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Susan G. Hilsenbeck
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Journal Articles

A Multiparameter Molecular Classifier to Predict Response to Neoadjuvant Lapatinib plus Trastuzumab without Chemotherapy in HER2+ Breast Cancer

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Jamunarani Veeraraghavan, Carolina Gutierrez, Carmine De Angelis, Robert Davis, Tao Wang, Tomas Pascual, Pier Selenica, Katherine Sanchez, Hiroaki Nitta, Monesh Kapadia, Anne C. Pavlick, Patricia Galvan, Brent Rexer, Andres Forero-Torres, Rita Nanda, Anna M. Storniolo, Ian E. Krop, Matthew P. Goetz, Julie R. Nangia, Antonio C. Wolff, Britta Weigelt, Jorge S. Reis-Filho, Susan G. Hilsenbeck, Aleix Prat, C. Kent Osborne, Rachel Schiff, Mothaffar F. Rimawi
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3101–3109.
https://doi.org/10.1158/1078-0432.CCR-22-3753
Published: 15 August 2023
View articletitled, A Multiparameter Molecular Classifier to Predict Response to Neoadjuvant Lapatinib plus Trastuzumab without Chemotherapy in HER2+ Breast Cancer
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Includes: Supplementary data
Journal Articles

A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop

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Daniel D. Von Hoff, Gary M. Clark, Charles A. Coltman, Mary L. Disis, S.G. Eckhardt, Lee M. Ellis, Margaret Foti, Elizabeth Garrett-Mayer, Mithat Gönen, Manuel Hidalgo, Susan G. Hilsenbeck, John H. Littlefield, Patricia M. LoRusso, H. Kim Lyerly, Neal J. Meropol, Jyoti D. Patel, Steven Piantadosi, Dean A. Post, Meredith M. Regan, Yu Shyr, Margaret A. Tempero, Joel E. Tepper, Jamie Von Roenn, Louis M. Weiner, Donn C. Young, Nu V. Vu
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5472–5481.
https://doi.org/10.1158/1078-0432.CCR-21-1799
Published: 15 October 2021
View articletitled, A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop
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Includes: Supplementary data
Journal Articles

Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

Free
Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, Agostina Nardone, Resel Pereira, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Tao Wang, Susan G. Hilsenbeck, Matteo Benelli, Ilenia Migliaccio, Cristina Guarducci, Luca Malorni, Lacey M. Litchfield, Jiangang Liu, Joshua Donaldson, Pier Selenica, David N. Brown, Britta Weigelt, Jorge S. Reis-Filho, Ben H. Park, Sara A. Hurvitz, Dennis J. Slamon, Mothaffar F. Rimawi, Valerie M. Jansen, Rinath Jeselsohn, C. Kent Osborne, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4939.
https://doi.org/10.1158/1078-0432.CCR-21-2431
Published: 01 September 2021
View articletitled, Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer
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Journal Articles

Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

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Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, Agostina Nardone, Resel Pereira, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Tao Wang, Susan G. Hilsenbeck, Matteo Benelli, Ilenia Migliaccio, Cristina Guarducci, Luca Malorni, Lacey M. Litchfield, Jiangang Liu, Joshua Donaldson, Pier Selenica, David N. Brown, Britta Weigelt, Jorge S. Reis-Filho, Ben H. Park, Sara A. Hurvitz, Dennis J. Slamon, Mothaffar F. Rimawi, Valerie M. Jansen, Rinath Jeselsohn, C. Kent Osborne, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4870–4882.
https://doi.org/10.1158/1078-0432.CCR-19-4191
Published: 01 September 2021
View articletitled, Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer
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Includes: Supplementary data
Journal Articles

Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer

Free
Xian Wang, Jamunarani Veeraraghavan, Chia-Chia Liu, Xixi Cao, Lanfang Qin, Jin-Ah Kim, Ying Tan, Suet Kee Loo, Yiheng Hu, Ling Lin, Sanghoon Lee, Martin J. Shea, Tamika Mitchell, Shunqiang Li, Matthew J. Ellis, Susan G. Hilsenbeck, Rachel Schiff, Xiao-Song Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2648–2662.
https://doi.org/10.1158/1078-0432.CCR-20-2961
Published: 01 May 2021
View articletitled, Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer
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Includes: Supplementary data
Journal Articles

TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer

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Mothaffar F. Rimawi, Polly Niravath, Tao Wang, Brent N. Rexer, Andres Forero, Antonio C. Wolff, Rita Nanda, Anna M. Storniolo, Ian Krop, Matthew P. Goetz, Julie R. Nangia, Sao Jiralerspong, Anne Pavlick, Jamunarani Veeraraghavan, Carmine De Angelis, Carolina Gutierrez, Rachel Schiff, Susan G. Hilsenbeck, C. Kent Osborne
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 821–827.
https://doi.org/10.1158/1078-0432.CCR-19-0851
Published: 14 February 2020
View articletitled, TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer
Open the PDF for TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy

