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Timothy F. Cloughesy
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Journal Articles

Evaluating the Base Excision Repair Inhibitor TRC102 and Temozolomide for Patients with Recurrent Glioblastoma in the Phase 2 Adult Brain Tumor Consortium Trial BERT

Manmeet S. Ahluwalia, Ahmad Ozair, Jan Drappatz, Xiaobu Ye, Sen Peng, Matthew Lee, Sanhita Rath, Harshil Dhruv, Yue Hao, Michael E. Berens, Tobias Walbert, Matthias Holdhoff, Glenn J. Lesser, Timothy F. Cloughesy, Andrew E. Sloan, Naoko Takebe, Marta Couce, David M. Peereboom, Burt Nabors, Patrick Y. Wen, Stuart A. Grossman, Lisa R. Rogers
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (15): 3167–3178.
https://doi.org/10.1158/1078-0432.CCR-23-4098
Published: 01 August 2024
View article titled, Evaluating the Base Excision Repair Inhibitor TRC102 and Temozolomide for Patients with Recurrent Glioblastoma in the Phase 2 Adult Brain Tumor Consortium Trial BERT
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Includes: Supplementary data
Journal Articles

Depth of Radiographic Response and Time to Tumor Regrowth Predicts Overall Survival Following Anti-VEGF Therapy in Recurrent Glioblastoma

Benjamin M. Ellingson, Akifumi Hagiwara, Connor J. Morris, Nicholas S. Cho, Sonoko Oshima, Francesco Sanvito, Talia C. Oughourlian, Donatello Telesca, Catalina Raymond, Lauren E. Abrey, Josep Garcia, Dana T. Aftab, Colin Hessel, Tamar Rachmilewitz Minei, Dror Harats, David A. Nathanson, Patrick Y. Wen, Timothy F. Cloughesy
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (20): 4186–4195.
https://doi.org/10.1158/1078-0432.CCR-23-1235
Published: 13 October 2023
View article titled, Depth of Radiographic Response and Time to Tumor Regrowth Predicts Overall Survival Following Anti-VEGF Therapy in Recurrent Glioblastoma
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Includes: Supplementary data
Journal Articles

Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study

Andrew B. Lassman, Juan Manuel Sepúlveda-Sánchez, Timothy F. Cloughesy, Miguel J. Gil-Gil, Vinay K. Puduvalli, Jeffrey J. Raizer, Filip Y.F. De Vos, Patrick Y. Wen, Nicholas A. Butowski, Paul M.J. Clement, Morris D. Groves, Cristóbal Belda-Iniesta, Pierre Giglio, Harris S. Soifer, Steven Rowsey, Cindy Xu, Francesca Avogadri, Ge Wei, Susan Moran, Patrick Roth
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2270–2277.
https://doi.org/10.1158/1078-0432.CCR-21-2664
Published: 01 June 2022
View article titled, Infigratinib in Patients with Recurrent Gliomas and <em>FGFR</em> Alterations: A Multicenter Phase II Study
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Includes: Supplementary data
Journal Articles

Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement

Stephen J. Bagley, Shawn Kothari, Rifaquat Rahman, Eudocia Q. Lee, Gavin P. Dunn, Evanthia Galanis, Susan M. Chang, Louis Burt Nabors, Manmeet S. Ahluwalia, Roger Stupp, Minesh P. Mehta, David A. Reardon, Stuart A. Grossman, Erik P. Sulman, John H. Sampson, Simon Khagi, Michael Weller, Timothy F. Cloughesy, Patrick Y. Wen, Mustafa Khasraw
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 594–602.
https://doi.org/10.1158/1078-0432.CCR-21-2750
Published: 15 February 2022
View article titled, Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement
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Journal Articles

Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial

Ingo K. Mellinghoff, Marta Penas-Prado, Katherine B. Peters, Howard A. Burris, III, Elizabeth A. Maher, Filip Janku, Gregory M. Cote, Macarena I. de la Fuente, Jennifer L. Clarke, Benjamin M. Ellingson, Saewon Chun, Robert J. Young, Hua Liu, Sung Choe, Min Lu, Kha Le, Islam Hassan, Lori Steelman, Shuchi S. Pandya, Timothy F. Cloughesy, Patrick Y. Wen
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4491–4499.
https://doi.org/10.1158/1078-0432.CCR-21-0611
Published: 15 August 2021
View article titled, Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
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Includes: Supplementary data
Journal Articles

Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma

Benjamin M. Ellingson, Jingwen Yao, Catalina Raymond, David A. Nathanson, Ararat Chakhoyan, Jeremy Simpson, James S. Garner, Alan G. Olivero, Lars U. Mueller, Jordi Rodon, Elizabeth Gerstner, Timothy F. Cloughesy, Patrick Y. Wen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3135–3144.
https://doi.org/10.1158/1078-0432.CCR-19-3817
Published: 01 July 2020
View article titled, Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma

