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Takuya Osada
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Journal Articles

Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Melinda L. Telli, Hiroshi Nagata, Irene Wapnir, Chaitanya R. Acharya, Kaitlin Zablotsky, Bernard A. Fox, Carlo B. Bifulco, Shawn M. Jensen, Carmen Ballesteros-Merino, Mai Hope Le, Robert H. Pierce, Erica Browning, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kim Jaffe, Jendy Sell, Kellie Malloy Foerter, David A. Canton, Christopher G. Twitty, Takuya Osada, H. Kim Lyerly, Erika J. Crosby
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (9): 2481–2493.
https://doi.org/10.1158/1078-0432.CCR-20-3944
Published: 01 May 2021
View article titled, Intratumoral Plasmid IL12 Expands CD8<sup>+</sup> T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy
Open the PDF for Intratumoral Plasmid IL12 Expands CD8<sup>+</sup> T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy in another window
Includes: Supplementary data
Journal Articles

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study

Erika J. Crosby, William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, Terry Hyslop, Sungjin Kim, Andre Rogatko, Veronica Lubkov, Joshua C. Snyder, Takuya Osada, Amy C. Hobeika, Michael A. Morse, H. Kim Lyerly, Zachary C. Hartman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (9): 2725–2736.
https://doi.org/10.1158/1078-0432.CCR-18-3102
Published: 01 May 2019
View article titled, Vaccine-Induced Memory CD8<sup>+</sup> T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study
Open the PDF for Vaccine-Induced Memory CD8<sup>+</sup> T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study in another window
Includes: Supplementary data
Journal Articles

Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy

H. Kim Lyerly, Takuya Osada, Zachary C. Hartman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 9–11.
https://doi.org/10.1158/1078-0432.CCR-18-2819
Published: 03 January 2019
View article titled, Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy
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Journal Articles

In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior

Takuya Osada, Kensuke Kaneko, William R. Gwin, Michael A. Morse, Amy Hobeika, Brian W. Pogue, Zachary C. Hartman, Philip F. Hughes, Timothy Haystead, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7531–7542.
https://doi.org/10.1158/1078-0432.CCR-17-1453
Published: 14 December 2017
View article titled, <em>In Vivo</em> Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior
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Includes: Supplementary data
Journal Articles

Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

Michael A. Morse, Robert Chapman, John Powderly, Kimberly Blackwell, Tibor Keler, Jennifer Green, Renee Riggs, Li-Zhen He, Venky Ramakrishna, Laura Vitale, Biwei Zhao, Stephen A. Butler, Amy Hobeika, Takuya Osada, Thomas Davis, Timothy Clay, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4844–4853.
https://doi.org/10.1158/1078-0432.CCR-11-0891
Published: 17 July 2011
View article titled, Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients
Open the PDF for Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients in another window
Includes: Supplementary data
Journal Articles

MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer

Michael A. Morse, Angeles A. Secord, Kimberly Blackwell, Amy C. Hobeika, Gomathinayagam Sinnathamby, Takuya Osada, Julie Hafner, Mohan Philip, Timothy M. Clay, H. Kim Lyerly, Ramila Philip
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3408–3419.
https://doi.org/10.1158/1078-0432.CCR-10-2614
Published: 15 May 2011
View article titled, MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer
Open the PDF for MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer in another window
Journal Articles

An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity

Zachary C. Hartman, Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei, Xiao-Yi Yang, Sharon Peplinski, Dong-Wan Kim, Wenle Xia, Neil Spector, Jeffrey Marks, William Barry, Amy Hobeika, Gayathri Devi, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1466–1477.
https://doi.org/10.1158/1078-0432.CCR-09-2549
Published: 28 February 2010
View article titled, An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity
Open the PDF for An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity in another window
Includes: Supplementary data
Journal Articles

Induction of Wilms' Tumor Protein (WT1)–Specific Antitumor Immunity Using a Truncated WT1-Expressing Adenovirus Vaccine

Takuya Osada, Christopher Y. Woo, Matthew McKinney, Xiao Yi Yang, Gangjun Lei, Heather G. LaBreche, Zachary C. Hartman, Donna Niedzwiecki, Nelson Chao, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2789–2796.
https://doi.org/10.1158/1078-0432.CCR-08-2589
Published: 15 April 2009
View article titled, Induction of Wilms' Tumor Protein (WT1)–Specific Antitumor Immunity Using a Truncated WT1-Expressing Adenovirus Vaccine
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Journal Articles

Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules

Michael A. Morse, Timothy M. Clay, Amy C. Hobeika, Takuya Osada, Shubi Khan, Stephen Chui, Donna Niedzwiecki, Dennis Panicali, Jeffrey Schlom, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (8): 3017–3024.
https://doi.org/10.1158/1078-0432.CCR-04-2172
Published: 18 April 2005
View article titled, Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules
Open the PDF for Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules in another window