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Carmine De Angelis, Chandandeep Nagi, Cliff C. Hoyt, Linying Liu, Kristin Roman, Chichung Wang, Yi Zheng, Jamunarani Veeraraghavan, Vidyalakshmi Sethunath, Paolo Nuciforo, Tao Wang, Anna Tsimelzon, Sufeng Mao, Susan G. Hilsenbeck, Meghana V. Trivedi, Maria Letizia Cataldo, Anne Pavlick, Antonio C. Wolff, Britta Weigelt, Jorge S. Reis-Filho, Aleix Prat, Carolina Gutierrez, Charles Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 738–745.
https://doi.org/10.1158/1078-0432.CCR-19-1402
Published: 03 February 2020
View articletitled, Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy
Open the PDF for Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy in another window
Includes: Supplementary data
Journal Articles

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

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Xiaowei Xu, Carmine De Angelis, Kathleen A. Burke, Agostina Nardone, Huizhong Hu, Lanfang Qin, Jamunarani Veeraraghavan, Vidyalakshmi Sethunath, Laura M. Heiser, Nicholas Wang, Charlotte K.Y. Ng, Edward S. Chen, Alexander Renwick, Tao Wang, Sarmistha Nanda, Martin Shea, Tamika Mitchell, Mahitha Rajendran, Ian Waters, Daniel J. Zabransky, Kenneth L. Scott, Carolina Gutierrez, Chandandeep Nagi, Felipe C. Geyer, Gary C. Chamness, Ben H. Park, Chad A. Shaw, Susan G. Hilsenbeck, Mothaffar F. Rimawi, Joe W. Gray, Britta Weigelt, Jorge S. Reis-Filho, C. Kent Osborne, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5123–5134.
https://doi.org/10.1158/1078-0432.CCR-16-2191
Published: 31 August 2017
View articletitled, HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer
Open the PDF for HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials

Free
Ying Yuan, Kenneth R. Hess, Susan G. Hilsenbeck, Mark R. Gilbert
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4291–4301.
https://doi.org/10.1158/1078-0432.CCR-16-0592
Published: 31 August 2016
View articletitled, Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials
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Includes: Supplementary data
Journal Articles

Abstract B04: Identification of molecular predictors of differential chemotherapy response using patient-derived xenografts

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Michael T. Lewis, Lacey E. Dobrolecki, Susan G. Hilsenbeck, Lukas M. Simon, Chad A. Shaw
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): B04.
https://doi.org/10.1158/1557-3265.PDX16-B04
Published: 15 August 2016
View articletitled, Abstract B04: Identification of molecular predictors of differential chemotherapy response using patient-derived xenografts
Journal Articles

Abstract 04: Impact of whole exome sequencing results on clinical decision making for pediatric solid tumor patients in the hypothetical scenario of tumor relapse: A survey of pediatric oncologists

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Abhishek Bavle, Tao Wang, Frank Y. Lin, Angshumoy Roy, Robin A. Kerstein, Sarah Scollon, Katie Bergstrom, Stephanie Gutierrez, Uma Ramamurthy, Yaping Yang, Christine M. Eng, Richard A. Gibbs, Murali M. Chintagumpala, Susan G. Hilsenbeck, Sharon E. Plon, Stacey L. Berg, D. Williams Parsons.
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): 04.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-04
Published: 03 January 2016
View articletitled, Abstract 04: Impact of whole exome sequencing results on clinical decision making for pediatric solid tumor patients in the hypothetical scenario of tumor relapse: A survey of pediatric oncologists
Journal Articles

Abstract IA16: Clinical genomics for children with solid tumors: Current realities and future opportunities

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D. William Parsons, Angshumoy Roy, Yaping Yang, Tao Wang, Sarah Scollon, Katie Bergstrom, Robin A. Kerstein, Stephanie Gutierrez, Abhishek Bavle, Frank Y. Lin, Dolores H. López-Terrada, Federico A. Monzon, Jed G. Nuchtern, Uma Ramamurthy, Amy L. McGuire, Susan G. Hilsenbeck, Jeffrey G. Reid, Donna M. Muzny, David A. Wheeler, Stacey L. Berg, Murali M. Chintagumpala, Christine M. Eng, Richard A. Gibbs, Sharon E. Plon
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): IA16.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-IA16
Published: 03 January 2016
View articletitled, Abstract IA16: Clinical genomics for children with solid tumors: Current realities and future opportunities
Journal Articles