Patrick Y. Wen, Timothy F. Cloughesy, Alan G. Olivero, Kari M. Morrissey, Timothy R. Wilson, Xuyang Lu, Lars U. Mueller, Alexandre F. Coimbra, Benjamin M. Ellingson, Elizabeth Gerstner, Eudocia Q. Lee, Jordi Rodon
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1820–1828.
https://doi.org/10.1158/1078-0432.CCR-19-2808
Published: 15 April 2020
View article titled, First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma
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Journal Articles

Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data

Steffen Ventz, Albert Lai, Timothy F. Cloughesy, Patrick Y. Wen, Lorenzo Trippa, Brian M. Alexander
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (16): 4993–5001.
https://doi.org/10.1158/1078-0432.CCR-19-0820
Published: 15 August 2019
View article titled, Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data
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Includes: Supplementary data
Journal Articles

Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation

Tom B. Davidson, Alexander Lee, Melody Hsu, Shaina Sedighim, Joey Orpilla, Janet Treger, Max Mastall, Saskia Roesch, Carmen Rapp, Mildred Galvez, Aaron Mochizuki, Joseph Antonios, Alejandro Garcia, Nikesh Kotecha, Nicholas Bayless, David Nathanson, Anthony Wang, Richard Everson, William H. Yong, Timothy F. Cloughesy, Linda M. Liau, Christel Herold-Mende, Robert M. Prins
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1913–1922.
https://doi.org/10.1158/1078-0432.CCR-18-1176
Published: 15 March 2019
View article titled, Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation
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Includes: Supplementary data
Journal Articles

Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE

Brian M. Alexander, Sujuan Ba, Mitchel S. Berger, Donald A. Berry, Webster K. Cavenee, Susan M. Chang, Timothy F. Cloughesy, Tao Jiang, Mustafa Khasraw, Wenbin Li, Robert Mittman, George H. Poste, Patrick Y. Wen, W.K. Alfred Yung, Anna D. Barker
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (4): 737–743.
https://doi.org/10.1158/1078-0432.CCR-17-0764
Published: 14 February 2018
View article titled, Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE
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Journal Articles

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Sara A. Byron, Nhan L. Tran, Rebecca F. Halperin, Joanna J. Phillips, John G. Kuhn, John F. de Groot, Howard Colman, Keith L. Ligon, Patrick Y. Wen, Timothy F. Cloughesy, Ingo K. Mellinghoff, Nicholas A. Butowski, Jennie W. Taylor, Jennifer L. Clarke, Susan M. Chang, Mitchel S. Berger, Annette M. Molinaro, Gerald M. Maggiora, Sen Peng, Sara Nasser, Winnie S. Liang, Jeffrey M. Trent, Michael E. Berens, John D. Carpten, David W. Craig, Michael D. Prados
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2): 295–305.
https://doi.org/10.1158/1078-0432.CCR-17-0963
Published: 15 January 2018
View article titled, Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma
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Includes: Supplementary data
Journal Articles

Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials

Benjamin M. Ellingson, Elizabeth R. Gerstner, Marion Smits, Raymond Y. Huang, Rivka Colen, Lauren E. Abrey, Dana T. Aftab, Gisela M. Schwab, Colin Hessel, Robert J. Harris, Ararat Chakhoyan, Renske Gahrmann, Whitney B. Pope, Kevin Leu, Catalina Raymond, Davis C. Woodworth, John de Groot, Patrick Y. Wen, Tracy T. Batchelor, Martin J. van den Bent, Timothy F. Cloughesy
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5745–5756.
https://doi.org/10.1158/1078-0432.CCR-16-2844
Published: 01 October 2017
View article titled, Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials
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Journal Articles

The Impact of T2/FLAIR Evaluation per RANO Criteria on Response Assessment of Recurrent Glioblastoma Patients Treated with Bevacizumab

Raymond Y. Huang, Rifaquat Rahman, Karla V. Ballman, Sara J. Felten, S. Keith Anderson, Benjamin M. Ellingson, Lakshmi Nayak, Eudocia Q. Lee, Lauren E. Abrey, Evanthia Galanis, David A. Reardon, Whitney B. Pope, Timothy F. Cloughesy, Patrick Y. Wen
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 575–581.
https://doi.org/10.1158/1078-0432.CCR-14-3040
Published: 31 January 2016
View article titled, The Impact of T2/FLAIR Evaluation per RANO Criteria on Response Assessment of Recurrent Glioblastoma Patients Treated with Bevacizumab
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Journal Articles

