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Theodore S. Hong
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Journal Articles

Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer

Open Access
Sophia C. Kamran, Yuzhen Zhou, Keisuke Otani, Michael Drumm, Yukako Otani, Shulin Wu, Chin-Lee Wu, Adam S. Feldman, Matthew Wszolek, Richard J. Lee, Philip J. Saylor, Jochen Lennerz, Eliezer Van Allen, Henning Willers, Theodore S. Hong, Yang Liu, Elai Davicioni, Ewan A. Gibb, William U. Shipley, Kent W. Mouw, Jason A. Efstathiou, David T. Miyamoto
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5116–5127.
https://doi.org/10.1158/1078-0432.CCR-23-0792
Published: 15 December 2023
View articletitled, Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer
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Includes: Supplementary data
Journal Articles

Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer

Available to Purchase
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1605–1619.
https://doi.org/10.1158/1078-0432.CCR-22-1630
Published: 14 April 2023
View articletitled, Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer
Open the PDF for Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response

Available to Purchase
Toni T. Seppälä, Jacquelyn W. Zimmerman, Reecha Suri, Haley Zlomke, Gabriel D. Ivey, Annamaria Szabolcs, Christopher R. Shubert, John L. Cameron, William R. Burns, Kelly J. Lafaro, Jin He, Christopher L. Wolfgang, Ying S. Zou, Lei Zheng, David A. Tuveson, James R. Eshlemann, David P. Ryan, Alec C. Kimmelman, Theodore S. Hong, David T. Ting, Elizabeth M. Jaffee, Richard A. Burkhart
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (15): 3296–3307.
https://doi.org/10.1158/1078-0432.CCR-21-4165
Published: 02 August 2022
View articletitled, Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response
Open the PDF for Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response in another window
Includes: Supplementary data
Journal Articles

Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas

Available to Purchase
Jennifer Y. Wo, Jeffrey W. Clark, Christine E. Eyler, Mari Mino-Kenudson, Samuel J. Klempner, Jill N. Allen, Florence K. Keane, Aparna R. Parikh, Eric Roeland, Lorraine C. Drapek, David P. Ryan, Ryan B. Corcoran, Emily Van Seventer, Isobel J. Fetter, Heather A. Shahzade, Melin J. Khandekar, Michael Lanuti, Christopher R. Morse, Rebecca S. Heist, Christine A. Ulysse, Benjamin Christopher, Christian Baglini, Beow Y. Yeap, John T. Mullen, Theodore S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6343–6353.
https://doi.org/10.1158/1078-0432.CCR-21-0331
Published: 01 December 2021
View articletitled, Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas
Open the PDF for Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer

Free
Aparna R. Parikh, Emily E. Van Seventer, Giulia Siravegna, Anna V. Hartwig, Ariel Jaimovich, Yupeng He, Katie Kanter, Madeleine G. Fish, Kathryn D. Fosbenner, Benchun Miao, Susannah Phillips, John H. Carmichael, Nihaarika Sharma, Joy Jarnagin, Islam Baiev, Yojan S. Shah, Isobel J. Fetter, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Jon S. Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Ryan D. Nipp, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Jennifer Y. Wo, Theodore S. Hong, Liliana Bordeianou, Cristina R. Ferrone, Motaz Qadan, Hiroko Kunitake, David Berger, Rocco Ricciardi, James C. Cusack, Victoria M. Raymond, AmirAli Talasaz, Genevieve M. Boland, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (20): 5586–5594.
https://doi.org/10.1158/1078-0432.CCR-21-0410
Published: 15 October 2021
View articletitled, Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection

Available to Purchase
Jimmy A. Guo, Hannah I. Hoffman, Stuti G. Shroff, Peter Chen, Peter G. Hwang, Daniel Y. Kim, Daniel W. Kim, Stephanie W. Cheng, Daniel Zhao, Brandon A. Mahal, Mohammed Alshalalfa, Andrzej Niemierko, Jennifer Y. Wo, Jay S. Loeffler, Carlos Fernandez-del Castillo, Tyler Jacks, Andrew J. Aguirre, Theodore S. Hong, Mari Mino-Kenudson, William L. Hwang
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2807–2815.
https://doi.org/10.1158/1078-0432.CCR-20-4382
Published: 15 May 2021
View articletitled, Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection
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Includes: Supplementary data
Journal Articles

Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers

Free
Aparna R. Parikh, Amikasra Mojtahed, Jaime L. Schneider, Katie Kanter, Emily E. Van Seventer, Isobel J. Fetter, Ashraf Thabet, Madeleine G. Fish, Bezaye Teshome, Kathryn Fosbenner, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, David P. Ryan, Bruce Giantonio, Lipika Goyal, Ryan D. Nipp, Eric Roeland, Colin D. Weekes, Jennifer Y. Wo, Andrew X. Zhu, Dora Dias-Santagata, A. John Iafrate, Jochen K. Lennerz, Theodore S. Hong, Giulia Siravegna, Nora Horick, Jeffrey W. Clark, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (8): 1877–1885.
https://doi.org/10.1158/1078-0432.CCR-19-3467
Published: 15 April 2020
View articletitled, Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers
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Includes: Supplementary data
Journal Articles

Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer

Free
Sophia C. Kamran, Jochen K. Lennerz, Claire A. Margolis, David Liu, Brendan Reardon, Stephanie A. Wankowicz, Emily E. Van Seventer, Adam Tracy, Jennifer Y. Wo, Scott L. Carter, Henning Willers, Ryan B. Corcoran, Theodore S. Hong, Eliezer M. Van Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5561–5571.
https://doi.org/10.1158/1078-0432.CCR-19-0908
Published: 13 September 2019
View articletitled, Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer
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Includes: Supplementary data
Journal Articles

Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma

Free
Hao Liu, Kamila Naxerova, Matthias Pinter, Joao Incio, Hang Lee, Kohei Shigeta, William W. Ho, Jonathan A. Crain, Alex Jacobson, Theodoros Michelakos, Daniella Dias-Santos, Andrea Zanconato, Theodore S. Hong, Jeffrey W. Clark, Janet E. Murphy, David P. Ryan, Vikram Deshpande, Keith D. Lillemoe, Carlos Fernandez-del Castillo, Michael Downes, Ronald M. Evans, James Michaelson, Cristina R. Ferrone, Yves Boucher, Rakesh K. Jain
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5959–5969.
https://doi.org/10.1158/1078-0432.CCR-17-0256
Published: 01 October 2017
View articletitled, Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma
Open the PDF for Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer

Free
Isabel Ferreiro-Neira, Nancy E. Torres, Lukas F. Liesenfeld, Carlos H.F. Chan, Tristan Penson, Yosef Landesman, William Senapedis, Sharon Shacham, Theodore S. Hong, James C. Cusack
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1663–1673.
https://doi.org/10.1158/1078-0432.CCR-15-0978
Published: 31 March 2016
View articletitled, XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer
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Includes: Supplementary data
Journal Articles

PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma

Free
Francesco Sabbatino, Vincenzo Villani, Jennifer H. Yearley, Vikram Deshpande, Lei Cai, Ioannis T. Konstantinidis, Christina Moon, Sjoerd Nota, Yangyang Wang, Ahmad Al-Sukaini, Andrew X. Zhu, Lipika Goyal, David T. Ting, Nabeel Bardeesy, Theodore S. Hong, Carlos Fernandez-del Castillo, Kenneth K. Tanabe, Keith D. Lillemoe, Soldano Ferrone, Cristina R. Ferrone
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 470–478.
https://doi.org/10.1158/1078-0432.CCR-15-0715
Published: 14 January 2016
View articletitled, PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma
Open the PDF for PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

Free
Darrell R. Borger, Lipika Goyal, Thomas Yau, Ronnie T. Poon, Marek Ancukiewicz, Vikram Deshpande, David C. Christiani, Hannah M. Liebman, Hua Yang, Hyeryun Kim, Katharine Yen, Jason E. Faris, A. John Iafrate, Eunice L. Kwak, Jeffrey W. Clark, Jill N. Allen, Lawrence S. Blaszkowsky, Janet E. Murphy, Supriya K. Saha, Theodore S. Hong, Jennifer Y. Wo, Cristina R. Ferrone, Kenneth K. Tanabe, Nabeel Bardeesy, Kimberly S. Straley, Sam Agresta, David P. Schenkein, Leif W. Ellisen, David P. Ryan, Andrew X. Zhu
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (7): 1884–1890.
https://doi.org/10.1158/1078-0432.CCR-13-2649
Published: 31 March 2014
View articletitled, Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma
Open the PDF for Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data