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Stephen Fawell
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Journal Articles

Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1

Anna D. Staniszewska, Domenic Pilger, Sonja J. Gill, Kunzah Jamal, Natacha Bohin, Sofia Guzzetti, Jacob Gordon, Gregory Hamm, Gill Mundin, Giuditta Illuzzi, Andy Pike, Lisa McWilliams, Gareth Maglennon, Jonathan Rose, Glen Hawthorne, Miguel Cortes Gonzalez, Christer Halldin, Peter Johnström, Magnus Schou, Susan E. Critchlow, Stephen Fawell, Jeffrey W. Johannes, Elisabetta Leo, Barry R. Davies, Sabina Cosulich, Jann N. Sarkaria, Mark J. O'Connor, Petra Hamerlik
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (7): 1338–1351.
https://doi.org/10.1158/1078-0432.CCR-23-2094
Published: 01 April 2024
View article titled, Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1
Open the PDF for Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1 in another window
Includes: Supplementary data
Journal Articles

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Giuditta Illuzzi, Anna D. Staniszewska, Sonja J. Gill, Andy Pike, Lisa McWilliams, Susan E. Critchlow, Anna Cronin, Stephen Fawell, Glen Hawthorne, Kunzah Jamal, Jeffrey Johannes, Emilyanne Leonard, Ruth Macdonald, Gareth Maglennon, Jenni Nikkilä, Mark J. O'Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James Yates, Sabina Cosulich, Elisabetta Leo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4724–4736.
https://doi.org/10.1158/1078-0432.CCR-22-0301
Published: 01 November 2022
View article titled, Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Open the PDF for Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper in another window
Includes: Supplementary data
Journal Articles

STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1

Theresa A. Proia, Maneesh Singh, Richard Woessner, Larissa Carnevalli, Gayathri Bommakanti, Lukasz Magiera, Srimathi Srinivasan, Shaun Grosskurth, Mike Collins, Chris Womack, Matthew Griffin, Minwei Ye, Susan Cantin, Deanna Russell, Mingchao Xie, Adina Hughes, Nanhua Deng, Deanna A. Mele, Stephen Fawell, Simon Barry, Corinne Reimer, J. Carl Barrett, Patricia McCoon
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6335–6349.
https://doi.org/10.1158/1078-0432.CCR-20-1066
Published: 01 December 2020
View article titled, <em>STAT3</em> Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1
Open the PDF for <em>STAT3</em> Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1 in another window
Includes: Supplementary data