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Timothy W. Synold
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Journal Articles

Pharmacokinetic analysis of carboplatin and fluorescein brain retention following ultrasound-based blood-brain barrier opening

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Karl J. Habashy, Timothy W. Synold, Ye Feng, Cristal Gomez, Christina Amidei, Rachel Ward, Sarah VanderMolen, Ashkan Zarrieneh, Kwang-Soo Kim, Mateo Gomez, Victor A. Arrieta, Jawad Fares, Kirsten B. Burdett, Hui Zhang, Crismita Dmello, Li Chen, John F. Bebawy, Michael Canney, Roger Stupp, Behnam Badie, Jana Portnow, Adam M. Sonabend
Journal: Clinical Cancer Research
Clin Cancer Res (2025)
https://doi.org/10.1158/1078-0432.CCR-25-0080
Published: 10 June 2025
View articletitled, Pharmacokinetic analysis of carboplatin and fluorescein brain retention following ultrasound-based blood-brain barrier opening
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Includes: Supplementary data
Journal Articles

Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma

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Robert Chen, Alex F. Herrera, Jessie Hou, Lu Chen, Jun Wu, Yuming Guo, Timothy W. Synold, Vu N. Ngo, Sandrine Puverel, Matthew Mei, Leslie Popplewell, Shuhua Yi, Joo Y. Song, Shu Tao, Xiwei Wu, Wing C. Chan, Stephen J. Forman, Larry W. Kwak, Steven T. Rosen, Edward M. Newman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1034–1044.
https://doi.org/10.1158/1078-0432.CCR-19-1768
Published: 02 March 2020
View articletitled, Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma
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Includes: Supplementary data
Journal Articles

The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA

Free
Long Gu, Robert Lingeman, Fumiko Yakushijin, Emily Sun, Qi Cui, Jianfei Chao, Weidong Hu, Hongzhi Li, Robert J. Hickey, Jeremy M. Stark, Yate-Ching Yuan, Yuan Chen, Steven L. Vonderfecht, Timothy W. Synold, Yanhong Shi, Karen L. Reckamp, David Horne, Linda H. Malkas
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 6053–6065.
https://doi.org/10.1158/1078-0432.CCR-18-0592
Published: 03 December 2018
View articletitled, The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA
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Includes: Supplementary data
Journal Articles

Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients

Free
Jana Portnow, Timothy W. Synold, Behnam Badie, Revathiswari Tirughana, Simon F. Lacey, Massimo D'Apuzzo, Marianne Z. Metz, Joseph Najbauer, Victoria Bedell, Tien Vo, Margarita Gutova, Paul Frankel, Mike Chen, Karen S. Aboody
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 2951–2960.
https://doi.org/10.1158/1078-0432.CCR-16-1518
Published: 14 June 2017
View articletitled, Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients
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Includes: Supplementary data
Journal Articles

Phase I Study of Pazopanib in Patients with Advanced Solid Tumors and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study

Free
Stephen I. Shibata, Vincent Chung, Timothy W. Synold, Jeffrey A. Longmate, A. Benjamin Suttle, Lone H. Ottesen, Heinz-Josef Lenz, Shivaani Kummar, R. Donald Harvey, Anne L. Hamilton, Bert H. O'Neil, John Sarantopoulos, Patricia LoRusso, Michelle A. Rudek, Afshin Dowlati, Daniel L. Mulkerin, Chandra P. Belani, Leena Gandhi, S. Cecilia Lau, S. Percy Ivy, Edward M. Newman
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3631–3639.
https://doi.org/10.1158/1078-0432.CCR-12-3214
Published: 30 June 2013
View articletitled, Phase I Study of Pazopanib in Patients with Advanced Solid Tumors and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study
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Includes: Supplementary data
Journal Articles

The Neuropharmacokinetics of Temozolomide in Patients with Resectable Brain Tumors: Potential Implications for the Current Approach to Chemoradiation

