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Stephen L. Lessnick
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Journal Articles

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner

Matt L. Harlow, Maggie H. Chasse, Elissa A. Boguslawski, Katie M. Sorensen, Jenna M. Gedminas, Susan M. Kitchen-Goosen, Scott B. Rothbart, Cenny Taslim, Stephen L. Lessnick, Anderson S. Peck, Zachary B. Madaj, Megan J. Bowman, Patrick J. Grohar
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (11): 3417–3429.
https://doi.org/10.1158/1078-0432.CCR-18-3511
Published: 03 June 2019
View article titled, Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner
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Includes: Supplementary data
Journal Articles

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor

Christy L. Osgood, Nichole Maloney, Christopher G. Kidd, Susan Kitchen-Goosen, Laura Segars, Meti Gebregiorgis, Girma M. Woldemichael, Min He, Savita Sankar, Stephen L. Lessnick, Min Kang, Malcolm Smith, Lisa Turner, Zachary B. Madaj, Mary E. Winn, Luz-Elena Núñez, Javier González-Sabín, Lee J. Helman, Francisco Morís, Patrick J. Grohar
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4105–4118.
https://doi.org/10.1158/1078-0432.CCR-15-2624
Published: 14 August 2016
View article titled, Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor
Open the PDF for Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor in another window
Includes: Supplementary data
Journal Articles

Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group

Kieuhoa T. Vo, Jeremy V. Edwards, C. Lorrie Epling, Elizabeth Sinclair, Douglas S. Hawkins, Holcombe E. Grier, Katherine A. Janeway, Phillip Barnette, Elizabeth McIlvaine, Mark D. Krailo, Donald A. Barkauskas, Katherine K. Matthay, Richard B. Womer, Richard G. Gorlick, Stephen L. Lessnick, Crystal L. Mackall, Steven G. DuBois
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (14): 3643–3650.
https://doi.org/10.1158/1078-0432.CCR-15-2516
Published: 14 July 2016
View article titled, Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group
Open the PDF for Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group in another window
Includes: Supplementary data
Journal Articles

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

Savita Sankar, Emily R. Theisen, Jared Bearss, Timothy Mulvihill, Laura M. Hoffman, Venkataswamy Sorna, Mary C. Beckerle, Sunil Sharma, Stephen L. Lessnick
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (17): 4584–4597.
https://doi.org/10.1158/1078-0432.CCR-14-0072
Published: 01 September 2014
View article titled, Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth
Open the PDF for Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth in another window
Includes: Supplementary data
Journal Articles

EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors

Christopher H. Evans, Fangjun Liu, Ryan M. Porter, Regina P. O'Sullivan, Taha Merghoub, Elaine P. Lunsford, Kyle Robichaud, Frans Van Valen, Stephen L. Lessnick, Mark C. Gebhardt, James W. Wells
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5341–5351.
https://doi.org/10.1158/1078-0432.CCR-12-1985
Published: 30 September 2012
View article titled, EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors
Open the PDF for EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors in another window
Includes: Supplementary data