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Susan E. Critchlow
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Journal Articles

Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1

Anna D. Staniszewska, Domenic Pilger, Sonja J. Gill, Kunzah Jamal, Natacha Bohin, Sofia Guzzetti, Jacob Gordon, Gregory Hamm, Gill Mundin, Giuditta Illuzzi, Andy Pike, Lisa McWilliams, Gareth Maglennon, Jonathan Rose, Glen Hawthorne, Miguel Cortes Gonzalez, Christer Halldin, Peter Johnström, Magnus Schou, Susan E. Critchlow, Stephen Fawell, Jeffrey W. Johannes, Elisabetta Leo, Barry R. Davies, Sabina Cosulich, Jann N. Sarkaria, Mark J. O'Connor, Petra Hamerlik
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (7): 1338–1351.
https://doi.org/10.1158/1078-0432.CCR-23-2094
Published: 01 April 2024
View article titled, Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1
Open the PDF for Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1 in another window
Includes: Supplementary data
Journal Articles

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Giuditta Illuzzi, Anna D. Staniszewska, Sonja J. Gill, Andy Pike, Lisa McWilliams, Susan E. Critchlow, Anna Cronin, Stephen Fawell, Glen Hawthorne, Kunzah Jamal, Jeffrey Johannes, Emilyanne Leonard, Ruth Macdonald, Gareth Maglennon, Jenni Nikkilä, Mark J. O'Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James Yates, Sabina Cosulich, Elisabetta Leo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4724–4736.
https://doi.org/10.1158/1078-0432.CCR-22-0301
Published: 01 November 2022
View article titled, Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Open the PDF for Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper in another window
Includes: Supplementary data
Journal Articles

Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors

James T. Lynch, Urszula M. Polanska, Oona Delpuech, Urs Hancox, Antonio G. Trinidad, Filippos Michopoulos, Carol Lenaghan, Robert McEwen, James Bradford, Radek Polanski, Rebecca Ellston, Alvaro Avivar-Valderas, James Pilling, Anna Staniszewska, Marie Cumberbatch, Susan E. Critchlow, Francisco Cruzalegui, Simon T. Barry
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (24): 7584–7595.
https://doi.org/10.1158/1078-0432.CCR-17-0676
Published: 14 December 2017
View article titled, Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors
Open the PDF for Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors in another window
Includes: Supplementary data
Journal Articles

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

Radosław Polański, Cassandra L. Hodgkinson, Alberto Fusi, Daisuke Nonaka, Lynsey Priest, Paul Kelly, Francesca Trapani, Paul W. Bishop, Anne White, Susan E. Critchlow, Paul D. Smith, Fiona Blackhall, Caroline Dive, Christopher J. Morrow
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 926–937.
https://doi.org/10.1158/1078-0432.CCR-13-2270
Published: 16 February 2014
View article titled, Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
Open the PDF for Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer in another window
Includes: Supplementary data