1158/1078-0432.CCR-07-0573

Published: 03 December 2007

View article titled, Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker?

Journal Articles

Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91

Stefan Rutkowski, André von Bueren, Katja von Hoff, Wolfgang Hartmann, Tarek Shalaby, Frank Deinlein, Monika Warmuth-Metz, Niels Soerensen, Angela Emser, Udo Bode, Uwe Mittler, Christian Urban, Martin Benesch, Rolf D. Kortmann, Paul G. Schlegel, Joachim Kuehl, Torsten Pietsch, Michael Grotzer

Clin Cancer Res (2007) 13 (9): 2651–2657.

https://doi.org/10.1158/1078-0432.CCR-06-1779

Published: 01 May 2007

View article titled, Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91

Journal Articles

Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Eva Wardelmann, Katharina Biermann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Nadja Thomas, Reinhard Büttner, Torsten Pietsch, Thomas Heinicke, Nicola Speidel, Daniel Pink, Peter Reichardt, Peter Hohenberger

Clin Cancer Res (2006) 12 (20): 6206.

https://doi.org/10.1158/1078-0432.CCR-06-1749

Published: 24 October 2006

View article titled, Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Journal Articles

Valproic Acid Prolongs Survival Time of Severe Combined Immunodeficient Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts

Qin Shu, Barbara Antalffy, Jack Meng Feng Su, Adekunle Adesina, Ching-Nan Ou, Torsten Pietsch, Susan M. Blaney, Ching C. Lau, Xiao-Nan Li

Clin Cancer Res (2006) 12 (15): 4687–4694.

https://doi.org/10.1158/1078-0432.CCR-05-2849

Published: 09 August 2006

View article titled, Valproic Acid Prolongs Survival Time of Severe Combined Immunodeficient Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts

Journal Articles

Phosphatidylinositol 3′-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN

Wolfgang Hartmann, Boris Digon-Söntgerath, Arend Koch, Anke Waha, Elmar Endl, Indra Dani, Dorota Denkhaus, Cynthia G. Goodyer, Niels Sörensen, Otmar D. Wiestler, Torsten Pietsch

Clin Cancer Res (2006) 12 (10): 3019–3027.

https://doi.org/10.1158/1078-0432.CCR-05-2187

Published: 17 May 2006

View article titled, Phosphatidylinositol 3′-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN

Journal Articles

Polyclonal Evolution of Multiple Secondary KIT Mutations in Gastrointestinal Stromal Tumors under Treatment with Imatinib Mesylate

Eva Wardelmann, Sabine Merkelbach-Bruse, Katharina Pauls, Nadja Thomas, Hans-Ulrich Schildhaus, Thomas Heinicke, Nicola Speidel, Torsten Pietsch, Reinhard Buettner, Daniel Pink, Peter Reichardt, Peter Hohenberger

Clin Cancer Res (2006) 12 (6): 1743–1749.

https://doi.org/10.1158/1078-0432.CCR-05-1211

Published: 21 March 2006

View article titled, Polyclonal Evolution of Multiple Secondary KIT Mutations in Gastrointestinal Stromal Tumors under Treatment with Imatinib Mesylate

Journal Articles

Elevated Expression of Wnt Antagonists Is a Common Event in Hepatoblastomas

Arend Koch, Andreas Waha, Wolfgang Hartmann, Aksana Hrychyk, Ulrich Schüller, Anke Waha, Keith A. Wharton, Jr, Serge Y. Fuchs, Dietrich von Schweinitz, Torsten Pietsch

Clin Cancer Res (2005) 11 (12): 4295–4304.

https://doi.org/10.1158/1078-0432.CCR-04-1162

Published: 15 June 2005

View article titled, Elevated Expression of Wnt Antagonists Is a Common Event in Hepatoblastomas

NARROW

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling

Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Long-Term Survival in Primary Glioblastoma With Versus Without Isocitrate Dehydrogenase Mutations

Anticancer Effects of Niclosamide in Human Glioblastoma

Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?

Activation of Phosphatidylinositol-3′-kinase/AKT Signaling Is Essential in Hepatoblastoma Survival

Medulloblastoma Variants: Age-Dependent Occurrence and Relation to Gorlin Syndrome—A New Clinical Perspective

Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas

Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker?

Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91

Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Valproic Acid Prolongs Survival Time of Severe Combined Immunodeficient Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts

Phosphatidylinositol 3′-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN

Polyclonal Evolution of Multiple Secondary KIT Mutations in Gastrointestinal Stromal Tumors under Treatment with Imatinib Mesylate

Elevated Expression of Wnt Antagonists Is a Common Event in Hepatoblastomas

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