Free
Jana Portnow, Behnam Badie, Mike Chen, An Liu, Suzette Blanchard, Timothy W. Synold
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 7092–7098.
https://doi.org/10.1158/1078-0432.CCR-09-1349
Published: 11 November 2009
View articletitled, The Neuropharmacokinetics of Temozolomide in Patients with Resectable Brain Tumors: Potential Implications for the Current Approach to Chemoradiation
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Journal Articles

Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function

Free
Chris H. Takimoto, Martin A. Graham, Graham Lockwood, Chee M. Ng, Andrew Goetz, Dennis Greenslade, Scot C. Remick, Sunil Sharma, Sridhar Mani, Ramesh K. Ramanathan, Timothy W. Synold, James H. Doroshow, Anne Hamilton, Daniel L. Mulkerin, Percy Ivy, Merrill J. Egorin, Jean L. Grem
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4832–4839.
https://doi.org/10.1158/1078-0432.CCR-07-0475
Published: 15 August 2007
View articletitled, Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function
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Journal Articles

Dose-Escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: A National Cancer Institute Organ Dysfunction Working Group Study

Free
Timothy W. Synold, Chris H. Takimoto, James H. Doroshow, David Gandara, Sridhar Mani, Scot C. Remick, Daniel L. Mulkerin, Anne Hamilton, Sunil Sharma, Ramesh K. Ramanathan, Heinz Josef Lenz, Martin Graham, Jeffrey Longmate, Bennett M. Kaufman, Percy Ivy
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3660–3666.
https://doi.org/10.1158/1078-0432.CCR-06-2385
Published: 15 June 2007
View articletitled, Dose-Escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: A National Cancer Institute Organ Dysfunction Working Group Study
Open the PDF for Dose-Escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: A National Cancer Institute Organ Dysfunction Working Group Study in another window
Journal Articles

Phase I Trial of Intraperitoneal Gemcitabine in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity

Free
Robert J. Morgan, Jr., Timothy W. Synold, Bixin Xi, Dean Lim, Stephen Shibata, Kim Margolin, Roderich E. Schwarz, Lucille Leong, George Somlo, Przemyslaw Twardowski, Yun Yen, Warren Chow, Merry Tetef, Paul Lin, Benjamin Paz, Mariana Koczywas, Lawrence Wagman, David Chu, Paul Frankel, Susan Stalter, James H. Doroshow
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (4): 1232–1237.
https://doi.org/10.1158/1078-0432.CCR-06-1735
Published: 22 February 2007
View articletitled, Phase I Trial of Intraperitoneal Gemcitabine in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity
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Journal Articles

Neurophysiological Study of Peripheral Neuropathy after High-Dose Paclitaxel: Lack of Neuroprotective Effect of Amifostine

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Harry Openshaw, Karen Beamon, Timothy W. Synold, Jeff Longmate, Neal E. Slatkin, James H. Doroshow, Stephen Forman, Kim Margolin, Robert Morgan, Stephen Shibata, George Somlo
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (2): 461–467.
https://doi.org/10.1158/1078-0432.CCR-0772-03
Published: 03 February 2004
View articletitled, Neurophysiological Study of Peripheral Neuropathy after High-Dose Paclitaxel: Lack of Neuroprotective Effect of Amifostine
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Journal Articles

Phase I Trial of 96-Hour Continuous Infusion of Dexrazoxane in Patients with Advanced Malignancies

Free
Merry L. Tetef, Timothy W. Synold, Warren Chow, Lucille Leong, Kim Margolin, Robert Morgan, James Raschko, Stephen Shibata, George Somlo, Yun Yen, Susan Groshen, Kay Johnson, Heinz-Josef Lenz, David Gandara, James H. Doroshow
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (6): 1569–1576.
Published: 01 June 2001
View articletitled, Phase I Trial of 96-Hour Continuous Infusion of Dexrazoxane in Patients with Advanced Malignancies
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Journal Articles

Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034

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Howard L. McLeod, James Cassidy, Robert H. Powrie, David G. Priest, Mark A. Zorbas, Timothy W. Synold, Stephen Shibata, Darcy Spicer, Donald Bissett, Yazdi K. Pithavala, Mary A. Collier, Linda J. Paradiso, John D. Roberts
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2677–2684.
Published: 01 July 2000
View articletitled, Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034
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