Quantification of Nonenhancing Tumor Burden in Gliomas Using Effective T2 Maps Derived from Dual-Echo Turbo Spin-Echo MRI

Benjamin M. Ellingson, Albert Lai, Huytram N. Nguyen, Phioanh L. Nghiemphu, Whitney B. Pope, Timothy F. Cloughesy
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (19): 4373–4383.
https://doi.org/10.1158/1078-0432.CCR-14-2862
Published: 30 September 2015
View article titled, Quantification of Nonenhancing Tumor Burden in Gliomas Using Effective T<sub>2</sub> Maps Derived from Dual-Echo Turbo Spin-Echo MRI
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Includes: Supplementary data
Journal Articles

Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas

Sichen Li, Reshmi Chowdhury, Fei Liu, Arthur P. Chou, Tie Li, Reema R. Mody, Jerry J. Lou, Weidong Chen, Jean Reiss, Horacio Soto, Robert Prins, Linda M. Liau, Paul S. Mischel, Phioanh L. Nghiemphu, William H. Yong, Timothy F. Cloughesy, Albert Lai
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5808–5822.
https://doi.org/10.1158/1078-0432.CCR-14-0234
Published: 13 November 2014
View article titled, Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in <em>IDH1</em>-Mutant Gliomas
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Includes: Supplementary data
Journal Articles

Treatment Response Evaluation Using 18F-FDOPA PET in Patients with Recurrent Malignant Glioma on Bevacizumab Therapy

Johannes Schwarzenberg, Johannes Czernin, Timothy F. Cloughesy, Benjamin M. Ellingson, Whitney B. Pope, Tristan Grogan, David Elashoff, Cheri Geist, Daniel H.S. Silverman, Michael E. Phelps, Wei Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (13): 3550–3559.
https://doi.org/10.1158/1078-0432.CCR-13-1440
Published: 30 June 2014
View article titled, Treatment Response Evaluation Using <sup>18</sup>F-FDOPA PET in Patients with Recurrent Malignant Glioma on Bevacizumab Therapy
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Journal Articles

The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

Beatrice Gini, Ciro Zanca, Deliang Guo, Tomoo Matsutani, Kenta Masui, Shiro Ikegami, Huijun Yang, David Nathanson, Genaro R. Villa, David Shackelford, Shaojun Zhu, Kazuhiro Tanaka, Ivan Babic, David Akhavan, Kelly Lin, Alvaro Assuncao, Yuchao Gu, Bruno Bonetti, Deborah S. Mortensen, Shuichan Xu, Heather K. Raymon, Webster K. Cavenee, Frank B. Furnari, C. David James, Guido Kroemer, James R. Heath, Kristen Hege, Rajesh Chopra, Timothy F. Cloughesy, Paul S. Mischel
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5722–5732.
https://doi.org/10.1158/1078-0432.CCR-13-0527
Published: 14 October 2013
View article titled, The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas
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Includes: Supplementary data
Journal Articles

Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

Eudocia Q. Lee, Vinay K. Puduvalli, Joel M. Reid, John G. Kuhn, Kathleen R. Lamborn, Timothy F. Cloughesy, Susan M. Chang, Jan Drappatz, W. K. Alfred Yung, Mark R. Gilbert, H. Ian Robins, Frank S. Lieberman, Andrew B. Lassman, Renee M. McGovern, Jihong Xu, Serena Desideri, Xiabu Ye, Matthew M. Ames, Igor Espinoza-Delgado, Michael D. Prados, Patrick Y. Wen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (21): 6032–6039.
https://doi.org/10.1158/1078-0432.CCR-12-1841
Published: 06 November 2012
View article titled, Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03
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Includes: Supplementary data
Journal Articles

New Strategies in the Molecular Targeting of Glioblastoma: How Do You Hit a Moving Target?

Timothy F. Cloughesy, Paul S. Mischel
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (1): 6–11.
https://doi.org/10.1158/1078-0432.CCR-09-2268
Published: 04 January 2011
View article titled, New Strategies in the Molecular Targeting of Glioblastoma: How Do You Hit a Moving Target?
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Journal Articles

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

Koji Yoshimoto, Julie Dang, Shaojun Zhu, David Nathanson, Tiffany Huang, Rebecca Dumont, David B. Seligson, William H. Yong, Zhenggang Xiong, Nagesh Rao, Henrik Winther, Arnab Chakravarti, Darell D. Bigner, Ingo K. Mellinghoff, Steve Horvath, Webster K. Cavenee, Timothy F. Cloughesy, Paul S. Mischel
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (2): 488–493.
https://doi.org/10.1158/1078-0432.CCR-07-1966
Published: 25 January 2008
View article titled, Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples
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Includes: Supplementary data