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy

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Mario Giuliano, Huizhong Hu, Yen-Chao Wang, Xiaoyong Fu, Agostina Nardone, Sabrina Herrera, Sufeng Mao, Alejandro Contreras, Carolina Gutierrez, Tao Wang, Susan G. Hilsenbeck, Carmine De Angelis, Nicholas J. Wang, Laura M. Heiser, Joe W. Gray, Sara Lopez-Tarruella, Anne C. Pavlick, Meghana V. Trivedi, Gary C. Chamness, Jenny C. Chang, C. Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17): 3995–4003.
https://doi.org/10.1158/1078-0432.CCR-14-2728
Published: 31 August 2015
View articletitled, Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy
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Includes: Supplementary data
Journal Articles

Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

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Matthew D. Burstein, Anna Tsimelzon, Graham M. Poage, Kyle R. Covington, Alejandro Contreras, Suzanne A.W. Fuqua, Michelle I Savage, C. Kent Osborne, Susan G. Hilsenbeck, Jenny C. Chang, Gordon B. Mills, Ching C. Lau, Powel H. Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1688–1698.
https://doi.org/10.1158/1078-0432.CCR-14-0432
Published: 31 March 2015
View articletitled, Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

AACR Cancer Progress Report 2014

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Carlos L. Arteaga, Peter C. Adamson, Jeffrey A. Engelman, Margaret Foti, Richard B. Gaynor, Susan G. Hilsenbeck, Paul J. Limburg, Scott W. Lowe, Elaine R. Mardis, Scott Ramsey, Timothy R. Rebbeck, Andrea L. Richardson, Eric H. Rubin, George J. Weiner
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19_Supplement): S1–S112.
https://doi.org/10.1158/1078-0432.CCR-14-2123
Published: 01 October 2014
View articletitled, AACR Cancer Progress Report 2014
Open the PDF for AACR Cancer Progress Report 2014 in another window
Includes: Supplementary data
Journal Articles

Progesterone Receptor Isoform-Specific Promoter Methylation: Association of PRA Promoter Methylation with Worse Outcome in Breast Cancer Patients

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Thushangi N. Pathiraja, Priya B. Shetty, Jaroslav Jelinek, Rong He, Ryan Hartmaier, Astrid L. Margossian, Susan G. Hilsenbeck, Jean-Pierre J. Issa, Steffi Oesterreich
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4177–4186.
https://doi.org/10.1158/1078-0432.CCR-10-2950
Published: 15 June 2011
View articletitled, Progesterone Receptor Isoform-Specific Promoter Methylation: Association of PRA Promoter Methylation with Worse Outcome in Breast Cancer Patients
Open the PDF for Progesterone Receptor Isoform-Specific Promoter Methylation: Association of PRA Promoter Methylation with Worse Outcome in Breast Cancer Patients in another window
Includes: Supplementary data
Journal Articles

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy

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Beate C. Litzenburger, Chad J. Creighton, Anna Tsimelzon, Bonita T. Chan, Susan G. Hilsenbeck, Tao Wang, Joan M. Carboni, Marco M. Gottardis, Fei Huang, Jenny C. Chang, Michael T. Lewis, Mothaffar F. Rimawi, Adrian V. Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2314–2327.
https://doi.org/10.1158/1078-0432.CCR-10-1903
Published: 14 April 2011
View articletitled, High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy
Open the PDF for High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy in another window
Includes: Supplementary data
Journal Articles

Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts

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Mothaffar F. Rimawi, Lisa S. Wiechmann, Yen-Chao Wang, Catherine Huang, Ilenia Migliaccio, Meng-Fen Wu, Carolina Gutierrez, Susan G. Hilsenbeck, Grazia Arpino, Suleiman Massarweh, Robin Ward, Robert Soliz, C. Kent Osborne, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1351–1361.
https://doi.org/10.1158/1078-0432.CCR-10-1905
Published: 15 March 2011
View articletitled, Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts
Open the PDF for Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts in another window
Journal Articles

The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice

Free
Yuxin Li, Yun Zhang, Jamal Hill, Qiang Shen, Hee-Tae Kim, Xiaochun Xu, Susan G. Hilsenbeck, Reid P. Bissonnette, William W. Lamph, Powel H. Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6224–6231.
https://doi.org/10.1158/1078-0432.CCR-06-2681
Published: 18 October 2007
View articletitled, The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice
Open the PDF for The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice in another window
Journal Articles

Association between the Estrogen Receptor α A908G Mutation and Outcomes in Invasive Breast Cancer

Free
Matthew H. Herynk, Irma Parra, Yukun Cui, Amanda Beyer, Meng-Fen Wu, Susan G. Hilsenbeck, Suzanne A.W. Fuqua
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (11): 3235–3243.
https://doi.org/10.1158/1078-0432.CCR-06-2608
Published: 01 June 2007
View articletitled, Association between the Estrogen Receptor α A908G Mutation and Outcomes in Invasive Breast Cancer
Open the PDF for Association between the Estrogen Receptor α A908G Mutation and Outcomes in Invasive Breast Cancer in another window